ATE241607T1 - Epoxybernsteinsäureamid-derivate - Google Patents
Epoxybernsteinsäureamid-derivateInfo
- Publication number
- ATE241607T1 ATE241607T1 AT98941728T AT98941728T ATE241607T1 AT E241607 T1 ATE241607 T1 AT E241607T1 AT 98941728 T AT98941728 T AT 98941728T AT 98941728 T AT98941728 T AT 98941728T AT E241607 T1 ATE241607 T1 AT E241607T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- heterocyclic
- group
- aryl
- aralkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25753897 | 1997-09-04 | ||
PCT/JP1998/003983 WO1999011640A1 (fr) | 1997-09-04 | 1998-09-04 | Derives d'epoxysuccinamide |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE241607T1 true ATE241607T1 (de) | 2003-06-15 |
Family
ID=17307684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98941728T ATE241607T1 (de) | 1997-09-04 | 1998-09-04 | Epoxybernsteinsäureamid-derivate |
Country Status (10)
Country | Link |
---|---|
US (2) | US6387908B1 (de) |
EP (2) | EP1342720A3 (de) |
JP (1) | JP4336039B2 (de) |
AT (1) | ATE241607T1 (de) |
AU (1) | AU8997898A (de) |
DE (1) | DE69815137T2 (de) |
DK (1) | DK1022276T3 (de) |
ES (1) | ES2201524T3 (de) |
PT (1) | PT1022276E (de) |
WO (1) | WO1999011640A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1465862A1 (de) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Cycloalkyl-ketoamiden derivate und ihre verwendung als cathepsin-k-inhibitoren |
US8013014B2 (en) * | 2002-07-05 | 2011-09-06 | Georgia Tech Research Corporation | Aza-peptide epoxides |
US7056947B2 (en) * | 2002-07-05 | 2006-06-06 | Georgia Tech Research Corp. | Aza-peptide epoxides |
AU2003261875A1 (en) * | 2002-09-11 | 2004-04-30 | Nippon Chemiphar Co., Ltd. | Amine derivative |
US7585988B2 (en) * | 2003-04-25 | 2009-09-08 | Nippon Chemiphar Co., Ltd. | Salt of (2S, 3S) -3- [[(1S) -1- isobutoxymethyl-3-methylbutyl] carbamoly] oxirane-2-carboxylic acid |
CA2557631A1 (en) * | 2004-02-18 | 2005-09-01 | Georgia Tech Research Corporation | Propenoyl hydrazides |
WO2007038772A1 (en) | 2005-09-28 | 2007-04-05 | American Life Science Pharmaceuticals | Novel drugs for dementia |
EP2019688A2 (de) * | 2006-05-22 | 2009-02-04 | Velcura Therapeutics, Inc. | Verwendung von cathepsin-k-antagonisten bei der knochenherstellung |
US20100216875A1 (en) * | 2006-12-20 | 2010-08-26 | Gregory Hook | Methods of treating alzheimer's disease |
CN101970007A (zh) | 2007-06-08 | 2011-02-09 | 日本化学医药株式会社 | 脑动脉瘤的治疗或预防药 |
US20100331545A1 (en) | 2007-10-24 | 2010-12-30 | Nippon Chemiphar Co., Ltd. | Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient |
WO2009065098A1 (en) * | 2007-11-16 | 2009-05-22 | Velcura Therapeutics, Inc. | Use of cathepsin k antagonists in the treatment of bone cancer |
JP2011241148A (ja) * | 2008-09-08 | 2011-12-01 | Nippon Chemiphar Co Ltd | 医療用固形製剤 |
JP2012148978A (ja) * | 2009-09-24 | 2012-08-09 | Nippon Chemiphar Co Ltd | 歯周病又は根尖性歯周炎の予防又は治療剤 |
KR20140034821A (ko) | 2011-05-16 | 2014-03-20 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 폐고혈압 및/또는 심부전의 치료 및/또는 예방을 위한 카텝신 k 억제의 용도 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5934711B2 (ja) | 1975-09-03 | 1984-08-24 | 大正製薬株式会社 | エポキシコハク酸エステル類の製法 |
JPS6059232B2 (ja) * | 1977-03-03 | 1985-12-24 | 大正製薬株式会社 | エポキシサクシニルアミノ酸誘導体 |
JPS6037104B2 (ja) * | 1977-03-04 | 1985-08-24 | 大正製薬株式会社 | エポキシコハク酸モノエステル誘導体 |
JPS5535012A (en) * | 1978-09-02 | 1980-03-11 | Taisho Pharmaceut Co Ltd | Compound of epoxysuccinylamino acid |
JPS55115878A (en) * | 1979-02-27 | 1980-09-06 | Taisho Pharmaceut Co Ltd | Epoxysuccinic acid derivative |
JPS5772913A (en) * | 1980-10-22 | 1982-05-07 | Nippon Chemiphar Co Ltd | Remedy for cardiac infraction |
JPS57169478A (en) * | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
JPS58126879A (ja) * | 1982-01-25 | 1983-07-28 | Nippon Chemiphar Co Ltd | 光学活性なピペラジン誘導体ならびに心筋梗塞の予防および治療剤 |
JPS6155509A (ja) | 1984-08-27 | 1986-03-20 | Dowa:Kk | 気化バ−ナにおける燃焼促進装置 |
EP0269311A3 (de) | 1986-11-17 | 1990-06-06 | Merck & Co. Inc. | Methoden zur Behandlung von Knochenleiden mittels Verabreichung von Cystein-Proteinaseinhibitoren |
JP2515114B2 (ja) * | 1987-01-23 | 1996-07-10 | 日本ケミフア株式会社 | 血小板凝集抑制剤 |
JP2515119B2 (ja) * | 1987-04-20 | 1996-07-10 | 日本ケミフア株式会社 | ピペラジン誘導体を含有する活性酸素産生抑制ならびに活性酸素除去作用を有する医薬組成物 |
JP2536754B2 (ja) * | 1987-05-08 | 1996-09-18 | 日本ケミファ株式会社 | ピペラジン誘導体 |
JPH0832698B2 (ja) * | 1987-05-08 | 1996-03-29 | 日本ケミファ株式会社 | ピペラジン誘導体 |
JP2554497B2 (ja) * | 1987-06-10 | 1996-11-13 | 日本ケミファ株式会社 | エポキシコハク酸誘導体を含有する医薬組成物 |
JPH02218610A (ja) | 1989-02-21 | 1990-08-31 | Toyo Jozo Co Ltd | 骨疾患の予防および治療剤 |
US5068354A (en) * | 1989-05-18 | 1991-11-26 | Taisho Pharmaceutical Co., Ltd. | Epoxysuccinic acid derivatives |
JPH02304075A (ja) * | 1989-05-18 | 1990-12-17 | Taisho Pharmaceut Co Ltd | エポキシコハク酸誘導体 |
JP2808877B2 (ja) * | 1990-09-29 | 1998-10-08 | 大正製薬株式会社 | エポキシスクシナム酸誘導体およびその中間体 |
CA2101417A1 (en) * | 1992-08-14 | 1994-02-15 | Ken-Ichi Saito | Prophylactic and therapeutic treatment of alzheimer's disease |
JPH06239835A (ja) | 1992-12-25 | 1994-08-30 | Mitsubishi Kasei Corp | アミノケトン誘導体 |
JPH06336428A (ja) * | 1993-05-27 | 1994-12-06 | Takeda Chem Ind Ltd | 免疫抑制剤 |
JPH07115985A (ja) * | 1993-10-26 | 1995-05-09 | Asahi Chem Ind Co Ltd | 生理活性物質am4299、それらの製法ならびに用途 |
US5556853A (en) * | 1993-10-29 | 1996-09-17 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives |
JPH08104683A (ja) * | 1993-10-29 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸誘導体 |
AU2537695A (en) * | 1994-05-31 | 1995-12-21 | Takeda Chemical Industries Ltd. | Epoxysuccinic acid derivatives, their production and use |
JPH08104684A (ja) | 1994-05-31 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸関連化合物 |
JPH0841043A (ja) | 1994-07-29 | 1996-02-13 | Taisho Pharmaceut Co Ltd | エポキシコハク酸誘導体 |
JPH0873352A (ja) * | 1994-09-06 | 1996-03-19 | Taisho Pharmaceut Co Ltd | 高血圧治療剤 |
EA000438B1 (ru) | 1995-03-31 | 1999-08-26 | Ниппон Кемифар Ко., Лтд. | Производные эпоксиянтарной кислоты |
JPH08325282A (ja) * | 1995-03-31 | 1996-12-10 | Nippon Chemiphar Co Ltd | ビスホスホン酸誘導体 |
WO1997003060A1 (fr) * | 1995-07-13 | 1997-01-30 | Senju Pharmaceutical Co., Ltd. | Derives de la piperazine et leurs utilisations |
ES2193615T3 (es) * | 1995-10-25 | 2003-11-01 | Senju Pharma Co | .nhibidor de la angiogenesis. |
US5733911A (en) * | 1996-01-26 | 1998-03-31 | Hitachi Chemical Co., Ltd. | Method for inducing death of neoplastic cells using piperazne derivatives |
US6997899B2 (en) * | 2002-12-17 | 2006-02-14 | Boston Scientific Scimed, Inc, | Rapid exchange dilation catheter for non-vascular applications |
-
1998
- 1998-09-04 DE DE69815137T patent/DE69815137T2/de not_active Expired - Lifetime
- 1998-09-04 US US09/508,026 patent/US6387908B1/en not_active Expired - Lifetime
- 1998-09-04 EP EP03011154A patent/EP1342720A3/de not_active Withdrawn
- 1998-09-04 WO PCT/JP1998/003983 patent/WO1999011640A1/ja active IP Right Grant
- 1998-09-04 AU AU89978/98A patent/AU8997898A/en not_active Abandoned
- 1998-09-04 PT PT98941728T patent/PT1022276E/pt unknown
- 1998-09-04 EP EP98941728A patent/EP1022276B1/de not_active Expired - Lifetime
- 1998-09-04 JP JP2000508679A patent/JP4336039B2/ja not_active Expired - Fee Related
- 1998-09-04 DK DK98941728T patent/DK1022276T3/da active
- 1998-09-04 AT AT98941728T patent/ATE241607T1/de active
- 1998-09-04 ES ES98941728T patent/ES2201524T3/es not_active Expired - Lifetime
-
2002
- 2002-01-08 US US10/042,994 patent/US6689785B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1342720A2 (de) | 2003-09-10 |
PT1022276E (pt) | 2003-10-31 |
DK1022276T3 (da) | 2003-09-29 |
US20020091131A1 (en) | 2002-07-11 |
US6689785B2 (en) | 2004-02-10 |
ES2201524T3 (es) | 2004-03-16 |
EP1022276A1 (de) | 2000-07-26 |
DE69815137D1 (de) | 2003-07-03 |
DE69815137T2 (de) | 2004-04-08 |
EP1022276A4 (de) | 2001-12-12 |
EP1342720A3 (de) | 2004-02-11 |
US6387908B1 (en) | 2002-05-14 |
AU8997898A (en) | 1999-03-22 |
JP4336039B2 (ja) | 2009-09-30 |
EP1022276B1 (de) | 2003-05-28 |
WO1999011640A1 (fr) | 1999-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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