AR045782A2 - Derivados de piperidina que tienen actividad farmaceutica - Google Patents

Derivados de piperidina que tienen actividad farmaceutica

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Publication number
AR045782A2
AR045782A2 ARP040103265A ARP040103265A AR045782A2 AR 045782 A2 AR045782 A2 AR 045782A2 AR P040103265 A ARP040103265 A AR P040103265A AR P040103265 A ARP040103265 A AR P040103265A AR 045782 A2 AR045782 A2 AR 045782A2
Authority
AR
Argentina
Prior art keywords
alkyl
phenyl
alkoxy
halogen
haloalkyl
Prior art date
Application number
ARP040103265A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0008626A external-priority patent/GB0008626D0/en
Priority claimed from GB0019111A external-priority patent/GB0019111D0/en
Priority claimed from SE0003664A external-priority patent/SE0003664D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR045782A2 publication Critical patent/AR045782A2/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Diabetes (AREA)
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  • Dermatology (AREA)
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  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
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  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
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Abstract

Compuestos de la fórmula (13a), (13) y (14) donde: L2 es H, terc-butoxicarbonilo o bencilo; L* es BOC o un grupo bencilo; t es 0 o 1; m y p son, independientemente, 0 1 o 2; X es CH2, C(O), O, S, S(O), S(O)2 o NR37; siempre que cuando m y p son ambos 1, entonces X no es CH2; R37 es H, alquilo C1-6, arilo (opcionalmente sustituido con halógeno, alquilo C1-6, haloalquilo C1-6, CN, NO2, alcoxi C1-6 o haloalcoxi C1-6) o heterociclilo (opcionalmente sustituido con halógeno, alquilo C1-6, haloalquilo C1-6, CN, NO2, alcoxi C1-6 o haloalcoxi C1-6); cuando X es O entonces R1 es ya sea fenilo sustituido con uno o más de F, Cl, alquilo C1-4 o alcoxi C1-4, o R1 es fenilo sustituido con R35 y R36; cuando X es CH2, C(O), S, S(O), S(O)2 o NR37 entonces R1 es fenilo sustituido con uno o más de F, Cl, alquilo C1-4 o alcoxi C1-4; R35 es H, ciano, S(O)2(alquilo C1-4), S(O)2(haloalquilo C1-4), halógeno, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4 o fenilo (opcionalmente sustituido con uno o dos átomos de halógeno o con un grupo de C(O)NR12´R13´, NR9´C(O)R10´,. S(O)2R15´, S(O)2NR42R43 o NR44S(O)2R45); R36 es H, halógeno o alquilo C1-4; R9´, R10´, R12´, R13´, R42, R43 y R44 son,, independientemente, H, alquilo C1-6 o fenilo y R15´y R45 son, independientemente, alquilo C1-6 o fenilo.
ARP040103265A 2000-04-08 2004-09-10 Derivados de piperidina que tienen actividad farmaceutica AR045782A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0008626A GB0008626D0 (en) 2000-04-08 2000-04-08 Chemical compounds
GB0019111A GB0019111D0 (en) 2000-08-03 2000-08-03 Chemical compounds
SE0003664A SE0003664D0 (sv) 2000-10-11 2000-10-11 Chemical compounds

Publications (1)

Publication Number Publication Date
AR045782A2 true AR045782A2 (es) 2005-11-16

Family

ID=27255657

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP010101549A AR033517A1 (es) 2000-04-08 2001-03-30 Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
ARP040103265A AR045782A2 (es) 2000-04-08 2004-09-10 Derivados de piperidina que tienen actividad farmaceutica

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ARP010101549A AR033517A1 (es) 2000-04-08 2001-03-30 Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos

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US (5) US6525070B2 (es)
EP (2) EP1493743B1 (es)
JP (1) JP2003530393A (es)
KR (1) KR20030005264A (es)
CN (2) CN1660839A (es)
AR (2) AR033517A1 (es)
AT (2) ATE407131T1 (es)
AU (2) AU4699701A (es)
BR (1) BR0109922A (es)
CA (1) CA2403012A1 (es)
DE (2) DE60135684D1 (es)
ES (1) ES2311772T3 (es)
HK (1) HK1051193A1 (es)
IL (1) IL151889A0 (es)
MX (1) MXPA02009885A (es)
MY (1) MY128441A (es)
NO (1) NO20024774L (es)
NZ (1) NZ521543A (es)
SA (1) SA01220034B1 (es)
WO (1) WO2001077101A1 (es)

Families Citing this family (82)

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AR033517A1 (es) * 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
ES2258642T3 (es) 2001-07-02 2006-09-01 Astrazeneca Ab Derivados de piperidina utiles como moduladores de la actividad del receptor de quimiocina.
GB0120461D0 (en) 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
AR036366A1 (es) 2001-08-29 2004-09-01 Schering Corp Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit
GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
GB0124020D0 (en) * 2001-10-05 2001-11-28 Astrazeneca Ab Chemical compounds
EP2243776A1 (en) * 2001-10-12 2010-10-27 High Point Pharmaceuticals, LLC Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor
AU2002363236A1 (en) * 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
AU2003209204A1 (en) * 2002-01-10 2003-07-30 University Of Washington Hydrogels formed by non-covalent linkages
TW200303304A (en) * 2002-02-18 2003-09-01 Astrazeneca Ab Chemical compounds
AU2003211385A1 (en) * 2002-02-28 2003-09-09 Takeda Chemical Industries, Ltd. Azole compounds
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0202838D0 (sv) * 2002-09-24 2002-09-24 Astrazeneca Ab Chemical compounds
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