DE69205327D1 - Harnstoffderivate, Verfahren zu ihrer Herstellung und diese enthaltende Medikamente. - Google Patents
Harnstoffderivate, Verfahren zu ihrer Herstellung und diese enthaltende Medikamente.Info
- Publication number
- DE69205327D1 DE69205327D1 DE69205327T DE69205327T DE69205327D1 DE 69205327 D1 DE69205327 D1 DE 69205327D1 DE 69205327 T DE69205327 T DE 69205327T DE 69205327 T DE69205327 T DE 69205327T DE 69205327 D1 DE69205327 D1 DE 69205327D1
- Authority
- DE
- Germany
- Prior art keywords
- halogen
- aryl
- substituted
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919110133A GB9110133D0 (en) | 1991-05-10 | 1991-05-10 | New urea derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same |
GB919112823A GB9112823D0 (en) | 1991-06-14 | 1991-06-14 | New urea derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same |
GB919127277A GB9127277D0 (en) | 1991-12-23 | 1991-12-23 | New urea derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69205327D1 true DE69205327D1 (de) | 1995-11-16 |
DE69205327T2 DE69205327T2 (de) | 1996-03-28 |
Family
ID=27265636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69205327T Expired - Fee Related DE69205327T2 (de) | 1991-05-10 | 1992-05-11 | Harnstoffderivate, Verfahren zu ihrer Herstellung und diese enthaltende Medikamente. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0512570B1 (de) |
JP (1) | JPH05140102A (de) |
KR (1) | KR920021523A (de) |
CN (1) | CN1067886A (de) |
AT (1) | ATE128975T1 (de) |
CA (1) | CA2068261A1 (de) |
DE (1) | DE69205327T2 (de) |
IL (1) | IL101785A0 (de) |
MX (1) | MX9202142A (de) |
TW (1) | TW200456B (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993024458A1 (en) * | 1992-05-28 | 1993-12-09 | Pfizer Inc. | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat) |
TW234123B (de) * | 1992-12-16 | 1994-11-11 | Takeda Pharm Industry Co Ltd | |
NZ250916A (en) * | 1993-02-27 | 1995-08-28 | Nihon Nohyaku Co Ltd | N-heteroaryl-n'-phenylureas, their use as acat inhibitors |
US5346914A (en) * | 1993-05-14 | 1994-09-13 | Abbott Laboratories | (4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase |
IL109568A0 (en) * | 1993-05-19 | 1994-08-26 | Fujisawa Pharmaceutical Co | Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
ES2076865B1 (es) * | 1993-07-05 | 1996-08-01 | Pfizer | Nuevos derivados de n-aril- y n-heteroaril-urea como inhibidores de acil-coenzima a: colesterol acil transferasa (acat). |
JP3720395B2 (ja) | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
PT841913E (pt) * | 1995-08-04 | 2003-06-30 | Warner Lambert Co | Utilizacao de derivados sulfamico acil sulfonamidas ou sulfonil carbamatos para a producao de um medicamento para reduzir os niveis de lipoproteinas |
IL123939A (en) * | 1995-10-05 | 2001-11-25 | Kyoto Pharma Ind | The history of the heterocycles and the pharmaceutical preparations containing them |
WO1999015520A1 (fr) * | 1997-09-19 | 1999-04-01 | Ono Pharmaceutical Co., Ltd. | Composes de benzene fusionnes ou non fusionnes |
EP1308438B9 (de) | 2000-08-10 | 2012-03-28 | Mitsubishi Tanabe Pharma Corporation | 3-substituierte harnstoffderivate und deren medizinische verwendung |
CN102050758A (zh) | 2000-09-14 | 2011-05-11 | 田边三菱制药株式会社 | 酰胺衍生物及其制备药物的用途 |
MXPA03008319A (es) * | 2001-03-16 | 2003-12-11 | Abbott Lab | Nuevas aminas como ligantes del receptor de histamina-3 y sus aplicaciones terapeuticas. |
US6969730B2 (en) | 2001-03-16 | 2005-11-29 | Abbott Laboratories | Amines as histamine-3 receptor ligands and their therapeutic applications |
DK1397130T3 (da) | 2001-06-20 | 2007-11-12 | Wyeth Corp | Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) |
TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
IL166313A0 (en) | 2002-07-17 | 2006-01-15 | Kyoto Pharma Ind | Indoline derivatives and pharmaceutical compositions containing the same |
AU2003296323A1 (en) | 2002-12-10 | 2004-06-30 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
AU2003296324A1 (en) | 2002-12-10 | 2004-06-30 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
CN1723197A (zh) | 2002-12-10 | 2006-01-18 | 惠氏公司 | 作为纤溶酶原激活物抑制剂-1(pai-1)的抑制剂的取代3-烷基和3-芳基烷基1h-吲哚-1-基乙酸衍生物 |
DE60306548T2 (de) | 2002-12-10 | 2007-06-21 | Wyeth | Substituierte 3-carbonyl-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren |
US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7435837B2 (en) | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
MX2007002178A (es) | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares. |
WO2006023864A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as pai-1 inhibitors |
JP2008510816A (ja) | 2004-08-23 | 2008-04-10 | ワイス | チアゾロ−ナフチル酸 |
BRPI0606871A2 (pt) | 2005-01-27 | 2009-07-21 | Wyeth Corp | "processos e compostos para a preparação de derivados de naftilindol substituìdos |
AU2006279496A1 (en) | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
PT2239211E (pt) | 2009-04-09 | 2014-05-07 | Nestec Sa | Cápsula para preparação de uma bebida com vedante de delaminação ou rompível numa parede de distribuição |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
AU632809B2 (en) * | 1989-05-25 | 1993-01-14 | Takeda Chemical Industries Ltd. | Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof |
AU7440691A (en) * | 1990-03-12 | 1991-10-10 | Yamanouchi Pharmaceutical Co., Ltd. | Monourea derivative and its salt |
-
1992
- 1992-05-05 IL IL101785A patent/IL101785A0/xx unknown
- 1992-05-07 KR KR1019920007739A patent/KR920021523A/ko not_active Application Discontinuation
- 1992-05-08 CA CA002068261A patent/CA2068261A1/en not_active Abandoned
- 1992-05-08 MX MX9202142A patent/MX9202142A/es unknown
- 1992-05-08 TW TW081103591A patent/TW200456B/zh active
- 1992-05-08 JP JP4116348A patent/JPH05140102A/ja active Pending
- 1992-05-09 CN CN92104292A patent/CN1067886A/zh active Pending
- 1992-05-11 DE DE69205327T patent/DE69205327T2/de not_active Expired - Fee Related
- 1992-05-11 AT AT92107863T patent/ATE128975T1/de active
- 1992-05-11 EP EP92107863A patent/EP0512570B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU1528292A (en) | 1992-11-12 |
ATE128975T1 (de) | 1995-10-15 |
KR920021523A (ko) | 1992-12-18 |
CA2068261A1 (en) | 1992-11-11 |
IL101785A0 (en) | 1992-12-30 |
CN1067886A (zh) | 1993-01-13 |
JPH05140102A (ja) | 1993-06-08 |
MX9202142A (es) | 1993-06-01 |
AU653019B2 (en) | 1994-09-15 |
EP0512570A1 (de) | 1992-11-11 |
DE69205327T2 (de) | 1996-03-28 |
TW200456B (de) | 1993-02-21 |
EP0512570B1 (de) | 1995-10-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |