FR2840899B1 - Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique - Google Patents

Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique

Info

Publication number
FR2840899B1
FR2840899B1 FR0207222A FR0207222A FR2840899B1 FR 2840899 B1 FR2840899 B1 FR 2840899B1 FR 0207222 A FR0207222 A FR 0207222A FR 0207222 A FR0207222 A FR 0207222A FR 2840899 B1 FR2840899 B1 FR 2840899B1
Authority
FR
France
Prior art keywords
therapeutics
preparation
acylaminothiazole derivatives
acylaminothiazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0207222A
Other languages
English (en)
Other versions
FR2840899A1 (fr
Inventor
Pierre Despeyroux
Daniel Frehel
Chantal Guenet
Corinne Heckel
Rebecca Pruss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to FR0207222A priority Critical patent/FR2840899B1/fr
Priority to ARP020102935A priority patent/AR039059A1/es
Priority to EP02794623A priority patent/EP1417189B1/fr
Priority to DE60208044T priority patent/DE60208044T2/de
Priority to TW091117569A priority patent/TWI318974B/zh
Priority to US10/485,837 priority patent/US7288659B2/en
Priority to JP2003519045A priority patent/JP2005500370A/ja
Priority to DK02794623T priority patent/DK1417189T3/da
Priority to PCT/FR2002/002802 priority patent/WO2003014095A1/fr
Priority to AT02794623T priority patent/ATE312828T1/de
Priority to ES02794623T priority patent/ES2254773T3/es
Publication of FR2840899A1 publication Critical patent/FR2840899A1/fr
Application granted granted Critical
Publication of FR2840899B1 publication Critical patent/FR2840899B1/fr
Priority to US11/858,454 priority patent/US20080058380A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
FR0207222A 2001-08-06 2002-06-12 Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique Expired - Fee Related FR2840899B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR0207222A FR2840899B1 (fr) 2002-06-12 2002-06-12 Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
ARP020102935A AR039059A1 (es) 2001-08-06 2002-08-02 Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios
AT02794623T ATE312828T1 (de) 2001-08-06 2002-08-05 Acylaminothiazolderivate, deren herstellung und deren therapeutische verwendung
TW091117569A TWI318974B (en) 2001-08-06 2002-08-05 Acylaminothiazole derivatives, their preparation and their therapeutic use
US10/485,837 US7288659B2 (en) 2001-08-06 2002-08-05 Acylaminothiazole derivatives, their preparation and therapeutic use
JP2003519045A JP2005500370A (ja) 2001-08-06 2002-08-05 アクリルアミノチアゾール誘導体、それらの製造および治療的使用
EP02794623A EP1417189B1 (fr) 2001-08-06 2002-08-05 Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
PCT/FR2002/002802 WO2003014095A1 (fr) 2001-08-06 2002-08-05 Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
DE60208044T DE60208044T2 (de) 2001-08-06 2002-08-05 Acylaminothiazolderivate, deren herstellung und deren therapeutische verwendung
ES02794623T ES2254773T3 (es) 2001-08-06 2002-08-05 Derivados de acilaminotiazol, su preparacion y su utilizacion en terapeutica.
DK02794623T DK1417189T3 (da) 2001-08-06 2002-08-05 Acylaminothiazolderivater, fremstilling og terapeutisk anvendelse heraf
US11/858,454 US20080058380A1 (en) 2001-08-06 2007-09-20 Acylaminothiazole derivatives, their preparation and their therapeutic use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0207222A FR2840899B1 (fr) 2002-06-12 2002-06-12 Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique

Publications (2)

Publication Number Publication Date
FR2840899A1 FR2840899A1 (fr) 2003-12-19
FR2840899B1 true FR2840899B1 (fr) 2005-02-25

Family

ID=29595171

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0207222A Expired - Fee Related FR2840899B1 (fr) 2001-08-06 2002-06-12 Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique

Country Status (1)

Country Link
FR (1) FR2840899B1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873370B1 (fr) * 2004-07-22 2006-10-20 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
FR2873374B1 (fr) * 2004-07-22 2006-10-20 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199901603T2 (xx) * 1996-11-22 2000-02-21 Elan Pharmaceuticals, Inc. N-(aril/heteroaril/alkilasetil) amino asit amidler, bunlar� i�eren farmas�tik bile�imler ve b�yle bile�ikler kullan�larak �-amiloid peptidinin sal�nmas�n� ve/veya sentezini inhibe etmek i�in y�ntemler.
AR016751A1 (es) * 1996-11-22 2001-08-01 Athena Neurosciences Inc Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo
ATE421509T1 (de) * 1996-12-23 2009-02-15 Elan Pharm Inc Cycloalkyl-, lactam-, lacton- und verwandte verbindungen als hemmer der beta- amyloidpeptidfreisetzung
HRP980093A2 (en) * 1997-02-28 1998-12-31 Lilly Co Eli Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds
US6486350B1 (en) * 1998-09-30 2002-11-26 Elan Pharmaceuticals Inc. Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
AU6229699A (en) * 1998-10-26 2000-05-15 Sumitomo Pharmaceuticals Company, Limited Beta-amyloid formation inhibitors

Also Published As

Publication number Publication date
FR2840899A1 (fr) 2003-12-19

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Effective date: 20130228