MA27138A1 - Composes heteroaryliques condenses a substituant azabicyclique pour le traitement d'une maladie - Google Patents
Composes heteroaryliques condenses a substituant azabicyclique pour le traitement d'une maladieInfo
- Publication number
- MA27138A1 MA27138A1 MA27603A MA27603A MA27138A1 MA 27138 A1 MA27138 A1 MA 27138A1 MA 27603 A MA27603 A MA 27603A MA 27603 A MA27603 A MA 27603A MA 27138 A1 MA27138 A1 MA 27138A1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- azabicyclic
- disease
- treatment
- heteroarylic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
DEPOSANT Société dite: PHARMACIA & UPJOHN COMPANY REVENDICATION DE PRIORITES US 2 Octobre 2001 60/326,565 US 2 Octobre 2001 60/326,629 US 15 Novembre 2001 60/334,886 US 12 Décembre 2001 60/339,633 Voir en annexe le titre de l'invention et le texte de l'abrégé Composés hétéroaryliques condensés à substituant azabicyclique pour le traitement d'une maladie La présente invention propose des composés de formule I, dans laquelle le substituant azabicyclo répond aux formules (II-VII), W répond aux formules (VIII-X). Ces composés peuvent être sous forme de sels ou compositions pharmaceutiques, de leurs mélanges racémiques ou de leurs énantiomères purs. Les composés de formule I sont utiles dans des produits pharmaceutiques, en cas d'implication d'(alpha)7.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32656501P | 2001-10-02 | 2001-10-02 | |
US32662901P | 2001-10-02 | 2001-10-02 | |
US33488601P | 2001-11-15 | 2001-11-15 | |
US33963301P | 2001-12-12 | 2001-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27138A1 true MA27138A1 (fr) | 2005-01-03 |
Family
ID=27502335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA27603A MA27138A1 (fr) | 2001-10-02 | 2004-04-01 | Composes heteroaryliques condenses a substituant azabicyclique pour le traitement d'une maladie |
Country Status (31)
Country | Link |
---|---|
US (3) | US6911543B2 (fr) |
EP (1) | EP1432707B1 (fr) |
JP (1) | JP4371811B2 (fr) |
KR (1) | KR100614900B1 (fr) |
AP (1) | AP1635A (fr) |
AR (1) | AR037740A1 (fr) |
AT (1) | ATE551340T1 (fr) |
BG (1) | BG108650A (fr) |
BR (1) | BR0213612A (fr) |
CA (1) | CA2462453C (fr) |
CO (1) | CO5570667A2 (fr) |
CZ (1) | CZ2004408A3 (fr) |
DK (1) | DK1432707T3 (fr) |
EA (1) | EA007429B1 (fr) |
ES (1) | ES2383001T3 (fr) |
GE (1) | GEP20063814B (fr) |
HR (1) | HRP20040259A2 (fr) |
HU (1) | HUP0402289A2 (fr) |
IL (1) | IL160884A0 (fr) |
IS (1) | IS7188A (fr) |
MA (1) | MA27138A1 (fr) |
MX (1) | MXPA04003007A (fr) |
MY (1) | MY138252A (fr) |
NO (1) | NO20041368L (fr) |
NZ (1) | NZ531786A (fr) |
OA (1) | OA12708A (fr) |
PL (1) | PL369895A1 (fr) |
RS (1) | RS28004A (fr) |
SK (1) | SK1562004A3 (fr) |
TN (1) | TNSN04052A1 (fr) |
WO (1) | WO2003029252A1 (fr) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR036040A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
US7977485B2 (en) * | 2002-06-10 | 2011-07-12 | Bayer Schering Pharma Aktiengesellshaft | 2-heteroaryl carboxamides |
WO2004013137A1 (fr) * | 2002-08-01 | 2004-02-12 | Pharmacia & Upjohn Company Llc | Composes azabicyclique de 1h-pyrazole et 1h-pyrrole servant a effectuer un traitement therapeutique |
JP4890762B2 (ja) | 2002-09-25 | 2012-03-07 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール、ベンゾチアゾール、及びベンゾイソチアゾール、並びにそれらの調製及び使用 |
AU2003269413A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
EP1562959A2 (fr) * | 2002-11-01 | 2005-08-17 | Pharmacia & Upjohn Company LLC | Composes possedant une activite d'agoniste du recepteur nicotinique $g(a)7 et d'antagoniste du recepteur 5ht3 pour traiter des maladies du systeme nerveux central |
US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
PT1949901E (pt) * | 2002-12-06 | 2014-05-23 | The Feinstein Inst Medical Res | Método para a determinação de um agonista colinérgico selectivo para um receptor nicotínico alfa 7 |
ATE428711T1 (de) | 2003-12-11 | 2009-05-15 | Aventis Pharma Inc | Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3- cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i- epsilon |
RU2389729C2 (ru) | 2003-12-22 | 2010-05-20 | Мемори Фармасьютиклз Корпорейшн | 1н-индазолы, 1, 2-бензизоксазолы и 1, 2-бензизотиазолы, их получение и применение |
JP2007516275A (ja) * | 2003-12-23 | 2007-06-21 | ファイザー・プロダクツ・インク | 認知増強および精神病性障害のための治療的組合せ |
MXPA06010852A (es) | 2004-03-25 | 2007-01-16 | Memory Pharm Corp | Indazoles, benzotiazoles, benzoisotiazoles, bencisoxazoles y preparacion y usos de los mismos. |
EP1742944B1 (fr) * | 2004-04-22 | 2010-11-10 | Memory Pharmaceuticals Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, leur preparation et leurs utilisations |
WO2005107719A2 (fr) * | 2004-05-06 | 2005-11-17 | Sandoz Ag | Composition pharmaceutique comprenant un medicament hydrophobe a solubilite amelioree |
WO2005111038A2 (fr) * | 2004-05-07 | 2005-11-24 | Memory Pharmaceuticals Corporation | 1h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, et chromones, leur preparation et leurs utilisations |
ES2342675T3 (es) * | 2004-12-22 | 2010-07-12 | Memory Pharmaceuticals Corporation | Ligandos del receptor alfa-7 nicotinico contra enfermedades relacionadas con el snc. |
EP1863485A2 (fr) * | 2005-03-18 | 2007-12-12 | Abbott Laboratories | Ligand du recepteur nicotinique neuronal alpha7 et compositions antipsychotiques |
FR2884822B1 (fr) * | 2005-04-22 | 2007-06-29 | Aventis Pharma Sa | Derives de triazines, leur preparation et leur application en therapeutique |
KR20080052630A (ko) * | 2005-09-01 | 2008-06-11 | 어레이 바이오파마 인크. | Raf 억제제 화합물 및 그의 사용 방법 |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
RU2476220C2 (ru) * | 2007-08-02 | 2013-02-27 | Таргасепт, Инк. | (2s,3r)-n-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид, новые солевые формы и способы их применения |
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US8431595B2 (en) | 2009-08-20 | 2013-04-30 | The University Of Tennessee Research Foundation | Furanopyridine cannabinoid compounds and related methods of use |
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EP2727604A4 (fr) | 2011-06-30 | 2015-03-18 | Toray Industries | Agent antiprurigineux |
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WO2014128585A1 (fr) | 2013-02-19 | 2014-08-28 | Pfizer Inc. | Composés d'azabenzimidazole en tant qu'inhibiteurs d'isozymes pde4 pour le traitement de troubles du snc et d'autres affections |
LT3102576T (lt) | 2014-02-03 | 2019-08-12 | Vitae Pharmaceuticals, Llc | Ror-gama dihidropirolopiridino inhibitoriai |
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AP2017009744A0 (en) | 2014-08-06 | 2017-02-28 | Pfizer | Imidazopyridazine compounds |
UA118989C2 (uk) | 2014-10-14 | 2019-04-10 | Вітае Фармасьютікалс, Інк. | Дигідропіролопіридинові інгібітори ror-гамма |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
CA2971413A1 (fr) | 2014-12-16 | 2016-06-23 | Axovant Sciences Gmbh | Composes amide de quinuclidine a substituants geminal, en tant qu'agonistes des recepteurs nicotiniques de l'acetylcholine ?7 |
CA2988968A1 (fr) * | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Composes d'aminobenzisoxazole en tant qu'agonistes des recepteurs de l'acetylcholine ?7-nicotinique |
US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
WO2017027600A1 (fr) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | Composés d'aminobenzisoxazole à substitution géminale utilisés en tant qu'agonistes de récepteurs de l'acétylcholine α7-nicotinique |
US11008340B2 (en) | 2015-11-20 | 2021-05-18 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
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MX2022015038A (es) | 2020-05-29 | 2023-01-04 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos como anthelminticos. |
AR127495A1 (es) | 2021-11-01 | 2024-01-31 | Boehringer Ingelheim Vetmedica Gmbh | Compuestos de pirrolopiridazina como antihelmínticos |
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-
2002
- 2002-10-01 AP APAP/P/2004/003002A patent/AP1635A/en active
- 2002-10-01 CZ CZ2004408A patent/CZ2004408A3/cs unknown
- 2002-10-01 CA CA002462453A patent/CA2462453C/fr not_active Expired - Fee Related
- 2002-10-01 IL IL16088402A patent/IL160884A0/xx unknown
- 2002-10-01 ES ES02778286T patent/ES2383001T3/es not_active Expired - Lifetime
- 2002-10-01 OA OA1200400087A patent/OA12708A/en unknown
- 2002-10-01 DK DK02778286.1T patent/DK1432707T3/da active
- 2002-10-01 NZ NZ531786A patent/NZ531786A/en unknown
- 2002-10-01 EP EP02778286A patent/EP1432707B1/fr not_active Expired - Lifetime
- 2002-10-01 RS YUP-280/04A patent/RS28004A/sr unknown
- 2002-10-01 EA EA200400387A patent/EA007429B1/ru unknown
- 2002-10-01 GE GE5551A patent/GEP20063814B/en unknown
- 2002-10-01 AT AT02778286T patent/ATE551340T1/de active
- 2002-10-01 US US10/262,257 patent/US6911543B2/en not_active Expired - Fee Related
- 2002-10-01 SK SK156-2004A patent/SK1562004A3/sk unknown
- 2002-10-01 BR BR0213612-0A patent/BR0213612A/pt not_active IP Right Cessation
- 2002-10-01 WO PCT/US2002/029827 patent/WO2003029252A1/fr active Application Filing
- 2002-10-01 KR KR1020047004871A patent/KR100614900B1/ko not_active IP Right Cessation
- 2002-10-01 JP JP2003532500A patent/JP4371811B2/ja not_active Expired - Fee Related
- 2002-10-01 HU HU0402289A patent/HUP0402289A2/hu unknown
- 2002-10-01 MX MXPA04003007A patent/MXPA04003007A/es unknown
- 2002-10-01 PL PL02369895A patent/PL369895A1/xx not_active Application Discontinuation
- 2002-10-02 MY MYPI20023689A patent/MY138252A/en unknown
- 2002-10-02 AR ARP020103718A patent/AR037740A1/es unknown
-
2004
- 2004-03-17 HR HR20040259A patent/HRP20040259A2/hr not_active Application Discontinuation
- 2004-03-18 IS IS7188A patent/IS7188A/is unknown
- 2004-03-24 BG BG108650A patent/BG108650A/xx unknown
- 2004-03-30 CO CO04030193A patent/CO5570667A2/es not_active Application Discontinuation
- 2004-04-01 NO NO20041368A patent/NO20041368L/no not_active Application Discontinuation
- 2004-04-01 TN TNP2004000052A patent/TNSN04052A1/fr unknown
- 2004-04-01 MA MA27603A patent/MA27138A1/fr unknown
-
2005
- 2005-05-26 US US11/137,912 patent/US20050222196A1/en not_active Abandoned
- 2005-05-26 US US11/139,066 patent/US20050234092A1/en not_active Abandoned
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