MX9204746A - Nuevos derivados de tiazolilbenzofuranos, procedimientos para la preparacion de los mismos y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de tiazolilbenzofuranos, procedimientos para la preparacion de los mismos y las composiciones farmaceuticas que los contienen.

Info

Publication number
MX9204746A
MX9204746A MX9204746A MX9204746A MX9204746A MX 9204746 A MX9204746 A MX 9204746A MX 9204746 A MX9204746 A MX 9204746A MX 9204746 A MX9204746 A MX 9204746A MX 9204746 A MX9204746 A MX 9204746A
Authority
MX
Mexico
Prior art keywords
alkyl
acyl
cyano
optionally substituted
halogen
Prior art date
Application number
MX9204746A
Other languages
English (en)
Inventor
Hiroshi Matsuda
Masaaki Matsuo
Kasuo Okumura
Shinji Shigenaga
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919117733A external-priority patent/GB9117733D0/en
Priority claimed from GB929201057A external-priority patent/GB9201057D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of MX9204746A publication Critical patent/MX9204746A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de la fórmula I: (fórmula) y las sales farmacéuticamente aceptables de los mismos.
MX9204746A 1991-08-16 1992-08-17 Nuevos derivados de tiazolilbenzofuranos, procedimientos para la preparacion de los mismos y las composiciones farmaceuticas que los contienen. MX9204746A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919117733A GB9117733D0 (en) 1991-08-16 1991-08-16 New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
GB929201057A GB9201057D0 (en) 1992-01-17 1992-01-17 New thiazolylbenzofuran derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
MX9204746A true MX9204746A (es) 1994-04-29

Family

ID=26299417

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9204746A MX9204746A (es) 1991-08-16 1992-08-17 Nuevos derivados de tiazolilbenzofuranos, procedimientos para la preparacion de los mismos y las composiciones farmaceuticas que los contienen.

Country Status (16)

Country Link
US (1) US5296495A (es)
EP (1) EP0528337B1 (es)
JP (1) JP2600644B2 (es)
KR (1) KR930004304A (es)
CN (1) CN1033088C (es)
AT (1) ATE185807T1 (es)
AU (1) AU665007B2 (es)
CA (1) CA2076192A1 (es)
DE (1) DE69230163T2 (es)
DK (1) DK0528337T3 (es)
ES (1) ES2137169T3 (es)
GR (1) GR3032425T3 (es)
HU (2) HUT64336A (es)
MX (1) MX9204746A (es)
SG (1) SG45259A1 (es)
TW (1) TW224464B (es)

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KR100329887B1 (ko) * 1992-11-02 2002-11-02 시오노기세이야쿠가부시키가이샤 (e)-알콕시이미노-및하이드록시이미노-아세트아미드화합물의제조방법 및 그의 제조용중간체
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ATE216384T1 (de) * 1996-01-22 2002-05-15 Fujisawa Pharmaceutical Co Thiazolylbenzofuranderivate und pharmazeutische zusammensetzungen die sie enthalten
DE69821132T2 (de) * 1997-10-27 2004-10-21 Takeda Chemical Industries Ltd 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US7163952B2 (en) 2001-12-03 2007-01-16 Japan Tobacco Inc. Azole compound and medicinal use thereof
EP1424101A3 (en) * 2002-11-29 2004-08-18 NOZAKI, Masako Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis
US7148248B2 (en) 2002-11-29 2006-12-12 Masako Nozaki Method of treating or inhibiting the development of brain inflammation and sepsis
WO2004089918A1 (ja) * 2003-04-09 2004-10-21 Japan Tobacco Inc. 複素芳香５員環化合物及びその医薬用途
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
US7638540B2 (en) * 2003-05-29 2009-12-29 The New Industry Research Organization Benzofuran compound and medicinal composition containing the same
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
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MX2007001561A (es) * 2004-08-04 2007-04-16 Schering Corp Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas.
WO2006046683A1 (en) * 2004-10-25 2006-05-04 Astellas Pharma Inc. Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists
CA2585122A1 (en) 2004-10-25 2006-05-04 Schering Corporation M1 and/or m3 receptor antagonists in combination with other actives for treating respiratory disorders
WO2006054793A1 (ja) * 2004-11-19 2006-05-26 The New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
CA2657902A1 (en) * 2006-07-11 2008-01-17 Schering Corporation Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
WO2008061236A2 (en) * 2006-11-16 2008-05-22 Allergan, Inc. Sulfoximines as kinase inhibitors
MX2011013679A (es) 2009-06-16 2012-01-20 Schering Corp Esteroides de heteroarilo [3.2-c] novedosos como agonistas de receptor de glucocorticoide composiciones y uso de los mismos.
CN103906733A (zh) 2011-06-24 2014-07-02 安姆根有限公司 Trpm8拮抗剂及其在治疗中的用途
MX2013015058A (es) 2011-06-24 2014-01-20 Amgen Inc Antagonistas de melastatina 8 de potencial receptor transitorio y su uso en tratamientos.
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
HUE035069T2 (en) * 2011-12-28 2018-05-02 Global Blood Therapeutics Inc Substituted benzaldehyde compounds and their use to increase tissue oxygenation
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
CA2903022C (en) 2013-03-15 2021-11-09 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
KR20150132146A (ko) 2013-03-15 2015-11-25 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
JP6809681B2 (ja) 2014-02-07 2021-01-06 グローバル ブラッド セラピューティクス インコーポレイテッド ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
SI3186233T1 (sl) * 2014-08-29 2022-04-29 Chdi Foundation, Inc. Sonde za slikanje proteina huntingtina
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
TW201731509A (zh) 2015-12-04 2017-09-16 全球血液治療公司 針對２-羥基-６-（（２-（１-異丙基-１ｈ-吡唑-５-基）吡啶-３-基）甲氧基）-苯甲醛之劑量方案
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
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Also Published As

Publication number Publication date
EP0528337B1 (en) 1999-10-20
KR930004304A (ko) 1993-03-22
CA2076192A1 (en) 1993-02-17
TW224464B (es) 1994-06-01
ES2137169T3 (es) 1999-12-16
EP0528337A1 (en) 1993-02-24
GR3032425T3 (en) 2000-05-31
ATE185807T1 (de) 1999-11-15
AU2102992A (en) 1993-02-18
DK0528337T3 (da) 2000-03-27
SG45259A1 (en) 1998-01-16
AU665007B2 (en) 1995-12-14
US5296495A (en) 1994-03-22
CN1070910A (zh) 1993-04-14
CN1033088C (zh) 1996-10-23
JPH05202040A (ja) 1993-08-10
HU9202656D0 (en) 1992-10-28
DE69230163T2 (de) 2000-03-23
HUT64336A (en) 1993-12-28
JP2600644B2 (ja) 1997-04-16
HU211630A9 (en) 1995-12-28
DE69230163D1 (de) 1999-11-25

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees