FR2823209B1 - Nouvelles thiohydantoines et leur utilisation en therapeutique - Google Patents
Nouvelles thiohydantoines et leur utilisation en therapeutiqueInfo
- Publication number
- FR2823209B1 FR2823209B1 FR0104552A FR0104552A FR2823209B1 FR 2823209 B1 FR2823209 B1 FR 2823209B1 FR 0104552 A FR0104552 A FR 0104552A FR 0104552 A FR0104552 A FR 0104552A FR 2823209 B1 FR2823209 B1 FR 2823209B1
- Authority
- FR
- France
- Prior art keywords
- thiohydantoins
- therapeutics
- novel
- novel thiohydantoins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0104552A FR2823209B1 (fr) | 2001-04-04 | 2001-04-04 | Nouvelles thiohydantoines et leur utilisation en therapeutique |
BR0207910-0A BR0207910A (pt) | 2001-04-04 | 2002-04-04 | HidantÈnios e sua utilização no tratamento do diabetes |
CA002444024A CA2444024A1 (fr) | 2001-04-04 | 2002-04-04 | Hiohydantoines et leur utilisation dans le traitement du diabete |
CZ20032696A CZ20032696A3 (cs) | 2001-04-04 | 2002-04-04 | Thiohydantoiny a jejich použití při léčení cukrovky |
MXPA03009083A MXPA03009083A (es) | 2001-04-04 | 2002-04-04 | Tiohidantoinas y su utilizacion en el tratamiento de diabetes. |
JP2002579441A JP2004525175A (ja) | 2001-04-04 | 2002-04-04 | チオヒダントイン及び糖尿病治療のためのその使用 |
CNA028075811A CN1500081A (zh) | 2001-04-04 | 2002-04-04 | 乙内酰硫脲及其在治疗糖尿病方面的用途 |
SK1233-2003A SK12332003A3 (sk) | 2001-04-04 | 2002-04-04 | Tiohydantoíny a ich použitie na liečenie cukrovky |
RU2003129532/04A RU2003129532A (ru) | 2001-04-04 | 2002-04-04 | Тиогидантоины и их применение при лечении диабета |
PL02364904A PL364904A1 (en) | 2001-04-04 | 2002-04-04 | Thiohydantoins and use thereof for treating diabetes |
HU0401537A HUP0401537A3 (en) | 2001-04-04 | 2002-04-04 | Thiohydantoins, process for their preparation, pharmaceutical compositions containing them and use thereof for preparation of pharmaceutical compositions |
KR10-2003-7012356A KR20030085565A (ko) | 2001-04-04 | 2002-04-04 | 티오하이단토인 유도체 및 당뇨병 치료를 위한 이들의 용도 |
YU75903A YU75903A (sh) | 2001-04-04 | 2002-04-04 | Tiohidantoini i njihovo korišćenje u lečenju dijabetisa |
US10/473,032 US20040116417A1 (en) | 2001-04-04 | 2002-04-04 | Thiohydantoins and use thereof for treating diabetes |
EP02730333A EP1373219A1 (fr) | 2001-04-04 | 2002-04-04 | Thiohydantoines et leur utilisation dans le traitement du diabete |
IL15819502A IL158195A0 (en) | 2001-04-04 | 2002-04-04 | Thiohydantoins and use thereof for treating diabetes |
EEP200300485A EE200300485A (et) | 2001-04-04 | 2002-04-04 | Tiohüdantoinid ja nende kasutamine diabeedi raviks |
PCT/FR2002/001167 WO2002081453A1 (fr) | 2001-04-04 | 2002-04-04 | Hiohydantoïnes et leur utilisation dans le traitement du diabete |
ZA200307372A ZA200307372B (en) | 2001-04-04 | 2003-09-22 | Thiohydantoins and use thereof for treating diabetes. |
BG108225A BG108225A (en) | 2001-04-04 | 2003-10-03 | Thiohydantoins and use thereof for treating diabetes |
NO20034430A NO20034430L (no) | 2001-04-04 | 2003-10-03 | Tiohydantoiner og anvendelse derav for behandling av diatbetes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0104552A FR2823209B1 (fr) | 2001-04-04 | 2001-04-04 | Nouvelles thiohydantoines et leur utilisation en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2823209A1 FR2823209A1 (fr) | 2002-10-11 |
FR2823209B1 true FR2823209B1 (fr) | 2003-12-12 |
Family
ID=8861916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0104552A Expired - Fee Related FR2823209B1 (fr) | 2001-04-04 | 2001-04-04 | Nouvelles thiohydantoines et leur utilisation en therapeutique |
Country Status (21)
Country | Link |
---|---|
US (1) | US20040116417A1 (fr) |
EP (1) | EP1373219A1 (fr) |
JP (1) | JP2004525175A (fr) |
KR (1) | KR20030085565A (fr) |
CN (1) | CN1500081A (fr) |
BG (1) | BG108225A (fr) |
BR (1) | BR0207910A (fr) |
CA (1) | CA2444024A1 (fr) |
CZ (1) | CZ20032696A3 (fr) |
EE (1) | EE200300485A (fr) |
FR (1) | FR2823209B1 (fr) |
HU (1) | HUP0401537A3 (fr) |
IL (1) | IL158195A0 (fr) |
MX (1) | MXPA03009083A (fr) |
NO (1) | NO20034430L (fr) |
PL (1) | PL364904A1 (fr) |
RU (1) | RU2003129532A (fr) |
SK (1) | SK12332003A3 (fr) |
WO (1) | WO2002081453A1 (fr) |
YU (1) | YU75903A (fr) |
ZA (1) | ZA200307372B (fr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
WO2004009558A2 (fr) | 2002-07-24 | 2004-01-29 | Ptc Therapeutics, Inc. | Composes d'acide benzoique a substitution ureido et leur utilisation pour la suppression de non-sens et le traitement de maladie |
ITMI20022748A1 (it) * | 2002-12-23 | 2004-06-24 | Eurand Int | Dispersioni solide stabilizzate di farmaco in un carrier organico e procedimento per la loro preparazione. |
ES2397389T3 (es) | 2003-07-30 | 2013-03-06 | Xenon Pharmaceuticals Inc. | Derivados de piridilo y su uso como agentes terapéuticos |
AR047557A1 (es) | 2003-07-30 | 2006-01-25 | Xenon Pharmaceuticals Inc | Compuestos derivados de piridazina y su uso como agentes terapeuticos |
US8034548B2 (en) * | 2003-12-19 | 2011-10-11 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies |
AU2005232526B2 (en) | 2004-02-24 | 2011-06-23 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
DE102004024011A1 (de) * | 2004-05-14 | 2005-12-01 | Bayer Chemicals Ag | Difluorbenzo-1,3-dioxole |
CN101083986A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途 |
AU2005286728A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
EP1830837B1 (fr) | 2004-09-20 | 2013-09-04 | Xenon Pharmaceuticals Inc. | Derives heterocycliques pour le traitement de maladies induites par des enzymes stearoyl-coadesaturases |
AR051090A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
MX2007003325A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa. |
AU2005286648A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
BRPI0515482A (pt) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
WO2006034446A2 (fr) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation comme agents therapeutiques |
AR051094A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
JP2009513563A (ja) * | 2005-06-03 | 2009-04-02 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトのステアロイル−CoAデサチュラーゼ阻害剤としてのアミノチアゾール誘導体 |
HUE027894T2 (en) * | 2006-03-27 | 2016-11-28 | Univ California | An androgen receptor modulator for the treatment of prostate cancer and androgen receptor related diseases |
AU2016201061B2 (en) * | 2006-03-27 | 2017-03-02 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
KR101456722B1 (ko) * | 2006-03-29 | 2014-10-31 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴티오히단토인 화합물 |
WO2008021338A2 (fr) | 2006-08-15 | 2008-02-21 | Wyeth | Dérivés d'oxazolidone tricycliques utiles en tant que modulateurs du récepteur de la progestérone |
TW200815428A (en) | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
US7652018B2 (en) | 2006-08-15 | 2010-01-26 | Wyeth Llc | Imidazolidin-2-one derivatives useful as PR modulators |
WO2008021337A1 (fr) | 2006-08-15 | 2008-02-21 | Wyeth | Dérivés oxazinan-2-one utiles comme modulateurs pr |
US7649007B2 (en) | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
FR2917735B1 (fr) * | 2007-06-21 | 2009-09-04 | Sanofi Aventis Sa | Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique |
PE20121470A1 (es) | 2007-10-26 | 2012-11-18 | Univ California | Compuestos de diarilhidantoina como antagonistas del receptor de androgeno |
WO2009145286A1 (fr) | 2008-05-30 | 2009-12-03 | 武田薬品工業株式会社 | Composé hétérocyclique |
MX2011011964A (es) | 2009-05-12 | 2012-02-23 | Janssen Pharmaceuticals Inc | Derivados de 1,2,3-triazolo[4,3-a]piridina y su uso para el tratamiento o prevencion de trastornos neurologicos y psiquiatricos. |
EA028869B1 (ru) * | 2010-02-16 | 2018-01-31 | Арагон Фармасьютикалс, Инк. | Модуляторы рецептора андрогенов и их применение |
PT2538785T (pt) * | 2010-02-24 | 2018-05-09 | Medivation Prostate Therapeutics Llc | Processos para a síntese de compostos de diariltiohidantoína e diarilhidantoína |
WO2013067142A1 (fr) * | 2011-11-02 | 2013-05-10 | Medivation Technologies, Inc. | Composés et méthodes de traitement |
CN104661658A (zh) | 2012-09-26 | 2015-05-27 | 阿拉贡药品公司 | 用于治疗非转移性去势抵抗性前列腺癌的抗雄激素 |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
ITUB20151256A1 (it) | 2015-05-28 | 2016-11-28 | Olon Spa | Processo industriale per la preparazione di enzalutamide |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
CN111479560A (zh) | 2017-10-16 | 2020-07-31 | 阿拉贡药品公司 | 用于治疗非转移性去势难治性前列腺癌的抗雄激素 |
CN117120436A (zh) * | 2021-03-30 | 2023-11-24 | 苏州开拓药业股份有限公司 | 一种一步法合成乙内酰硫脲衍生物的方法 |
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GB1472467A (en) * | 1974-04-19 | 1977-05-04 | Wyeth John & Brother Ltd | Thiohydantoins |
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US5554607A (en) * | 1995-11-28 | 1996-09-10 | American Home Products Corporation | Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis |
US5821372A (en) * | 1995-11-28 | 1998-10-13 | American Home Products Corporation | 2-thioxo-imidazolidin-4-one derivatives |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
-
2001
- 2001-04-04 FR FR0104552A patent/FR2823209B1/fr not_active Expired - Fee Related
-
2002
- 2002-04-04 JP JP2002579441A patent/JP2004525175A/ja not_active Withdrawn
- 2002-04-04 CA CA002444024A patent/CA2444024A1/fr not_active Abandoned
- 2002-04-04 HU HU0401537A patent/HUP0401537A3/hu unknown
- 2002-04-04 PL PL02364904A patent/PL364904A1/xx not_active Application Discontinuation
- 2002-04-04 EE EEP200300485A patent/EE200300485A/xx unknown
- 2002-04-04 US US10/473,032 patent/US20040116417A1/en not_active Abandoned
- 2002-04-04 SK SK1233-2003A patent/SK12332003A3/sk unknown
- 2002-04-04 CZ CZ20032696A patent/CZ20032696A3/cs unknown
- 2002-04-04 MX MXPA03009083A patent/MXPA03009083A/es unknown
- 2002-04-04 YU YU75903A patent/YU75903A/sh unknown
- 2002-04-04 IL IL15819502A patent/IL158195A0/xx unknown
- 2002-04-04 CN CNA028075811A patent/CN1500081A/zh active Pending
- 2002-04-04 RU RU2003129532/04A patent/RU2003129532A/ru not_active Application Discontinuation
- 2002-04-04 BR BR0207910-0A patent/BR0207910A/pt not_active Application Discontinuation
- 2002-04-04 KR KR10-2003-7012356A patent/KR20030085565A/ko not_active Application Discontinuation
- 2002-04-04 EP EP02730333A patent/EP1373219A1/fr not_active Withdrawn
- 2002-04-04 WO PCT/FR2002/001167 patent/WO2002081453A1/fr not_active Application Discontinuation
-
2003
- 2003-09-22 ZA ZA200307372A patent/ZA200307372B/en unknown
- 2003-10-03 BG BG108225A patent/BG108225A/xx unknown
- 2003-10-03 NO NO20034430A patent/NO20034430L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0401537A3 (en) | 2005-06-28 |
FR2823209A1 (fr) | 2002-10-11 |
SK12332003A3 (sk) | 2004-04-06 |
CZ20032696A3 (cs) | 2003-12-17 |
KR20030085565A (ko) | 2003-11-05 |
BG108225A (en) | 2005-04-30 |
PL364904A1 (en) | 2004-12-27 |
WO2002081453A1 (fr) | 2002-10-17 |
EE200300485A (et) | 2004-02-16 |
JP2004525175A (ja) | 2004-08-19 |
CN1500081A (zh) | 2004-05-26 |
NO20034430D0 (no) | 2003-10-03 |
HUP0401537A2 (hu) | 2005-01-28 |
YU75903A (sh) | 2006-05-25 |
US20040116417A1 (en) | 2004-06-17 |
BR0207910A (pt) | 2004-08-03 |
IL158195A0 (en) | 2004-03-28 |
EP1373219A1 (fr) | 2004-01-02 |
WO2002081453A8 (fr) | 2002-11-14 |
NO20034430L (no) | 2003-10-06 |
ZA200307372B (en) | 2004-09-22 |
CA2444024A1 (fr) | 2002-10-17 |
RU2003129532A (ru) | 2005-04-10 |
MXPA03009083A (es) | 2004-11-22 |
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