DE60229267D1 - Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen - Google Patents
Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogenInfo
- Publication number
- DE60229267D1 DE60229267D1 DE60229267T DE60229267T DE60229267D1 DE 60229267 D1 DE60229267 D1 DE 60229267D1 DE 60229267 T DE60229267 T DE 60229267T DE 60229267 T DE60229267 T DE 60229267T DE 60229267 D1 DE60229267 D1 DE 60229267D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- levetiracetam
- analogue
- producing
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 2
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 title 1
- 229960004002 levetiracetam Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- HPHUVLMMVZITSG-LURJTMIESA-N levetiracetam Chemical compound CC[C@@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-LURJTMIESA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01119396 | 2001-08-10 | ||
| PCT/EP2002/008717 WO2003014080A2 (en) | 2001-08-10 | 2002-08-05 | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60229267D1 true DE60229267D1 (de) | 2008-11-20 |
Family
ID=8178301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60229267T Expired - Lifetime DE60229267D1 (de) | 2001-08-10 | 2002-08-05 | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7122682B2 (de) |
| EP (1) | EP1419144B1 (de) |
| JP (1) | JP4334344B2 (de) |
| AT (1) | ATE410412T1 (de) |
| AU (1) | AU2002329233B2 (de) |
| CA (1) | CA2455155C (de) |
| DE (1) | DE60229267D1 (de) |
| ES (1) | ES2314090T3 (de) |
| IL (2) | IL160045A0 (de) |
| WO (1) | WO2003014080A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60229267D1 (de) * | 2001-08-10 | 2008-11-20 | Ucb Pharma Sa | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
| US7132552B2 (en) * | 2003-02-03 | 2006-11-07 | Teva Pharmaceutical Industries, Ltd. | Process for producing levetiracetam |
| EP1663968A1 (de) * | 2003-09-05 | 2006-06-07 | Ranbaxy Laboratories Limited | Verfahren zur herstellung von reinem levetiracetam |
| BRPI0414436A (pt) | 2003-09-24 | 2006-11-14 | Ucb Sa | processo para a preparação de derivados de 2-oxo-1-pirrolidina e seus sais |
| BRPI0416692A (pt) * | 2003-11-19 | 2007-01-30 | Array Biopharma Inc | inibidores heterocìclicos de mek e métodos de emprego destes |
| CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| US20080146819A1 (en) * | 2005-03-10 | 2008-06-19 | Rubamin Limited | Process for Preparing Levetiracetam |
| ES2530398T3 (es) * | 2005-09-15 | 2015-03-02 | Ucb Pharma Sa | Pirrolidin-2-onas 4-sustituidas y su uso |
| US8338621B2 (en) * | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
| US20100076204A1 (en) * | 2006-07-25 | 2010-03-25 | Zach System S.P.A. | Process for the preparation of levetiracetam |
| EP2147911A1 (de) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Verfahren zur Herstellung von Levetiracetam |
| US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
| CN106631961A (zh) * | 2013-06-19 | 2017-05-10 | 成都百途医药科技有限公司 | 一种奥拉西坦的合成方法 |
| CN103553998B (zh) * | 2013-11-06 | 2015-11-25 | 温州智创科技有限公司 | (s)-奥拉西坦晶型iii的制备方法 |
| CN103553997B (zh) * | 2013-11-06 | 2015-11-25 | 温州智创科技有限公司 | 一种(s)-奥拉西坦晶型iii的制备方法 |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| WO2016191435A1 (en) | 2015-05-25 | 2016-12-01 | Peng Wang | Processes to produce brivaracetam |
| CN106591179B (zh) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用 |
| WO2019028671A1 (zh) * | 2017-08-08 | 2019-02-14 | 浙江华海药业股份有限公司 | 一种左乙拉西坦的制备方法 |
| WO2019028666A1 (zh) * | 2017-08-08 | 2019-02-14 | 浙江华海药业股份有限公司 | 一种左乙拉西坦的合成方法 |
| CN110799494B (zh) * | 2017-08-08 | 2023-06-06 | 浙江华海药业股份有限公司 | 一种无溶剂制备左乙拉西坦的方法 |
| CN110452157B (zh) * | 2018-12-28 | 2020-11-03 | 广州市朗启医药科技有限责任公司 | 常山酮及其中间体的合成方法 |
| CN113816872A (zh) * | 2020-06-19 | 2021-12-21 | 浙江华海药业股份有限公司 | 一种（s）-2-氨基丁酰胺的合成方法 |
| US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
| CN114409586A (zh) * | 2021-12-23 | 2022-04-29 | 山东诚汇双达药业有限公司 | 一种左乙拉西坦的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| GB8412358D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6686477B2 (en) * | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
| DE60229267D1 (de) * | 2001-08-10 | 2008-11-20 | Ucb Pharma Sa | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
-
2002
- 2002-08-05 DE DE60229267T patent/DE60229267D1/de not_active Expired - Lifetime
- 2002-08-05 EP EP02764832A patent/EP1419144B1/de not_active Expired - Lifetime
- 2002-08-05 AU AU2002329233A patent/AU2002329233B2/en not_active Ceased
- 2002-08-05 WO PCT/EP2002/008717 patent/WO2003014080A2/en active Application Filing
- 2002-08-05 CA CA2455155A patent/CA2455155C/en not_active Expired - Fee Related
- 2002-08-05 JP JP2003519030A patent/JP4334344B2/ja not_active Expired - Fee Related
- 2002-08-05 ES ES02764832T patent/ES2314090T3/es not_active Expired - Lifetime
- 2002-08-05 IL IL16004502A patent/IL160045A0/xx unknown
- 2002-08-05 US US10/486,342 patent/US7122682B2/en not_active Expired - Fee Related
- 2002-08-05 AT AT02764832T patent/ATE410412T1/de not_active IP Right Cessation
-
2004
- 2004-01-26 IL IL160045A patent/IL160045A/en not_active IP Right Cessation
-
2006
- 2006-07-18 US US11/488,073 patent/US7563912B2/en not_active Expired - Fee Related
- 2006-10-02 US US11/540,519 patent/US20070142647A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040204476A1 (en) | 2004-10-14 |
| CA2455155C (en) | 2012-04-10 |
| AU2002329233B2 (en) | 2007-08-16 |
| JP4334344B2 (ja) | 2009-09-30 |
| IL160045A (en) | 2010-06-30 |
| US7122682B2 (en) | 2006-10-17 |
| US20060258734A1 (en) | 2006-11-16 |
| IL160045A0 (en) | 2004-06-20 |
| US7563912B2 (en) | 2009-07-21 |
| WO2003014080A2 (en) | 2003-02-20 |
| EP1419144B1 (de) | 2008-10-08 |
| US20070142647A1 (en) | 2007-06-21 |
| WO2003014080A3 (en) | 2003-11-06 |
| JP2005507378A (ja) | 2005-03-17 |
| CA2455155A1 (en) | 2003-02-20 |
| EP1419144A2 (de) | 2004-05-19 |
| ES2314090T3 (es) | 2009-03-16 |
| ATE410412T1 (de) | 2008-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |