ATE415387T1 - Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten - Google Patents
Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivatenInfo
- Publication number
- ATE415387T1 ATE415387T1 AT03734040T AT03734040T ATE415387T1 AT E415387 T1 ATE415387 T1 AT E415387T1 AT 03734040 T AT03734040 T AT 03734040T AT 03734040 T AT03734040 T AT 03734040T AT E415387 T1 ATE415387 T1 AT E415387T1
- Authority
- AT
- Austria
- Prior art keywords
- cysteine
- benzimidoic
- benzonitriles
- producing
- peptidal
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 150000008359 benzonitriles Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 235000018417 cysteine Nutrition 0.000 abstract 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- -1 aryl nitrile Chemical class 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- MJWAGSZZOQMRNY-SNVBAGLBSA-N chembl11301 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC=CN=2)O)=N1 MJWAGSZZOQMRNY-SNVBAGLBSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 abstract 1
- 150000002505 iron Chemical class 0.000 abstract 1
- 239000000797 iron chelating agent Substances 0.000 abstract 1
- 229940075525 iron chelating agent Drugs 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000002769 thiazolinyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
- C07C257/08—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38101702P | 2002-05-15 | 2002-05-15 | |
| US38101202P | 2002-05-15 | 2002-05-15 | |
| US38102102P | 2002-05-15 | 2002-05-15 | |
| US38087802P | 2002-05-15 | 2002-05-15 | |
| US38089402P | 2002-05-15 | 2002-05-15 | |
| US38089502P | 2002-05-15 | 2002-05-15 | |
| US38091002P | 2002-05-15 | 2002-05-15 | |
| US38088002P | 2002-05-15 | 2002-05-15 | |
| US38090302P | 2002-05-15 | 2002-05-15 | |
| US38090902P | 2002-05-15 | 2002-05-15 | |
| US38101302P | 2002-05-15 | 2002-05-15 | |
| US39283302P | 2002-06-27 | 2002-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE415387T1 true ATE415387T1 (de) | 2008-12-15 |
Family
ID=29554649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03734040T ATE415387T1 (de) | 2002-05-15 | 2003-05-15 | Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten |
Country Status (6)
| Country | Link |
|---|---|
| US (17) | US6794515B2 (de) |
| EP (2) | EP1506162B1 (de) |
| JP (3) | JP2005538950A (de) |
| AT (1) | ATE415387T1 (de) |
| AU (2) | AU2003239472A1 (de) |
| WO (2) | WO2003097622A2 (de) |
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| US6794515B2 (en) * | 2002-05-15 | 2004-09-21 | Genzyme Corporation | Synthesis of 2-alkylcysteine via substituted thiazoline amide |
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| DE602005023466D1 (de) | 2004-07-22 | 2010-10-21 | Mitsubishi Gas Chemical Co | Asymmetrische l-aminosäureamid-hydrolase und dafür codierende dna |
| DE102005054362A1 (de) * | 2004-12-01 | 2006-06-08 | Degussa Ag | Verfahren zur Herstellung von Amino- oder Hydroxybenzonitrilen |
| EP1866293A1 (de) | 2005-03-31 | 2007-12-19 | UCB Pharma, S.A. | Eine oxazol- oder thiazolgruppe enthaltende verbindungen, verfahren zu deren herstellung und ihre anwendungen |
| EA200701852A1 (ru) | 2005-04-28 | 2008-04-28 | Пфайзер Лимитед | Производные аминокислот |
| JP2006312614A (ja) * | 2005-05-09 | 2006-11-16 | Ajinomoto Co Inc | チアゾリン化合物および光学活性α−アルキルシステインの製造方法 |
| US7947837B2 (en) * | 2006-10-25 | 2011-05-24 | Polyera Corporation | Organic semiconductor materials and methods of preparing and use thereof |
| WO2009005775A2 (en) * | 2007-06-29 | 2009-01-08 | University Of South Florida | Enantioselective ring-opening of aziridines |
| EP2334620B1 (de) * | 2008-09-05 | 2018-09-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur enantioselektiven trennung chiraler systeme mit verbindungsbildung unter anwendung von zwei aufeinanderfolgenden kristallisationsschritten |
| US8765817B1 (en) | 2008-12-03 | 2014-07-01 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| US8349899B1 (en) | 2008-12-03 | 2013-01-08 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| EP3300717B1 (de) * | 2009-06-29 | 2020-09-23 | Inolex Investment Corporation | Nichtpetrochemisch gewonnene kationische emulgatoren als neutralisierte aminosäureester und zugehörige zusammensetzungen und verfahren |
| US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
| US9279022B1 (en) | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
| WO2012054633A2 (en) * | 2010-10-20 | 2012-04-26 | Bioformix, Llc | Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent |
| US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
| US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
| JP2014532625A (ja) | 2011-10-19 | 2014-12-08 | シラス・インコーポレイテッド | メチレンβ−ジケトンモノマー、メチレンβ−ジケトンモノマーを製造するための方法、これらから作られる重合可能な組成物および製品 |
| CN102775399A (zh) * | 2011-12-27 | 2012-11-14 | 盛世泰科生物医药技术(苏州)有限公司 | arylhydrocarbon受体(AHR)的内源性配体,2-(1’H3’-吲哚羰基)噻唑-4-羧酸甲酯的合成新方法 |
| EP2831125B1 (de) | 2012-03-30 | 2016-10-05 | Sirrus, Inc. | Verfahren zur aktivierung von polymerisierbaren zusammensetzungen, polymerisierbare systeme und damit hergestellte produkte |
| EP3626784A1 (de) | 2012-03-30 | 2020-03-25 | Sirrus, Inc. | Tinte und beschichtungsformulierungen sowie polymerisierbare systeme zur herstellung davon |
| WO2013149168A1 (en) | 2012-03-30 | 2013-10-03 | Bioformix, Inc. | Composite and laminate articles and polymerizable systems for producing the same |
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| US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
| US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
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| US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
| US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
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| DE20000122U1 (de) * | 2000-01-05 | 2000-04-20 | ABT Advanced Bioanalytical Technology GmbH & Co KG, 01454 Radeberg | Mobiles Handgerät mit wiederverwendbarem Biosensor |
| AU3033700A (en) | 2000-01-14 | 2001-07-24 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
| AT500490A1 (de) | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| US6794515B2 (en) * | 2002-05-15 | 2004-09-21 | Genzyme Corporation | Synthesis of 2-alkylcysteine via substituted thiazoline amide |
| ITVR20020062A1 (it) * | 2002-06-03 | 2003-12-03 | Andrea Pretto | Preparazione estemporanea di periossiacidi organici stabili nel tempo |
-
2003
- 2003-05-15 US US10/438,744 patent/US6794515B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/439,263 patent/US6982335B2/en not_active Expired - Lifetime
- 2003-05-15 EP EP03734040A patent/EP1506162B1/de not_active Expired - Lifetime
- 2003-05-15 US US10/439,282 patent/US6878828B2/en not_active Expired - Lifetime
- 2003-05-15 AU AU2003239472A patent/AU2003239472A1/en not_active Abandoned
- 2003-05-15 EP EP03753073A patent/EP1529037B1/de not_active Expired - Lifetime
- 2003-05-15 WO PCT/US2003/015553 patent/WO2003097622A2/en not_active Ceased
- 2003-05-15 AT AT03734040T patent/ATE415387T1/de not_active IP Right Cessation
- 2003-05-15 JP JP2004505355A patent/JP2005538950A/ja active Pending
- 2003-05-15 US US10/438,770 patent/US7002036B2/en not_active Expired - Fee Related
- 2003-05-15 US US10/439,265 patent/US7038073B2/en not_active Expired - Lifetime
- 2003-05-15 JP JP2004505315A patent/JP4414331B2/ja not_active Expired - Fee Related
- 2003-05-15 US US10/439,286 patent/US6875883B2/en not_active Expired - Lifetime
- 2003-05-15 AU AU2003247374A patent/AU2003247374A1/en not_active Abandoned
- 2003-05-15 WO PCT/US2003/015339 patent/WO2003097582A2/en not_active Ceased
- 2003-05-15 US US10/439,342 patent/US6846958B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/438,745 patent/US6861532B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/438,757 patent/US7115769B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/439,341 patent/US6875882B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/439,313 patent/US6903220B2/en not_active Expired - Lifetime
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2004
- 2004-12-09 US US11/008,084 patent/US7294718B2/en not_active Expired - Lifetime
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2005
- 2005-03-21 US US11/085,824 patent/US7285676B2/en not_active Expired - Lifetime
- 2005-10-03 US US11/242,640 patent/US7285670B2/en not_active Expired - Lifetime
- 2005-11-28 US US11/287,891 patent/US20060142586A1/en not_active Abandoned
- 2005-12-16 US US11/305,305 patent/US7576234B2/en not_active Expired - Fee Related
-
2006
- 2006-08-23 US US11/508,679 patent/US20060281926A1/en not_active Abandoned
- 2006-08-28 JP JP2006231196A patent/JP2007001986A/ja active Pending
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