DK3186233T3 - Prober til billeddannelse af huntingtin-protein - Google Patents
Prober til billeddannelse af huntingtin-protein Download PDFInfo
- Publication number
- DK3186233T3 DK3186233T3 DK15836321.8T DK15836321T DK3186233T3 DK 3186233 T3 DK3186233 T3 DK 3186233T3 DK 15836321 T DK15836321 T DK 15836321T DK 3186233 T3 DK3186233 T3 DK 3186233T3
- Authority
- DK
- Denmark
- Prior art keywords
- probs
- imagination
- huntingtin protein
- huntingtin
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- Theoretical Computer Science (AREA)
- Pulmonology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462043603P | 2014-08-29 | 2014-08-29 | |
PCT/US2015/047407 WO2016033445A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3186233T3 true DK3186233T3 (da) | 2021-11-22 |
Family
ID=55400648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15836321.8T DK3186233T3 (da) | 2014-08-29 | 2015-08-28 | Prober til billeddannelse af huntingtin-protein |
Country Status (20)
Country | Link |
---|---|
US (3) | US10479802B2 (da) |
EP (2) | EP4006016A3 (da) |
JP (2) | JP6817207B2 (da) |
KR (2) | KR102586736B1 (da) |
CN (2) | CN116655618A (da) |
AU (1) | AU2015308774B2 (da) |
BR (1) | BR112017004141B8 (da) |
CA (1) | CA2959501C (da) |
DK (1) | DK3186233T3 (da) |
EA (1) | EA035646B1 (da) |
ES (1) | ES2898965T3 (da) |
HR (1) | HRP20211778T1 (da) |
HU (1) | HUE056957T2 (da) |
IL (1) | IL250803B (da) |
MX (2) | MX2017002703A (da) |
PL (1) | PL3186233T3 (da) |
PT (1) | PT3186233T (da) |
SG (1) | SG11201701600QA (da) |
SI (1) | SI3186233T1 (da) |
WO (1) | WO2016033445A1 (da) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3186241B1 (en) | 2014-08-29 | 2020-10-07 | CHDI Foundation, Inc. | Probes for imaging huntington protein |
HUE057702T2 (hu) | 2014-08-29 | 2022-05-28 | Chdi Foundation Inc | Szondák huntingtin fehérje képalkotáshoz |
US10479802B2 (en) | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
CN107105655A (zh) | 2014-08-29 | 2017-08-29 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
US10137211B2 (en) | 2015-08-28 | 2018-11-27 | Chdi Foundation, Inc. | Probes for imaging Huntingtin protein |
SG10202006688RA (en) | 2016-03-11 | 2020-08-28 | Ac Immune Sa | Bicyclic compounds for diagnosis and therapy |
CN107056723A (zh) * | 2017-04-21 | 2017-08-18 | 云南大学 | 一种具有抑制血管内皮生长因子受体信号传导的化合物 |
TWI802591B (zh) | 2017-09-14 | 2023-05-21 | 日商第一三共股份有限公司 | 具有環狀構造的化合物 |
EP3820868A1 (de) | 2018-04-20 | 2021-05-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
CN112533928A (zh) | 2018-06-08 | 2021-03-19 | Ac免疫有限公司 | 用于诊断的新化合物 |
TW202039481A (zh) | 2018-12-21 | 2020-11-01 | 美商西建公司 | Ripk2之噻吩并吡啶抑制劑 |
JP2022521431A (ja) | 2019-02-25 | 2022-04-07 | シーエイチディーアイ ファウンデーション,インコーポレーテッド | 変異型ハンチンチンタンパク質を標的とするための化合物及びその使用 |
CN111635400A (zh) | 2019-03-02 | 2020-09-08 | 察略盛医药科技(上海)有限公司 | 吡唑并[1,5-a]吡啶类衍生物、及其制备方法和用途 |
US20210236663A1 (en) * | 2019-12-18 | 2021-08-05 | Chdi Foundation, Inc. | Compounds and probes for imaging huntingtin protein |
CN115515961A (zh) | 2020-05-07 | 2022-12-23 | Ac免疫有限公司 | 用于诊断的新化合物 |
EP4192819A1 (en) * | 2020-08-06 | 2023-06-14 | CHDI Foundation, Inc. | Heterobiaryl compounds and imaging agents for imaging huntingtin protein |
JP2024513913A (ja) * | 2021-04-08 | 2024-03-27 | シーエイチディーアイ ファウンデーション,インコーポレーテッド | ハンチンチンタンパク質をイメージングするためのイソインドリノン化合物及びイメージング剤 |
