ATE5138T1 - Thiazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents

Thiazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE5138T1
ATE5138T1 AT80304740T AT80304740T ATE5138T1 AT E5138 T1 ATE5138 T1 AT E5138T1 AT 80304740 T AT80304740 T AT 80304740T AT 80304740 T AT80304740 T AT 80304740T AT E5138 T1 ATE5138 T1 AT E5138T1
Authority
AT
Austria
Prior art keywords
thiazole derivatives
production
pharmaceutical compositions
compositions containing
halogen
Prior art date
Application number
AT80304740T
Other languages
English (en)
Inventor
Ikuo Ueda
Daizou Morino
Koichi Daiichishinkitano Cor Takimoto
Yodogawa-Ku
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Application granted granted Critical
Publication of ATE5138T1 publication Critical patent/ATE5138T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT80304740T 1980-01-03 1980-12-29 Thiazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. ATE5138T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8000162 1980-01-03
EP80304740A EP0032058B1 (de) 1980-01-03 1980-12-29 Thiazolderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE5138T1 true ATE5138T1 (de) 1983-11-15

Family

ID=10510425

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80304740T ATE5138T1 (de) 1980-01-03 1980-12-29 Thiazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Country Status (6)

Country Link
US (1) US4411900A (de)
EP (1) EP0032058B1 (de)
JP (1) JPS56103168A (de)
AT (1) ATE5138T1 (de)
CA (1) CA1154764A (de)
DE (1) DE3065435D1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995281A (ja) * 1982-11-19 1984-06-01 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
JPS59155375A (ja) * 1983-02-22 1984-09-04 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
IT1190375B (it) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica
JP2690742B2 (ja) * 1987-03-30 1997-12-17 第一製薬株式会社 複素環アミン誘導体
US4935424A (en) * 1988-05-27 1990-06-19 Warner-Lambert Company 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents
DE3923675A1 (de) * 1989-07-18 1991-01-24 Basf Ag Amonoalkylsubstituierte 2-aminothiazole und diese enthaltende therapeutische mittel
US5130443A (en) * 1991-04-29 1992-07-14 Xerox Corporation Process for the preparation of anilides
JPH07157477A (ja) 1993-12-02 1995-06-20 Asahi Kagaku Kogyo Kk チアゾール誘導体の製造方法
GB0009479D0 (en) * 2000-04-17 2000-06-07 Cipla Limited Antihistaminic compounds
CA2653497A1 (en) * 2006-05-26 2007-12-06 Neuromed Pharmaceuticals Ltd. Heterocyclic compounds as calcium channel blockers
WO2009006899A1 (en) * 2007-07-11 2009-01-15 Fertin Pharma A/S Compressed chewing gum tablet comprising taste-masking agent
WO2009006898A1 (en) * 2007-07-11 2009-01-15 Fertin Pharma A/S Stable medicated chewing gum comprising cyclodextrin inclusion complex
CN102993117A (zh) * 2012-11-28 2013-03-27 张家港市大伟助剂有限公司 2-胺基-5-(4-胺基苯基)-噻唑的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE485737A (de) * 1947-11-12
US2909523A (en) * 1957-10-11 1959-10-20 American Cyanamid Co Substituted piperazines and method of preparing the same
DE1595923A1 (de) * 1965-02-20 1969-11-27 Merck Ag E 1-Aralkyl-4-(thiazolyl-2)-piperazine und Verfahren zu ihrer Herstellung
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
GB1184714A (en) * 1965-12-16 1970-03-18 Science Union & Cie Di- and Tri-Phenylpropyl Piperazine Derivatives
US3519637A (en) * 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
US3491098A (en) * 1967-05-29 1970-01-20 Sterling Drug Inc 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
GB1239553A (de) * 1967-08-16 1971-07-21
GB1240648A (en) * 1967-08-16 1971-07-28 Wyeth John & Brother Ltd N-substituted isatins
BE747274R (fr) * 1969-03-20 1970-08-17 Fujisawa Pharmaceutical Co Procedes de preparation de composes d'aminocarbonylalkyle n-substitues et n,n-disubstitues et nouveaux produits ainsi obtenus
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
US3751416A (en) * 1971-05-27 1973-08-07 American Cyanamid Co 3-(2-(4-phenyl-1-piperazinyl)-ethyl)indolines
FR2141526B1 (de) * 1971-06-14 1975-05-30 Roussel Uclaf
US3772919A (en) * 1972-02-09 1973-11-20 Hunter Eng Co Balancing apparatus for rotating bodies and method of producing frequency stable phase delay
FR2176528B1 (de) * 1972-03-22 1975-04-25 Roussel Uclaf
JPS5070389A (de) * 1973-10-30 1975-06-11

Also Published As

Publication number Publication date
JPH0114229B2 (de) 1989-03-10
US4411900A (en) 1983-10-25
EP0032058A1 (de) 1981-07-15
DE3065435D1 (en) 1983-12-01
EP0032058B1 (de) 1983-10-26
CA1154764A (en) 1983-10-04
JPS56103168A (en) 1981-08-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee