DK1022276T3 - Epoxysuccinamidderivater - Google Patents

Epoxysuccinamidderivater

Info

Publication number
DK1022276T3
DK1022276T3 DK98941728T DK98941728T DK1022276T3 DK 1022276 T3 DK1022276 T3 DK 1022276T3 DK 98941728 T DK98941728 T DK 98941728T DK 98941728 T DK98941728 T DK 98941728T DK 1022276 T3 DK1022276 T3 DK 1022276T3
Authority
DK
Denmark
Prior art keywords
alkyl
heterocyclic
group
aryl
aralkyl
Prior art date
Application number
DK98941728T
Other languages
English (en)
Inventor
Yutaka Nomura
Toshihiro Takahashi
Yasushi Yoshino
Koichiro Nishioka
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Application granted granted Critical
Publication of DK1022276T3 publication Critical patent/DK1022276T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98941728T 1997-09-04 1998-09-04 Epoxysuccinamidderivater DK1022276T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25753897 1997-09-04
PCT/JP1998/003983 WO1999011640A1 (fr) 1997-09-04 1998-09-04 Derives d'epoxysuccinamide

Publications (1)

Publication Number Publication Date
DK1022276T3 true DK1022276T3 (da) 2003-09-29

Family

ID=17307684

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98941728T DK1022276T3 (da) 1997-09-04 1998-09-04 Epoxysuccinamidderivater

Country Status (10)

Country Link
US (2) US6387908B1 (da)
EP (2) EP1022276B1 (da)
JP (1) JP4336039B2 (da)
AT (1) ATE241607T1 (da)
AU (1) AU8997898A (da)
DE (1) DE69815137T2 (da)
DK (1) DK1022276T3 (da)
ES (1) ES2201524T3 (da)
PT (1) PT1022276E (da)
WO (1) WO1999011640A1 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1465862A1 (en) 2002-01-17 2004-10-13 SmithKline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
US8013014B2 (en) * 2002-07-05 2011-09-06 Georgia Tech Research Corporation Aza-peptide epoxides
US7056947B2 (en) * 2002-07-05 2006-06-06 Georgia Tech Research Corp. Aza-peptide epoxides
CN100349855C (zh) * 2002-09-11 2007-11-21 日本化学医药株式会社 胺衍生物
CA2523233C (en) 2003-04-25 2012-03-20 Nippon Chemiphar Co., Ltd. Salt of (2s,3s)-3-[[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid
US7482379B2 (en) * 2004-02-18 2009-01-27 Georgia Tech Research Corporation Propenoyl hydrazides
WO2007038772A1 (en) 2005-09-28 2007-04-05 American Life Science Pharmaceuticals Novel drugs for dementia
JP2010503610A (ja) * 2006-05-22 2010-02-04 ベルキュラ セラピューティクス インコーポレイティッド 骨産生におけるカテプシンｋアンタゴニストの使用
US20100216875A1 (en) * 2006-12-20 2010-08-26 Gregory Hook Methods of treating alzheimer's disease
US20110092484A1 (en) 2007-06-08 2011-04-21 Nippon Chemiphar Co., Ltd. Therapeutic or prophylactic agent for cerebral aneurysm
US20100331545A1 (en) * 2007-10-24 2010-12-30 Nippon Chemiphar Co., Ltd. Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient
WO2009065098A1 (en) * 2007-11-16 2009-05-22 Velcura Therapeutics, Inc. Use of cathepsin k antagonists in the treatment of bone cancer
JP2011241148A (ja) * 2008-09-08 2011-12-01 Nippon Chemiphar Co Ltd 医療用固形製剤
JP2012148978A (ja) * 2009-09-24 2012-08-09 Nippon Chemiphar Co Ltd 歯周病又は根尖性歯周炎の予防又は治療剤
MX2013013281A (es) 2011-05-16 2013-12-06 Bayer Ip Gmbh Uso de la inhibicion de la catepsina k para el tratamiento y/o profilaxis de hipertension pulmonar y/o insuficiencia cardiaca.

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5934711B2 (ja) 1975-09-03 1984-08-24 大正製薬株式会社 エポキシコハク酸エステル類の製法
JPS6059232B2 (ja) * 1977-03-03 1985-12-24 大正製薬株式会社 エポキシサクシニルアミノ酸誘導体
JPS6037104B2 (ja) * 1977-03-04 1985-08-24 大正製薬株式会社 エポキシコハク酸モノエステル誘導体
JPS5535012A (en) * 1978-09-02 1980-03-11 Taisho Pharmaceut Co Ltd Compound of epoxysuccinylamino acid
JPS55115878A (en) * 1979-02-27 1980-09-06 Taisho Pharmaceut Co Ltd Epoxysuccinic acid derivative
JPS5772913A (en) * 1980-10-22 1982-05-07 Nippon Chemiphar Co Ltd Remedy for cardiac infraction
JPS57169478A (en) * 1981-04-10 1982-10-19 Nippon Chemiphar Co Ltd Piperazine derivative
JPS58126879A (ja) * 1982-01-25 1983-07-28 Nippon Chemiphar Co Ltd 光学活性なピペラジン誘導体ならびに心筋梗塞の予防および治療剤
JPS6155509A (ja) 1984-08-27 1986-03-20 Dowa:Kk 気化バ−ナにおける燃焼促進装置
EP0269311A3 (en) 1986-11-17 1990-06-06 Merck & Co. Inc. Methods of treating bone diseases by administration of a cysteine proteinase inhibitor
JP2515114B2 (ja) * 1987-01-23 1996-07-10 日本ケミフア株式会社 血小板凝集抑制剤
JP2515119B2 (ja) * 1987-04-20 1996-07-10 日本ケミフア株式会社 ピペラジン誘導体を含有する活性酸素産生抑制ならびに活性酸素除去作用を有する医薬組成物
JP2536754B2 (ja) * 1987-05-08 1996-09-18 日本ケミファ株式会社 ピペラジン誘導体
JPH0832698B2 (ja) * 1987-05-08 1996-03-29 日本ケミファ株式会社 ピペラジン誘導体
JP2554497B2 (ja) * 1987-06-10 1996-11-13 日本ケミファ株式会社 エポキシコハク酸誘導体を含有する医薬組成物
JPH02218610A (ja) 1989-02-21 1990-08-31 Toyo Jozo Co Ltd 骨疾患の予防および治療剤
JPH02304075A (ja) * 1989-05-18 1990-12-17 Taisho Pharmaceut Co Ltd エポキシコハク酸誘導体
US5068354A (en) * 1989-05-18 1991-11-26 Taisho Pharmaceutical Co., Ltd. Epoxysuccinic acid derivatives
JP2808877B2 (ja) * 1990-09-29 1998-10-08 大正製薬株式会社 エポキシスクシナム酸誘導体およびその中間体
CA2101417A1 (en) * 1992-08-14 1994-02-15 Ken-Ichi Saito Prophylactic and therapeutic treatment of alzheimer's disease
JPH06239835A (ja) 1992-12-25 1994-08-30 Mitsubishi Kasei Corp アミノケトン誘導体
JPH06336428A (ja) * 1993-05-27 1994-12-06 Takeda Chem Ind Ltd 免疫抑制剤
JPH07115985A (ja) * 1993-10-26 1995-05-09 Asahi Chem Ind Co Ltd 生理活性物質ａｍ４２９９、それらの製法ならびに用途
JPH08104683A (ja) * 1993-10-29 1996-04-23 Takeda Chem Ind Ltd エポキシコハク酸誘導体
US5556853A (en) * 1993-10-29 1996-09-17 Takeda Chemical Industries, Ltd. Epoxysuccinic acid derivatives
JPH08104684A (ja) 1994-05-31 1996-04-23 Takeda Chem Ind Ltd エポキシコハク酸関連化合物
CA2190151A1 (en) * 1994-05-31 1995-12-07 Shigetoshi Tsubotani Epoxysuccinic acid derivatives, their production and use
JPH0841043A (ja) 1994-07-29 1996-02-13 Taisho Pharmaceut Co Ltd エポキシコハク酸誘導体
JPH0873352A (ja) * 1994-09-06 1996-03-19 Taisho Pharmaceut Co Ltd 高血圧治療剤
ATE225781T1 (de) 1995-03-31 2002-10-15 Nippon Chemiphar Co Derivate der epoxybernsteinsäure
JPH08325282A (ja) * 1995-03-31 1996-12-10 Nippon Chemiphar Co Ltd ビスホスホン酸誘導体
CA2226740A1 (en) * 1995-07-13 1997-01-30 Mitsuyoshi Azuma Piperazine derivative and its uses
ATE230389T1 (de) * 1995-10-25 2003-01-15 Senju Pharma Co Angiogenese inhibitoren
US5733911A (en) * 1996-01-26 1998-03-31 Hitachi Chemical Co., Ltd. Method for inducing death of neoplastic cells using piperazne derivatives
US6997899B2 (en) * 2002-12-17 2006-02-14 Boston Scientific Scimed, Inc, Rapid exchange dilation catheter for non-vascular applications

Also Published As

Publication number Publication date
JP4336039B2 (ja) 2009-09-30
US20020091131A1 (en) 2002-07-11
PT1022276E (pt) 2003-10-31
EP1342720A3 (en) 2004-02-11
DE69815137T2 (de) 2004-04-08
ES2201524T3 (es) 2004-03-16
ATE241607T1 (de) 2003-06-15
EP1342720A2 (en) 2003-09-10
EP1022276A4 (en) 2001-12-12
WO1999011640A1 (fr) 1999-03-11
EP1022276B1 (en) 2003-05-28
EP1022276A1 (en) 2000-07-26
DE69815137D1 (de) 2003-07-03
US6387908B1 (en) 2002-05-14
US6689785B2 (en) 2004-02-10
AU8997898A (en) 1999-03-22

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