AU6229699A - Beta-amyloid formation inhibitors - Google Patents

Beta-amyloid formation inhibitors

Info

Publication number
AU6229699A
AU6229699A AU62296/99A AU6229699A AU6229699A AU 6229699 A AU6229699 A AU 6229699A AU 62296/99 A AU62296/99 A AU 62296/99A AU 6229699 A AU6229699 A AU 6229699A AU 6229699 A AU6229699 A AU 6229699A
Authority
AU
Australia
Prior art keywords
beta
amyloid formation
formation inhibitors
inhibitors
amyloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU62296/99A
Inventor
Akira Ito
Shinichi Kojima
Toshio Nishihara
Tomohiro Toyoda
Yasushi Tsutsumi
Hiroshi Yamaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Publication of AU6229699A publication Critical patent/AU6229699A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU62296/99A 1998-10-26 1999-10-25 Beta-amyloid formation inhibitors Abandoned AU6229699A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30431798 1998-10-26
JP10/304317 1998-10-26
PCT/JP1999/005871 WO2000024392A1 (en) 1998-10-26 1999-10-25 β-AMYLOID FORMATION INHIBITORS

Publications (1)

Publication Number Publication Date
AU6229699A true AU6229699A (en) 2000-05-15

Family

ID=17931581

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62296/99A Abandoned AU6229699A (en) 1998-10-26 1999-10-25 Beta-amyloid formation inhibitors

Country Status (2)

Country Link
AU (1) AU6229699A (en)
WO (1) WO2000024392A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
WO2001087354A2 (en) 2000-05-17 2001-11-22 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
CA2321348A1 (en) 2000-09-27 2002-03-27 Blaise Magloire N'zemba Aromatic derivatives with hiv integrase inhibitory properties
FR2840899B1 (en) * 2002-06-12 2005-02-25 Sanofi Synthelabo ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS
AR039059A1 (en) 2001-08-06 2005-02-09 Sanofi Aventis COMPOUND DERIVED FROM ACILAMINOTIAZOL, ITS USE, PROCEDURES TO PREPARE IT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND INTERMEDIARY COMPOUNDS
DE10221052A1 (en) * 2002-05-10 2003-12-04 Transmit Technologietransfer Active substances for therapy, diagnostics and prophylaxis of diseases in which abnormal protein structures occur
WO2004033439A1 (en) * 2002-10-09 2004-04-22 Pfizer Products Inc. Thiazole compounds for the treatment of neurodegenerative disorders
WO2004050613A2 (en) * 2002-12-02 2004-06-17 Gilead Sciences, Inc. 2-substituted-3-propenamide derivatives and methods of using the same
FR2850380B1 (en) * 2003-01-23 2006-07-07 Sanofi Synthelabo ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS
BRPI0409721A (en) 2003-05-12 2006-05-02 Pfizer Prod Inc isoxazole and isothiazole compounds for the treatment of neurodegenerative disorders
BRPI0506880A (en) * 2004-01-16 2007-06-26 Sanofi Aventis acylaminothiazole derivatives, their preparation and their application in therapeutic
FR2865206B1 (en) * 2004-01-16 2009-02-06 Sanofi Synthelabo ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP1709018B1 (en) * 2004-01-16 2011-07-20 Sanofi-Aventis Acylaminothiazole derivatives and use thereof as beta-amyloid inhibitors
TWI396543B (en) 2005-05-12 2013-05-21 Sankyo Co Substituted acrylamide derivatives and pharmaceutical compositions thereof
GEP201706703B (en) 2008-06-17 2017-07-25 Millennium Pharmaceuticals Inc (A Delaware Corporation) Boronate ester compounds and pharmaceutical compositions thereof
JP5401544B2 (en) 2008-07-15 2014-01-29 ノバルティス アーゲー Heteroaryl derivatives as DGAT1 inhibitors
MA39964A (en) 2014-05-20 2015-11-26 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
JP2021512166A (en) * 2018-01-30 2021-05-13 フォグホーン セラピューティクス インコーポレイテッドＦｏｇｈｏｒｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Compounds and their use
EP3862012A4 (en) 2018-10-01 2022-08-17 Toru Miyazaki Therapeutic agent for neurodegenerative disease
CN111518048B (en) * 2019-02-01 2024-04-30 鲁南制药集团股份有限公司 MAGL inhibitors, methods of preparation and uses
CN111518047B (en) * 2019-02-01 2024-05-24 鲁南制药集团股份有限公司 MAGL inhibitor and preparation method and application thereof
CN111518049B (en) * 2019-02-01 2024-05-03 鲁南制药集团股份有限公司 MAGL inhibitor, preparation method and application
WO2021106988A1 (en) * 2019-11-27 2021-06-03 杏林製薬株式会社 G9a INHIBITOR

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284632A1 (en) * 1987-03-30 1988-10-05 Shosuke Okamoto Phenylalanine derivative and proteinase inhibitor
EP0367393A3 (en) * 1988-10-31 1991-03-27 Takeda Chemical Industries, Ltd. New heterocyclic compounds, production and use thereof
EP0587377A3 (en) * 1992-09-10 1994-09-21 Lilly Co Eli Thiazolidinone derivatives as hypoglycemic agents and for treating alzheimer's disease
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
ES2171646T3 (en) * 1995-02-15 2002-09-16 Richter Gedeon Vegyeszet USE OF VINPOCETIN DERIVATIVES FOR THE INHIBITION OR PRODUCTION OF BETA-PROTEIN AMYLOID.
WO1996039194A1 (en) * 1995-06-06 1996-12-12 Athena Neurosciences, Inc. Novel cathepsin and methods and compositions for inhibition thereof
GB9514867D0 (en) * 1995-07-20 1995-09-20 British Biotech Pharm Metalloproteinase inhibitors
AU7113996A (en) * 1995-09-22 1997-04-09 Eli Lilly And Company Methods of treating beta-amyloid-associated conditions
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
ES2212142T3 (en) * 1996-12-17 2004-07-16 Warner-Lambert Company Llc USE OF METALOPROTEINASA MATRIX INHIBITORS TO PROMOTE WOUND HEALING.
AU5923998A (en) * 1997-01-31 1998-08-25 Avid Therapeutics Inc. 2-benzoylamino-3-phenylpropenamide derivatives and methods of using the same

Also Published As

Publication number Publication date
WO2000024392A1 (en) 2000-05-04

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase