AR036366A1 - Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit - Google Patents
Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kitInfo
- Publication number
- AR036366A1 AR036366A1 ARP020103217A ARP020103217A AR036366A1 AR 036366 A1 AR036366 A1 AR 036366A1 AR P020103217 A ARP020103217 A AR P020103217A AR P020103217 A ARP020103217 A AR P020103217A AR 036366 A1 AR036366 A1 AR 036366A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- aryl
- cycloalkyl
- haloalkyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 title 1
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 23
- 125000000217 alkyl group Chemical group 0.000 abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- -1 alkyl ketone Chemical class 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000006557 (C2-C5) alkylene group Chemical group 0.000 abstract 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de piperidina, que comprenden un compuesto representado por la fórmula estructural (1) o una de sus sales o solvatos aceptables para uso farmacéutico; en la cual: R es grupo (2); R2 se selecciona del grupo integrado por H, alquilo, arilo, arilalquilo, heteroarilalquilo, alquilcetona, arilcetona, alquilo, haloalquilo, cicloalquilo, cicloheteroalquilo, cicloalquilalquilo, alquilsulfonilo, arilsulfonilo, alcoxialquilo, o amida; R3 se selecciona del grupo integrado por arilo, heteroarilo de 6 elementos, fluorenilo, y difenilmetilo, heteroaril-N-óxido de 6 elementos, fórmulas (3) y (4), en donde dicho arilo, fluorenilo, difenilo o heteroarilo se sustituye en forma opcional con 1-4 sustituyentes que pueden ser iguales o diferentes y se seleccionan en forma independiente del grupo integrado poro R11, R12, R13, R14 y R15; R4 es de 1-3 sustituyentes seleccionados del grupo integrado por H, halo, alquilo, haloalquilo, alcoxi, cicloalquilo, cicloheteroalquilo, amida, CF3, COF3, arilo, heteroarilo, -XR7, -C(O)cicloalquilo C3-8,-C(O)cicloheteroalquilo C3-8, -alquil- C1-6-N(R21)SO2R22, -alquil- C1-6-C(O)NR20R21, -CN, -CO2H, -CO2R22, R8-aril-alquilo C1-6, R8-heteroaril-alquilo C1-6, -C(O)-alquilo C1-6, R8-aril-C(O)-, -C(O)NR21R22, -C(O)NH2, -C(O)N(H)OH, alquil-C1-6-N(R21)C(O)R22, alquil- C1-6-N(R21)CO2R22, alquil- C1-6-N(R21)C(O)NR21R22, alquil- C1-6-NR21R22, alquil-C1-6-NH2, alquil-C1-6-SO2NR21R22 y -SO2NR21R22, en donde R4 puede ser igual o diferente y se selecciona en forma independiente cuando hay más de un R4 presente; R5 se selecciona del grupo integrado por H, arilalquilo, alquilo C1-6, R8-aril alquilo- C1-6-, R8-heteroaril -alquilo- C1-6, -SO2-alquilo- C1-6, -SO2-cicloalquilo-C3-6, -SO2-arilo, R8-aril-SO2-, -C(O)-alquilo-C1-6, -C(O)-cicloalquilo-C4-6, R8-aril-C(O)-, -C(O)NR21R22 y -SO2NR21R22; R6 es H, -alquilo- C1-6 ó -haloalquilo C1-6; R7 se selecciona del grupo integrado por arilo, arilo sustituido, heteroarilo, alquilo, haloalquilo y cicloalquilo; R8 es de 1, 2 ó 3 sustituyentes seleccionados del grupo integrado por H, halo, alquilo C1-6, alcoxi C1-6, -CF3, -OCF3, CH3C(O)-, -CN, CH3SO2-, CF3SO2- y -NH2, donde R8 puede ser igual o diferente y se selecciona en forma independiente en los casos en que haya más de un R8 presente; R9, R10 y B pueden ser iguales o diferentes y se seleccionan cada uno del grupo integrado por hidrógeno, alquilo C1-6, y haloalquilo C1-6; R11 y R12 pueden ser iguales o diferentes y se seleccionan en forma independiente del grupo integrado por alquilo C1-6, haloalquilo C1-6, halógeno, -NR19R20, -OH, CF3, -OCH3, -O-acilo y -OCF3; R13 se selecciona del grupo