FR2940284B1 - Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique - Google Patents

Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique

Info

Publication number
FR2940284B1
FR2940284B1 FR0807257A FR0807257A FR2940284B1 FR 2940284 B1 FR2940284 B1 FR 2940284B1 FR 0807257 A FR0807257 A FR 0807257A FR 0807257 A FR0807257 A FR 0807257A FR 2940284 B1 FR2940284 B1 FR 2940284B1
Authority
FR
France
Prior art keywords
cycloamino
imidazo
pyridinyl
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0807257A
Other languages
English (en)
Other versions
FR2940284A1 (fr
Inventor
Mathieu Barrague
Yulin Chiang
Pascal George
William Metz
Frederic Puech
Mireille Sevrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0807257A priority Critical patent/FR2940284B1/fr
Priority to ARP090104907A priority patent/AR074685A1/es
Priority to EP09805730A priority patent/EP2385946A1/fr
Priority to JP2011541567A priority patent/JP2012512853A/ja
Priority to MX2011006627A priority patent/MX2011006627A/es
Priority to TW098143412A priority patent/TW201028420A/zh
Priority to SG2011043833A priority patent/SG172181A1/en
Priority to CA2747365A priority patent/CA2747365A1/fr
Priority to PCT/FR2009/052594 priority patent/WO2010070238A1/fr
Priority to AU2009329427A priority patent/AU2009329427A1/en
Priority to KR1020117016682A priority patent/KR20110095964A/ko
Priority to BRPI0923182A priority patent/BRPI0923182A2/pt
Priority to CN2009801571394A priority patent/CN102325773A/zh
Priority to UY32347A priority patent/UY32347A/es
Publication of FR2940284A1 publication Critical patent/FR2940284A1/fr
Application granted granted Critical
Publication of FR2940284B1 publication Critical patent/FR2940284B1/fr
Priority to IL213580A priority patent/IL213580A0/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0807257A 2008-12-19 2008-12-19 Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique Expired - Fee Related FR2940284B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR0807257A FR2940284B1 (fr) 2008-12-19 2008-12-19 Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
ARP090104907A AR074685A1 (es) 2008-12-19 2009-12-16 Derivados de 6-cicloamino -2,3-di- piridinil-imidazo (1,2-beta) -piridazina, su preparacion, composiciones farmaceuticas que los comprenden y su uso en la elaboracion de un medicamento para el tratamiento de enfermedades mediadas por la fosforilacion de las caseinas quinasa 1 epsilon y delta.
BRPI0923182A BRPI0923182A2 (pt) 2008-12-19 2009-12-17 derivados de 6-cicloamino-2,3-di-piridinil-imidazo[1,2-b]piridazina, o respectivo preparo e a respectivo preparo e a respectiva aplicação terapêutica
MX2011006627A MX2011006627A (es) 2008-12-19 2009-12-17 Derivados de 6-cicloamino-2,3-di-piridinil-imidazo[1,2-b]-piridazi na, su preparacion y su uso en terapeutica.
TW098143412A TW201028420A (en) 2008-12-19 2009-12-17 6-cycloamino-2,3-dipyridylimidazo[1,2-b]-pyridazine derivatives, preparation and therapeutic use thereof
SG2011043833A SG172181A1 (en) 2008-12-19 2009-12-17 Derivatives of 6-cycloamino-2,3-di-pyridinyl-imidazo[1,2-b]-pyridazine, preparation and therapeutic application thereof
CA2747365A CA2747365A1 (fr) 2008-12-19 2009-12-17 Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo[1,2-b]-pyridazine, leur preparation et leur application en therapeutique
PCT/FR2009/052594 WO2010070238A1 (fr) 2008-12-19 2009-12-17 DÉRIVÉS DE 6-CYCLOAMINO-2,3-DI-PYRIDINYL-IMIDAZO[1,2-b]-PYRIDAZINE, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
EP09805730A EP2385946A1 (fr) 2008-12-19 2009-12-17 Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo[1,-2-b]-pyridazine, leur preparation et leur application en therapeutique
KR1020117016682A KR20110095964A (ko) 2008-12-19 2009-12-17 6-시클로아미노-2,3-디-피리디닐-이미다조［1,2-ｂ］-피리다진의 유도체, 그의 제조법 및 치료 용도
JP2011541567A JP2012512853A (ja) 2008-12-19 2009-12-17 ６−シクロアミノ−２，３−ジ−ピリジニル−イミダゾ［１，２−ｂ］−ピリダジン誘導体、この調製および治療用途
CN2009801571394A CN102325773A (zh) 2008-12-19 2009-12-17 6-环氨基-2,3-二吡啶基咪唑并[1,2-b]-哒嗪衍生物及其制备和治疗应用
AU2009329427A AU2009329427A1 (en) 2008-12-19 2009-12-17 Derivatives of 6-cycloamino-2,3-di-pyridinyl-imidazo[1,2-b]-pyridazine, preparation and therapeutic application thereof
UY32347A UY32347A (es) 2008-12-19 2009-12-18 DERIVADOS DE 6-CICLOAMINO-2,3-DI-PIRIDINIL-IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACIÓN Y SU APLICACIÓN EN TERAPEUTICA
IL213580A IL213580A0 (en) 2008-12-19 2011-06-15 Derivatives of 6-cycloamino-2,3-di-pyridinyl-imidazo[1,2-b]-pyridazine, preparation and therapeutic application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0807257A FR2940284B1 (fr) 2008-12-19 2008-12-19 Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2940284A1 FR2940284A1 (fr) 2010-06-25
FR2940284B1 true FR2940284B1 (fr) 2011-02-18

Family

ID=40848284

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0807257A Expired - Fee Related FR2940284B1 (fr) 2008-12-19 2008-12-19 Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique

Country Status (12)

Country Link
EP (1) EP2385946A1 (fr)
JP (1) JP2012512853A (fr)
KR (1) KR20110095964A (fr)
CN (1) CN102325773A (fr)
AR (1) AR074685A1 (fr)
AU (1) AU2009329427A1 (fr)
BR (1) BRPI0923182A2 (fr)
CA (1) CA2747365A1 (fr)
FR (1) FR2940284B1 (fr)
SG (1) SG172181A1 (fr)
TW (1) TW201028420A (fr)
WO (1) WO2010070238A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6267231B2 (ja) 2012-12-21 2018-01-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ カゼインキナーゼ１δ／ε阻害剤としての新規な置換イミダゾール
US9475817B2 (en) 2012-12-21 2016-10-25 Bristol-Myers Squibb Company Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors
US9944648B2 (en) 2014-01-09 2018-04-17 Intra-Cellular Therapies, Inc. Organic compounds
US9956220B2 (en) 2014-06-19 2018-05-01 Bristol-Myers Squibb Company Imidazo-pyridazine derivatives as casein kinase 1 δ/ϵ inhibitors
IL312114A (en) 2021-10-14 2024-06-01 Incyte Corp Quinoline compounds as Kras inhibitors
WO2023147015A1 (fr) * 2022-01-27 2023-08-03 The Broad Institute, Inc. Inhibiteurs hétérocycliques substitués de csnk1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001333A1 (fr) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
TWI283243B (en) * 2002-09-19 2007-07-01 Schering Corp Novel pyrazolopyridines as cyclin dependent kinase inhibitors
JP4817661B2 (ja) * 2002-12-18 2011-11-16 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとしてのトリアゾロピリダジン
DK1747220T3 (da) 2003-12-11 2009-08-10 Aventis Pharma Inc Substituerede 1H-pyrrolo[3,2-B, 3,2-C og 2,3-C]pyridin-2-carboxamider og relaterede analoger som inhibitorer af casein kinase I epsilon
WO2005107760A1 (fr) * 2004-04-30 2005-11-17 Irm Llc Composes et compositions en tant qu'inducteurs de la differenciation de keratinocytes
US20080167314A1 (en) * 2004-12-28 2008-07-10 Osamu Uchikawa Condensed Imidazole Compound And Use Thereof
GB0515026D0 (en) * 2005-07-21 2005-08-31 Novartis Ag Organic compounds
DE102005042742A1 (de) * 2005-09-02 2007-03-08 Schering Ag Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
FR2918061B1 (fr) * 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
FR2918986B1 (fr) * 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
BRPI0923182A2 (pt) 2019-09-24
CN102325773A (zh) 2012-01-18
FR2940284A1 (fr) 2010-06-25
CA2747365A1 (fr) 2010-06-24
SG172181A1 (en) 2011-07-28
EP2385946A1 (fr) 2011-11-16
TW201028420A (en) 2010-08-01
KR20110095964A (ko) 2011-08-25
WO2010070238A1 (fr) 2010-06-24
AU2009329427A1 (en) 2011-07-07
AR074685A1 (es) 2011-02-02
JP2012512853A (ja) 2012-06-07

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Effective date: 20140829