DE3686979D1 - Cephemverbindungen und verfahren zu ihrer herstellung. - Google Patents
Cephemverbindungen und verfahren zu ihrer herstellung.Info
- Publication number
- DE3686979D1 DE3686979D1 DE8686101938T DE3686979T DE3686979D1 DE 3686979 D1 DE3686979 D1 DE 3686979D1 DE 8686101938 T DE8686101938 T DE 8686101938T DE 3686979 T DE3686979 T DE 3686979T DE 3686979 D1 DE3686979 D1 DE 3686979D1
- Authority
- DE
- Germany
- Prior art keywords
- heterocyclic group
- halogen
- hydrogen
- cephem
- connections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858504072A GB8504072D0 (en) | 1985-02-18 | 1985-02-18 | Cephem compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3686979D1 true DE3686979D1 (de) | 1992-11-26 |
DE3686979T2 DE3686979T2 (de) | 1993-03-11 |
Family
ID=10574636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686101938T Expired - Fee Related DE3686979T2 (de) | 1985-02-18 | 1986-02-15 | Cephemverbindungen und verfahren zu ihrer herstellung. |
Country Status (6)
Country | Link |
---|---|
US (2) | US4861769A (de) |
EP (1) | EP0192210B1 (de) |
JP (1) | JPS61246189A (de) |
AT (1) | ATE81655T1 (de) |
DE (1) | DE3686979T2 (de) |
GB (1) | GB8504072D0 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0830051B2 (ja) * | 1986-05-21 | 1996-03-27 | 武田薬品工業株式会社 | 4−ハロゲノ−2−置換オキシイミノ−3−オキソ酪酸のエステルまたはアミドの製造法 |
DE4030706A1 (de) * | 1990-09-28 | 1992-04-02 | Bayer Ag | Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE4037841A1 (de) * | 1990-11-28 | 1992-06-04 | Bayer Ag | Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
CA2123788C (en) * | 1992-09-18 | 2001-03-13 | Hiroshi Akagi | Cephem compound, process for producing the compound, and pharmaceutical composition containing the same |
DE69521378T2 (de) * | 1994-03-17 | 2002-05-29 | Otsuka Kagaku K.K., Osaka | Cephemderivat, verfahren zu dessen herstellung und dieses enthaltendes antibakterielles mittel |
US5949237A (en) * | 1996-02-03 | 1999-09-07 | Forschungszentrum Karlsruhe Gmbh | Microwave cavity resonator for continuous spectroscopic gas analysis |
EP3616695A1 (de) | 2011-09-09 | 2020-03-04 | Merck Sharp & Dohme Corp. | Verfahren zur behandlung von intrapulmonalen infektionen |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
KR102329764B1 (ko) | 2013-03-15 | 2021-11-23 | 머크 샤프 앤드 돔 코포레이션 | 세프톨로잔 항균성 조성물 |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
US20140274991A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
EP3043797B1 (de) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Behandlung von infektionen mit ceftolozan/tazobactam bei personen mit beeinträchtigter nierenfunktion |
US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1602725A (en) * | 1977-04-27 | 1981-11-18 | Glaxo Operations Ltd | 7-(a-oxyiminoacetamido)-ceph-3-em-4-carboxylic acid derivatives |
AR228726A1 (es) * | 1978-05-26 | 1983-04-15 | Glaxo Group Ltd | Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato |
US4341775A (en) * | 1978-09-11 | 1982-07-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4468515A (en) * | 1978-12-29 | 1984-08-28 | Fujisawa Pharmaceutical Co., Ltd. | 2-Substituted oxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acids |
US4431642A (en) * | 1980-12-01 | 1984-02-14 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
HU189290B (en) * | 1982-05-31 | 1986-06-30 | Banyu Pharmaceutical Co Ltd,Jp | Process for preparing new 2-oxo-1-azetidine-sulphonic acid derivatives and pharmaceutically acceptable salts thereof, further pharmaceutical compositions containing such derivatives as active substances |
SE8303727L (sv) * | 1982-06-30 | 1984-02-03 | Glaxo Group Ltd | Cefalosporinantibiotika |
DE3316797A1 (de) * | 1983-05-07 | 1984-11-08 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von cephemverbindungen |
-
1985
- 1985-02-18 GB GB858504072A patent/GB8504072D0/en active Pending
-
1986
- 1986-02-12 US US06/828,527 patent/US4861769A/en not_active Expired - Fee Related
- 1986-02-15 EP EP86101938A patent/EP0192210B1/de not_active Expired - Lifetime
- 1986-02-15 AT AT86101938T patent/ATE81655T1/de not_active IP Right Cessation
- 1986-02-15 DE DE8686101938T patent/DE3686979T2/de not_active Expired - Fee Related
- 1986-02-18 JP JP61034500A patent/JPS61246189A/ja active Pending
-
1989
- 1989-05-17 US US07/352,989 patent/US4973699A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE81655T1 (de) | 1992-11-15 |
DE3686979T2 (de) | 1993-03-11 |
EP0192210A2 (de) | 1986-08-27 |
US4861769A (en) | 1989-08-29 |
JPS61246189A (ja) | 1986-11-01 |
GB8504072D0 (en) | 1985-03-20 |
US4973699A (en) | 1990-11-27 |
EP0192210A3 (en) | 1988-03-30 |
EP0192210B1 (de) | 1992-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE150462T1 (de) | Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung | |
ATE127801T1 (de) | Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung. | |
IL107426A0 (en) | Heterocyclic compounds, processes for the preparation thereof, and pharmaceutical compositions containing the same | |
ATE185807T1 (de) | Thiazolylbenzofuranderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten | |
FI863917A (fi) | Menetelmä valmistaa farmakologisesti käyttökelpoisia kinatsoliinijohdannaisia | |
HUP0203425A2 (en) | Quinazoline derivatives, process for their preparation and their use | |
BG103417A (en) | Condensed pyrimidine bicyclic derivatives | |
DE69021755D1 (de) | Benzopyranderivate und Verfahren zu ihrer Herstellung. | |
ATE172731T1 (de) | Pyrazolopyridinverbindung und verfahren zu ihrer herstellung | |
TW369535B (en) | A pyrazolopyridine compound and the process for preparing thereof | |
IL74031A0 (en) | Cyanoguanidinophenyldihydropyridazinone derivatives,their preparation and pharmaceutical compositions containing them | |
DE3686979D1 (de) | Cephemverbindungen und verfahren zu ihrer herstellung. | |
ATE141606T1 (de) | Cephemverbindungen und verfahren zu ihrer herstellung | |
DE3688087D1 (de) | Cephemverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate. | |
DE69330601D1 (de) | Serotoninergische ergolin derivate | |
ATE41659T1 (de) | Benzothiazepinderivate, verfahren zur herstellung und pharmazeutische zusammensetzungen. | |
IL81337A (en) | Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them | |
IE873212L (en) | Medicaments based on derivatives of 3,4-di-phenylpiperidine,¹the use of the derivatives as medicaments, and novel¹3,4-diphenylpiperidine derivatives and a process for the¹preparation therefor | |
ATE131480T1 (de) | Pyrimidoindolderivate und verfahren zu ihrer herstellung | |
FR2781482B1 (fr) | Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
ATE21908T1 (de) | Derivate von 1,4-diaminocyclitol, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
PT79486B (fr) | Procede de preparation de nouveaux derives de thieno<2,3-b>pyrrole et de compositions pharmaceutiques les contenant | |
ATE10934T1 (de) | Peptid, verfahren zu dessen herstellung und dessen verwendung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |