DE69010232D1 - 2-(1-Piperazinyl)-4-phenylcycloalkanpyridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten. - Google Patents
2-(1-Piperazinyl)-4-phenylcycloalkanpyridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten.Info
- Publication number
- DE69010232D1 DE69010232D1 DE69010232T DE69010232T DE69010232D1 DE 69010232 D1 DE69010232 D1 DE 69010232D1 DE 69010232 T DE69010232 T DE 69010232T DE 69010232 T DE69010232 T DE 69010232T DE 69010232 D1 DE69010232 D1 DE 69010232D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- piperazinyl
- processes
- preparation
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5254489 | 1989-03-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69010232D1 true DE69010232D1 (de) | 1994-08-04 |
| DE69010232T2 DE69010232T2 (de) | 1994-12-01 |
Family
ID=12917732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69010232T Expired - Lifetime DE69010232T2 (de) | 1989-03-03 | 1990-02-20 | 2-(1-Piperazinyl)-4-phenylcycloalkanpyridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5021421A (de) |
| EP (1) | EP0385237B1 (de) |
| KR (1) | KR0149649B1 (de) |
| AT (1) | ATE107922T1 (de) |
| AU (1) | AU623981B2 (de) |
| CA (1) | CA2011346C (de) |
| DD (1) | DD292909A5 (de) |
| DE (1) | DE69010232T2 (de) |
| DK (1) | DK0385237T3 (de) |
| ES (1) | ES2058630T3 (de) |
| FI (1) | FI94413C (de) |
| HK (1) | HK1005872A1 (de) |
| HU (1) | HU204810B (de) |
| NO (1) | NO177095C (de) |
| RU (1) | RU2075478C1 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041443A (en) * | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
| PT706796E (pt) * | 1993-06-25 | 2001-06-29 | Pola Chem Ind Inc | Inibidor de reincorporacao de dopamina |
| CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
| US6458789B1 (en) | 1999-09-29 | 2002-10-01 | Lion Bioscience Ag | 2-aminopyridine derivatives and combinatorial libraries thereof |
| EP1474401A2 (de) * | 2002-02-05 | 2004-11-10 | Novo Nordisk A/S | Neue aryl- und heteroarylpiperazine |
| CA2602348C (en) | 2005-03-31 | 2011-03-01 | Pfizer Products Inc. | Cyclopentapyridine and tetrahydroquinoline derivatives |
| RU2499795C2 (ru) | 2005-07-04 | 2013-11-27 | Хай Пойнт Фармасьютикалс, ЛЛС | Антагонисты гистаминовых н3-рецепторов |
| JP2009537596A (ja) | 2006-05-23 | 2009-10-29 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | ６−（４−シクロプロピルピペリジン−１−イル）−２’−メチル−［３，４’］−ビピリジン及びその医薬としての使用 |
| WO2007137968A1 (en) | 2006-05-29 | 2007-12-06 | High Point Pharmaceuticals, Llc | 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
| AU2007255724B2 (en) * | 2006-06-09 | 2012-05-10 | Dainippon Sumitomo Pharma Co., Ltd. | Novel tape preparation |
| ES2348685T3 (es) * | 2006-07-14 | 2010-12-10 | MERCK SHARP & DOHME CORP. | Antagonistas diazepan sustituidos de receptores de orexinas. |
| JP2010510314A (ja) | 2006-11-22 | 2010-04-02 | シーサイド セラピューティクス，エルエルシー | 精神遅滞、ダウン症候群、脆弱ｘ症候群および自閉症の治療方法 |
