SG11201701600QA - Probes for imaging huntingtin protein - Google Patents
Probes for imaging huntingtin proteinInfo
- Publication number
- SG11201701600QA SG11201701600QA SG11201701600QA SG11201701600QA SG11201701600QA SG 11201701600Q A SG11201701600Q A SG 11201701600QA SG 11201701600Q A SG11201701600Q A SG 11201701600QA SG 11201701600Q A SG11201701600Q A SG 11201701600QA SG 11201701600Q A SG11201701600Q A SG 11201701600QA
- Authority
- SG
- Singapore
- Prior art keywords
- probes
- huntingtin protein
- imaging
- imaging huntingtin
- protein
- Prior art date
Links
- 102000016252 Huntingtin Human genes 0.000 title 1
- 108050004784 Huntingtin Proteins 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 239000000523 sample Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- Theoretical Computer Science (AREA)
- Pulmonology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043603P | 2014-08-29 | 2014-08-29 | |
| PCT/US2015/047407 WO2016033445A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201701600QA true SG11201701600QA (en) | 2017-03-30 |
Family
ID=55400648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201701600QA SG11201701600QA (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10479802B2 (en) |
| EP (2) | EP3186233B8 (en) |
| JP (2) | JP6817207B2 (en) |
| KR (2) | KR102456946B1 (en) |
| CN (2) | CN107108534B (en) |
| AU (1) | AU2015308774B2 (en) |
| BR (1) | BR112017004141B8 (en) |
| CA (1) | CA2959501C (en) |
| DK (1) | DK3186233T3 (en) |
| EA (1) | EA035646B1 (en) |
| ES (1) | ES2898965T3 (en) |
| HR (1) | HRP20211778T1 (en) |
| HU (1) | HUE056957T2 (en) |
| IL (1) | IL250803B (en) |
| MX (2) | MX2017002703A (en) |
| PL (1) | PL3186233T3 (en) |
| PT (1) | PT3186233T (en) |
| SG (1) | SG11201701600QA (en) |
| SI (1) | SI3186233T1 (en) |
| WO (1) | WO2016033445A1 (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3186233T1 (en) * | 2014-08-29 | 2022-04-29 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| BR112017004136B1 (en) | 2014-08-29 | 2022-05-03 | Chdi Foundation, Inc | Imaging agent, its use and compounds |
| EP3190888B1 (en) | 2014-08-29 | 2020-06-10 | CHDI Foundation, Inc. | Probes for imaging huntingtin protein |
| JP6754353B2 (en) | 2014-08-29 | 2020-09-09 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | Huntington protein imaging probe |
| HRP20211156T1 (en) | 2015-08-28 | 2021-12-24 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN109071528B (en) | 2016-03-11 | 2023-02-17 | Ac免疫有限公司 | Bicyclic compounds for diagnosis and therapy |
| CN107056723A (en) * | 2017-04-21 | 2017-08-18 | 云南大学 | It is a kind of that there is the compound for suppressing vascular endothelial growth factor receptor signal transduction |
| AU2018333913B2 (en) | 2017-09-14 | 2022-11-17 | Daiichi Sankyo Company, Limited | Compound having cyclic structure |
| KR20210005081A (en) | 2018-04-20 | 2021-01-13 | 바이엘 악티엔게젤샤프트 | Heterocyclene derivatives as pest control agents |
| IL279219B2 (en) | 2018-06-08 | 2024-08-01 | Ac Immune Sa | Novel compounds for diagnosis |
| AR117472A1 (en) | 2018-12-21 | 2021-08-11 | Celgene Corp | RIPK2 TIENOPYRIDINE INHIBITORS |
| JP2022521431A (en) | 2019-02-25 | 2022-04-07 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | Compounds for targeting mutant huntingtin proteins and their use |
