ES2073258T3 - Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica. - Google Patents

Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.

Info

Publication number
ES2073258T3
ES2073258T3 ES92402131T ES92402131T ES2073258T3 ES 2073258 T3 ES2073258 T3 ES 2073258T3 ES 92402131 T ES92402131 T ES 92402131T ES 92402131 T ES92402131 T ES 92402131T ES 2073258 T3 ES2073258 T3 ES 2073258T3
Authority
ES
Spain
Prior art keywords
group
application
radical
preparation
therapeutics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92402131T
Other languages
English (en)
Inventor
Jean-Louis Vidaluc
Dennis Bigg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Application granted granted Critical
Publication of ES2073258T3 publication Critical patent/ES2073258T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVOS DERIVADOS DE LA UREA QUE CORRESPONDE A LA FORMULA GENERAL 1 EN LA QUE: R1 REPRESENTA UN GRUPO ALQUILO EN C1-C4; R2 REPRESENTA: LOALQUILMETILO DONDE EL RADICAL CICLOALQUILO COMPRENDE DE 5 A 7 ATOMOS DE CARBONO, NDE EL CICLO AROMATICO LLEVA UN GRUPO ALQUILO EN C1-C4, UN GRUPO ALKOXI EN C1-C4, UN ATOMO DE HALOGENO O UN GRUPO NITRO; A REPRESENTA UN ATOMO DE OXIGENO O UN RADICAL METILENO; N REPRESENTA 1 O 2; X REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE; B REPRESENTA UN ENLACE DIRECTO, UN RADICAL METILENO O UN RADICAL CARBONILO; ASI COMO LAS SALES TERAPEUTICAMENTE ACEPTABLES DE ESTAS MOLECULAS. LA INVENCION SE REFIERE TAMBIEN A LA APLICACION DE LOS COMPUESTOS DE FORMULA GENERAL 1 EN TERAPIA Y LOS PROCESOS DE PREPARACION.
ES92402131T 1991-07-25 1992-07-23 Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica. Expired - Lifetime ES2073258T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9109446A FR2679555B1 (fr) 1991-07-25 1991-07-25 Nouveaux derives de l'uree, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ES2073258T3 true ES2073258T3 (es) 1995-08-01

Family

ID=9415541

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92402131T Expired - Lifetime ES2073258T3 (es) 1991-07-25 1992-07-23 Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.

Country Status (8)

Country Link
US (1) US5288758A (es)
EP (1) EP0526313B1 (es)
JP (1) JPH05194359A (es)
AT (1) ATE121385T1 (es)
DE (1) DE69202120T2 (es)
DK (1) DK0526313T3 (es)
ES (1) ES2073258T3 (es)
FR (1) FR2679555B1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2141763T3 (es) * 1992-03-31 2000-04-01 Glaxo Group Ltd Fenilcarbonatos y fenilureas sustituidos, su preparacion y su uso como antagonistas de 5-ht4.
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
KR970703301A (ko) * 1994-05-18 1997-07-03 쇼오다 오사무 신규 디아미노메틸리덴 유도체(novel diamincmethylidene derivative)
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
EP1891954A3 (en) 1998-09-30 2009-01-14 Takeda Pharmaceutical Company Limited Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
AU2005214249A1 (en) * 2004-02-20 2005-09-01 Astellas Pharma Inc. Fluorene derivative
WO2005079845A1 (ja) * 2004-02-20 2005-09-01 Astellas Pharma Inc. 片頭痛予防薬
TW200638926A (en) * 2005-02-08 2006-11-16 Astellas Pharma Inc A therapeutic agent for irritable bowel disease
US8076348B2 (en) * 2005-08-08 2011-12-13 Astellas Pharma Inc. Acylguanidine derivative or salt thereof
PE20070797A1 (es) * 2005-11-25 2007-09-27 Basf Ag Compuestos de indanil- y tetrahidronaftil-amino-tiourea para combatir pestes animales
EP2533645B1 (en) * 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3061640A (en) * 1959-03-30 1962-10-30 Monsanto Chemicals 3, 4-dichlorophenyl dialkylaminoalkyl ureas and thioureas
US3049562A (en) * 1961-03-09 1962-08-14 American Cyanamid Co 1-(aralkyl, lower alkylamino lower alkyl), 1-phenyl, 3, 3-dilower alkylureas
US3903154A (en) * 1973-08-03 1975-09-02 Chevron Res Herbicidal substituted-haloethyl urea
WO1980000151A1 (en) * 1978-07-03 1980-02-07 American Home Prod N-(3-alkylaminopropyl)-n'-phenylureas
US4297373A (en) * 1980-10-09 1981-10-27 American Home Products Corporation Method of suppressing cardiac arrhythmias
US4474707A (en) * 1980-10-09 1984-10-02 American Home Products Corporation N-3-Propenylaminopropyl-N'-phenylureas
US5015644A (en) * 1987-06-02 1991-05-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
US5106873A (en) * 1990-06-26 1992-04-21 Warner-Lambert Company ACAT inhibitors

Also Published As

Publication number Publication date
DE69202120D1 (de) 1995-05-24
JPH05194359A (ja) 1993-08-03
US5288758A (en) 1994-02-22
EP0526313B1 (fr) 1995-04-19
DK0526313T3 (da) 1995-08-21
DE69202120T2 (de) 1995-11-30
EP0526313A1 (fr) 1993-02-03
FR2679555B1 (fr) 1993-11-19
FR2679555A1 (fr) 1993-01-29
ATE121385T1 (de) 1995-05-15

Similar Documents

Publication Publication Date Title
NO953305D0 (no) Antranilsyrederivat
ES2073258T3 (es) Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
NO308601B1 (no) Tricykliske benzazepiner og farmasøytisk preparat inneholdende disse
LU91210I2 (fr) Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
NZ330973A (en) Azolobenzazepine derivatives as neurologically active agents
ATE175661T1 (de) Benzamid-derivate als vasopressin-antagonisten
ATE25682T1 (de) Indol-3-carboxamid-derivate.
DE3876813D1 (de) 3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a.
MX9806171A (es) Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.
DE69429570D1 (de) Galanthamin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente
HUP9801072A2 (hu) Szubsztituált 6-és 7-amino-tetrahidro-izokinolin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
FI844333A0 (fi) 11-substituerade 5h,11h-pyrrolo/2,1-c/ /1,4/benzoxazepiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
NZ221699A (en) Pyridazinone derivatives; pharmaceutical compositions and intermediates
DK521685A (da) Spergualin-derivater og anvendelse deraf til fremstilling af laegemidler med immunosuppressiv virkning
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
NO870423D0 (no) 5-substituert octahydroindolizin-analgetika-forbindelser og 7-keto-mellomprodukt.
ATE226585T1 (de) Thiazolobenzoheterocyclen, ihre herstellung und diese enthaltende phatrmazeutische zubereitungen
ATE42291T1 (de) Spiro(indolo(1,7-ab>(1,5>benzodiazepin-2,4'piperidine> und zwischenprodukte, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
NO961719D0 (no) 3-aryl-4-alkyl og 4,5-dialkyl-4H-1,2,4-triazoler som er anvendbare som hukommelsesforsterkere
ES8602676A1 (es) Un procedimiento para la preparacion de nuevos derivados de pirrolo-(2,1-a)isoquilonina.
ATE92074T1 (de) Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DK378087A (da) Tetracycliske indolderivater
AP9400608A0 (en) "New nicotinic acid derivative".
DE69528984D1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
DK0686641T3 (da) 2'-Deoxy-5-fluoruridinderivat, farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf, og antitumorlægem

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 526313

Country of ref document: ES