ATE185807T1 - Thiazolylbenzofuranderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten - Google Patents
Thiazolylbenzofuranderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthaltenInfo
- Publication number
- ATE185807T1 ATE185807T1 AT92113705T AT92113705T ATE185807T1 AT E185807 T1 ATE185807 T1 AT E185807T1 AT 92113705 T AT92113705 T AT 92113705T AT 92113705 T AT92113705 T AT 92113705T AT E185807 T1 ATE185807 T1 AT E185807T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- acyl
- cyano
- optionally substituted
- halogen
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- IQDNFLQNJPENQU-UHFFFAOYSA-N 2-(1-benzofuran-2-yl)-1,3-thiazole Chemical class C1=CSC(C=2OC3=CC=CC=C3C=2)=N1 IQDNFLQNJPENQU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 14
- 125000002252 acyl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052727 yttrium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919117733A GB9117733D0 (en) | 1991-08-16 | 1991-08-16 | New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
| GB929201057A GB9201057D0 (en) | 1992-01-17 | 1992-01-17 | New thiazolylbenzofuran derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE185807T1 true ATE185807T1 (de) | 1999-11-15 |
Family
ID=26299417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92113705T ATE185807T1 (de) | 1991-08-16 | 1992-08-12 | Thiazolylbenzofuranderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5296495A (de) |
| EP (1) | EP0528337B1 (de) |
| JP (1) | JP2600644B2 (de) |
| KR (1) | KR930004304A (de) |
| CN (1) | CN1033088C (de) |
| AT (1) | ATE185807T1 (de) |
| AU (1) | AU665007B2 (de) |
| CA (1) | CA2076192A1 (de) |
| DE (1) | DE69230163T2 (de) |
| DK (1) | DK0528337T3 (de) |
| ES (1) | ES2137169T3 (de) |
| GR (1) | GR3032425T3 (de) |
| HU (2) | HUT64336A (de) |
| MX (1) | MX9204746A (de) |
| SG (1) | SG45259A1 (de) |
| TW (1) | TW224464B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2102078A1 (en) * | 1992-11-02 | 1994-05-03 | Akira Takase | A process for producing (e)-alkoxyimino or hydroxyiminoacetamide compounds and intermediates therefor |
| KR100329887B1 (ko) * | 1992-11-02 | 2002-11-02 | 시오노기세이야쿠가부시키가이샤 | (e)-알콕시이미노-및하이드록시이미노-아세트아미드화합물의제조방법 및 그의 제조용중간체 |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| EP1170009B1 (de) * | 1996-01-22 | 2004-04-07 | Fujisawa Pharmaceutical Co., Ltd. | Thiazolylbenzofuranderivate und ihre Verwendung als SRS-A- und Leukotrien-Antagonisten |
| ATE257703T1 (de) * | 1997-10-27 | 2004-01-15 | Takeda Chemical Industries Ltd | 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes |
| US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| WO2003048140A1 (en) | 2001-12-03 | 2003-06-12 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| US7148248B2 (en) | 2002-11-29 | 2006-12-12 | Masako Nozaki | Method of treating or inhibiting the development of brain inflammation and sepsis |
| EP1424101A3 (de) * | 2002-11-29 | 2004-08-18 | NOZAKI, Masako | Verwendung eines Leukotrien- C4/ D4 -rezeptorantagonisten zur Herstellung eines Medikamentes zur Behandlung oder Vorbeugung von Gehirnentzündung und -sepsis |
| HK1078086A1 (en) * | 2003-04-09 | 2006-03-03 | 日本烟草产业株式会社 | Heteroaromatic pentacyclic compound and medicinal use thereof |
| JP2005008631A (ja) * | 2003-05-29 | 2005-01-13 | New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
| WO2004106317A1 (ja) | 2003-05-29 | 2004-12-09 | The New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
| ITTO20040125A1 (it) * | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
| KR101213926B1 (ko) | 2004-07-14 | 2012-12-18 | 인플러메이션 리서치 센터 컴퍼니 엘티디. | 종양 세포의 전이를 저해하는 방법 및 약제학적 조성물 |
| JP2008509143A (ja) * | 2004-08-04 | 2008-03-27 | シェーリング コーポレイション | 気道疾患の処置のためのプレコナリルを含む薬学的処方物 |
| JP2008517938A (ja) | 2004-10-25 | 2008-05-29 | シェーリング コーポレイション | 呼吸器障害を処置するために他の活性剤と組み合わせたｍ１レセプターアンタゴニストおよび／またはｍ３レセプターアンタゴニスト |
| WO2006046683A1 (en) * | 2004-10-25 | 2006-05-04 | Astellas Pharma Inc. | Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists |
| US8084492B2 (en) * | 2004-11-19 | 2011-12-27 | The New Industry Research Organization | Benzofuran compound and pharmaceutical composition containing the same |
| WO2008008327A2 (en) * | 2006-07-11 | 2008-01-17 | Schering Corporation | Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound |
| WO2008061236A2 (en) * | 2006-11-16 | 2008-05-22 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