| CN111635400A (en) | 2019-03-02 | 2020-09-08 | 察略盛医药科技(上海)有限公司 | Pyrazolo [1,5-a ] pyridine derivative, and preparation method and application thereof |
| WO2021127265A1 (en) * | 2019-12-18 | 2021-06-24 | Chdi Foundation, Inc. | Compounds and probes for imaging huntingtin protein |
| JP2023525081A (en) | 2020-05-07 | 2023-06-14 | エーシー・イミューン・エス・アー | Novel compounds for diagnostics |
| BR112023002139A2 (en) * | 2020-08-06 | 2023-04-18 | Chdi Foundation Inc | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR HUNTINGTIN PROTEIN |
| WO2022216947A1 (en) * | 2021-04-08 | 2022-10-13 | Chdi Foundation, Inc. | Isoindolinone compounds and imaging agents for imaging huntingtin protein |
| MX2023012652A (en) | 2021-04-27 | 2024-01-08 | Chdi Foundation Inc | Deuterated compounds and imaging agents for imaging huntingtin protein. |
| JP2024529298A (en) | 2021-07-09 | 2024-08-06 | プレキシウム インコーポレイテッド | Aryl compounds and pharmaceutical compositions that modulate IKZF2 - Patent application |
| CN118215667A (en) | 2021-11-10 | 2024-06-18 | Ac免疫有限公司 | 4H-imidazo [1,5-B ] pyrazole derivatives for diagnostic use |
| WO2023083998A1 (en) | 2021-11-10 | 2023-05-19 | Ac Immune Sa | Dihydropyrrolo[3,4c]-pyrazole derivatives and their use in diagnosis |
| EP4430044A1 (en) | 2021-11-10 | 2024-09-18 | AC Immune SA | Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis |
| WO2024126840A1 (en) | 2022-12-16 | 2024-06-20 | Ac Immune Sa | Novel compounds for diagnosis |
| WO2024126842A1 (en) | 2022-12-16 | 2024-06-20 | Ac Immune Sa | Novel compounds for diagnosis |
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| BR112017004136B1 (en) | 2014-08-29 | 2022-05-03 | Chdi Foundation, Inc | Imaging agent, its use and compounds |
| EP3190888B1 (en) | 2014-08-29 | 2020-06-10 | CHDI Foundation, Inc. | Probes for imaging huntingtin protein |
| JP6754353B2 (en) | 2014-08-29 | 2020-09-09 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | Huntington protein imaging probe |
| SI3186233T1 (en) | 2014-08-29 | 2022-04-29 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| HRP20211156T1 (en) | 2015-08-28 | 2021-12-24 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
-
2015
- 2015-08-28 SI SI201531751T patent/SI3186233T1/en unknown
- 2015-08-28 CN CN201580058282.3A patent/CN107108534B/en active Active
- 2015-08-28 EP EP15836321.8A patent/EP3186233B8/en active Active
- 2015-08-28 EA EA201790407A patent/EA035646B1/en unknown
- 2015-08-28 CA CA2959501A patent/CA2959501C/en active Active
- 2015-08-28 HU HUE15836321A patent/HUE056957T2/en unknown
- 2015-08-28 BR BR112017004141A patent/BR112017004141B8/en active IP Right Grant
- 2015-08-28 EP EP21192872.6A patent/EP4006016A3/en not_active Withdrawn
- 2015-08-28 WO PCT/US2015/047407 patent/WO2016033445A1/en active Application Filing
- 2015-08-28 KR KR1020177008383A patent/KR102456946B1/en active IP Right Grant
- 2015-08-28 JP JP2017530971A patent/JP6817207B2/en active Active
- 2015-08-28 US US15/507,208 patent/US10479802B2/en active Active
- 2015-08-28 PT PT158363218T patent/PT3186233T/en unknown
- 2015-08-28 HR HRP20211778TT patent/HRP20211778T1/en unknown
- 2015-08-28 DK DK15836321.8T patent/DK3186233T3/en active
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