AR045782A2 - Derivados de piperidina que tienen actividad farmaceutica - Google Patents
Derivados de piperidina que tienen actividad farmaceuticaInfo
- Publication number
- AR045782A2 AR045782A2 ARP040103265A ARP040103265A AR045782A2 AR 045782 A2 AR045782 A2 AR 045782A2 AR P040103265 A ARP040103265 A AR P040103265A AR P040103265 A ARP040103265 A AR P040103265A AR 045782 A2 AR045782 A2 AR 045782A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- alkoxy
- halogen
- haloalkyl
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
Abstract
Compuestos de la fórmula (13a), (13) y (14) donde: L2 es H, terc-butoxicarbonilo o bencilo; L* es BOC o un grupo bencilo; t es 0 o 1; m y p son, independientemente, 0 1 o 2; X es CH2, C(O), O, S, S(O), S(O)2 o NR37; siempre que cuando m y p son ambos 1, entonces X no es CH2; R37 es H, alquilo C1-6, arilo (opcionalmente sustituido con halógeno, alquilo C1-6, haloalquilo C1-6, CN, NO2, alcoxi C1-6 o haloalcoxi C1-6) o heterociclilo (opcionalmente sustituido con halógeno, alquilo C1-6, haloalquilo C1-6, CN, NO2, alcoxi C1-6 o haloalcoxi C1-6); cuando X es O entonces R1 es ya sea fenilo sustituido con uno o más de F, Cl, alquilo C1-4 o alcoxi C1-4, o R1 es fenilo sustituido con R35 y R36; cuando X es CH2, C(O), S, S(O), S(O)2 o NR37 entonces R1 es fenilo sustituido con uno o más de F, Cl, alquilo C1-4 o alcoxi C1-4; R35 es H, ciano, S(O)2(alquilo C1-4), S(O)2(haloalquilo C1-4), halógeno, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4 o fenilo (opcionalmente sustituido con uno o dos átomos de halógeno o con un grupo de C(O)NR12´R13´, NR9´C(O)R10´,. S(O)2R15´, S(O)2NR42R43 o NR44S(O)2R45); R36 es H, halógeno o alquilo C1-4; R9´, R10´, R12´, R13´, R42, R43 y R44 son,, independientemente, H, alquilo C1-6 o fenilo y R15´y R45 son, independientemente, alquilo C1-6 o fenilo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0008626A GB0008626D0 (en) | 2000-04-08 | 2000-04-08 | Chemical compounds |
GB0019111A GB0019111D0 (en) | 2000-08-03 | 2000-08-03 | Chemical compounds |
SE0003664A SE0003664D0 (sv) | 2000-10-11 | 2000-10-11 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045782A2 true AR045782A2 (es) | 2005-11-16 |
Family
ID=27255657
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010101549A AR033517A1 (es) | 2000-04-08 | 2001-03-30 | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
ARP040103265A AR045782A2 (es) | 2000-04-08 | 2004-09-10 | Derivados de piperidina que tienen actividad farmaceutica |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010101549A AR033517A1 (es) | 2000-04-08 | 2001-03-30 | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
Country Status (20)
Country | Link |
---|---|
US (5) | US6525070B2 (es) |
EP (2) | EP1493743B1 (es) |
JP (1) | JP2003530393A (es) |
KR (1) | KR20030005264A (es) |
CN (2) | CN1660839A (es) |
AR (2) | AR033517A1 (es) |
AT (2) | ATE407131T1 (es) |
AU (2) | AU4699701A (es) |
BR (1) | BR0109922A (es) |
CA (1) | CA2403012A1 (es) |
DE (2) | DE60135684D1 (es) |
ES (1) | ES2311772T3 (es) |
HK (1) | HK1051193A1 (es) |
IL (1) | IL151889A0 (es) |
MX (1) | MXPA02009885A (es) |
MY (1) | MY128441A (es) |
NO (1) | NO20024774L (es) |
NZ (1) | NZ521543A (es) |
SA (1) | SA01220034B1 (es) |
WO (1) | WO2001077101A1 (es) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR033517A1 (es) * | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
ES2258642T3 (es) | 2001-07-02 | 2006-09-01 | Astrazeneca Ab | Derivados de piperidina utiles como moduladores de la actividad del receptor de quimiocina. |
GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
AR036366A1 (es) | 2001-08-29 | 2004-09-01 | Schering Corp | Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit |
GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
GB0124020D0 (en) * | 2001-10-05 | 2001-11-28 | Astrazeneca Ab | Chemical compounds |
EP2243776A1 (en) * | 2001-10-12 | 2010-10-27 | High Point Pharmaceuticals, LLC | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor |
AU2002363236A1 (en) * | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
AU2003209204A1 (en) * | 2002-01-10 | 2003-07-30 | University Of Washington | Hydrogels formed by non-covalent linkages |
TW200303304A (en) * | 2002-02-18 | 2003-09-01 | Astrazeneca Ab | Chemical compounds |
AU2003211385A1 (en) * | 2002-02-28 | 2003-09-09 | Takeda Chemical Industries, Ltd. | Azole compounds |
SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
SE0202838D0 (sv) * | 2002-09-24 | 2002-09-24 | Astrazeneca Ab | Chemical compounds |
US7759336B2 (en) * | 2002-12-10 | 2010-07-20 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compounds and medicinal use thereof |
EP1587804A1 (en) * | 2003-01-17 | 2005-10-26 | Warner-Lambert Company LLC | Androgen receptor antagonists |
US20040192738A1 (en) * | 2003-03-18 | 2004-09-30 | Aventis Pharma Deutschland Gmbh | 2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it |
SE0300850D0 (sv) * | 2003-03-25 | 2003-03-25 | Astrazeneca Ab | Chemical compounds |
SE0300957D0 (sv) * | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
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