integrado por hidrógeno, R11, H, fenilo, -NO2, -CN, -CH2F, -CHF2, CHO, -CH=NOR19, piridil-N-óxido, pirimidinilo, pirazinilo, N(R20)CONR20R21, -NHCONH(cloro-alquilo C1-6), -NHCONH-cicloalquil C3-10 alquilo C1-6, -NHCO alquilo C1-6, -NHCOCF3, -NHCOCF3, -NHSO2N (alquilo C1-6)2, -NHSO2 alquilo C1-6, -N(SO2CF3)2, -NHCO2 alquilo C1-6, cicloalquilo C3-10, -SR22, -SOR22, -SO2R22, -SO2NH alquilo C1-6, -OSO2 alquilo C1-6, -OSO2CF3, hidroxi alquilo C1-6, -CONR19R20, -CON(CH2CH2-O-CH3)2, -OCONH alquilo C1-6, -CO2R19, -Si(CH3)3 y -B(OC(CH3)2)2; R14 se selecciona del grupo integrado por alquilo C1-6, haloalquilo C1-6 -NH2 y R15-fenilo; R15 es de 1-3 sustituyentes seleccionados del grupo integrado por hidrógeno, alquilo C1-6, -haloalquilo C1-6, -CF3, -CO2R20, -CN, alcoxi C1-6, y halógeno; donde R15 puede ser igual o diferente y se selecciona en forma independiente en los casos en que hay más de un R15 presente; R16 y R17 pueden ser iguales o diferentes y se seleccionan, cada uno en forma independiente, del grupo integrado por hidrógeno y alquilo C1-6; o R16 y R17 juntos son un grupo alquileno de C2-5 y con el átomo al que están unidos forman un anillo espiro C3-6; R19, R20 y R21 pueden ser iguales o diferentes y se seleccionan, cada uno en forma independiente, del grupo integrado por H, alquilo C1-6 y cicloalquilo C3-6; R22 se selecciona del grupo integrado por alquilo C1-6, haloalquilo C1-6, hidroxialquilo C2-6, alquileno C2-6, cicloalquilo C3-6, arilo y arilo-alquilo C1-6; A se selecciona del grupo integrado por H, alquilo C1-6 y alquenilo C2-6; M es arilo o heteroarilo sustituido en forma opcional con R4; Q es CH ó N; y X se selecciona del grupo integrado por CH2, SO2, SO, S y O, con la siguiente salvedad: cuando R1 es fenilo, piridilo, tiofenilo o naftilo, R2 no puede ser H, alquilo C1-6 ó -C(O)-alquilo C1-6. También se refiere al uso de una combinación de un compuesto de la presente y uno o más agentes antivirales u otros agentes útiles para la fabricación de medicamento en el tratamiento del Virus de Inmunodeficiencia Humana (VIH). Se refiere, asimismo, al uso de un compuesto de la presente, solo o en combinación con otro agente, para la fabricación de medicamentos en el tratamiento del rechazo al trasplante de órganos sólidos, de la enfermedad injerto vs. huésped, de la artritis, de la artritis reumatoide, de la enfermedad inflamatoria del intestino, de la dermatitis atópica, de la soriasis, del asma, de las alergias o de la esclerosis múltiple y un kit.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31568301P | 2001-08-29 | 2001-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036366A1 true AR036366A1 (es) | 2004-09-01 |
Family
ID=23225580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103217A AR036366A1 (es) | 2001-08-29 | 2002-08-27 | Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US20040010008A1 (es) |
| EP (1) | EP1421075B1 (es) |
| JP (2) | JP4223950B2 (es) |
| KR (1) | KR20040029057A (es) |
| CN (1) | CN1304389C (es) |
| AR (1) | AR036366A1 (es) |
| AT (1) | ATE328879T1 (es) |
| BR (1) | BR0212108A (es) |
| CA (1) | CA2457861A1 (es) |
| CY (1) | CY1105198T1 (es) |
| DE (1) | DE60212146T2 (es) |
| DK (1) | DK1421075T3 (es) |
| EC (1) | ECSP044993A (es) |
| ES (1) | ES2264491T3 (es) |
| HU (1) | HUP0402019A3 (es) |
| IL (1) | IL160060A0 (es) |
| MX (1) | MXPA04001886A (es) |
| NO (1) | NO20041266L (es) |
| PL (1) | PL368827A1 (es) |
| PT (1) | PT1421075E (es) |
| RU (1) | RU2004109510A (es) |
| WO (1) | WO2003020716A1 (es) |
