ATE410430T1 - 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose - Google Patents

2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose

Info

Publication number
ATE410430T1
ATE410430T1 AT04793412T AT04793412T ATE410430T1 AT E410430 T1 ATE410430 T1 AT E410430T1 AT 04793412 T AT04793412 T AT 04793412T AT 04793412 T AT04793412 T AT 04793412T AT E410430 T1 ATE410430 T1 AT E410430T1
Authority
AT
Austria
Prior art keywords
buoxazole
tuberculosis
dihydro
compounds
treatment
Prior art date
Application number
AT04793412T
Other languages
English (en)
Inventor
Hidetsugu Tsubouchi
Hirofumi Sasaki
Motohiro Itotani
Yoshikazu Haraguchi
Shin Miyamura
Makoto Matsumoto
Hiroyuki Hashizume
Tatsuo Tomishige
Masanori Kawasaki
Kinue Ohguro
Takumi Sumida
Takeshi Hasegawa
Kazuho Tanaka
Isao Takemura
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of ATE410430T1 publication Critical patent/ATE410430T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04793412T 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose ATE410430T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003373206 2003-10-31
JP2004111720 2004-04-06

Publications (1)

Publication Number Publication Date
ATE410430T1 true ATE410430T1 (de) 2008-10-15

Family

ID=34554779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04793412T ATE410430T1 (de) 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose

Country Status (19)

Country Link
US (1) US8163753B2 (de)
EP (1) EP1678185B1 (de)
KR (1) KR100851802B1 (de)
AR (1) AR046777A1 (de)
AT (1) ATE410430T1 (de)
AU (1) AU2004285811B2 (de)
BR (1) BRPI0414909A (de)
CA (1) CA2539335A1 (de)
CY (1) CY1108481T1 (de)
DE (1) DE602004017037D1 (de)
DK (1) DK1678185T3 (de)
ES (1) ES2314460T3 (de)
MY (1) MY146646A (de)
PL (1) PL1678185T3 (de)
PT (1) PT1678185E (de)
RU (1) RU2365593C2 (de)
SI (1) SI1678185T1 (de)
TW (1) TWI335331B (de)
WO (1) WO2005042542A1 (de)

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ATE410430T1 (de) * 2003-10-31 2008-10-15 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose
MX2007004661A (es) 2004-10-18 2007-06-22 Lilly Co Eli Derivados de 1-(hetero)aril-3-amino-pirrolidina para usarse como antagonistas del receptor mglur3.
WO2006125181A2 (en) * 2005-05-19 2006-11-23 Xenon Pharmaceuticals Inc. Piperidine derivatives and their use as stearoyl-coa desaturase modulators
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
EP1906926B1 (de) * 2005-07-28 2010-12-01 Otsuka Pharmaceutical Co., Ltd. Pharmazeutische zusammensetzung mit 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolderivaten
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
JP5105818B2 (ja) * 2005-10-05 2012-12-26 大塚製薬株式会社 医薬組成物
TWI368509B (en) * 2005-10-05 2012-07-21 Otsuka Pharma Co Ltd Antituberculous therapeutic drugs and kit containing the same
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US20080275035A1 (en) * 2005-12-23 2008-11-06 Jan Jiricek Nitroimidazole Compounds
CA2651700A1 (en) * 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US7678791B2 (en) 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
AR070301A1 (es) 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
JP5613656B2 (ja) * 2008-03-26 2014-10-29 グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
ES2530266T3 (es) * 2009-07-31 2015-02-27 Global Alliance For Tb Drug Development Análogos de nitroimidazooxazina y sus usos
CN103596960B (zh) 2011-04-15 2016-11-16 大塚制药株式会社 6,7-二氢咪唑并[2,1-b][1,3]噁嗪杀菌剂
KR20130083592A (ko) * 2012-01-13 2013-07-23 현대약품 주식회사 치환된 피페리딘 유도체 및 이의 제조방법
KR101650716B1 (ko) * 2012-11-22 2016-08-24 한국화학연구원 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
IN2013DE02954A (de) * 2013-10-04 2015-04-10 Council Scient Ind Res
KR102582563B1 (ko) * 2014-06-20 2023-09-25 재단법인 한국파스퇴르연구소 항감염 화합물
EP2974729A1 (de) 2014-07-17 2016-01-20 Abivax Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten
AR101704A1 (es) * 2014-08-28 2017-01-04 Otsuka Pharma Co Ltd Compuestos heterocíclicos fusionados
EP3201266B1 (de) * 2014-10-01 2019-12-11 Henkel IP & Holding GmbH Härtungsbeschleuniger für anaerobe härtbare zusammensetzungen
CN107108650B (zh) 2014-10-21 2019-10-18 印度科学工业研究所 抗分枝杆菌剂取代的1,2,3-三唑-1-基-甲基-2,3-二氢-2-甲基-6-硝基咪唑并[2,1-b]噁唑及其制备方法
MX2017009810A (es) * 2015-01-29 2018-11-09 Medshine Discovery Inc Derivado de nitroimidazol contra tuberculosis pulmonar.
EP3421454B9 (de) * 2016-02-26 2023-08-09 Otsuka Pharmaceutical Co., Ltd. Piperidinderivate
WO2018112842A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
KR102887592B1 (ko) 2018-06-11 2025-11-18 오츠카 세이야쿠 가부시키가이샤 델라마니드 함유 조성물
EP3669873A1 (de) 2018-12-20 2020-06-24 Abivax Chinolinderivate zur verwendung bei der behandlung von entzündlichen krankheiten
CN112300192B (zh) * 2019-08-02 2023-08-11 南京长澳医药科技有限公司 硝基咪唑类化合物及其制备方法和用途

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EP0294176A3 (de) 1987-06-02 1989-12-27 Corning Glass Works Leichte laminierte Strukturen oder Verbundsstrukturen
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US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
JP3174524B2 (ja) 1997-02-21 2001-06-11 日本碍子株式会社 台板の下面清掃機構付きプッシャー型連続炉
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DE60041464D1 (de) 1999-09-29 2009-03-12 Ibiden Co Ltd Wabenförmiger Filter und Anordnung von keramischen Filtern
AR041198A1 (es) 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
US7368579B2 (en) * 2002-10-15 2008-05-06 Otsuka Pharmaceutical Co., Ltd. 1-substituted-4-nitroimidazole compound and process for producing the same
ATE410430T1 (de) * 2003-10-31 2008-10-15 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose
EP1906926B1 (de) * 2005-07-28 2010-12-01 Otsuka Pharmaceutical Co., Ltd. Pharmazeutische zusammensetzung mit 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolderivaten

Also Published As

Publication number Publication date
HK1097258A1 (zh) 2007-06-22
SI1678185T1 (sl) 2009-02-28
AU2004285811A1 (en) 2005-05-12
RU2365593C2 (ru) 2009-08-27
ES2314460T3 (es) 2009-03-16
TW200528460A (en) 2005-09-01
PT1678185E (pt) 2009-01-13
AR046777A1 (es) 2005-12-21
WO2005042542A1 (en) 2005-05-12
AU2004285811B2 (en) 2008-06-12
CY1108481T1 (el) 2014-04-09
TWI335331B (en) 2011-01-01
KR100851802B1 (ko) 2008-08-13
KR20060085644A (ko) 2006-07-27
RU2006118794A (ru) 2007-12-10
PL1678185T3 (pl) 2009-04-30
BRPI0414909A (pt) 2006-11-07
US8163753B2 (en) 2012-04-24
US20080119478A1 (en) 2008-05-22
DK1678185T3 (da) 2008-12-08
EP1678185B1 (de) 2008-10-08
CA2539335A1 (en) 2005-05-12
EP1678185A1 (de) 2006-07-12
MY146646A (en) 2012-09-14
DE602004017037D1 (de) 2008-11-20

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