CY1108481T1 - Ενωσεις 2,3-διϋδρο-6-νιτροϊμιδαζο[2,1-β]οξαζολιου για τη θεραπεια φυματιωσης - Google Patents
Ενωσεις 2,3-διϋδρο-6-νιτροϊμιδαζο[2,1-β]οξαζολιου για τη θεραπεια φυματιωσηςInfo
- Publication number
- CY1108481T1 CY1108481T1 CY20081101251T CY081101251T CY1108481T1 CY 1108481 T1 CY1108481 T1 CY 1108481T1 CY 20081101251 T CY20081101251 T CY 20081101251T CY 081101251 T CY081101251 T CY 081101251T CY 1108481 T1 CY1108481 T1 CY 1108481T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- group
- nitroimidazo
- dihydro
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ένωση 2,3-διϋδρο-6-νιτροϊμιδαζο[2,1-b]οξαζολίου που αντιπροσωπεύεται από τον ακόλουθο γενικό τύπο : στο παραπάνω τύπο (Ι) το R1 αντιπροσωπεύει άτομο υδρογόνου ή C1-C6 αλκύλ ομάδα, το n αντιπροσωπεύει ακέραιο 0 έως 6, τα R1 και -(CH2)nR2 μπορεί να σχηματίσουν σπείρο δακτύλιο, που αντιπροσωπεύεται από το τύπο (30) παρακάτω όπου με το γειτονικό άτομο άνθρακα (στο τύπο παρακάτω το RRR αντιπροσωπεύει πιπεριδύλ ομάδα, η οποία μπορεί να έχει υποκατάστατες επί του δακτυλίου πιπεριδίνης) (30) και το R2 αντιπροσωπεύει βενζοθειαζολόξυ ομάδα, κινολυλόξυ ομάδα, πυριδυλόξυ ομάδα ή τις παρόμοιες.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003373206 | 2003-10-31 | ||
JP2004111720 | 2004-04-06 | ||
EP04793412A EP1678185B1 (en) | 2003-10-31 | 2004-10-29 | 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds for the treatment of tuberculosis |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108481T1 true CY1108481T1 (el) | 2014-04-09 |
Family
ID=34554779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101251T CY1108481T1 (el) | 2003-10-31 | 2008-11-03 | Ενωσεις 2,3-διϋδρο-6-νιτροϊμιδαζο[2,1-β]οξαζολιου για τη θεραπεια φυματιωσης |
Country Status (20)
Country | Link |
---|---|
US (1) | US8163753B2 (el) |
EP (1) | EP1678185B1 (el) |
KR (1) | KR100851802B1 (el) |
AR (1) | AR046777A1 (el) |
AT (1) | ATE410430T1 (el) |
AU (1) | AU2004285811B2 (el) |
BR (1) | BRPI0414909A (el) |
CA (1) | CA2539335A1 (el) |
CY (1) | CY1108481T1 (el) |
DE (1) | DE602004017037D1 (el) |
DK (1) | DK1678185T3 (el) |
ES (1) | ES2314460T3 (el) |
HK (1) | HK1097258A1 (el) |
MY (1) | MY146646A (el) |
PL (1) | PL1678185T3 (el) |
PT (1) | PT1678185E (el) |
RU (1) | RU2365593C2 (el) |
SI (1) | SI1678185T1 (el) |
TW (1) | TWI335331B (el) |
WO (1) | WO2005042542A1 (el) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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PL1678185T3 (pl) * | 2003-10-31 | 2009-04-30 | Otsuka Pharma Co Ltd | Związki 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu do leczenia gruźlicy |
AU2005295860A1 (en) | 2004-10-18 | 2006-04-27 | Eli Lilly And Company | 1-(hetero)aryl-3-amino-pyrollidine derivatives for use as mGluR3 receptor antagonists |
WO2006125181A2 (en) * | 2005-05-19 | 2006-11-23 | Xenon Pharmaceuticals Inc. | Piperidine derivatives and their use as stearoyl-coa desaturase modulators |
US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
MX2008001210A (es) * | 2005-07-28 | 2008-03-24 | Otsuka Pharma Co Ltd | Composicion farmaceutica que comprende derivados de 2,3-dihidro-6-nitroimidazo{2,1-b]oxazol. |
JP2007106746A (ja) * | 2005-09-13 | 2007-04-26 | Tosoh Corp | 新規アリールホモピペラジン類、またはその塩と製造方法 |
JP5105818B2 (ja) * | 2005-10-05 | 2012-12-26 | 大塚製薬株式会社 | 医薬組成物 |
TW201434467A (zh) * | 2005-10-05 | 2014-09-16 | Otsuka Pharma Co Ltd | 抗結核治療藥物及含彼之套組 |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
WO2007075872A2 (en) * | 2005-12-23 | 2007-07-05 | Novartis Ag | Nitroimidazole compounds |
CA2651700A1 (en) * | 2006-05-22 | 2007-11-29 | Merck Frosst Canada Ltd. | Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
WO2008008480A2 (en) | 2006-07-12 | 2008-01-17 | Cumbre Pharmaceuticals Inc. | Nitroheteroaryl-containing rifamycin derivatives |
AR070301A1 (es) * | 2007-05-08 | 2010-03-31 | Otsuka Pharma Co Ltd | Compuesto epoxi y metodo para producir el mismo |
BRPI0909028A2 (pt) * | 2008-03-26 | 2015-09-22 | Global Alliance For Tb Drug Dev | nitroimidazóis bicíclicos covalentemente ligados a fenil oxazolidinonas substituídas, composições farmacêuticas e uso dos mesmos |
US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
CN102741259B (zh) | 2009-07-31 | 2016-04-13 | 全球结核病药物研发联盟 | 硝基咪唑并噁嗪和硝基咪唑并噁唑的类似物及其用途 |
US9051333B2 (en) | 2011-04-15 | 2015-06-09 | Otsuka Pharmaceutical Co., Ltd. | 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides |
KR20130083592A (ko) * | 2012-01-13 | 2013-07-23 | 현대약품 주식회사 | 치환된 피페리딘 유도체 및 이의 제조방법 |
KR101650716B1 (ko) * | 2012-11-22 | 2016-08-24 | 한국화학연구원 | 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물 |
IN2013DE02954A (el) * | 2013-10-04 | 2015-04-10 | Council Scient Ind Res | |
WO2015193506A1 (en) * | 2014-06-20 | 2015-12-23 | Institut Pasteur Korea | Anti-infective compounds |
EP2974729A1 (en) | 2014-07-17 | 2016-01-20 | Abivax | Quinoline derivatives for use in the treatment of inflammatory diseases |
AR101704A1 (es) * | 2014-08-28 | 2017-01-04 | Otsuka Pharma Co Ltd | Compuestos heterocíclicos fusionados |
KR102485775B1 (ko) * | 2014-10-01 | 2023-01-06 | 헨켈 아게 운트 코. 카게아아 | 혐기 경화성 조성물을 위한 경화 촉진제 |
WO2016063298A1 (en) * | 2014-10-21 | 2016-04-28 | Council Of Scientific & Industrial Research | Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof |
RU2675622C1 (ru) * | 2015-01-29 | 2018-12-21 | Медшайн Дискавери Инк. | Производное нитроимидазола против туберкулеза легких |
CN108884044B (zh) * | 2016-02-26 | 2023-01-31 | 大塚制药株式会社 | 哌啶衍生物 |
WO2018112842A1 (en) * | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
AU2019287313A1 (en) | 2018-06-11 | 2021-01-07 | Otsuka Pharmaceutical Co., Ltd. | Delamanid-containing composition |
CN112300192B (zh) * | 2019-08-02 | 2023-08-11 | 南京长澳医药科技有限公司 | 硝基咪唑类化合物及其制备方法和用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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CA1253674A (en) | 1984-06-13 | 1989-05-09 | Louis J. Manfredo | Reaction bonded carbide, nitride, boride, silicide or sulfide bodies |
RU1383752C (ru) | 1986-08-25 | 1993-11-30 | Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе | 4-Хлор-5-нитро-6-метилтиено [2,3-D]пиримидин, обладающий противотуберкулезной активностью |
EP0294176A3 (en) | 1987-06-02 | 1989-12-27 | Corning Glass Works | Lightweight laminated or composite structures |
AU6355190A (en) * | 1989-06-13 | 1991-01-17 | Smithkline Beecham Corporation | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
US5668127A (en) * | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
US6087358A (en) * | 1995-06-26 | 2000-07-11 | Pathogenesis Corporation | Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof |
JP3174524B2 (ja) | 1997-02-21 | 2001-06-11 | 日本碍子株式会社 | 台板の下面清掃機構付きプッシャー型連続炉 |
JP2001072472A (ja) | 1999-06-29 | 2001-03-21 | Ibiden Co Ltd | 炭化珪素焼成用治具 |
EP1688171B2 (en) | 1999-09-29 | 2013-03-27 | Ibiden Co., Ltd. | Honeycomb filter and ceramic filter assembly |
AR041198A1 (es) | 2002-10-11 | 2005-05-04 | Otsuka Pharma Co Ltd | Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen |
US7368579B2 (en) | 2002-10-15 | 2008-05-06 | Otsuka Pharmaceutical Co., Ltd. | 1-substituted-4-nitroimidazole compound and process for producing the same |
PL1678185T3 (pl) * | 2003-10-31 | 2009-04-30 | Otsuka Pharma Co Ltd | Związki 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu do leczenia gruźlicy |
MX2008001210A (es) * | 2005-07-28 | 2008-03-24 | Otsuka Pharma Co Ltd | Composicion farmaceutica que comprende derivados de 2,3-dihidro-6-nitroimidazo{2,1-b]oxazol. |
-
2004
- 2004-10-29 PL PL04793412T patent/PL1678185T3/pl unknown
- 2004-10-29 BR BRPI0414909-2A patent/BRPI0414909A/pt not_active IP Right Cessation
- 2004-10-29 WO PCT/JP2004/016492 patent/WO2005042542A1/en active Application Filing
- 2004-10-29 EP EP04793412A patent/EP1678185B1/en not_active Not-in-force
- 2004-10-29 DK DK04793412T patent/DK1678185T3/da active
- 2004-10-29 AT AT04793412T patent/ATE410430T1/de active
- 2004-10-29 AU AU2004285811A patent/AU2004285811B2/en not_active Ceased
- 2004-10-29 RU RU2006118794/04A patent/RU2365593C2/ru not_active IP Right Cessation
- 2004-10-29 DE DE602004017037T patent/DE602004017037D1/de active Active
- 2004-10-29 ES ES04793412T patent/ES2314460T3/es active Active
- 2004-10-29 PT PT04793412T patent/PT1678185E/pt unknown
- 2004-10-29 US US10/574,597 patent/US8163753B2/en not_active Expired - Fee Related
- 2004-10-29 TW TW093132982A patent/TWI335331B/zh not_active IP Right Cessation
- 2004-10-29 KR KR1020067006629A patent/KR100851802B1/ko not_active IP Right Cessation
- 2004-10-29 CA CA002539335A patent/CA2539335A1/en not_active Abandoned
- 2004-10-29 AR ARP040103961A patent/AR046777A1/es not_active Application Discontinuation
- 2004-10-29 SI SI200430914T patent/SI1678185T1/sl unknown
- 2004-10-30 MY MYPI20044505A patent/MY146646A/en unknown
-
2007
- 2007-02-09 HK HK07101546.0A patent/HK1097258A1/xx not_active IP Right Cessation
-
2008
- 2008-11-03 CY CY20081101251T patent/CY1108481T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR20060085644A (ko) | 2006-07-27 |
SI1678185T1 (sl) | 2009-02-28 |
US8163753B2 (en) | 2012-04-24 |
TW200528460A (en) | 2005-09-01 |
US20080119478A1 (en) | 2008-05-22 |
AU2004285811A1 (en) | 2005-05-12 |
WO2005042542A1 (en) | 2005-05-12 |
DK1678185T3 (da) | 2008-12-08 |
KR100851802B1 (ko) | 2008-08-13 |
EP1678185A1 (en) | 2006-07-12 |
DE602004017037D1 (de) | 2008-11-20 |
RU2006118794A (ru) | 2007-12-10 |
TWI335331B (en) | 2011-01-01 |
PL1678185T3 (pl) | 2009-04-30 |
RU2365593C2 (ru) | 2009-08-27 |
EP1678185B1 (en) | 2008-10-08 |
ATE410430T1 (de) | 2008-10-15 |
HK1097258A1 (en) | 2007-06-22 |
PT1678185E (pt) | 2009-01-13 |
AU2004285811B2 (en) | 2008-06-12 |
AR046777A1 (es) | 2005-12-21 |
CA2539335A1 (en) | 2005-05-12 |
ES2314460T3 (es) | 2009-03-16 |
BRPI0414909A (pt) | 2006-11-07 |
MY146646A (en) | 2012-09-14 |
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