PE20020294A1 - Derivados de pirrolidina como inhibidores de la enzima conversor de endotelina - Google Patents
Derivados de pirrolidina como inhibidores de la enzima conversor de endotelinaInfo
- Publication number
- PE20020294A1 PE20020294A1 PE2001000711A PE2001000711A PE20020294A1 PE 20020294 A1 PE20020294 A1 PE 20020294A1 PE 2001000711 A PE2001000711 A PE 2001000711A PE 2001000711 A PE2001000711 A PE 2001000711A PE 20020294 A1 PE20020294 A1 PE 20020294A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- arylalkyl
- endothelin
- sulfonil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRROLIDINA DE FORMULA I DONDE R1 ES H, ALQUILCARBONILO, ARILCARBONILO; R2 ES ALQUILO, ALQUILCICLOALQUILO, ALQUILCICLOALQUILALQUILO, CICLOALQUILO, ENTRE OTROS; A ES CO-R3, CH(OH)R4, CONR5R6; R3 Y R4 SON ALQUILO, ARILO, ARILALQUINILO, ARILALQUILO, ENTRE OTROS; R5 ES H, ALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ENTRE OTROS; R6 ES ALQUILO, ALQUILCARBONILALQUILO, CIANOALQUILO, -CHR7-COR8, CH2CH2COR8, GRUPO IIc, ENTRE OTROS, R7 ES H, ALQUILO, ALQUENILO, ALQUILTIOALQUILO, ENTRE OTROS; R7A Y R10 SON H, ALQUILO; R8 ES OR9, NR10R11; R9 ES H, ALQUILO, ARILALQUILO; R11 ES ALQUILO, ARILO, HETEROARILO, ENTRE OTROS; R12 ES ALQUILO, ARILO, ARILALQUILO; Y ES O, O-S(O2), OCO; m ES 0-2; X ES SO2, CO, COO, SO2NH, CONR13; R13 ES H, ALQUILO, ARILO, CARBOXIALQUILO. SON COMPUESTOS PREFERIDOS ACIDO (2S,4S)-1-[4-MERCAPTO-1-(NAFTALEN-2-SULFONIL)-PIRROLIDIN-2-CARBONIL]PIPERIDIN-4-CARBOXILICO ETIL ESTER; ACIDO (2S,4R)-4-MERCAPTO-1-(NAFTALEN-2-SULFONIL)-PIRROLIDIN-2-CARBOXILICO BENCIL METIL AMIDA, ENTRE OTROS; TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES INHIBIDOR DE ZINC HIDROLASA ESPECIALMENTE DE ENZIMA CONVERSORA DE ENDOTELINA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ISQUEMIA DE MIOCARDIO, INSUFICIENCIA CARDIACA CONGESTIVA, ARRITMIA, HIPERTENSION, HIPERTENSION PULMONAR, ASMA, VASOESPASMO CEREBRAL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00114947 | 2000-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020294A1 true PE20020294A1 (es) | 2002-04-17 |
Family
ID=8169224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000711A PE20020294A1 (es) | 2000-07-19 | 2001-07-16 | Derivados de pirrolidina como inhibidores de la enzima conversor de endotelina |
Country Status (16)
Country | Link |
---|---|
US (1) | US6541638B2 (es) |
EP (1) | EP1303485A1 (es) |
JP (1) | JP4068452B2 (es) |
KR (1) | KR100568841B1 (es) |
CN (1) | CN1620433A (es) |
AR (1) | AR033984A1 (es) |
AU (1) | AU2001270627A1 (es) |
BR (1) | BR0112580A (es) |
CA (1) | CA2414311C (es) |
GT (1) | GT200100145A (es) |
MX (1) | MXPA03000223A (es) |
PA (1) | PA8522501A1 (es) |
PE (1) | PE20020294A1 (es) |
UY (1) | UY26847A1 (es) |
WO (1) | WO2002006222A1 (es) |
ZA (1) | ZA200300167B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100613196B1 (ko) * | 2000-07-19 | 2006-08-18 | 에프. 호프만-라 로슈 아게 | 메탈로프로테아제 억제제로서의 피롤리딘 유도체 |
WO2002053534A1 (fr) | 2000-12-28 | 2002-07-11 | Daiichi Pharmaceutical Co., Ltd. | Inhibiteurs de vla-4 |
EP1481967B1 (en) | 2002-03-05 | 2011-05-04 | Sumitomo Chemical Company, Limited | Process for the preparation of biaryl compounds |
ES2537514T3 (es) | 2003-04-04 | 2015-06-09 | Incyte Corporation | Composiciones, métodos y kits relacionados con la escisión de HER-2 |
CA2521937A1 (en) | 2003-04-10 | 2004-10-28 | Amgen, Inc. | Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof |
WO2004092164A1 (en) | 2003-04-10 | 2004-10-28 | Amgen, Inc. | Cyclic amine derivatives and their use in the treatment of inflammation-related disorders mediated by bradykinin |
KR20060036399A (ko) | 2003-06-20 | 2006-04-28 | 암젠 인코포레이티드 | 피페라진 유도체 및 사용 방법 |
ES2382806T3 (es) | 2003-07-24 | 2012-06-13 | Daiichi Sankyo Company, Limited | Compuesto ácido ciclohexanocarboxílico |
CN1294120C (zh) * | 2003-10-21 | 2007-01-10 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其应用 |
EP2010167A2 (en) * | 2006-04-13 | 2009-01-07 | Actelion Pharmaceuticals Ltd. | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
ES2350548B1 (es) * | 2009-06-25 | 2011-09-29 | Institut Univ. De Ciència I Tecnologia, S.A. | N-fenil-1-sulfonil-2-pirrolidinacarboxamidas para la identificacion de actividad biologica y farmacologica. |
EP2730571A1 (en) * | 2012-11-12 | 2014-05-14 | Universitat De Barcelona | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
JP7163916B2 (ja) * | 2017-07-05 | 2022-11-01 | 日産化学株式会社 | ベンジル化合物 |
CN110078593A (zh) * | 2018-11-15 | 2019-08-02 | 南通正达农化有限公司 | 一种苹果蠹蛾性信息素的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
JP3091297B2 (ja) * | 1992-01-10 | 2000-09-25 | 住友製薬株式会社 | ピロリジン誘導体およびその製造方法 |
DK0927161T3 (da) * | 1996-08-28 | 2003-02-17 | Procter & Gamble | Substitueret cyklisk amin-metalloproteaseinhibitorer |
BR9712792A (pt) * | 1996-08-28 | 1999-12-14 | Procter & Gamble | Inibidores de metaloprotease bidentada. |
AU736136B2 (en) * | 1997-07-10 | 2001-07-26 | Merck Sharp & Dohme Corp. | Crystalline forms of antibiotic side chain intermediates |
BR9910098A (pt) * | 1998-05-01 | 2000-12-26 | Kyoto Pharma Ind | Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos |
-
2001
- 2001-07-10 BR BR0112580-0A patent/BR0112580A/pt not_active IP Right Cessation
- 2001-07-10 AU AU2001270627A patent/AU2001270627A1/en not_active Abandoned
- 2001-07-10 WO PCT/EP2001/007950 patent/WO2002006222A1/en not_active Application Discontinuation
- 2001-07-10 MX MXPA03000223A patent/MXPA03000223A/es not_active Application Discontinuation
- 2001-07-10 KR KR1020037000781A patent/KR100568841B1/ko not_active IP Right Cessation
- 2001-07-10 CN CNA018130232A patent/CN1620433A/zh active Pending
- 2001-07-10 CA CA002414311A patent/CA2414311C/en not_active Expired - Fee Related
- 2001-07-10 JP JP2002512128A patent/JP4068452B2/ja not_active Expired - Fee Related
- 2001-07-10 EP EP01949485A patent/EP1303485A1/en not_active Withdrawn
- 2001-07-16 PE PE2001000711A patent/PE20020294A1/es not_active Application Discontinuation
- 2001-07-16 PA PA20018522501A patent/PA8522501A1/es unknown
- 2001-07-17 UY UY26847A patent/UY26847A1/es not_active Application Discontinuation
- 2001-07-17 US US09/907,135 patent/US6541638B2/en not_active Expired - Fee Related
- 2001-07-17 AR ARP010103416A patent/AR033984A1/es unknown
- 2001-07-18 GT GT200100145A patent/GT200100145A/es unknown
-
2003
- 2003-01-07 ZA ZA200300167A patent/ZA200300167B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US6541638B2 (en) | 2003-04-01 |
MXPA03000223A (es) | 2003-06-06 |
CA2414311C (en) | 2008-01-08 |
CN1620433A (zh) | 2005-05-25 |
AR033984A1 (es) | 2004-01-21 |
UY26847A1 (es) | 2002-01-31 |
EP1303485A1 (en) | 2003-04-23 |
AU2001270627A1 (en) | 2002-01-30 |
GT200100145A (es) | 2002-05-16 |
KR20030016416A (ko) | 2003-02-26 |
ZA200300167B (en) | 2004-04-07 |
JP2004504297A (ja) | 2004-02-12 |
PA8522501A1 (es) | 2002-09-17 |
WO2002006222A1 (en) | 2002-01-24 |
KR100568841B1 (ko) | 2006-04-10 |
US20020049243A1 (en) | 2002-04-25 |
CA2414311A1 (en) | 2002-01-24 |
JP4068452B2 (ja) | 2008-03-26 |
BR0112580A (pt) | 2003-06-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20020294A1 (es) | Derivados de pirrolidina como inhibidores de la enzima conversor de endotelina | |
AR045782A2 (es) | Derivados de piperidina que tienen actividad farmaceutica | |
DE59401923D1 (de) | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel | |
PE20081135A1 (es) | Derivados que contienen sulfamoilo y sus usos | |
KR870007205A (ko) | 펩티딜아미노디올 | |
TR200000837A2 (tr) | Anti-kanser bileşimleri hazırlamak için işlem ve ara maddeler. | |
EA200200253A1 (ru) | Ингибиторы клеточной адгезии | |
ATE415387T1 (de) | Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten | |
AR047339A1 (es) | Derivados de difenilazetidona.proceso de obtencion. | |
PE20061121A1 (es) | Compuestos derivados de 2-alcoxi-3,4,5-trihidroxi-alquilamidas | |
EP0330461A3 (en) | Piperidine derivatives | |
ATE170177T1 (de) | Biphenylderivate, verfahren zu ihrer herstellung, und ihre verwendung zur behandlung von bluthochdruck und herzkrankheiten | |
EA200201264A1 (ru) | 5-хлор-3(4-метансульфонилфенил)-6'-метил-[2,3']бипиридинил в чистой кристаллической форме и способ синтеза | |
PE20001495A1 (es) | Derivados de mevinolina | |
NO951147L (no) | Substituerte heterocykliske karboksylsyreamidestere, deres fremstilling og deres anvendelse som legemiddel | |
DE59307409D1 (de) | Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester | |
ATE360424T1 (de) | 2,3,4,5-tetrahydrobenzo[fö]1,4öoxazepin-5- carbonsäureamid derivate als gamma-secretase inhibitoren zur behandlung von alzheimer | |
AR031808A1 (es) | 2-piridonas antimicrobianas, sus composiciones y usos | |
CO5200782A1 (es) | Las rutas sinteticas eficientes para la preparacion de los inhibidores d ela proteasa del rinovirus y los intermedios claves | |
US6852713B2 (en) | Lactam derivatives and methods of their use | |
Fukushima et al. | Synthesis and Structure–Activity Relationships of Potent 1-(2-Substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine Dipeptidyl Peptidase IV Inhibitors | |
DE69527854T2 (de) | Derivate substituierter amidinonaphthylester | |
KR960704888A (ko) | AMPA-수용체에 작용하는 알콕시-치환 β-카르보린 (Alkoxy-Substituted β-Carbolines Acting on The AMPA-Receptor) | |
DE60003711D1 (de) | Verfahren zur herstellung von peptidzwischenprodukten | |
DE3789729D1 (de) | Peptidderivate und Verfahren zu deren Herstellung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |