DK1678185T3 - 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose - Google Patents

2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose

Info

Publication number
DK1678185T3
DK1678185T3 DK04793412T DK04793412T DK1678185T3 DK 1678185 T3 DK1678185 T3 DK 1678185T3 DK 04793412 T DK04793412 T DK 04793412T DK 04793412 T DK04793412 T DK 04793412T DK 1678185 T3 DK1678185 T3 DK 1678185T3
Authority
DK
Denmark
Prior art keywords
nitroimidazo
tuberculosis
dihydro
treatment
oxazole compounds
Prior art date
Application number
DK04793412T
Other languages
English (en)
Inventor
Hidetsugu Tsubouchi
Hirofumi Sasaki
Motohiro Itotani
Yoshikazu Haraguchi
Shin Miyamura
Makoto Matsumoto
Hiroyuki Hashizume
Tatsuo Grand Kawauch Tomishige
Masanori Kawasaki
Kinue Ohguro
Takumi Sumida
Takeshi Hasegawa
Kazuho Tanaka
Isao Takemura
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of DK1678185T3 publication Critical patent/DK1678185T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK04793412T 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose DK1678185T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003373206 2003-10-31
JP2004111720 2004-04-06
PCT/JP2004/016492 WO2005042542A1 (en) 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis

Publications (1)

Publication Number Publication Date
DK1678185T3 true DK1678185T3 (da) 2008-12-08

Family

ID=34554779

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04793412T DK1678185T3 (da) 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose

Country Status (20)

Country Link
US (1) US8163753B2 (da)
EP (1) EP1678185B1 (da)
KR (1) KR100851802B1 (da)
AR (1) AR046777A1 (da)
AT (1) ATE410430T1 (da)
AU (1) AU2004285811B2 (da)
BR (1) BRPI0414909A (da)
CA (1) CA2539335A1 (da)
CY (1) CY1108481T1 (da)
DE (1) DE602004017037D1 (da)
DK (1) DK1678185T3 (da)
ES (1) ES2314460T3 (da)
HK (1) HK1097258A1 (da)
MY (1) MY146646A (da)
PL (1) PL1678185T3 (da)
PT (1) PT1678185E (da)
RU (1) RU2365593C2 (da)
SI (1) SI1678185T1 (da)
TW (1) TWI335331B (da)
WO (1) WO2005042542A1 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1678185T3 (da) * 2003-10-31 2008-12-08 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose
CA2584422A1 (en) * 2004-10-18 2006-04-27 Eli Lilly And Company 1-(hetero)aryl-3-amino-pyrollidine derivatives for use as mglur3 receptor antagonists
WO2006125181A2 (en) * 2005-05-19 2006-11-23 Xenon Pharmaceuticals Inc. Piperidine derivatives and their use as stearoyl-coa desaturase modulators
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
KR101294921B1 (ko) * 2005-07-28 2013-08-08 오츠카 세이야쿠 가부시키가이샤 2,3-디히드로-6-니트로이미다조〔2,1-ｂ〕옥사졸 유도체 함유 제약 조성물
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
TWI368509B (en) * 2005-10-05 2012-07-21 Otsuka Pharma Co Ltd Antituberculous therapeutic drugs and kit containing the same
JP5105818B2 (ja) * 2005-10-05 2012-12-26 大塚製薬株式会社 医薬組成物
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
EP1984369A2 (en) * 2005-12-23 2008-10-29 Novartis AG Nitroimidazole compounds
WO2007134457A1 (en) * 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2008008480A2 (en) 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Nitroheteroaryl-containing rifamycin derivatives
AR070301A1 (es) * 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
NZ587096A (en) * 2008-03-26 2011-11-25 Global Alliance For Tb Drug Dev Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
KR101738868B1 (ko) * 2009-07-31 2017-05-23 글로벌 알리앙스 포 티비 드럭 디벨롭먼트 니트로이미다조옥사진 및 니트로이미다조옥사졸 동족체 및 이들의 용도
JP5916739B2 (ja) 2011-04-15 2016-05-11 大塚製薬株式会社 ６，７−ジヒドロイミダゾ［２，１−ｂ］［１，３］オキサジン化合物
KR20130083592A (ko) * 2012-01-13 2013-07-23 현대약품 주식회사 치환된 피페리딘 유도체 및 이의 제조방법
KR101650716B1 (ko) * 2012-11-22 2016-08-24 한국화학연구원 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
WO2015049693A1 (en) * 2013-10-04 2015-04-09 Council Of Scientific & Industrial Research 6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF
JP2017518339A (ja) * 2014-06-20 2017-07-06 インスティチュート パスツール コリア 抗感染化合物
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
TWI687409B (zh) * 2014-08-28 2020-03-11 日商大塚製藥股份有限公司 稠合雜環化合物
CN106715559B (zh) * 2014-10-01 2020-02-28 汉高知识产权控股有限责任公司 用于厌氧性可固化组合物的固化促进剂
WO2016063298A1 (en) * 2014-10-21 2016-04-28 Council Of Scientific & Industrial Research Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof
CN107207532B (zh) * 2015-01-29 2019-07-30 南京明德新药研发股份有限公司 抗肺结核病的硝基咪唑衍生物
WO2017146246A1 (ja) * 2016-02-26 2017-08-31 大塚製薬株式会社 ピペリジン誘導体
WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
US20210251902A1 (en) 2018-06-11 2021-08-19 Otsuka Pharmaceutical Co., Ltd. Delamanid-containing composition
EP3669873A1 (en) 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use ine the traeatment of inflammation diseases
CN112300192B (zh) * 2019-08-02 2023-08-11 南京长澳医药科技有限公司 硝基咪唑类化合物及其制备方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1253674A (en) 1984-06-13 1989-05-09 Louis J. Manfredo Reaction bonded carbide, nitride, boride, silicide or sulfide bodies
RU1383752C (ru) 1986-08-25 1993-11-30 Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе 4-Хлор-5-нитро-6-метилтиено [2,3-D]пиримидин, обладающий противотуберкулезной активностью
EP0294176A3 (en) 1987-06-02 1989-12-27 Corning Glass Works Lightweight laminated or composite structures
KR920702621A (ko) * 1989-06-13 1992-10-06 스튜어트 알. 슈터 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제
US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
JP3174524B2 (ja) 1997-02-21 2001-06-11 日本碍子株式会社 台板の下面清掃機構付きプッシャー型連続炉
JP2001072472A (ja) 1999-06-29 2001-03-21 Ibiden Co Ltd 炭化珪素焼成用治具
EP1666121B1 (en) 1999-09-29 2009-01-21 Ibiden Co., Ltd. Honeycomb filter and ceramic filter assembly
AR041198A1 (es) 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
US7368579B2 (en) * 2002-10-15 2008-05-06 Otsuka Pharmaceutical Co., Ltd. 1-substituted-4-nitroimidazole compound and process for producing the same
DK1678185T3 (da) * 2003-10-31 2008-12-08 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose
KR101294921B1 (ko) * 2005-07-28 2013-08-08 오츠카 세이야쿠 가부시키가이샤 2,3-디히드로-6-니트로이미다조〔2,1-ｂ〕옥사졸 유도체 함유 제약 조성물

Also Published As

Publication number Publication date
CA2539335A1 (en) 2005-05-12
ATE410430T1 (de) 2008-10-15
EP1678185B1 (en) 2008-10-08
PT1678185E (pt) 2009-01-13
US8163753B2 (en) 2012-04-24
CY1108481T1 (el) 2014-04-09
WO2005042542A1 (en) 2005-05-12
DE602004017037D1 (de) 2008-11-20
AU2004285811B2 (en) 2008-06-12
TWI335331B (en) 2011-01-01
HK1097258A1 (en) 2007-06-22
KR100851802B1 (ko) 2008-08-13
RU2365593C2 (ru) 2009-08-27
MY146646A (en) 2012-09-14
ES2314460T3 (es) 2009-03-16
AR046777A1 (es) 2005-12-21
PL1678185T3 (pl) 2009-04-30
RU2006118794A (ru) 2007-12-10
TW200528460A (en) 2005-09-01
BRPI0414909A (pt) 2006-11-07
US20080119478A1 (en) 2008-05-22
KR20060085644A (ko) 2006-07-27
SI1678185T1 (sl) 2009-02-28
EP1678185A1 (en) 2006-07-12
AU2004285811A1 (en) 2005-05-12

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