| JP2012530140A (ja) | 2009-06-16 | 2012-11-29 | メルク・シャープ・アンド・ドーム・コーポレーション | グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用 |
| CA2839699A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| AU2012272898A1 (en) | 2011-06-24 | 2013-04-11 | Amgen Inc. | TRPM8 antagonists and their use in treatments |
| SG11201403645VA (en) * | 2011-12-28 | 2014-07-30 | Global Blood Therapeutics Inc | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation |
| ES2790358T3 (es) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| ES2890077T3 (es) | 2013-03-15 | 2022-01-17 | Global Blood Therapeutics Inc | Compuestos y usos de los mismos para la modulación de la hemoglobina |
| EA201591426A1 (ru) | 2013-03-15 | 2016-02-29 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| PE20160179A1 (es) | 2014-02-07 | 2016-05-20 | Global Blood Therapeutics Inc | Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido |
| SI3186233T1 (sl) * | 2014-08-29 | 2022-04-29 | Chdi Foundation, Inc. | Sonde za slikanje proteina huntingtina |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| SG11201804647TA (en) | 2015-12-04 | 2018-06-28 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| TWI825524B (zh) | 2016-05-12 | 2023-12-11 | 美商全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| WO2018115984A1 (en) | 2016-12-19 | 2018-06-28 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammation |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| WO2024239000A2 (en) * | 2023-05-18 | 2024-11-21 | Enveda Therapeutics, Inc. | G-protein coupled receptor antagonist |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62142168A (ja) * | 1985-10-16 | 1987-06-25 | Mitsubishi Chem Ind Ltd | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
| US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
| US4908357A (en) * | 1986-04-30 | 1990-03-13 | Fmc Corporation | Photoactive azole pesticides |
| US5001140A (en) * | 1989-04-17 | 1991-03-19 | Hoffmann-La Roche Inc. | Cycloalkylthiazoles |
| JPH02169584A (ja) * | 1988-12-22 | 1990-06-29 | Mitsubishi Kasei Corp | ビニルチアゾール誘導体およびそれを有効成分とする薬剤 |
| US5032588A (en) * | 1989-12-08 | 1991-07-16 | Abbott Laboratories | Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
| DE3941438A1 (de) * | 1989-12-15 | 1991-06-20 | Hoechst Ag | Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
-
1992
- 1992-08-06 JP JP4210308A patent/JP2600644B2/ja not_active Expired - Fee Related
- 1992-08-12 DE DE69230163T patent/DE69230163T2/de not_active Expired - Fee Related
- 1992-08-12 SG SG1996002173A patent/SG45259A1/en unknown
- 1992-08-12 ES ES92113705T patent/ES2137169T3/es not_active Expired - Lifetime
- 1992-08-12 EP EP92113705A patent/EP0528337B1/de not_active Expired - Lifetime
- 1992-08-12 AT AT92113705T patent/ATE185807T1/de not_active IP Right Cessation
- 1992-08-12 US US07/929,751 patent/US5296495A/en not_active Expired - Fee Related
- 1992-08-12 DK DK92113705T patent/DK0528337T3/da active
- 1992-08-13 AU AU21029/92A patent/AU665007B2/en not_active Ceased
- 1992-08-14 TW TW081106455A patent/TW224464B/zh active
- 1992-08-14 HU HU9202656A patent/HUT64336A/hu unknown
- 1992-08-14 KR KR1019920014712A patent/KR930004304A/ko not_active Ceased
- 1992-08-14 CA CA002076192A patent/CA2076192A1/en not_active Abandoned
- 1992-08-15 CN CN92110877A patent/CN1033088C/zh not_active Expired - Fee Related
- 1992-08-17 MX MX9204746A patent/MX9204746A/es not_active IP Right Cessation
-
1995
- 1995-06-22 HU HU95P/P00346P patent/HU211630A9/hu unknown
-
2000
- 2000-01-19 GR GR20000400122T patent/GR3032425T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2076192A1 (en) | 1993-02-17 |
| DE69230163T2 (de) | 2000-03-23 |
| ES2137169T3 (es) | 1999-12-16 |
| EP0528337B1 (de) | 1999-10-20 |
| TW224464B (de) | 1994-06-01 |
| MX9204746A (es) | 1994-04-29 |
| JPH05202040A (ja) | 1993-08-10 |
| HU211630A9 (en) | 1995-12-28 |
| DE69230163D1 (de) | 1999-11-25 |
| HU9202656D0 (en) | 1992-10-28 |
| GR3032425T3 (en) | 2000-05-31 |
| US5296495A (en) | 1994-03-22 |
| HUT64336A (en) | 1993-12-28 |
| AU665007B2 (en) | 1995-12-14 |
| JP2600644B2 (ja) | 1997-04-16 |
| KR930004304A (ko) | 1993-03-22 |
| AU2102992A (en) | 1993-02-18 |
| EP0528337A1 (de) | 1993-02-24 |
| CN1070910A (zh) | 1993-04-14 |
| DK0528337T3 (da) | 2000-03-27 |
| SG45259A1 (en) | 1998-01-16 |
| CN1033088C (zh) | 1996-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |