ES2058630T3 - Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2058630T3
ES2058630T3 ES90103244T ES90103244T ES2058630T3 ES 2058630 T3 ES2058630 T3 ES 2058630T3 ES 90103244 T ES90103244 T ES 90103244T ES 90103244 T ES90103244 T ES 90103244T ES 2058630 T3 ES2058630 T3 ES 2058630T3
Authority
ES
Spain
Prior art keywords
alkil
replaced
same
derivatives
fenilcicloalcanopiridinas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90103244T
Other languages
English (en)
Inventor
Katsuhiko Hino
Naoki Kai
Masato Sakamoto
Tatsuya Kon
Makoto Oka
Kiyoshi Furakawa
Yoshiaki Ochi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2058630T3 publication Critical patent/ES2058630T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVOS DERIVADOS DE 2-(1-PIPERAZINIL)-4-FENIL-CICLOALKANOPIRIDINA DE LA FORMULA (I) SE PRESENTAN, DONDE N ES 3,4,5,6 O 7; R1 ES UN ATOMO DE HIDROGENO, ALKIL C1-C10, ALKENIL C2-C6, ALKINIL C2-C6, CICLOALKIL C3-C8, CICLOALKIL(C1-C4) C3-C6 ALKIL, ALKIL DE HIDROXIDO (C2, C6), ALKIL C1-C3 DE ALCOXIDO C2-C6, ALKIL DE ACILOXIDO C2- C6) ALKIL, DE AROIL C1-C6 SUSTITUIDO O NO SUSTITUIDO, ARIL SUSTITUIDO O NO SUSTITUIDO, HETEROARIL, O ACIL; R2 Y R3 SON LO MISMO O DIFERENTE Y CADA UNA SON UN ATOMO DE HIDROGENO, ATOMO HALOGENO, ALKIL C1-C6, ALKOXIDO C1-C6, TRIFLUOROMETIL, O HIDROXIDO; R4, R5 Y R6 SON LO MISMO O DIFERENTE Y SON CADA UNO UN ATOMO DE HIDROGENO, ALKIL C1-C6 O FENIL, O DOS DE ENTRE R4, R5 Y R6 SE COMBINAN PARA FORMAR UN ENLACE SIMPLE O ALKILENO C1-C3; R7 Y R8 SON LO MISMO O DIFERENTE Y CADA UNO REPRESENTAN UN ATOMO DE HIDROGENO O ALKIL C1-C3; M ES 2 O 3, O UNA SAL DE ADICCION ACIDA DE LOS MISMOS. DICHOS COMPUESTOS SON UTILES COMO DROGA SICOTROPICA. TAMBIEN SE PRESENTA UN PROCESO PARA LA PREPARACION DE LOS MISMOS.
ES90103244T 1989-03-03 1990-02-20 Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2058630T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5254489 1989-03-03

Publications (1)

Publication Number Publication Date
ES2058630T3 true ES2058630T3 (es) 1994-11-01

Family

ID=12917732

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90103244T Expired - Lifetime ES2058630T3 (es) 1989-03-03 1990-02-20 Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
US (1) US5021421A (es)
EP (1) EP0385237B1 (es)
KR (1) KR0149649B1 (es)
AT (1) ATE107922T1 (es)
AU (1) AU623981B2 (es)
CA (1) CA2011346C (es)
DD (1) DD292909A5 (es)
DE (1) DE69010232T2 (es)
DK (1) DK0385237T3 (es)
ES (1) ES2058630T3 (es)
FI (1) FI94413C (es)
HK (1) HK1005872A1 (es)
HU (1) HU204810B (es)
NO (1) NO177095C (es)
RU (1) RU2075478C1 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041443A (en) * 1989-02-21 1991-08-20 Dainippon Pharmaceutical Co., Ltd. Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
ES2157258T3 (es) * 1993-06-25 2001-08-16 Pola Chem Ind Inc Inhibidores de la reincorporacion de dopamina destinados para el tratamiento del sindrome de parkinson.
CA2144669A1 (en) * 1994-03-29 1995-09-30 Kozo Akasaka Biphenyl derivatives
US6458789B1 (en) 1999-09-29 2002-10-01 Lion Bioscience Ag 2-aminopyridine derivatives and combinatorial libraries thereof
IL162859A0 (en) * 2002-02-05 2005-11-20 Novo Nordisk As Novel aryl-and heteroarylpiperazines
MX2007012082A (es) 2005-03-31 2007-11-20 Pfizer Prod Inc Derivados de ciclopentapiridina y tetrahidroquinolina.
AU2006264966B2 (en) 2005-07-04 2013-02-21 High Point Pharmaceuticals, Llc Histamine H3 receptor antagonists
EP2038256A1 (en) 2006-05-23 2009-03-25 TransTech Pharma, Inc 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament
CA2659570C (en) 2006-05-29 2015-10-06 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
CA2653827C (en) * 2006-06-09 2014-04-08 Dainippon Sumitomo Pharma Co., Ltd. Novel blonanserin tape preparation
JP5479893B2 (ja) * 2006-07-14 2014-04-23 メルク・シャープ・アンド・ドーム・コーポレーション 置換ジアゼパンオレキシン受容体アンタゴニスト
CA2670116C (en) 2006-11-22 2015-03-10 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
CN101531634B (zh) * 2008-03-10 2013-09-18 北京德众万全医药科技有限公司 一种高纯度的布南色林及其制备方法
CN101530412A (zh) * 2008-03-10 2009-09-16 北京德众万全医药科技有限公司 一种布南色林的药物组合物及其制备方法
CN101747273B (zh) * 2008-12-02 2012-03-07 浙江华海药业股份有限公司 布南色林中间体的制备方法
CN101747272B (zh) * 2008-12-02 2012-11-28 浙江华海药业股份有限公司 布南色林晶型b及其制备方法
CN101766626B (zh) * 2008-12-30 2012-03-07 丽珠医药集团股份有限公司 一种治疗精神分裂症的含布南色林的口服制剂
US20120121515A1 (en) 2009-03-13 2012-05-17 Lenny Dang Methods and compositions for cell-proliferation-related disorders
ES2632954T3 (es) 2009-06-29 2017-09-18 Agios Pharmaceuticals, Inc. Derivados de quinolina-8-sulfonamida que tienen una actividad anticancerosa
CN101619039B (zh) * 2009-06-30 2011-04-13 严洁 2-(4-乙基-1-哌嗪基)-4-(4-氟苯基)-5,6,7,8,9,10-六氢芳辛并[b]吡啶及其组合物
WO2011050210A1 (en) 2009-10-21 2011-04-28 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
CA2793836C (en) 2009-10-21 2020-03-24 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
KR20130137595A (ko) 2010-08-10 2013-12-17 루핀 리미티드 블로난세린을 함유하는 경구용 서방성 약학 조성물
CN102372673B (zh) * 2010-08-27 2014-04-09 天津市医药集团技术发展有限公司 布南色林结晶及其制备方法
CN102093289B (zh) * 2010-10-29 2012-12-19 常州华生制药有限公司 布南色林中间体的制备方法
CN102030707A (zh) * 2010-11-12 2011-04-27 深圳万和制药有限公司 布南色林中间体的制备方法
SG194697A1 (en) 2011-05-03 2013-12-30 Agios Pharmaceuticals Inc Pyruvate kinase activators for use in therapy
CN102827170A (zh) * 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN115536635A (zh) 2012-01-06 2022-12-30 法国施维雅药厂 治疗活性化合物及其使用方法
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
EP2906212A4 (en) 2012-10-15 2016-06-08 Agios Pharmaceuticals Inc THERAPEUTIC COMPOUNDS AND COMPOSITIONS
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
EP3019480B1 (en) 2013-07-11 2020-05-06 Agios Pharmaceuticals, Inc. 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
KR20240010105A (ko) 2014-03-14 2024-01-23 아지오스 파마슈티컬스 아이엔씨. 치료적으로 활성인 화합물의 약제학적 조성물
CN104311487B (zh) * 2014-09-22 2016-08-24 江苏正大丰海制药有限公司 一种布南色林晶型及其制备方法
US11234976B2 (en) 2015-06-11 2022-02-01 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
CA3216701A1 (en) 2015-10-15 2017-04-20 Les Laboratoires Servier Combination therapy for treating malignancies
US10653710B2 (en) 2015-10-15 2020-05-19 Agios Pharmaceuticals, Inc. Combination therapy for treating malignancies
KR20190028109A (ko) 2017-09-08 2019-03-18 연성정밀화학(주) 블로난세린 함유 서방성 제제
CN110575438A (zh) * 2018-06-07 2019-12-17 湖南省湘中制药有限公司 一种布南色林固体分散体的制备及其应用
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
EP3939954A4 (en) 2019-03-13 2023-01-04 Otsuka Pharmaceutical Co., Ltd. METHOD FOR INTRODUCING A DEUTERED LOWER ALKYL INTO AN AMINE FRACTION OF A COMPOUND CONTAINING A SECONDARY AMINE
CN113698346A (zh) * 2020-05-22 2021-11-26 湖南省湘中制药有限公司 一种布南色林工艺杂质b的制备方法
CN113698347A (zh) * 2020-05-22 2021-11-26 湖南省湘中制药有限公司 一种布南色林工艺杂质f的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54128588A (en) * 1978-03-29 1979-10-05 Dainippon Pharmaceut Co Ltd Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
DE3124673A1 (de) * 1981-06-24 1983-01-13 Bayer Ag, 5090 Leverkusen Subsituierte 2-amino-pyridinderivate, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln, sowie deren herstellung
FR2602771B1 (fr) * 1986-08-12 1988-11-04 Rhone Poulenc Sante Nouveaux derives de la benzyl-4 piperazine, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
DD292909A5 (de) 1991-08-14
KR900014358A (ko) 1990-10-23
KR0149649B1 (ko) 1998-10-15
AU623981B2 (en) 1992-05-28
AU5060490A (en) 1990-09-06
EP0385237B1 (en) 1994-06-29
DE69010232T2 (de) 1994-12-01
NO900991D0 (no) 1990-03-01
HK1005872A1 (en) 1999-01-29
US5021421A (en) 1991-06-04
RU2075478C1 (ru) 1997-03-20
FI94413B (fi) 1995-05-31
CA2011346A1 (en) 1990-09-03
DE69010232D1 (de) 1994-08-04
CA2011346C (en) 1999-08-03
ATE107922T1 (de) 1994-07-15
HU204810B (en) 1992-02-28
DK0385237T3 (da) 1994-07-25
FI901030A0 (fi) 1990-03-01
HU901275D0 (en) 1990-05-28
NO177095B (no) 1995-04-10
NO177095C (no) 1995-07-19
HUT53361A (en) 1990-10-28
FI94413C (fi) 1995-09-11
EP0385237A3 (en) 1991-03-20
NO900991L (no) 1990-09-04
EP0385237A2 (en) 1990-09-05

Similar Documents

Publication Publication Date Title
ES2058630T3 (es) Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen.
ES2053508T3 (es) Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos.
ES2093753T3 (es) Derivados de estireno.
HUP9903766A2 (en) Pyridyl alkene- and pyridyl alkine- acid amides, use of them as cytostatics and immunosuppressives, process for their preparation and pharmaceuticals containing the same
AR028531A1 (es) Compuestos organicos
SE8101409L (sv) Karbostyrilderivat och forfarande for framstellning derav
SE8200916L (sv) Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma
GB1014053A (en) 7-hydroxy-coumarin derivatives and process for their production
MX162950B (es) Procedimiento para preparar derivados de acidos piridoncarboxilicos
NO158578C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,1-benzoksazin-2-on-derivater.
ES479820A1 (es) Procedimiento para la preparacion de isoquinoleinas.
DE3882438T2 (de) Alkansulfonanilid-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung.
ATE5138T1 (de) Thiazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DK212387D0 (da) Benzhydrylpiperazinderivater eller farmaceutisk acceptable syreadditonssalte og kvaternaere ammoni-umsalte deraf, deres fremstilling og anvendelse
SE7712733L (sv) Substituerade o-fenylendiaminderivat, sett for framstellning samt anvendning derav som lekemedel
IT1228454B (it) Derivati del 1-arilsolfonil 2 piperidone, loro procedimento di preparazione e loro impiego come farmaci.
ES8103081A1 (es) Procedimiento para la obtencion de diazatriciclos
DE3063450D1 (en) Theophylline derivatives, process for their preparation and medicaments containing these compounds
AR009144A1 (es) Compuestos heterociclicos guanidilamino, composicion farmaceutica que comprende dicho compuesto y uso del mismo para la fabricacion de un medicamento
PT83975B (pt) Processo para a preparacao de derivados de 5-aminoalquil-beta-carbolinas e de composicoes farmaceuticas que os contem
HUP0104949A2 (hu) Antibakteriális hatású higromicinszármazékok és eljárás előállításukra, valamint az ezeket tartalmazó gyógyszerkészítmények
ES8608509A1 (es) Procedimiento para preparar nuevos derivador de 2-(1-imidazolil)-etanol
DE59005445D1 (de) Picolylselenobenzamide von Aminopyridinen, Anilinen und Picolylaminen.
DK523482A (da) Oximer af 3'''-dehydro-kardenolid-tridigitoxosider, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 385237

Country of ref document: ES