DE69815137D1 - Epoxybernsteinsäureamid-derivate - Google Patents

Epoxybernsteinsäureamid-derivate

Info

Publication number
DE69815137D1
DE69815137D1 DE69815137T DE69815137T DE69815137D1 DE 69815137 D1 DE69815137 D1 DE 69815137D1 DE 69815137 T DE69815137 T DE 69815137T DE 69815137 T DE69815137 T DE 69815137T DE 69815137 D1 DE69815137 D1 DE 69815137D1
Authority
DE
Germany
Prior art keywords
alkyl
heterocyclic
group
aryl
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69815137T
Other languages
English (en)
Other versions
DE69815137T2 (de
Inventor
Yutaka Nomura
Toshihiro Takahashi
Yasushi Yoshino
Koichiro Nishioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Publication of DE69815137D1 publication Critical patent/DE69815137D1/de
Application granted granted Critical
Publication of DE69815137T2 publication Critical patent/DE69815137T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69815137T 1997-09-04 1998-09-04 Epoxybernsteinsäureamid-derivate Expired - Lifetime DE69815137T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25753897 1997-09-04
JP25753897 1997-09-04
PCT/JP1998/003983 WO1999011640A1 (fr) 1997-09-04 1998-09-04 Derives d'epoxysuccinamide

Publications (2)

Publication Number Publication Date
DE69815137D1 true DE69815137D1 (de) 2003-07-03
DE69815137T2 DE69815137T2 (de) 2004-04-08

Family

ID=17307684

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69815137T Expired - Lifetime DE69815137T2 (de) 1997-09-04 1998-09-04 Epoxybernsteinsäureamid-derivate

Country Status (10)

Country Link
US (2) US6387908B1 (de)
EP (2) EP1022276B1 (de)
JP (1) JP4336039B2 (de)
AT (1) ATE241607T1 (de)
AU (1) AU8997898A (de)
DE (1) DE69815137T2 (de)
DK (1) DK1022276T3 (de)
ES (1) ES2201524T3 (de)
PT (1) PT1022276E (de)
WO (1) WO1999011640A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062192A1 (en) 2002-01-17 2003-07-31 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
US8013014B2 (en) * 2002-07-05 2011-09-06 Georgia Tech Research Corporation Aza-peptide epoxides
US7056947B2 (en) * 2002-07-05 2006-06-06 Georgia Tech Research Corp. Aza-peptide epoxides
KR20050042798A (ko) 2002-09-11 2005-05-10 닛뽕 케미파 가부시키가이샤 아민 유도체
AU2004234235A1 (en) * 2003-04-25 2004-11-11 Nippon Chemiphar Co., Ltd. Salt of (2s,3s)-3-[[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid
AU2005214388A1 (en) * 2004-02-18 2005-09-01 Georgia Tech Research Corporation Propenoyl hydrazides
US20080227806A1 (en) * 2005-09-28 2008-09-18 American Life Science Pharmaceuticals Novel Drugs for Dementia
AU2007253796A1 (en) * 2006-05-22 2007-11-29 Velcura Therapeutics, Inc. Use of Cathepsin K antagonists in bone production
US20100216875A1 (en) * 2006-12-20 2010-08-26 Gregory Hook Methods of treating alzheimer's disease
WO2008149971A1 (ja) 2007-06-08 2008-12-11 Kyoto University 脳動脈瘤の治療または予防薬
WO2009054454A1 (ja) 2007-10-24 2009-04-30 National University Corporation Tokyo Medical And Dental University カテプシン阻害剤を有効成分として含有するＴｏｌｌ様受容体のシグナル伝達の調整剤
WO2009065098A1 (en) * 2007-11-16 2009-05-22 Velcura Therapeutics, Inc. Use of cathepsin k antagonists in the treatment of bone cancer
JP2011241148A (ja) * 2008-09-08 2011-12-01 Nippon Chemiphar Co Ltd 医療用固形製剤
JP2012148978A (ja) * 2009-09-24 2012-08-09 Nippon Chemiphar Co Ltd 歯周病又は根尖性歯周炎の予防又は治療剤
US9943522B2 (en) 2011-05-16 2018-04-17 Bayer Intellectual Property Gmbh Use of cathepsin K inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5934711B2 (ja) 1975-09-03 1984-08-24 大正製薬株式会社 エポキシコハク酸エステル類の製法
JPS6037104B2 (ja) * 1977-03-04 1985-08-24 大正製薬株式会社 エポキシコハク酸モノエステル誘導体
JPS6059232B2 (ja) * 1977-03-03 1985-12-24 大正製薬株式会社 エポキシサクシニルアミノ酸誘導体
JPS5535012A (en) * 1978-09-02 1980-03-11 Taisho Pharmaceut Co Ltd Compound of epoxysuccinylamino acid
JPS55115878A (en) * 1979-02-27 1980-09-06 Taisho Pharmaceut Co Ltd Epoxysuccinic acid derivative
JPS5772913A (en) * 1980-10-22 1982-05-07 Nippon Chemiphar Co Ltd Remedy for cardiac infraction
JPS57169478A (en) * 1981-04-10 1982-10-19 Nippon Chemiphar Co Ltd Piperazine derivative
JPS58126879A (ja) * 1982-01-25 1983-07-28 Nippon Chemiphar Co Ltd 光学活性なピペラジン誘導体ならびに心筋梗塞の予防および治療剤
JPS6155509A (ja) 1984-08-27 1986-03-20 Dowa:Kk 気化バ−ナにおける燃焼促進装置
EP0269311A3 (de) 1986-11-17 1990-06-06 Merck & Co. Inc. Methoden zur Behandlung von Knochenleiden mittels Verabreichung von Cystein-Proteinaseinhibitoren
JP2515114B2 (ja) * 1987-01-23 1996-07-10 日本ケミフア株式会社 血小板凝集抑制剤
JP2515119B2 (ja) * 1987-04-20 1996-07-10 日本ケミフア株式会社 ピペラジン誘導体を含有する活性酸素産生抑制ならびに活性酸素除去作用を有する医薬組成物
JPH0832698B2 (ja) * 1987-05-08 1996-03-29 日本ケミファ株式会社 ピペラジン誘導体
JP2536754B2 (ja) * 1987-05-08 1996-09-18 日本ケミファ株式会社 ピペラジン誘導体
JP2554497B2 (ja) * 1987-06-10 1996-11-13 日本ケミファ株式会社 エポキシコハク酸誘導体を含有する医薬組成物
JPH02218610A (ja) 1989-02-21 1990-08-31 Toyo Jozo Co Ltd 骨疾患の予防および治療剤
US5068354A (en) * 1989-05-18 1991-11-26 Taisho Pharmaceutical Co., Ltd. Epoxysuccinic acid derivatives
JPH02304075A (ja) * 1989-05-18 1990-12-17 Taisho Pharmaceut Co Ltd エポキシコハク酸誘導体
JP2808877B2 (ja) * 1990-09-29 1998-10-08 大正製薬株式会社 エポキシスクシナム酸誘導体およびその中間体
CA2101417A1 (en) * 1992-08-14 1994-02-15 Ken-Ichi Saito Prophylactic and therapeutic treatment of alzheimer's disease
JPH06239835A (ja) 1992-12-25 1994-08-30 Mitsubishi Kasei Corp アミノケトン誘導体
JPH06336428A (ja) * 1993-05-27 1994-12-06 Takeda Chem Ind Ltd 免疫抑制剤
JPH07115985A (ja) * 1993-10-26 1995-05-09 Asahi Chem Ind Co Ltd 生理活性物質ａｍ４２９９、それらの製法ならびに用途
JPH08104683A (ja) * 1993-10-29 1996-04-23 Takeda Chem Ind Ltd エポキシコハク酸誘導体
US5556853A (en) * 1993-10-29 1996-09-17 Takeda Chemical Industries, Ltd. Epoxysuccinic acid derivatives
EP0763029A1 (de) * 1994-05-31 1997-03-19 Takeda Chemical Industries, Ltd. Epoxybernsteinsäurederivate, ihre herstellung und verwendung
JPH08104684A (ja) 1994-05-31 1996-04-23 Takeda Chem Ind Ltd エポキシコハク酸関連化合物
JPH0841043A (ja) * 1994-07-29 1996-02-13 Taisho Pharmaceut Co Ltd エポキシコハク酸誘導体
JPH0873352A (ja) * 1994-09-06 1996-03-19 Taisho Pharmaceut Co Ltd 高血圧治療剤
JPH08325282A (ja) * 1995-03-31 1996-12-10 Nippon Chemiphar Co Ltd ビスホスホン酸誘導体
AU716620B2 (en) 1995-03-31 2000-03-02 Nippon Chemiphar Co. Ltd. Epoxysuccinic acid derivatives
US5935959A (en) * 1995-07-13 1999-08-10 Senju Pharmaceutical Co., Ltd. Piperazine derivatives and use as cysteine inhibitors
ATE230275T1 (de) * 1995-10-25 2003-01-15 Senju Pharma Co Angiogense-inhibitor
US5733911A (en) * 1996-01-26 1998-03-31 Hitachi Chemical Co., Ltd. Method for inducing death of neoplastic cells using piperazne derivatives
US6997899B2 (en) * 2002-12-17 2006-02-14 Boston Scientific Scimed, Inc, Rapid exchange dilation catheter for non-vascular applications

Also Published As

Publication number Publication date
EP1022276B1 (de) 2003-05-28
EP1342720A2 (de) 2003-09-10
US20020091131A1 (en) 2002-07-11
EP1022276A4 (de) 2001-12-12
DE69815137T2 (de) 2004-04-08
EP1342720A3 (de) 2004-02-11
US6387908B1 (en) 2002-05-14
DK1022276T3 (da) 2003-09-29
AU8997898A (en) 1999-03-22
ES2201524T3 (es) 2004-03-16
JP4336039B2 (ja) 2009-09-30
US6689785B2 (en) 2004-02-10
PT1022276E (pt) 2003-10-31
WO1999011640A1 (fr) 1999-03-11
ATE241607T1 (de) 2003-06-15
EP1022276A1 (de) 2000-07-26

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