FR2917735B1 - Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique - Google Patents

Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique

Info

Publication number
FR2917735B1
FR2917735B1 FR0704422A FR0704422A FR2917735B1 FR 2917735 B1 FR2917735 B1 FR 2917735B1 FR 0704422 A FR0704422 A FR 0704422A FR 0704422 A FR0704422 A FR 0704422A FR 2917735 B1 FR2917735 B1 FR 2917735B1
Authority
FR
France
Prior art keywords
preparation
therapeutic use
new substituted
substituted indazoles
indazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0704422A
Other languages
English (en)
Other versions
FR2917735A1 (fr
Inventor
Michel Aletru
Dominique Damour
Catherine Monseau
Patrick Mougenot
Claudie Namane
Frederico Nardi
Patrick Nemecek
Christophe Philippo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39126183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2917735(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0704422A priority Critical patent/FR2917735B1/fr
Priority to TW097121798A priority patent/TW200909425A/zh
Priority to CL2008001815A priority patent/CL2008001815A1/es
Priority to EP08826411A priority patent/EP2170865A2/fr
Priority to PCT/FR2008/000843 priority patent/WO2009010660A2/fr
Priority to JP2010512736A priority patent/JP2010530402A/ja
Priority to PA20088785301A priority patent/PA8785301A1/es
Priority to PE2008001047A priority patent/PE20090369A1/es
Priority to ARP080102600A priority patent/AR067051A1/es
Priority to UY31166A priority patent/UY31166A1/es
Publication of FR2917735A1 publication Critical patent/FR2917735A1/fr
Publication of FR2917735B1 publication Critical patent/FR2917735B1/fr
Application granted granted Critical
Priority to US12/636,357 priority patent/US20100298377A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
FR0704422A 2007-06-21 2007-06-21 Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique Expired - Fee Related FR2917735B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR0704422A FR2917735B1 (fr) 2007-06-21 2007-06-21 Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
TW097121798A TW200909425A (en) 2007-06-21 2008-06-11 Novel substituted indazoles, preparation thereof and therapeutic use thereof
PA20088785301A PA8785301A1 (es) 2007-06-21 2008-06-18 "nuevos indazoles sustituidos, su preparacion y su utilizacion en terapeutica
EP08826411A EP2170865A2 (fr) 2007-06-21 2008-06-18 Indazoles substitues, leur preparation et leur utilisation en therapeutique
PCT/FR2008/000843 WO2009010660A2 (fr) 2007-06-21 2008-06-18 Indazoles substitues, leur preparation et leur utilisation en therapeutique
JP2010512736A JP2010530402A (ja) 2007-06-21 2008-06-18 置換インダゾール類、それらの調製および治療におけるその使用
CL2008001815A CL2008001815A1 (es) 2007-06-21 2008-06-18 Compuestos derivados de indazol; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso para tratar cancer.
PE2008001047A PE20090369A1 (es) 2007-06-21 2008-06-19 Nuevos indazoles sustituidos, su preparacion y su utilizacion en terapeutica
ARP080102600A AR067051A1 (es) 2007-06-21 2008-06-19 Indazoles sustituidos, su preparacion y su utilizacion terapeutica
UY31166A UY31166A1 (es) 2007-06-21 2008-06-20 Nuevos indazoles sustituidos, su preparación y su utilización en terapeutica
US12/636,357 US20100298377A1 (en) 2007-06-21 2009-12-11 Novel substituted indazoles, the preparation thereof and use of same in therapeutics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0704422A FR2917735B1 (fr) 2007-06-21 2007-06-21 Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique

Publications (2)

Publication Number Publication Date
FR2917735A1 FR2917735A1 (fr) 2008-12-26
FR2917735B1 true FR2917735B1 (fr) 2009-09-04

Family

ID=39126183

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0704422A Expired - Fee Related FR2917735B1 (fr) 2007-06-21 2007-06-21 Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique

Country Status (11)

Country Link
US (1) US20100298377A1 (fr)
EP (1) EP2170865A2 (fr)
JP (1) JP2010530402A (fr)
AR (1) AR067051A1 (fr)
CL (1) CL2008001815A1 (fr)
FR (1) FR2917735B1 (fr)
PA (1) PA8785301A1 (fr)
PE (1) PE20090369A1 (fr)
TW (1) TW200909425A (fr)
UY (1) UY31166A1 (fr)
WO (1) WO2009010660A2 (fr)

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HUE028259T2 (en) 2009-08-10 2016-12-28 Samumed Llc Inhibitors of Wnt signaling signal indazole and their therapeutic use
EP3305073B1 (fr) * 2009-12-21 2019-05-15 Samumed, LLC 1h-pyrazolo [3,4-b] pyridines et leurs utilisations thérapeutiques
WO2012135799A1 (fr) * 2011-04-01 2012-10-04 University Of Utah Research Foundation Analogues de 3-(1h-benzo[d]imidazol-2-yl)-1h-indazole substitués en tant qu'inhibiteurs de la pdk1 kinase
SG11201400666PA (en) 2011-09-14 2014-09-26 Samumed Llc Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
KR20130073822A (ko) * 2011-12-23 2013-07-03 가부시키가이샤 한도오따이 에네루기 켄큐쇼 이온 액체, 비수 전해질 및 축전 장치
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
HUE046216T2 (hu) 2012-05-04 2020-02-28 Samumed Llc 1H-pirazolo [3,4-b]piridin-származékok és terápiás alkalmazásuk
CN105120862A (zh) 2013-01-08 2015-12-02 萨穆梅德有限公司 Wnt信号途径的3-(苯并咪唑-2-基)-吲唑抑制剂及其治疗应用
CA2905242C (fr) 2013-03-15 2016-11-29 Pfizer Inc. Composes indoliques activant l'ampk
WO2016040193A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques
WO2016040182A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine et ses utilisations thérapeutiques
WO2016040190A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques
WO2016040184A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040185A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 2-1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine et ses utilisations thérapeutiques
WO2016040181A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040180A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040188A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
US10206909B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10231956B2 (en) 2015-08-03 2019-03-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10463651B2 (en) 2015-08-03 2019-11-05 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
US10285983B2 (en) 2015-08-03 2019-05-14 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof
US10206908B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
US10188634B2 (en) 2015-08-03 2019-01-29 Samumed, Llc 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023975A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines et leus utilisations thérapeutiques
US10166218B2 (en) 2015-08-03 2019-01-01 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
US10604512B2 (en) 2015-08-03 2020-03-31 Samumed, Llc 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof
WO2017024015A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques
WO2017024021A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles et leurs utilisations thérapeutiques
WO2017023980A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines et leurs utilisations thérapeutiques
WO2017023989A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques
US10226453B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023972A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques
US10519169B2 (en) 2015-08-03 2019-12-31 Samumed, Llc 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10226448B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
MX2018005694A (es) 2015-11-06 2018-11-09 Samumed Llc 2- (1h-indazol-3-il) -3h-imidazo[4,5-c] piridinas y usos antiinflamatorios de las mismas.
CN109476660B (zh) 2016-06-01 2023-04-04 拜斯丽治疗有限公司 N-(5-(3-(7-(3-氟苯基)-3h-咪唑并[4,5-c]吡啶-2-基)-1h-吲唑-5-基)吡啶-3-基)-3-甲基丁酰胺的制备方法
KR102593742B1 (ko) 2016-10-21 2023-10-24 사뮤메드, 엘엘씨 인다졸-3-카복사마이드를 사용하는 방법 및 wnt/b-카테닌 신호전달 경로 억제제로서의 그들의 용도
US10758523B2 (en) 2016-11-07 2020-09-01 Samumed, Llc Single-dose, ready-to-use injectable formulations
GB201714740D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses

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FR2690440B1 (fr) * 1992-04-27 1995-05-19 Rhone Poulenc Agrochimie Arylpyrazoles fongicides.
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
FR2823209B1 (fr) * 2001-04-04 2003-12-12 Fournier Lab Sa Nouvelles thiohydantoines et leur utilisation en therapeutique
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
FR2838739B1 (fr) * 2002-04-19 2004-05-28 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
WO2006135383A2 (fr) * 2004-08-04 2006-12-21 Myriad Genetics, Inc. Indazoles
DE102005059479A1 (de) 2005-12-13 2007-06-14 Merck Patent Gmbh Hydroxychinolinderivate
MX2010004682A (es) 2007-11-06 2010-05-19 Organon Nv Metodo de supresion de hormonas en humanos.

Also Published As

Publication number Publication date
CL2008001815A1 (es) 2009-09-11
PA8785301A1 (es) 2009-01-23
JP2010530402A (ja) 2010-09-09
WO2009010660A2 (fr) 2009-01-22
US20100298377A1 (en) 2010-11-25
TW200909425A (en) 2009-03-01
WO2009010660A3 (fr) 2009-04-16
AR067051A1 (es) 2009-09-30
UY31166A1 (es) 2009-01-30
PE20090369A1 (es) 2009-04-30
EP2170865A2 (fr) 2010-04-07
FR2917735A1 (fr) 2008-12-26

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Effective date: 20130228