CN117545512A (zh) | 2021-04-27 | 2024-02-09 | Chdi基金会股份有限公司 | 用于对亨廷顿蛋白成像的氘化化合物和成像剂 |
EP4367112A1 (en) | 2021-07-09 | 2024-05-15 | Plexium, Inc. | Aryl compounds and pharmaceutical compositions that modulate ikzf2 |
WO2023083961A1 (en) | 2021-11-10 | 2023-05-19 | Ac Immune Sa | Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis |
WO2023083998A1 (en) | 2021-11-10 | 2023-05-19 | Ac Immune Sa | Dihydropyrrolo[3,4c]-pyrazole derivatives and their use in diagnosis |
AU2022385416A1 (en) | 2021-11-10 | 2024-05-02 | Ac Immune Sa | 4h-imidazo[1,5-b]pyrazole derivatives for diagnosis |
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HUE057702T2 (hu) | 2014-08-29 | 2022-05-28 | Chdi Foundation Inc | Szondák huntingtin fehérje képalkotáshoz |
CN107105655A (zh) | 2014-08-29 | 2017-08-29 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
EP3186241B1 (en) | 2014-08-29 | 2020-10-07 | CHDI Foundation, Inc. | Probes for imaging huntington protein |
US10479802B2 (en) | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
US10137211B2 (en) | 2015-08-28 | 2018-11-27 | Chdi Foundation, Inc. | Probes for imaging Huntingtin protein |
-
2015
- 2015-08-28 US US15/507,208 patent/US10479802B2/en active Active
- 2015-08-28 SG SG11201701600QA patent/SG11201701600QA/en unknown
- 2015-08-28 KR KR1020227035965A patent/KR102586736B1/ko active IP Right Grant
- 2015-08-28 PL PL15836321T patent/PL3186233T3/pl unknown
- 2015-08-28 DK DK15836321.8T patent/DK3186233T3/da active
- 2015-08-28 BR BR112017004141A patent/BR112017004141B8/pt active IP Right Grant
- 2015-08-28 CN CN202310475134.8A patent/CN116655618A/zh active Pending
- 2015-08-28 HR HRP20211778TT patent/HRP20211778T1/hr unknown
- 2015-08-28 EA EA201790407A patent/EA035646B1/ru unknown
- 2015-08-28 CA CA2959501A patent/CA2959501C/en active Active
- 2015-08-28 WO PCT/US2015/047407 patent/WO2016033445A1/en active Application Filing
- 2015-08-28 PT PT158363218T patent/PT3186233T/pt unknown
- 2015-08-28 MX MX2017002703A patent/MX2017002703A/es unknown
- 2015-08-28 KR KR1020177008383A patent/KR102456946B1/ko active IP Right Grant
- 2015-08-28 ES ES15836321T patent/ES2898965T3/es active Active
- 2015-08-28 HU HUE15836321A patent/HUE056957T2/hu unknown
- 2015-08-28 CN CN201580058282.3A patent/CN107108534B/zh active Active
- 2015-08-28 AU AU2015308774A patent/AU2015308774B2/en active Active
- 2015-08-28 JP JP2017530971A patent/JP6817207B2/ja active Active
- 2015-08-28 SI SI201531751T patent/SI3186233T1/sl unknown
- 2015-08-28 EP EP21192872.6A patent/EP4006016A3/en not_active Withdrawn
- 2015-08-28 EP EP15836321.8A patent/EP3186233B8/en active Active
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2017
- 2017-02-27 IL IL250803A patent/IL250803B/en active IP Right Grant
- 2017-02-28 MX MX2021003311A patent/MX2021003311A/es unknown
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2019
- 2019-08-02 US US16/530,594 patent/US11059836B2/en active Active
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2020
- 2020-12-24 JP JP2020214504A patent/JP7126541B2/ja active Active
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2022
- 2022-08-05 US US17/881,895 patent/US20230212190A1/en active Pending
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