ATE551340T1 - Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheiten - Google Patents
Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheitenInfo
- Publication number
- ATE551340T1 ATE551340T1 AT02778286T AT02778286T ATE551340T1 AT E551340 T1 ATE551340 T1 AT E551340T1 AT 02778286 T AT02778286 T AT 02778286T AT 02778286 T AT02778286 T AT 02778286T AT E551340 T1 ATE551340 T1 AT E551340T1
- Authority
- AT
- Austria
- Prior art keywords
- annated
- azabicyclic
- diseases
- substituted
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32656501P | 2001-10-02 | 2001-10-02 | |
| US32662901P | 2001-10-02 | 2001-10-02 | |
| US33488601P | 2001-11-15 | 2001-11-15 | |
| US33963301P | 2001-12-12 | 2001-12-12 | |
| PCT/US2002/029827 WO2003029252A1 (en) | 2001-10-02 | 2002-10-01 | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE551340T1 true ATE551340T1 (de) | 2012-04-15 |
Family
ID=27502335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02778286T ATE551340T1 (de) | 2001-10-02 | 2002-10-01 | Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheiten |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US6911543B2 (de) |
| EP (1) | EP1432707B1 (de) |
| JP (1) | JP4371811B2 (de) |
| KR (1) | KR100614900B1 (de) |
| AP (1) | AP1635A (de) |
| AR (1) | AR037740A1 (de) |
| AT (1) | ATE551340T1 (de) |
| BG (1) | BG108650A (de) |
| BR (1) | BR0213612A (de) |
| CA (1) | CA2462453C (de) |
| CO (1) | CO5570667A2 (de) |
| CZ (1) | CZ2004408A3 (de) |
| DK (1) | DK1432707T3 (de) |
| EA (1) | EA007429B1 (de) |
| ES (1) | ES2383001T3 (de) |
| GE (1) | GEP20063814B (de) |
| HR (1) | HRP20040259A2 (de) |
| HU (1) | HUP0402289A2 (de) |
| IL (1) | IL160884A0 (de) |
| IS (1) | IS7188A (de) |
| MA (1) | MA27138A1 (de) |
| MX (1) | MXPA04003007A (de) |
| MY (1) | MY138252A (de) |
| NO (1) | NO20041368L (de) |
| NZ (1) | NZ531786A (de) |
| OA (1) | OA12708A (de) |
| PL (1) | PL369895A1 (de) |
| RS (1) | RS28004A (de) |
| SK (1) | SK1562004A3 (de) |
| TN (1) | TNSN04052A1 (de) |
| WO (1) | WO2003029252A1 (de) |
Families Citing this family (53)
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|---|---|---|---|---|
| AR036040A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| BR0312446A (pt) | 2002-06-10 | 2005-04-19 | Bayer Healthcare Ag | 2-heteroaril carboxamidas |
| WO2004013137A1 (en) * | 2002-08-01 | 2004-02-12 | Pharmacia & Upjohn Company Llc | 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity |
| SK288115B6 (sk) | 2002-09-25 | 2013-09-03 | Memory Pharmaceuticals Corporation | Indazoles, pharmaceutical compositions comprising them and their use |
| BR0315056A (pt) * | 2002-11-01 | 2005-08-16 | Pharmacia & Upjohn Co Llc | Compostos tendo tanto atividade agonista nicotìnica de alfa7 quanto atividade antagonista de 5ht3 para o tratamento de doenças do sistema nervoso central |
| WO2004039366A1 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
| US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| CN1735414A (zh) * | 2002-12-06 | 2006-02-15 | 北岸长岛犹太人研究学院 | 用α7受体结合类胆碱激动剂抑制炎症 |
| BRPI0417520A (pt) | 2003-12-11 | 2007-03-06 | Aventis Pharma Inc | 1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon |
| DK1697378T3 (da) | 2003-12-22 | 2008-03-17 | Memory Pharm Corp | Indoler, 1H-indazoler, 1,2-benzisoxazoler og 1,2-benzisothiazoler og fremstilling og anvendelser deraf |
| JP2007516275A (ja) * | 2003-12-23 | 2007-06-21 | ファイザー・プロダクツ・インク | 認知増強および精神病性障害のための治療的組合せ |
| JP4995075B2 (ja) | 2004-03-25 | 2012-08-08 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール、ベンゾチアゾール、ベンゾイソチアゾール、ベンズイソキサゾール、ならびにそれらの調製および使用 |
| JP2007534692A (ja) * | 2004-04-22 | 2007-11-29 | メモリー・ファーマシューティカルズ・コーポレイション | インドール、１ｈ−インダゾール、１，２−ベンズイソキサゾール、１，２−ベンゾイソチアゾール、ならびにその調製および使用 |
| EP1744750A2 (de) * | 2004-05-06 | 2007-01-24 | Sandoz AG | Pharmazeutische zusammensetzung mit wasserabweisendem wirkstoff mit erhöhter löslichkeit |
| US7632831B2 (en) * | 2004-05-07 | 2009-12-15 | Memory Pharmaceuticals Corporation | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
| DE602005019094D1 (de) | 2004-12-22 | 2010-03-11 | Memory Pharmaceutical Corp | Nikotinische alpha-7-rezeptorliganden gegen erkrankungen des zns |
| CA2601509A1 (en) * | 2005-03-18 | 2006-09-28 | Abbott Laboratories | Alpha7 neuronal nicotinic receptor ligand and antipsychotic compositions |
| FR2884822B1 (fr) * | 2005-04-22 | 2007-06-29 | Aventis Pharma Sa | Derives de triazines, leur preparation et leur application en therapeutique |
| KR20080052630A (ko) * | 2005-09-01 | 2008-06-11 | 어레이 바이오파마 인크. | Ｒａｆ 억제제 화합물 및 그의 사용 방법 |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| RU2010107462A (ru) * | 2007-08-02 | 2011-09-10 | Таргасепт, Инк. (Us) | ЛЕЧЕНИЕ α7-СЕЛЕКТИВНЫМИ ЛИГАНДАМИ |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| HUE037938T2 (hu) | 2008-11-19 | 2018-09-28 | Forum Pharmaceuticals Inc | Skizofrénia negatív tüneteinek kezelése (R)-7-klór-N-(kinuklidin-3-il)benzo[b]tiofén-2-karboxamiddal és ennek gyógyszerészetileg elfogadható sójával |
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| RU2011150248A (ru) * | 2009-05-11 | 2013-06-20 | Энвиво Фармасьютикалз, Инк. | Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы |
| WO2011022692A2 (en) * | 2009-08-20 | 2011-02-24 | University Of Tennessee Research Foundation, The | Furanopyridine cannabinoid compounds and related methods of use |
| US9062042B2 (en) * | 2010-01-11 | 2015-06-23 | Astraea Therapeutics, Llc | Nicotinic acetylcholine receptor modulators |
| GB201002563D0 (en) | 2010-02-15 | 2010-03-31 | Cambridge Entpr Ltd | Compounds |
| PT3029039T (pt) | 2010-05-17 | 2017-11-28 | Forum Pharmaceuticals Inc | Formulações farmacêuticas que compreendem formas cristalinas de cloridrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo(b)tiofeno-2-carboxamida mono-hidratado |
| KR20140027939A (ko) | 2011-06-30 | 2014-03-07 | 도레이 카부시키가이샤 | 지양제 |
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| CN105121439A (zh) | 2013-02-19 | 2015-12-02 | 辉瑞公司 | 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物 |
| RS59007B1 (sr) | 2014-02-03 | 2019-08-30 | Vitae Pharmaceuticals Llc | Dihidropirolopiridinski inhibitori ror-gama |
| JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
| PE20170295A1 (es) | 2014-08-06 | 2017-03-30 | Pfizer | Compuestos de imidazopiridazina |
| SI3207043T1 (sl) | 2014-10-14 | 2019-04-30 | Vitae Pharmaceuticals, Inc. | Dihidropirolopiridinovi inhibitorji za ROR-gama |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| JP6612874B2 (ja) | 2014-12-16 | 2019-11-27 | アクソファント サイエンシーズ ゲーエムベーハー | α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換キヌクリジンアミド化合物 |
| RU2017145964A (ru) * | 2015-06-10 | 2019-07-10 | Аксовант Сайенсиз Гмбх | Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов |
| US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
| JP2018523707A (ja) | 2015-08-12 | 2018-08-23 | アクソバント サイエンシズ ゲーエムベーハー | α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物 |
| EP3868750A1 (de) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals, LLC | Modulatoren von ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| BR112018016689A2 (pt) | 2016-02-16 | 2019-02-12 | Univ Vanderbilt | moduladores alostéricos positivos do receptor muscarínico de acetilcolina m1 |
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-
2002
- 2002-10-01 BR BR0213612-0A patent/BR0213612A/pt not_active IP Right Cessation
- 2002-10-01 AP APAP/P/2004/003002A patent/AP1635A/en active
- 2002-10-01 DK DK02778286.1T patent/DK1432707T3/da active
- 2002-10-01 CZ CZ2004408A patent/CZ2004408A3/cs unknown
- 2002-10-01 CA CA002462453A patent/CA2462453C/en not_active Expired - Fee Related
- 2002-10-01 IL IL16088402A patent/IL160884A0/xx unknown
- 2002-10-01 SK SK156-2004A patent/SK1562004A3/sk unknown
- 2002-10-01 US US10/262,257 patent/US6911543B2/en not_active Expired - Fee Related
- 2002-10-01 PL PL02369895A patent/PL369895A1/xx not_active Application Discontinuation
- 2002-10-01 MX MXPA04003007A patent/MXPA04003007A/es unknown
- 2002-10-01 NZ NZ531786A patent/NZ531786A/en unknown
- 2002-10-01 OA OA1200400087A patent/OA12708A/en unknown
- 2002-10-01 WO PCT/US2002/029827 patent/WO2003029252A1/en active Application Filing
- 2002-10-01 EP EP02778286A patent/EP1432707B1/de not_active Expired - Lifetime
- 2002-10-01 JP JP2003532500A patent/JP4371811B2/ja not_active Expired - Fee Related
- 2002-10-01 HU HU0402289A patent/HUP0402289A2/hu unknown
- 2002-10-01 EA EA200400387A patent/EA007429B1/ru unknown
- 2002-10-01 KR KR1020047004871A patent/KR100614900B1/ko not_active IP Right Cessation
- 2002-10-01 GE GE5551A patent/GEP20063814B/en unknown
- 2002-10-01 AT AT02778286T patent/ATE551340T1/de active
- 2002-10-01 ES ES02778286T patent/ES2383001T3/es not_active Expired - Lifetime
- 2002-10-01 RS YUP-280/04A patent/RS28004A/sr unknown
- 2002-10-02 AR ARP020103718A patent/AR037740A1/es unknown
- 2002-10-02 MY MYPI20023689A patent/MY138252A/en unknown
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2004
- 2004-03-17 HR HR20040259A patent/HRP20040259A2/hr not_active Application Discontinuation
- 2004-03-18 IS IS7188A patent/IS7188A/is unknown
- 2004-03-24 BG BG108650A patent/BG108650A/xx unknown
- 2004-03-30 CO CO04030193A patent/CO5570667A2/es not_active Application Discontinuation
- 2004-04-01 NO NO20041368A patent/NO20041368L/no not_active Application Discontinuation
- 2004-04-01 MA MA27603A patent/MA27138A1/fr unknown
- 2004-04-01 TN TNP2004000052A patent/TNSN04052A1/fr unknown
-
2005
- 2005-05-26 US US11/139,066 patent/US20050234092A1/en not_active Abandoned
- 2005-05-26 US US11/137,912 patent/US20050222196A1/en not_active Abandoned
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