CY1108025T1 - Παραγωγα n-[φαινυλο (πιπεριδινο-2-υλο)μεθυλο] βενζαμιδιου, η διαδικασια παρασκευης τους και η εφαρμογη τους στη θεραπευτικη - Google Patents

Παραγωγα n-[φαινυλο (πιπεριδινο-2-υλο)μεθυλο] βενζαμιδιου, η διαδικασια παρασκευης τους και η εφαρμογη τους στη θεραπευτικη

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Publication number
CY1108025T1
CY1108025T1 CY20071100988T CY071100988T CY1108025T1 CY 1108025 T1 CY1108025 T1 CY 1108025T1 CY 20071100988 T CY20071100988 T CY 20071100988T CY 071100988 T CY071100988 T CY 071100988T CY 1108025 T1 CY1108025 T1 CY 1108025T1
Authority
CY
Cyprus
Prior art keywords
group
corresponds
hydrogen atom
alkyl
formula
Prior art date
Application number
CY20071100988T
Other languages
English (en)
Inventor
Gihad Dargazanli
Geneviève ESTENNE-BOUHTOU
Pascale Magat
Benoit Marabout
Florence Medaisko
Pierre Roger
Mireille Sevrin
Corinne Veronique
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1108025T1 publication Critical patent/CY1108025T1/el

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Ενώσεις με γενικό τύπο (I), όπου το Α αντιστοιχεί είτε σε μια ομάδα με τύπο N-R1 όπου το R1 αντιστοιχεί σε ένα άτομο υδρογόνου, μια αλκυλομάδα, μια κυκλοαλκυλομάδα, μια φαινυλαλ-κυλομάδα, μια αλκενυλομάδα ή μια αλκυνυλομάδα, είτε μια ομάδα του τύπου N+ (O-)R1, όπου το R, είναι όπως ορίσαμε προηγουμένως, είτε ακόμη σε μια ομάδα με τύπο N+(R')R1, όπου το R' αντιστοιχεί σε μια αλκυλομάδα και το R1 είναι όπως ορίσαμε προηγουμένως, το Χ αντιστοιχεί σε ένα άτομο υδρογόνου ή σε έναν ή περισσότερους υποκατάστατες οι οποίοι επιλέγονται από τα άτομα αλογόνων και τις ομάδες τριφθορομελο-, αλκυλο- και αλκοξυ-, το R2 αντιστοιχεί σε ένα άτομο υδρογόνου, έναν ή περισσότερους υποκατάστατες που επιλέγονται από τα άτομα αλογόνων και τις ομάδες τριφθορομεθυλο-, αλκυλο-, αλκοξυ-, αμινο- με τύπο NR3R4, όπου τα R3 και R4 αντιστοιχούν καθένα σε ένα άτομο υδρογόνου ή σε μια αλκυλομάδα, ή σχηματίζουν με το άτομο αζώτου που τα φέρει έναν κύκλο πυρρολιδίνης, πιπεριδίνης ή μορφολίνης, είτε μια φαινυλομάδα που ενδεχομένως φέρει εποκαταστάτη. Εφαρμογή στη θεραπευτική.
CY20071100988T 2002-04-19 2007-07-24 Παραγωγα n-[φαινυλο (πιπεριδινο-2-υλο)μεθυλο] βενζαμιδιου, η διαδικασια παρασκευης τους και η εφαρμογη τους στη θεραπευτικη CY1108025T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0204916A FR2838739B1 (fr) 2002-04-19 2002-04-19 Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique
EP03740634A EP1499589B1 (fr) 2002-04-19 2003-04-17 Derives de n-¬phenyl(piperidin-2-yl)methyl|benzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CY1108025T1 true CY1108025T1 (el) 2013-09-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100988T CY1108025T1 (el) 2002-04-19 2007-07-24 Παραγωγα n-[φαινυλο (πιπεριδινο-2-υλο)μεθυλο] βενζαμιδιου, η διαδικασια παρασκευης τους και η εφαρμογη τους στη θεραπευτικη

Country Status (35)

Country Link
US (2) US7326722B2 (el)
EP (1) EP1499589B1 (el)
JP (1) JP4597532B2 (el)
KR (2) KR101019313B1 (el)
CN (1) CN100482646C (el)
AR (1) AR039413A1 (el)
AT (1) ATE361279T1 (el)
AU (1) AU2003262420B2 (el)
BR (1) BR0309397A (el)
CA (1) CA2481461C (el)
CO (1) CO5631432A2 (el)
CY (1) CY1108025T1 (el)
DE (1) DE60313602T2 (el)
DK (1) DK1499589T3 (el)
EA (1) EA007225B1 (el)
EC (1) ECSP045369A (el)
ES (1) ES2286444T3 (el)
FR (1) FR2838739B1 (el)
HR (1) HRP20040977B1 (el)
IL (2) IL164400A0 (el)
IS (1) IS2540B (el)
MA (1) MA27192A1 (el)
ME (1) MEP25608A (el)
MX (1) MXPA04010326A (el)
NO (1) NO329065B1 (el)
NZ (1) NZ536015A (el)
PL (1) PL373195A1 (el)
PT (1) PT1499589E (el)
RS (1) RS51888B (el)
SI (1) SI1499589T1 (el)
TN (1) TNSN04208A1 (el)
TW (1) TWI306402B (el)
UA (1) UA78025C2 (el)
WO (1) WO2003089411A1 (el)
ZA (1) ZA200408154B (el)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861073B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
WO2005044810A1 (en) * 2003-10-30 2005-05-19 Janssen Pharmaceutica, N.V. Glyt2 modulators
WO2005092442A2 (en) * 2004-03-22 2005-10-06 Apkarian Vania A Method and compositions for treatment of chronic neuropathic pain
UA88518C2 (ru) 2005-04-08 2009-10-26 Пфайзер Продактс Инк. Бицикло[3,1,0]гетероариламиды как ингибиторы транспорта глицина типа i
JP2009179562A (ja) * 2006-08-11 2009-08-13 Taisho Pharmaceutical Co Ltd グリシントランスポーター阻害剤
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
TW200911808A (en) * 2007-07-23 2009-03-16 Astrazeneca Ab Novel compounds
JP5619609B2 (ja) 2007-08-22 2014-11-05 アボット ゲーエムベーハーウント カンパニー カーゲー 4−ベンジルアミノキノリン類、これらを含む医薬組成物およびこれらの使用
WO2009121872A2 (en) 2008-04-01 2009-10-08 Abbott Gmbh & Co. Kg Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
AR075182A1 (es) * 2009-01-28 2011-03-16 Astrazeneca Ab Compuestos 2-aza-biciclo (2.2.2) octano y sus usos
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
JP5618047B2 (ja) * 2010-01-29 2014-11-05 国立大学法人千葉大学 ポジトロン断層撮影法およびポジトロン放出化合物
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2013015274A (es) 2011-06-24 2014-03-31 Amgen Inc Anatagonista trpm8 y su uso en tratamientos.
JP2014517074A (ja) 2011-06-24 2014-07-17 アムジエン・インコーポレーテツド Trpm8アンタゴニストおよび治療におけるそれらの使用
JP2014521682A (ja) 2011-08-05 2014-08-28 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー アミノクロマン、アミノチオクロマンおよびアミノ−1,2,3,4−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用
WO2013072520A1 (en) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
FR2983197B1 (fr) * 2011-11-29 2014-07-25 Assist Publ Hopitaux De Paris Utilisation de phacetoperane pour traiter un trouble deficit de l'attention hyperactivite
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2015055771A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
EP3057960B1 (en) 2013-10-17 2019-02-27 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
US20170143681A1 (en) 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
FR3045044B1 (fr) * 2015-12-11 2019-04-19 Liphatech Composition et appat rodonticide comprenant du flocoumafene, procede de lutte contre des rongeurs cibles nuisibles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254569A (en) * 1991-01-14 1993-10-19 The Du Pont Merck Pharmaceutical Company (Amidomethyl)nitrogen heterocyclic analgesics
JP3026845B2 (ja) * 1991-02-20 2000-03-27 日清製粉株式会社 ピペリジン誘導体
US5524569A (en) 1995-03-20 1996-06-11 Rich; William A. Anchor cover
BR9907953A (pt) * 1998-03-06 2000-10-24 Janssen Pharmaceutica Nv Inibidores de transporte de glicina
EP1296950A2 (en) * 2000-04-20 2003-04-02 NPS Allelix Corp. Aminopiperidines for use as glyt-1 inhibitors

Also Published As

Publication number Publication date
NZ536015A (en) 2006-11-30
IL164400A0 (en) 2005-12-18
FR2838739A1 (fr) 2003-10-24
EP1499589A1 (fr) 2005-01-26
KR20040103973A (ko) 2004-12-09
CA2481461C (en) 2010-01-12
RS91404A (en) 2007-02-05
MA27192A1 (fr) 2005-01-03
UA78025C2 (en) 2007-02-15
HRP20040977A2 (en) 2004-12-31
DK1499589T3 (da) 2007-09-10
EA007225B1 (ru) 2006-08-25
US20070197601A1 (en) 2007-08-23
WO2003089411A1 (fr) 2003-10-30
AU2003262420B2 (en) 2009-02-19
ATE361279T1 (de) 2007-05-15
CN1662497A (zh) 2005-08-31
AR039413A1 (es) 2005-02-16
JP2005527593A (ja) 2005-09-15
BR0309397A (pt) 2005-03-01
MEP25608A (en) 2010-06-10
AU2003262420A1 (en) 2003-11-03
IL164400A (en) 2010-11-30
DE60313602T2 (de) 2008-01-10
EA200401172A1 (ru) 2005-04-28
ES2286444T3 (es) 2007-12-01
CA2481461A1 (en) 2003-10-30
ECSP045369A (es) 2005-03-10
JP4597532B2 (ja) 2010-12-15
KR20080075236A (ko) 2008-08-14
TNSN04208A1 (fr) 2007-03-12
RS51888B (en) 2012-02-29
EP1499589B1 (fr) 2007-05-02
IS7479A (is) 2004-09-30
PT1499589E (pt) 2007-08-10
NO329065B1 (no) 2010-08-09
FR2838739B1 (fr) 2004-05-28
TWI306402B (en) 2009-02-21
SI1499589T1 (sl) 2007-10-31
KR101019313B1 (ko) 2011-03-07
IS2540B (is) 2009-09-15
PL373195A1 (en) 2005-08-22
NO20044388L (no) 2005-01-19
DE60313602D1 (de) 2007-06-14
HRP20040977B1 (en) 2008-04-30
CN100482646C (zh) 2009-04-29
CO5631432A2 (es) 2006-04-28
US7326722B2 (en) 2008-02-05
ZA200408154B (en) 2005-10-10
TW200306830A (en) 2003-12-01
MXPA04010326A (es) 2005-07-05
US20050159450A1 (en) 2005-07-21

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