ES2073258T3 - Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica. - Google Patents
Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.Info
- Publication number
- ES2073258T3 ES2073258T3 ES92402131T ES92402131T ES2073258T3 ES 2073258 T3 ES2073258 T3 ES 2073258T3 ES 92402131 T ES92402131 T ES 92402131T ES 92402131 T ES92402131 T ES 92402131T ES 2073258 T3 ES2073258 T3 ES 2073258T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- application
- radical
- preparation
- therapeutics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NUEVOS DERIVADOS DE LA UREA QUE CORRESPONDE A LA FORMULA GENERAL 1 EN LA QUE: R1 REPRESENTA UN GRUPO ALQUILO EN C1-C4; R2 REPRESENTA: LOALQUILMETILO DONDE EL RADICAL CICLOALQUILO COMPRENDE DE 5 A 7 ATOMOS DE CARBONO, NDE EL CICLO AROMATICO LLEVA UN GRUPO ALQUILO EN C1-C4, UN GRUPO ALKOXI EN C1-C4, UN ATOMO DE HALOGENO O UN GRUPO NITRO; A REPRESENTA UN ATOMO DE OXIGENO O UN RADICAL METILENO; N REPRESENTA 1 O 2; X REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE; B REPRESENTA UN ENLACE DIRECTO, UN RADICAL METILENO O UN RADICAL CARBONILO; ASI COMO LAS SALES TERAPEUTICAMENTE ACEPTABLES DE ESTAS MOLECULAS. LA INVENCION SE REFIERE TAMBIEN A LA APLICACION DE LOS COMPUESTOS DE FORMULA GENERAL 1 EN TERAPIA Y LOS PROCESOS DE PREPARACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9109446A FR2679555B1 (fr) | 1991-07-25 | 1991-07-25 | Nouveaux derives de l'uree, leur preparation et leur application en therapeutique. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2073258T3 true ES2073258T3 (es) | 1995-08-01 |
Family
ID=9415541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92402131T Expired - Lifetime ES2073258T3 (es) | 1991-07-25 | 1992-07-23 | Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5288758A (es) |
EP (1) | EP0526313B1 (es) |
JP (1) | JPH05194359A (es) |
AT (1) | ATE121385T1 (es) |
DE (1) | DE69202120T2 (es) |
DK (1) | DK0526313T3 (es) |
ES (1) | ES2073258T3 (es) |
FR (1) | FR2679555B1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9206989D0 (en) * | 1992-03-31 | 1992-05-13 | Glaxo Group Ltd | Chemical compounds |
ES2141763T3 (es) * | 1992-03-31 | 2000-04-01 | Glaxo Group Ltd | Fenilcarbonatos y fenilureas sustituidos, su preparacion y su uso como antagonistas de 5-ht4. |
KR970703301A (ko) * | 1994-05-18 | 1997-07-03 | 쇼오다 오사무 | 신규 디아미노메틸리덴 유도체(novel diamincmethylidene derivative) |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
CN1163224C (zh) | 1998-09-30 | 2004-08-25 | 武田药品工业株式会社 | 改善膀胱排泄能力的药物 |
JPWO2005080322A1 (ja) * | 2004-02-20 | 2007-10-25 | アステラス製薬株式会社 | フルオレン誘導体 |
JPWO2005079845A1 (ja) * | 2004-02-20 | 2007-08-02 | アステラス製薬株式会社 | 片頭痛予防薬 |
EP1852129A4 (en) * | 2005-02-08 | 2009-07-15 | Astellas Pharma Inc | REMEDIES FOR IRRITATION SYNDROME |
EP1923387B1 (en) * | 2005-08-08 | 2011-10-19 | Astellas Pharma Inc. | Acylguanidine derivative or salt thereof |
PE20070797A1 (es) | 2005-11-25 | 2007-09-27 | Basf Ag | Compuestos de indanil- y tetrahidronaftil-amino-tiourea para combatir pestes animales |
WO2011100373A1 (en) * | 2010-02-09 | 2011-08-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
AU2016268096B2 (en) | 2015-05-22 | 2021-04-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3061640A (en) * | 1959-03-30 | 1962-10-30 | Monsanto Chemicals | 3, 4-dichlorophenyl dialkylaminoalkyl ureas and thioureas |
US3049562A (en) * | 1961-03-09 | 1962-08-14 | American Cyanamid Co | 1-(aralkyl, lower alkylamino lower alkyl), 1-phenyl, 3, 3-dilower alkylureas |
US3903154A (en) * | 1973-08-03 | 1975-09-02 | Chevron Res | Herbicidal substituted-haloethyl urea |
JPH0140026B2 (es) * | 1978-07-03 | 1989-08-24 | Amerikan Hoomu Purodakutsu Corp | |
US4474707A (en) * | 1980-10-09 | 1984-10-02 | American Home Products Corporation | N-3-Propenylaminopropyl-N'-phenylureas |
US4297373A (en) * | 1980-10-09 | 1981-10-27 | American Home Products Corporation | Method of suppressing cardiac arrhythmias |
US5015644A (en) * | 1987-06-02 | 1991-05-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds |
US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
US5106873A (en) * | 1990-06-26 | 1992-04-21 | Warner-Lambert Company | ACAT inhibitors |
-
1991
- 1991-07-25 FR FR9109446A patent/FR2679555B1/fr not_active Expired - Fee Related
-
1992
- 1992-07-22 US US07/918,424 patent/US5288758A/en not_active Expired - Fee Related
- 1992-07-23 DK DK92402131.4T patent/DK0526313T3/da active
- 1992-07-23 DE DE69202120T patent/DE69202120T2/de not_active Expired - Fee Related
- 1992-07-23 AT AT92402131T patent/ATE121385T1/de not_active IP Right Cessation
- 1992-07-23 JP JP4197005A patent/JPH05194359A/ja not_active Withdrawn
- 1992-07-23 EP EP92402131A patent/EP0526313B1/fr not_active Expired - Lifetime
- 1992-07-23 ES ES92402131T patent/ES2073258T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH05194359A (ja) | 1993-08-03 |
ATE121385T1 (de) | 1995-05-15 |
DE69202120T2 (de) | 1995-11-30 |
DK0526313T3 (da) | 1995-08-21 |
EP0526313A1 (fr) | 1993-02-03 |
EP0526313B1 (fr) | 1995-04-19 |
FR2679555B1 (fr) | 1993-11-19 |
US5288758A (en) | 1994-02-22 |
DE69202120D1 (de) | 1995-05-24 |
FR2679555A1 (fr) | 1993-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2073258T3 (es) | Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica. | |
NO953305L (no) | Antranilsyrederivat | |
NO308601B1 (no) | Tricykliske benzazepiner og farmasøytisk preparat inneholdende disse | |
FI924397A0 (fi) | Substituerade pyrimidiner. | |
NZ330973A (en) | Azolobenzazepine derivatives as neurologically active agents | |
DE3876813D1 (de) | 3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a. | |
ATE175661T1 (de) | Benzamid-derivate als vasopressin-antagonisten | |
MX9806171A (es) | Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa. | |
DE69429570D1 (de) | Galanthamin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente | |
HUP9801072A2 (hu) | Szubsztituált 6-és 7-amino-tetrahidro-izokinolin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
FI844333L (fi) | 11-substituerade 5h,11h-pyrrolo/2,1-c/ /1,4/benzoxazepiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel. | |
NZ221699A (en) | Pyridazinone derivatives; pharmaceutical compositions and intermediates | |
DE69418744D1 (de) | Verwendung von Pregnanderivaten zur Behandlung von Tumoren | |
DK521685D0 (da) | Spergualin-derivater og anvendelse deraf til fremstilling af laegemidler med immunosuppressiv virkning | |
ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
NO870423D0 (no) | 5-substituert octahydroindolizin-analgetika-forbindelser og 7-keto-mellomprodukt. | |
DE69808922D1 (de) | Thiazolobenzoheterocyclen, ihre herstellung und diese enthaltende phatrmazeutische zubereitungen | |
ATE42291T1 (de) | Spiro(indolo(1,7-ab>(1,5>benzodiazepin-2,4'piperidine> und zwischenprodukte, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. | |
NO961719L (no) | 3-aryl-4-alkyl og 4,5-dialkyl-4H-1,2,4-triazoler som er anvendbare som hukommelsesforsterkere | |
ES8602676A1 (es) | Un procedimiento para la preparacion de nuevos derivados de pirrolo-(2,1-a)isoquilonina. | |
DK378087A (da) | Tetracycliske indolderivater | |
ATE92074T1 (de) | Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
AP9400608A0 (en) | "New nicotinic acid derivative". | |
DE69528984D1 (de) | Hemmung der leukotrienbiosynthese mittels harnstoffderivaten | |
DK0686641T3 (da) | 2'-Deoxy-5-fluoruridinderivat, farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf, og antitumorlægem |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 526313 Country of ref document: ES |