| ZA (1) | ZA200401594B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0108876D0 (en) * | 2001-04-09 | 2001-05-30 | Novartis Ag | Organic Compounds |
| US7307090B2 (en) | 2001-07-02 | 2007-12-11 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| GB0223223D0 (en) * | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
| US20040082612A1 (en) * | 2002-10-15 | 2004-04-29 | Baxter Ellen W | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| JP4757802B2 (ja) * | 2003-11-03 | 2011-08-24 | シェーリング コーポレイション | ケモカインレセプターの阻害剤として有用なビピペリジニル誘導体 |
| AU2004289690A1 (en) * | 2003-11-10 | 2005-05-26 | Schering Aktiengesellschaft | Benzylether amine compounds useful as CCR-5 antagonists |
| WO2005101838A2 (en) | 2004-04-13 | 2005-10-27 | Incyte Corporation | Piperazinylpiperidine derivatives as chemokine receptor antagonists |
| US7880002B2 (en) | 2004-12-29 | 2011-02-01 | Millennium Pharmaceuticals, Inc. | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists |
| WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| EP1844037A1 (en) * | 2005-01-20 | 2007-10-17 | Pfizer Limited | Chemical compounds |
| WO2006091534A1 (en) * | 2005-02-23 | 2006-08-31 | Schering Corporation | Piperidinyl piperidine derivatives useful as inhibitors of chemokine receptors |
| US20070010565A1 (en) * | 2005-04-25 | 2007-01-11 | Olaf Prien | New thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents |
| EP2402316A1 (en) | 2005-07-21 | 2012-01-04 | AstraZeneca AB (Publ) | Piperidine derivatives |
| US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| WO2009043747A2 (en) * | 2007-10-01 | 2009-04-09 | F. Hoffmann-La Roche Ag | N-heterocyclic biaryl carboxamides as ccr receptor antagonists |
| JP5432249B2 (ja) | 2008-06-18 | 2014-03-05 | エフ．ホフマン−ラ ロシュ アーゲー | 新規なヘテロアリールカルボキシアミド誘導体 |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| JP2017501164A (ja) | 2013-12-19 | 2017-01-12 | バイエル ファーマ アクチエンゲゼルシャフト | 置換されたピペリジニルテトラヒドロキノリン類 |
| WO2015091420A1 (de) * | 2013-12-19 | 2015-06-25 | Bayer Pharma Aktiengesellschaft | Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten |
| WO2015091415A1 (de) | 2013-12-19 | 2015-06-25 | Bayer Pharma Aktiengesellschaft | Substituierte bipiperidinyl-derivate als adrenorezeptor alpha 2c antagonisten |
| WO2015091414A2 (de) | 2013-12-19 | 2015-06-25 | Bayer Pharma Aktiengesellschaft | Substituierte piperidinyl-tetrahydrochinoline |
| EA037555B1 (ru) | 2015-04-02 | 2021-04-13 | Проксимэйджен, Элэлси | Применение 6-{4-[1-(пропан-2-ил)пиперидин-4-ил]-1,4-диазепан-1-ил}-n-(пиридин-4-ил)пиридин-2-карбоксамида для лечения раковых заболеваний цнс |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
| JP2024534781A (ja) | 2021-08-18 | 2024-09-26 | ケモセントリックス，インコーポレイティド | Ｃｃｒ６阻害剤としてのアリールスルホニル（ヒドロキシ）ピペリジン |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588722A (en) * | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
| TW531537B (en) * | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
| US5952349A (en) * | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
| JP3068206B2 (ja) * | 1996-07-10 | 2000-07-24 | シェーリング コーポレイション | ムスカリン様アンタゴニストとしての１，４―ジ―置換ピペリジン |
| EP1175402B1 (en) * | 1999-05-04 | 2005-07-20 | Schering Corporation | Piperidine derivatives useful as ccr5 antagonists |
| WO2001030348A1 (en) * | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
| AR033517A1 (es) * | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0108876D0 (en) * | 2001-04-09 | 2001-05-30 | Novartis Ag | Organic Compounds |
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