| EP2014656A3 (de) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | Neue heterocyclische H3-Antagonisten |
| CN101531634B (zh) * | 2008-03-10 | 2013-09-18 | 北京德众万全医药科技有限公司 | 一种高纯度的布南色林及其制备方法 |
| CN101530412A (zh) * | 2008-03-10 | 2009-09-16 | 北京德众万全医药科技有限公司 | 一种布南色林的药物组合物及其制备方法 |
| CN101747273B (zh) * | 2008-12-02 | 2012-03-07 | 浙江华海药业股份有限公司 | 布南色林中间体的制备方法 |
| CN101747272B (zh) * | 2008-12-02 | 2012-11-28 | 浙江华海药业股份有限公司 | 布南色林晶型b及其制备方法 |
| CN101766626B (zh) * | 2008-12-30 | 2012-03-07 | 丽珠医药集团股份有限公司 | 一种治疗精神分裂症的含布南色林的口服制剂 |
| MX346801B (es) | 2009-03-13 | 2017-03-31 | Agios Pharmaceuticals Inc | Métodos y composiciones para trastornos relacionados con la proliferación celular. |
| KR101850813B1 (ko) | 2009-06-29 | 2018-04-20 | 아지오스 파마슈티컬스 아이엔씨. | 치료용 화합물 및 조성물 |
| CN101619039B (zh) * | 2009-06-30 | 2011-04-13 | 严洁 | 2-(4-乙基-1-哌嗪基)-4-(4-氟苯基)-5,6,7,8,9,10-六氢芳辛并[b]吡啶及其组合物 |
| ES2594402T3 (es) | 2009-10-21 | 2016-12-20 | Agios Pharmaceuticals, Inc. | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| EP2525790B1 (de) | 2009-10-21 | 2020-05-27 | Agios Pharmaceuticals, Inc. | Verfahren und zusammensetzungen für zellproliferationsbedingte erkrankungen |
| BR112013002280A2 (pt) | 2010-08-10 | 2016-05-24 | Lupin Ltd | composições farmacêuticas orais de liberação controlada compreendendo blonanseina |
| CN102372673B (zh) * | 2010-08-27 | 2014-04-09 | 天津市医药集团技术发展有限公司 | 布南色林结晶及其制备方法 |
| CN102093289B (zh) * | 2010-10-29 | 2012-12-19 | 常州华生制药有限公司 | 布南色林中间体的制备方法 |
| CN102030707A (zh) * | 2010-11-12 | 2011-04-27 | 深圳万和制药有限公司 | 布南色林中间体的制备方法 |
| ME03074B (de) | 2011-05-03 | 2019-01-20 | Agios Pharmaceuticals Inc | Pyruvatkinaseaktivatoren zur verwendung in der therapie |
| CN102827170A (zh) * | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| HUE038403T2 (hu) | 2012-01-06 | 2018-10-29 | Agios Pharmaceuticals Inc | Terápiásan alkalmazható vegyületek és alkalmazási módszereik |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| AU2013331626B2 (en) | 2012-10-15 | 2018-08-02 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CA2917671A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| US9968595B2 (en) | 2014-03-14 | 2018-05-15 | Agios Pharmaceuticals, Inc. | Pharmaceutical compositions of therapeutically active compounds |
| CN104311487B (zh) * | 2014-09-22 | 2016-08-24 | 江苏正大丰海制药有限公司 | 一种布南色林晶型及其制备方法 |
| JP7320339B2 (ja) | 2015-06-11 | 2023-08-03 | アジオス ファーマシューティカルズ， インコーポレイテッド | ピルビン酸キナーゼ活性化因子を使用する方法 |
| KR20180067658A (ko) | 2015-10-15 | 2018-06-20 | 아지오스 파마슈티컬스 아이엔씨. | 악성 종양의 치료를 위한 조합물 요법 |
| MX2018004587A (es) | 2015-10-15 | 2018-08-14 | Agios Pharmaceuticals Inc | Terapia de combinacion para tratar tumores malignos. |
| KR20190028109A (ko) | 2017-09-08 | 2019-03-18 | 연성정밀화학(주) | 블로난세린 함유 서방성 제제 |
| CN110575438A (zh) * | 2018-06-07 | 2019-12-17 | 湖南省湘中制药有限公司 | 一种布南色林固体分散体的制备及其应用 |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| EP3939954A4 (de) | 2019-03-13 | 2023-01-04 | Otsuka Pharmaceutical Co., Ltd. | Verfahren zur einführung eines deuterierten niederalkyls in eine aminfraktion einer ein sekundäres amin enthaltenden verbindung |
| CN113698347A (zh) * | 2020-05-22 | 2021-11-26 | 湖南省湘中制药有限公司 | 一种布南色林工艺杂质f的制备方法 |
| CN113698346A (zh) * | 2020-05-22 | 2021-11-26 | 湖南省湘中制药有限公司 | 一种布南色林工艺杂质b的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54128588A (en) * | 1978-03-29 | 1979-10-05 | Dainippon Pharmaceut Co Ltd | Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline |
| DE3124673A1 (de) * | 1981-06-24 | 1983-01-13 | Bayer Ag, 5090 Leverkusen | Subsituierte 2-amino-pyridinderivate, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln, sowie deren herstellung |
| FR2602771B1 (fr) * | 1986-08-12 | 1988-11-04 | Rhone Poulenc Sante | Nouveaux derives de la benzyl-4 piperazine, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1990
- 1990-02-20 DE DE69010232T patent/DE69010232T2/de not_active Expired - Lifetime
- 1990-02-20 EP EP90103244A patent/EP0385237B1/de not_active Expired - Lifetime
- 1990-02-20 AT AT90103244T patent/ATE107922T1/de not_active IP Right Cessation
- 1990-02-20 US US07/481,183 patent/US5021421A/en not_active Expired - Lifetime
- 1990-02-20 ES ES90103244T patent/ES2058630T3/es not_active Expired - Lifetime
- 1990-02-20 DK DK90103244.1T patent/DK0385237T3/da active
- 1990-03-01 DD DD90338287A patent/DD292909A5/de unknown
- 1990-03-01 FI FI901030A patent/FI94413C/fi active IP Right Grant
- 1990-03-01 AU AU50604/90A patent/AU623981B2/en not_active Expired
- 1990-03-01 NO NO900991A patent/NO177095C/no not_active IP Right Cessation
- 1990-03-02 CA CA002011346A patent/CA2011346C/en not_active Expired - Lifetime
- 1990-03-02 HU HU901275A patent/HU204810B/hu unknown
- 1990-03-03 KR KR1019900002874A patent/KR0149649B1/ko not_active IP Right Cessation
-
1992
- 1992-11-12 RU RU92004429/04A patent/RU2075478C1/ru active
-
1998
- 1998-06-05 HK HK98105004A patent/HK1005872A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO900991D0 (no) | 1990-03-01 |
| EP0385237B1 (de) | 1994-06-29 |
| FI901030A0 (fi) | 1990-03-01 |
| RU2075478C1 (ru) | 1997-03-20 |
| NO900991L (no) | 1990-09-04 |
| HU204810B (en) | 1992-02-28 |
| HUT53361A (en) | 1990-10-28 |
| EP0385237A3 (de) | 1991-03-20 |
| EP0385237A2 (de) | 1990-09-05 |
| FI94413C (fi) | 1995-09-11 |
| CA2011346A1 (en) | 1990-09-03 |
| NO177095C (no) | 1995-07-19 |
| DE69010232T2 (de) | 1994-12-01 |
| HK1005872A1 (en) | 1999-01-29 |
| US5021421A (en) | 1991-06-04 |
| AU623981B2 (en) | 1992-05-28 |
| KR0149649B1 (ko) | 1998-10-15 |
| DK0385237T3 (da) | 1994-07-25 |
| NO177095B (no) | 1995-04-10 |
| KR900014358A (ko) | 1990-10-23 |
| ATE107922T1 (de) | 1994-07-15 |
| ES2058630T3 (es) | 1994-11-01 |
| HU901275D0 (en) | 1990-05-28 |
| AU5060490A (en) | 1990-09-06 |
| FI94413B (fi) | 1995-05-31 |
| CA2011346C (en) | 1999-08-03 |
| DD292909A5 (de) | 1991-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP |