PE20061164A1 - Piperazin-piperidinas sustituidas con pirazinilo con actividad antagonista de cxcr3 - Google Patents
Piperazin-piperidinas sustituidas con pirazinilo con actividad antagonista de cxcr3Info
- Publication number
- PE20061164A1 PE20061164A1 PE2006000176A PE2006000176A PE20061164A1 PE 20061164 A1 PE20061164 A1 PE 20061164A1 PE 2006000176 A PE2006000176 A PE 2006000176A PE 2006000176 A PE2006000176 A PE 2006000176A PE 20061164 A1 PE20061164 A1 PE 20061164A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cxcr3
- substituted
- piperazin
- pyrazinyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE X ES N, O, ALQUILO, CICLOALQUILO, ENTRE OTROS; R1 Y R2 SON H, ALQUILO, ALCOXI, ALQUENILO, CARBONILO, ARILO, ENTRE OTROS; R3 Y R6 SON H, ALQUILO, HALOGENO, HIDROXIALQUILO,ENTRE OTROS; R7 Y R8 SON H, ALQUILARILO,-CN, ALCOXI, ENTRE OTROS; m ES 0 A 4; n ES 0 A 4; p ES 0 A 5. R10 ES H, ALQUILO, CICLOALQUILO, ARILO, ENTRE OTROS; R11 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R12 ES H, ALQUILO, ENTRE OTROS; EL ANILLO D ES UN FENILO NO SUSTITUIDO O SUSTITUIDO CON R20 DONDE R20 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; Y ES -(CR13R13)r-, -(CHR13)r, ENTRE OTROS; R13 ES H, ALQUILO, ALQUILARILO, ENTRE OTROS; r ES 1 A 4. SON COMPUESTOS PREFERIDOS a, b, c, ENTRE OTROS . SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO PREPARACION. LOS COMPUESTOS SON ANTAGONICOS DE QUIMIOCINAS COMO CXCR3 Y SON UTILES PARA EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, ESCLEROSIS MULTIPLE, MENINGITIS VIRAL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65333805P | 2005-02-16 | 2005-02-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061164A1 true PE20061164A1 (es) | 2006-10-27 |
Family
ID=36636289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000176A PE20061164A1 (es) | 2005-02-16 | 2006-02-14 | Piperazin-piperidinas sustituidas con pirazinilo con actividad antagonista de cxcr3 |
Country Status (17)
Country | Link |
---|---|
US (1) | US7868005B2 (es) |
EP (1) | EP1856098B1 (es) |
JP (1) | JP2008530220A (es) |
KR (1) | KR20070107060A (es) |
CN (1) | CN101142209A (es) |
AR (1) | AR054224A1 (es) |
AU (1) | AU2006214380A1 (es) |
BR (1) | BRPI0607946A2 (es) |
CA (1) | CA2598458A1 (es) |
IL (1) | IL185073A0 (es) |
MX (1) | MX2007009947A (es) |
NO (1) | NO20074698L (es) |
PE (1) | PE20061164A1 (es) |
RU (1) | RU2007134260A (es) |
TW (1) | TW200640903A (es) |
WO (1) | WO2006088921A2 (es) |
ZA (1) | ZA200706789B (es) |
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CN101189238A (zh) * | 2005-02-16 | 2008-05-28 | 先灵公司 | 具有cxcr3拮抗剂活性的哌嗪-哌啶 |
EP1856097B1 (en) * | 2005-02-16 | 2012-07-11 | Schering Corporation | Pyridyl and phenyl substituted piperazine-piperidines with cxcr3 antagonist activity |
JP2008530213A (ja) * | 2005-02-16 | 2008-08-07 | シェーリング コーポレイション | Cxcr3アンタゴニスト活性を有する、ヘテロアリールで置換されたピラジニル−ピペラジン−ピペリジン |
US7868005B2 (en) | 2005-02-16 | 2011-01-11 | Schering Corporation | Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity |
ATE518855T1 (de) * | 2005-02-16 | 2011-08-15 | Schering Corp | Neue heterozyklische substituierte pyridin- oder phenylverbindungen mit cxcr3-antagonistischer aktivität |
ES2382163T3 (es) * | 2005-10-11 | 2012-06-05 | Schering Corporation | Compuestos heterocíclicos sustituidos con actividad antagonista de CXCR3 |
CA2646958A1 (en) * | 2006-03-21 | 2007-09-27 | Schering Corporation | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity |
AR061975A1 (es) * | 2006-07-14 | 2008-08-10 | Schering Corp | Compuestos de piperazina 1,4-sustituida con actividad antagonista de cxcr3, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor de quimioquina cxcr3 |
-
2006
- 2006-02-14 US US11/354,138 patent/US7868005B2/en active Active
- 2006-02-14 WO PCT/US2006/005267 patent/WO2006088921A2/en active Application Filing
- 2006-02-14 RU RU2007134260/04A patent/RU2007134260A/ru not_active Application Discontinuation
- 2006-02-14 PE PE2006000176A patent/PE20061164A1/es not_active Application Discontinuation
- 2006-02-14 CA CA002598458A patent/CA2598458A1/en not_active Abandoned
- 2006-02-14 MX MX2007009947A patent/MX2007009947A/es unknown
- 2006-02-14 KR KR1020077019297A patent/KR20070107060A/ko not_active Application Discontinuation
- 2006-02-14 CN CNA2006800081411A patent/CN101142209A/zh active Pending
- 2006-02-14 BR BRPI0607946-6A patent/BRPI0607946A2/pt not_active IP Right Cessation
- 2006-02-14 JP JP2007556255A patent/JP2008530220A/ja active Pending
- 2006-02-14 EP EP06735090A patent/EP1856098B1/en active Active
- 2006-02-14 AU AU2006214380A patent/AU2006214380A1/en not_active Abandoned
- 2006-02-15 TW TW095105141A patent/TW200640903A/zh unknown
- 2006-02-15 AR AR20060100549A patent/AR054224A1/es not_active Application Discontinuation
-
2007
- 2007-08-06 IL IL185073A patent/IL185073A0/en unknown
- 2007-08-15 ZA ZA200706789A patent/ZA200706789B/xx unknown
- 2007-09-14 NO NO20074698A patent/NO20074698L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20070107060A (ko) | 2007-11-06 |
AR054224A1 (es) | 2007-06-13 |
WO2006088921A3 (en) | 2006-11-02 |
TW200640903A (en) | 2006-12-01 |
BRPI0607946A2 (pt) | 2009-10-20 |
WO2006088921A2 (en) | 2006-08-24 |
RU2007134260A (ru) | 2009-03-27 |
MX2007009947A (es) | 2007-09-26 |
ZA200706789B (en) | 2008-11-26 |
CA2598458A1 (en) | 2006-08-24 |
US20070054919A1 (en) | 2007-03-08 |
AU2006214380A1 (en) | 2006-08-24 |
CN101142209A (zh) | 2008-03-12 |
US7868005B2 (en) | 2011-01-11 |
IL185073A0 (en) | 2007-12-03 |
EP1856098A2 (en) | 2007-11-21 |
EP1856098B1 (en) | 2012-08-01 |
JP2008530220A (ja) | 2008-08-07 |
NO20074698L (no) | 2007-11-16 |
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