ECSP044993A - Derivados de piperidina utiles como antagonistas de ccr5 - Google Patents
Derivados de piperidina utiles como antagonistas de ccr5Info
- Publication number
- ECSP044993A ECSP044993A EC2004004993A ECSP044993A ECSP044993A EC SP044993 A ECSP044993 A EC SP044993A EC 2004004993 A EC2004004993 A EC 2004004993A EC SP044993 A ECSP044993 A EC SP044993A EC SP044993 A ECSP044993 A EC SP044993A
- Authority
- EC
- Ecuador
- Prior art keywords
- compound
- treatment
- ccg5
- antagonists
- piperidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención provee un compuesto de fórmula ó una de sus sales ó solvaltos aceptables para uso farmacéutico, en la cual R1, R2, R3, R9, R10, A y B son lo definido en la memoria descriptiva. La presente invención también provee composiciones farmacéuticas que contienen el compuesto de la invención y métodos de tratamiento que utilizan el compuesto de la invención. La invención también se refiere al uso de una combinación de un compuesto de esta invención y uno o más agentes antivirales u otros agentes útiles en el tratamiento del Virus de Inmunodeficiencia Humana (VIH). La invención se refiere asimismo al uso de un compuesto de esta invención, solo ó en combinación con otro agente, en el tratamiento del rechazo al trasplante de órganos sólidos, de la enfermedad injerto vs. Huésped, de la artritis, de la artritis reumatoide, de la enfermedad inflamatoria del intestino, de la dermatitis atópica, de la soriaris, del asma, de las alergias ó de la esclerosis múltiple
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31568301P | 2001-08-29 | 2001-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP044993A true ECSP044993A (es) | 2004-04-28 |
Family
ID=23225580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004004993A ECSP044993A (es) | 2001-08-29 | 2004-02-27 | Derivados de piperidina utiles como antagonistas de ccr5 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20040010008A1 (es) |
| EP (1) | EP1421075B1 (es) |
| JP (2) | JP4223950B2 (es) |
| KR (1) | KR20040029057A (es) |
| CN (1) | CN1304389C (es) |
| AR (1) | AR036366A1 (es) |
| AT (1) | ATE328879T1 (es) |
| BR (1) | BR0212108A (es) |
| CA (1) | CA2457861A1 (es) |
| CY (1) | CY1105198T1 (es) |
| DE (1) | DE60212146T2 (es) |
| DK (1) | DK1421075T3 (es) |
| EC (1) | ECSP044993A (es) |
| ES (1) | ES2264491T3 (es) |
| HK (1) | HK1061563A1 (es) |
| HU (1) | HUP0402019A3 (es) |
| IL (1) | IL160060A0 (es) |
| MX (1) | MXPA04001886A (es) |
| NO (1) | NO20041266L (es) |
| PL (1) | PL368827A1 (es) |
| PT (1) | PT1421075E (es) |
| RU (1) | RU2004109510A (es) |
| WO (1) | WO2003020716A1 (es) |
| ZA (1) | ZA200401594B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0108876D0 (en) * | 2001-04-09 | 2001-05-30 | Novartis Ag | Organic Compounds |
| RU2004100839A (ru) | 2001-07-02 | 2005-06-20 | Астразенека Аб (Se) | Производные пиперидина полезные в качестве модуляторов активности рецепторов хемокинов |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| GB0223223D0 (en) * | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
| AU2003301299A1 (en) * | 2002-10-15 | 2004-05-04 | Janssen Pharmaceutica, N.V. | Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| CN101798299A (zh) * | 2003-11-03 | 2010-08-11 | 先灵公司 | 用作趋化因子受体抑制剂的双六氢吡啶衍生物 |
| EP1687268A1 (en) * | 2003-11-10 | 2006-08-09 | Schering Aktiengesellschaft | Benzylether amine compounds useful as ccr-5 antagonists |
| WO2005101838A2 (en) | 2004-04-13 | 2005-10-27 | Incyte Corporation | Piperazinylpiperidine derivatives as chemokine receptor antagonists |
| WO2006071958A1 (en) * | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| US7880002B2 (en) | 2004-12-29 | 2011-02-01 | Millennium Pharmaceuticals, Inc. | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists |
| JP2008528477A (ja) * | 2005-01-20 | 2008-07-31 | ファイザー・リミテッド | 化合物 |
| MX2007010257A (es) * | 2005-02-23 | 2007-09-11 | Schering Corp | Derivados de piperidinil piperidina utiles como inhibidores de receptores de quimiocinas. |
| US20070010565A1 (en) * | 2005-04-25 | 2007-01-11 | Olaf Prien | New thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents |
| US8314127B2 (en) | 2005-07-21 | 2012-11-20 | Astrazeneca Ab | Piperidine derivatives |
| US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| MX2010003621A (es) * | 2007-10-01 | 2010-04-14 | Hoffmann La Roche | N-heterociclil biaril carboxamidas como antagonistas del receptor ccr. |
| AU2009259496A1 (en) | 2008-06-18 | 2009-12-23 | F. Hoffmann-La Roche Ag | Novel heteroaryl carboxamide derivatives |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| JP2017503783A (ja) | 2013-12-19 | 2017-02-02 | バイエル ファーマ アクチエンゲゼルシャフト | アドレナリン受容体アルファ２ｃ拮抗薬としての置換されたビピペリジニル誘導体 |
| TN2016000249A1 (en) | 2013-12-19 | 2017-10-06 | Bayer Pharma AG | Substituted piperidinyl-tetrahydroquinolines. |
| EP3083610A1 (de) | 2013-12-19 | 2016-10-26 | Bayer Pharma Aktiengesellschaft | Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten |
| JOP20200052A1 (ar) | 2013-12-19 | 2017-06-16 | Bayer Pharma AG | بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c |
| JP6927882B2 (ja) | 2015-04-02 | 2021-09-01 | プロキシマジェン，リミティド ライアビリティ カンパニー | 癌の新治療法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588722A (en) * | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
| TW531537B (en) * | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
| IL127942A0 (en) * | 1996-07-10 | 1999-11-30 | Schering Corp | 1,4-Di-substituted piperidines as muscarinic antagonists |
| US5952349A (en) * | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
| CN1151131C (zh) * | 1999-05-04 | 2004-05-26 | 先灵公司 | 用作ccr5拮抗剂的哌啶衍生物 |
| WO2001030348A1 (en) * | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
| AR033517A1 (es) * | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0108876D0 (en) * | 2001-04-09 | 2001-05-30 | Novartis Ag | Organic Compounds |
-
2002
- 2002-08-27 AR ARP020103217A patent/AR036366A1/es unknown
- 2002-08-28 JP JP2003524986A patent/JP4223950B2/ja not_active Expired - Fee Related
- 2002-08-28 KR KR10-2004-7002835A patent/KR20040029057A/ko not_active Application Discontinuation
- 2002-08-28 AT AT02766142T patent/ATE328879T1/de not_active IP Right Cessation
- 2002-08-28 WO PCT/US2002/027389 patent/WO2003020716A1/en active IP Right Grant
- 2002-08-28 MX MXPA04001886A patent/MXPA04001886A/es active IP Right Grant
- 2002-08-28 PT PT02766142T patent/PT1421075E/pt unknown
- 2002-08-28 IL IL16006002A patent/IL160060A0/xx unknown
- 2002-08-28 HU HU0402019A patent/HUP0402019A3/hu unknown
- 2002-08-28 EP EP02766142A patent/EP1421075B1/en not_active Expired - Lifetime
- 2002-08-28 RU RU2004109510/04A patent/RU2004109510A/ru not_active Application Discontinuation
- 2002-08-28 DK DK02766142T patent/DK1421075T3/da active
- 2002-08-28 ES ES02766142T patent/ES2264491T3/es not_active Expired - Lifetime
- 2002-08-28 BR BR0212108-5A patent/BR0212108A/pt not_active IP Right Cessation
- 2002-08-28 US US10/229,466 patent/US20040010008A1/en not_active Abandoned
- 2002-08-28 PL PL02368827A patent/PL368827A1/xx not_active Application Discontinuation
- 2002-08-28 CN CNB028166795A patent/CN1304389C/zh not_active Expired - Fee Related
- 2002-08-28 DE DE60212146T patent/DE60212146T2/de not_active Expired - Lifetime
- 2002-08-28 CA CA002457861A patent/CA2457861A1/en not_active Abandoned
-
2003
- 2003-07-29 US US10/629,466 patent/US7442703B2/en not_active Expired - Fee Related
- 2003-07-29 US US10/628,933 patent/US7384948B2/en not_active Expired - Fee Related
-
2004
- 2004-02-25 ZA ZA200401594A patent/ZA200401594B/en unknown
- 2004-02-27 EC EC2004004993A patent/ECSP044993A/es unknown
- 2004-03-26 NO NO20041266A patent/NO20041266L/no not_active Application Discontinuation
- 2004-06-19 HK HK04104463A patent/HK1061563A1/xx not_active IP Right Cessation
-
2006
- 2006-09-06 CY CY20061101271T patent/CY1105198T1/el unknown
-
2008
- 2008-04-17 US US12/104,914 patent/US8034933B2/en not_active Expired - Fee Related
- 2008-05-22 JP JP2008134844A patent/JP2008222722A/ja active Pending
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