FR2928924B1 - Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique - Google Patents

Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique

Info

Publication number
FR2928924B1
FR2928924B1 FR0801585A FR0801585A FR2928924B1 FR 2928924 B1 FR2928924 B1 FR 2928924B1 FR 0801585 A FR0801585 A FR 0801585A FR 0801585 A FR0801585 A FR 0801585A FR 2928924 B1 FR2928924 B1 FR 2928924B1
Authority
FR
France
Prior art keywords
pyridines
imidazo
heteroaryl
preparation
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0801585A
Other languages
English (en)
Other versions
FR2928924A1 (fr
Inventor
Peretti Danielle De
Yannick Evanno
David Machnik
Nathalie Rakotoarisoa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39764971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2928924(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0801585A priority Critical patent/FR2928924B1/fr
Priority to PE2009000414A priority patent/PE20091694A1/es
Priority to ARP090100988A priority patent/AR070995A1/es
Priority to KR1020107023402A priority patent/KR20100124830A/ko
Priority to TW098109256A priority patent/TW200942541A/zh
Priority to MEP-2010-150A priority patent/ME01112B/me
Priority to CA2719118A priority patent/CA2719118C/fr
Priority to AU2009253232A priority patent/AU2009253232B2/en
Priority to MX2010010268A priority patent/MX2010010268A/es
Priority to JP2011500259A priority patent/JP5508384B2/ja
Priority to PCT/FR2009/000298 priority patent/WO2009144392A1/fr
Priority to CL2009000699A priority patent/CL2009000699A1/es
Priority to CN201310049249.7A priority patent/CN103145747B/zh
Priority to UY0001031730A priority patent/UY31730A/es
Priority to NZ588083A priority patent/NZ588083A/en
Priority to CN200980118584.XA priority patent/CN102036989B/zh
Priority to EP09754042.1A priority patent/EP2262804B1/fr
Priority to BRPI0910309A priority patent/BRPI0910309A2/pt
Priority to EA201071111A priority patent/EA201071111A1/ru
Publication of FR2928924A1 publication Critical patent/FR2928924A1/fr
Publication of FR2928924B1 publication Critical patent/FR2928924B1/fr
Application granted granted Critical
Priority to US12/881,820 priority patent/US8088765B2/en
Priority to IL208247A priority patent/IL208247A0/en
Priority to CO10115913A priority patent/CO6300864A2/es
Priority to ZA2010/06725A priority patent/ZA201006725B/en
Priority to MA33274A priority patent/MA32248B1/fr
Priority to US13/291,660 priority patent/US8598166B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
FR0801585A 2008-03-21 2008-03-21 Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique Active FR2928924B1 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR0801585A FR2928924B1 (fr) 2008-03-21 2008-03-21 Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
PE2009000414A PE20091694A1 (es) 2008-03-21 2009-03-19 DERIVADOS POLISUSTITUIDOS DE 6-HETEROARIL-IMIDAZO[1,2-a] PIRIDINAS COMO MODULADORES DE LOS RECEPTORES NOT Y SU PREPARACION
ARP090100988A AR070995A1 (es) 2008-03-21 2009-03-19 Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridina,composiciones farmaceuticas que los contienen, proceso de preparacion de los mismos, intermediarios de sintesis y uso de los mismos en el tratamiento o prevencion de enfermedades que implican receptores nucleares nurr-1,tales como enfe
NZ588083A NZ588083A (en) 2008-03-21 2009-03-20 Polysubstituted derivatives of 6-heteroaryl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
EP09754042.1A EP2262804B1 (fr) 2008-03-21 2009-03-20 Dérivés polysubstitues de 6-heteroaryle-imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
MEP-2010-150A ME01112B (me) 2008-03-21 2009-03-20 VIŠESUPSTITUISANI 6-HETEROARILIMIDAZO[1,2-α] PIRIDIN DERIVATI, NJIHOVO DOBIJANJE I NJIHOVA TERAPEUTSKA UPOTREBA
CA2719118A CA2719118C (fr) 2008-03-21 2009-03-20 Derives polysubstitues de 6-heteroaryle-imidazo[1,2-.alpha.]pyridines, leur preparation et leur application en therapeutique
AU2009253232A AU2009253232B2 (en) 2008-03-21 2009-03-20 Polysubstituted derivatives of 6-heteroaryl-imidazo[1,2-a] pyridines, and preparation and therapeutic use thereof
MX2010010268A MX2010010268A (es) 2008-03-21 2009-03-20 Derivados polisustituidos de 6-heteroaril-imidazo [1,2-a] piridinas, su preparacion y su aplicación en terapeutica.
JP2011500259A JP5508384B2 (ja) 2008-03-21 2009-03-20 ６−ヘテロアリールイミダゾ［ｌ，２−ａ］−ピリジンの多置換誘導体、並びにこれらの調製および治療的使用
PCT/FR2009/000298 WO2009144392A1 (fr) 2008-03-21 2009-03-20 DÉRIVÉS POLYSUBSTITUES DE 6-HETEROARYLE-IMIDAZO[1,2-α]PYRIDINES, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
CL2009000699A CL2009000699A1 (es) 2008-03-21 2009-03-20 Compuestos derivados de 6-heteroaril-imidazo[1,2-a]piridinas polisustituidas; composicion farmaceutica; procedimiento de sintesis; compuestos intermediarios; y su uso para tratar o prevenir enfermedades neurodegenerativas, psiquiatricas, inflamatorias, traumatismos cerebrales y de la epilepsia, osteoporosis, cancer, parkinson, entre otras.
CN201310049249.7A CN103145747B (zh) 2008-03-21 2009-03-20 6-杂芳基咪唑并[1,2-a]吡啶的多取代衍生物及其制备方法和治疗用途
UY0001031730A UY31730A (es) 2008-03-21 2009-03-20 Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica.
KR1020107023402A KR20100124830A (ko) 2008-03-21 2009-03-20 6-헤테로아릴-이미다조［1,2-ａ］피리딘의 다중치환된 유도체, 및 그의 제법 및 치료 용도
CN200980118584.XA CN102036989B (zh) 2008-03-21 2009-03-20 6-杂芳基咪唑并[1,2-a]吡啶的多取代衍生物及其制备方法和治疗用途
TW098109256A TW200942541A (en) 2008-03-21 2009-03-20 Polysubstituted 6-heteroarylimidazo[1,2-α]pyridine derivatives, preparation thereof and therapeutic use thereof
BRPI0910309A BRPI0910309A2 (pt) 2008-03-21 2009-03-20 derivados poli-substituídos de 2-aril --fenil-imidazo [1,2-a] piridinas, o respectivo preparo e a respectiva aplicação em terapêtica
EA201071111A EA201071111A1 (ru) 2008-03-21 2009-03-20 ПОЛИЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 6-ГЕТЕРОАРИЛИМИДАЗО[1,2-a]ПИРИДИНОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
US12/881,820 US8088765B2 (en) 2008-03-21 2010-09-14 Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
IL208247A IL208247A0 (en) 2008-03-21 2010-09-19 Polysubstituted derivatives of 6-heteroaryl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
CO10115913A CO6300864A2 (es) 2008-03-21 2010-09-20 Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridinas su preparacion y su aplicacion en terapeutica
ZA2010/06725A ZA201006725B (en) 2008-03-21 2010-09-20 Polysubstituted derivatives of 6-heteroaryl-imidazo[1,2-a]pyridines,and preparation and therapeutic use thereof
MA33274A MA32248B1 (fr) 2008-03-21 2010-10-19 Dérivés polysubstitues de 6-heteroaryle-imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
US13/291,660 US8598166B2 (en) 2008-03-21 2011-11-08 Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0801585A FR2928924B1 (fr) 2008-03-21 2008-03-21 Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2928924A1 FR2928924A1 (fr) 2009-09-25
FR2928924B1 true FR2928924B1 (fr) 2010-04-23

Family

ID=39764971

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0801585A Active FR2928924B1 (fr) 2008-03-21 2008-03-21 Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique

Country Status (23)

Country Link
US (2) US8088765B2 (fr)
EP (1) EP2262804B1 (fr)
JP (1) JP5508384B2 (fr)
KR (1) KR20100124830A (fr)
CN (2) CN102036989B (fr)
AR (1) AR070995A1 (fr)
AU (1) AU2009253232B2 (fr)
BR (1) BRPI0910309A2 (fr)
CA (1) CA2719118C (fr)
CL (1) CL2009000699A1 (fr)
CO (1) CO6300864A2 (fr)
EA (1) EA201071111A1 (fr)
FR (1) FR2928924B1 (fr)
IL (1) IL208247A0 (fr)
MA (1) MA32248B1 (fr)
ME (1) ME01112B (fr)
MX (1) MX2010010268A (fr)
NZ (1) NZ588083A (fr)
PE (1) PE20091694A1 (fr)
TW (1) TW200942541A (fr)
UY (1) UY31730A (fr)
WO (1) WO2009144392A1 (fr)
ZA (1) ZA201006725B (fr)

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FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
JP5658664B2 (ja) 2008-06-25 2015-01-28 フォルム ファーマシューティカルズ、インコーポレイテッド １，２−二置換複素環式化合物
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
EP2427454B1 (fr) * 2009-05-07 2013-03-20 Envivo Pharmaceuticals, Inc. Composés hétérocycliques de phénoxyméthyle
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
TWI429628B (zh) * 2010-03-29 2014-03-11 Univ Taipei Medical 吲哚基或吲哚啉基羥肟酸化合物
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US8975276B2 (en) 2011-06-29 2015-03-10 Bristol-Myers Squibb Company Inhibitors of PDE10
CN103214481B (zh) * 2012-01-21 2016-08-03 中国科学院上海药物研究所 新型咪唑并[1,2-a]吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途
US20170107216A1 (en) 2015-10-19 2017-04-20 Incyte Corporation Heterocyclic compounds as immunomodulators
PL3377488T3 (pl) 2015-11-19 2022-12-19 Incyte Corporation Związki heterocykliczne jako immunomodulatory
MD3394033T2 (ro) 2015-12-22 2021-04-30 Incyte Corp Compuși heterociclici ca imunomodulatori
US20170320875A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2017205464A1 (fr) 2016-05-26 2017-11-30 Incyte Corporation Composés hétérocycliques utilisés comme immunomodulateurs
MY197280A (en) 2016-06-20 2023-06-09 Incyte Corp Heterocyclic compounds as immunomodulators
EP3484866B1 (fr) 2016-07-14 2022-09-07 Incyte Corporation Composés hétérocycliques utilisés comme immunomodulateurs
WO2018044783A1 (fr) 2016-08-29 2018-03-08 Incyte Corporation Composés hétérocycliques utilisés comme immunomodulateurs
CN106631970A (zh) * 2016-12-14 2017-05-10 贵州大学 一种6‑苯甲酰基‑1h‑吲哚的制备方法
WO2018119236A1 (fr) 2016-12-22 2018-06-28 Incyte Corporation Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs
ES2899402T3 (es) 2016-12-22 2022-03-11 Incyte Corp Derivados de piridina como inmunomoduladores
KR20190111025A (ko) 2016-12-22 2019-10-01 인사이트 코포레이션 면역조절제로서의 벤조옥사졸 유도체
MD3558990T2 (ro) 2016-12-22 2023-02-28 Incyte Corp Derivați tetrahidro imidazo[4,5-c]piridină ca inductori de internalizare a PD-L1
PE20211911A1 (es) 2018-03-30 2021-09-28 Incyte Corp Compuestos heterociclicos como inmunomoduladores
JOP20200288A1 (ar) 2018-05-11 2020-11-11 Incyte Corp مشتقات تترا هيدرو – إيميدازو[4، 5-c]بيريدين كمعدِّلات مناعية pd-l1
AR119624A1 (es) 2019-08-09 2021-12-29 Incyte Corp Sales de un inhibidor de pd-1 / pd-l1
EP4037773A1 (fr) 2019-09-30 2022-08-10 Incyte Corporation Composés pyrido[3,2-d]pyrimidine en tant qu'immunomodulateurs
KR20220101664A (ko) 2019-11-11 2022-07-19 인사이트 코포레이션 Pd-1/pd-l1 억제제의 염 및 결정질 형태
KR20230014706A (ko) * 2020-04-24 2023-01-30 더 리전츠 오브 더 유니버시티 오브 캘리포니아 Nurr1 수용체 조절제 및 이의 용도
WO2022099075A1 (fr) 2020-11-06 2022-05-12 Incyte Corporation Forme cristalline d'un inhibiteur pd-1/pd-l1
PE20231438A1 (es) 2020-11-06 2023-09-14 Incyte Corp Proceso para hacer un inhibidor de pd-1/pd-l1 y sales y formas cristalinas del mismo
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
WO2023285466A1 (fr) 2021-07-16 2023-01-19 Sanofi Dérivés d'imidazo[1,2-b][1,2,4]triazol pour utilisation en thérapie

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FR2928921B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928923B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2928922B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
US8598166B2 (en) 2013-12-03
WO2009144392A1 (fr) 2009-12-03
CA2719118C (fr) 2016-07-26
AR070995A1 (es) 2010-05-19
CN103145747B (zh) 2015-06-17
NZ588083A (en) 2012-07-27
BRPI0910309A2 (pt) 2015-09-29
CA2719118A1 (fr) 2009-12-03
EP2262804A1 (fr) 2010-12-22
IL208247A0 (en) 2010-12-30
US8088765B2 (en) 2012-01-03
EA201071111A1 (ru) 2011-08-30
JP5508384B2 (ja) 2014-05-28
ME01112B (me) 2012-12-20
AU2009253232A1 (en) 2009-12-03
EP2262804B1 (fr) 2014-12-03
TW200942541A (en) 2009-10-16
CO6300864A2 (es) 2011-07-21
CN102036989B (zh) 2014-05-07
AU2009253232B2 (en) 2013-07-11
US20110065700A1 (en) 2011-03-17
US20120053202A1 (en) 2012-03-01
JP2011515381A (ja) 2011-05-19
MA32248B1 (fr) 2011-04-01
KR20100124830A (ko) 2010-11-29
PE20091694A1 (es) 2009-11-20
ZA201006725B (en) 2011-11-30
MX2010010268A (es) 2011-04-05
CN103145747A (zh) 2013-06-12
FR2928924A1 (fr) 2009-09-25
UY31730A (es) 2009-11-10
CN102036989A (zh) 2011-04-27
CL2009000699A1 (es) 2010-04-09

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