ES2088903T3 - Nuevos inhibidores de la s-adenosilmetionina descarboxilasa. - Google Patents

Nuevos inhibidores de la s-adenosilmetionina descarboxilasa.

Info

Publication number
ES2088903T3
ES2088903T3 ES89401845T ES89401845T ES2088903T3 ES 2088903 T3 ES2088903 T3 ES 2088903T3 ES 89401845 T ES89401845 T ES 89401845T ES 89401845 T ES89401845 T ES 89401845T ES 2088903 T3 ES2088903 T3 ES 2088903T3
Authority
ES
Spain
Prior art keywords
chem
decarboxylase inhibitors
adenosylmetionin
new
adenosinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89401845T
Other languages
English (en)
Inventor
Patrick Casara
Charles Danzin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2088903T3 publication Critical patent/ES2088903T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTE INVENTO RELATA AL NUEVO COMPONENTE QUIMICO UTIL COMO INHIBIDOR DECARBOXILASO METIONINA ADENOSIL-S, AL PROCESO UTIL PARA SU PREPARACION Y A SU USO EN EL TRATAMIENTO DE UNA VARIEDAD DE ESTADOS DE ENFERMEDAD Y CONDICION ASOCIADOS CON UNA PROLIFERACION RAPIDA DE CRECIMIENTO CELULAR.
ES89401845T 1988-07-21 1989-06-28 Nuevos inhibidores de la s-adenosilmetionina descarboxilasa. Expired - Lifetime ES2088903T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88401896A EP0351475A1 (en) 1988-07-21 1988-07-21 S-Adenosylmethionine decarboxylase inhibitors

Publications (1)

Publication Number Publication Date
ES2088903T3 true ES2088903T3 (es) 1996-10-01

Family

ID=8200409

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89401845T Expired - Lifetime ES2088903T3 (es) 1988-07-21 1989-06-28 Nuevos inhibidores de la s-adenosilmetionina descarboxilasa.

Country Status (8)

Country Link
US (1) US5416076A (es)
EP (1) EP0351475A1 (es)
AT (1) ATE137759T1 (es)
DE (1) DE68926418T2 (es)
ES (1) ES2088903T3 (es)
GR (1) GR3019893T3 (es)
HU (1) HU204536B (es)
ZA (1) ZA895387B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308837A (en) * 1990-08-22 1994-05-03 Merrell Dow Pharmaceuticals Inc. 5'-amine substituted adenosine analogs as immunosuppressants
ZA916464B (en) * 1990-08-22 1992-05-27 Merrell Dow Pharma 5'-amine substituted adenosine analogs as immunosuppressants
US5750496A (en) * 1996-08-12 1998-05-12 Utah State University Method of controlling cryptosporidium infectons using protease inhibitors
US5733889A (en) * 1996-10-29 1998-03-31 The Metrohealth System Treatment for cardiac arrhythmias
US6534651B2 (en) * 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US20030224970A1 (en) * 2002-05-17 2003-12-04 Sanjoy Mahanty Methods for the identification of inhibitors of S-adenosylmethionine decarboxylase as antibiotics
EP1834669A1 (en) * 2006-03-15 2007-09-19 Heinrich-Pette-Institut Use of specific hydrazone compounds for the treatment of viral infections
WO2008157438A1 (en) * 2007-06-15 2008-12-24 Genzyme Corporation Inhibitors of s-adenosyl-l-methionine decarboxylase
EP2170057A4 (en) * 2007-08-02 2012-02-15 Southern Res Inst 5'-SUBSTITUTED ADENOSYNE, THEIR PREPARATION AND THEIR USE AS AN INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134918A (en) * 1977-09-06 1979-01-16 Merrell Toraude Et Compagnie Alpha-halomethyl derivatives of amines
US4794174A (en) * 1987-02-10 1988-12-27 Southern Research Institute 5'deoxy-5'-substituted adenosines

Also Published As

Publication number Publication date
US5416076A (en) 1995-05-16
DE68926418D1 (de) 1996-06-13
EP0351475A1 (en) 1990-01-24
HU204536B (en) 1992-01-28
ZA895387B (en) 1990-04-25
GR3019893T3 (en) 1996-08-31
ATE137759T1 (de) 1996-05-15
DE68926418T2 (de) 1996-09-19
HUT50354A (en) 1990-01-29

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