ATE410412T1 - Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen - Google Patents
Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogenInfo
- Publication number
- ATE410412T1 ATE410412T1 AT02764832T AT02764832T ATE410412T1 AT E410412 T1 ATE410412 T1 AT E410412T1 AT 02764832 T AT02764832 T AT 02764832T AT 02764832 T AT02764832 T AT 02764832T AT E410412 T1 ATE410412 T1 AT E410412T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- analogues
- preparing
- oxopyrrolidine
- levetiracetam
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 title 1
- 229960004002 levetiracetam Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- HPHUVLMMVZITSG-LURJTMIESA-N levetiracetam Chemical compound CC[C@@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-LURJTMIESA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01119396 | 2001-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE410412T1 true ATE410412T1 (de) | 2008-10-15 |
Family
ID=8178301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02764832T ATE410412T1 (de) | 2001-08-10 | 2002-08-05 | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7122682B2 (de) |
| EP (1) | EP1419144B1 (de) |
| JP (1) | JP4334344B2 (de) |
| AT (1) | ATE410412T1 (de) |
| AU (1) | AU2002329233B2 (de) |
| CA (1) | CA2455155C (de) |
| DE (1) | DE60229267D1 (de) |
| ES (1) | ES2314090T3 (de) |
| IL (2) | IL160045A0 (de) |
| WO (1) | WO2003014080A2 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE410412T1 (de) * | 2001-08-10 | 2008-10-15 | Ucb Pharma Sa | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
| EP1517893A2 (de) * | 2003-02-03 | 2005-03-30 | Teva Pharmaceutical Industries Limited | Verfahren zur herstellung von levetiracetam |
| EP1663968A1 (de) * | 2003-09-05 | 2006-06-07 | Ranbaxy Laboratories Limited | Verfahren zur herstellung von reinem levetiracetam |
| US7629474B2 (en) * | 2003-09-24 | 2009-12-08 | Ucb Pharma S.A. | Process for preparing 2-oxo-1-pyrrolidine derivatives |
| WO2005051302A2 (en) * | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Bicyclic inhibitors of mek and methods of use thereof |
| CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| US20080146819A1 (en) * | 2005-03-10 | 2008-06-19 | Rubamin Limited | Process for Preparing Levetiracetam |
| MY143249A (en) * | 2005-09-15 | 2011-04-15 | Ucb Pharma Sa | 4-substituted pyrrolidin-2-ones and their use |
| US8338621B2 (en) | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
| CN101511786A (zh) * | 2006-07-25 | 2009-08-19 | Zach系统股份公司 | 制备左乙拉西坦的方法 |
| EP2147911A1 (de) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Verfahren zur Herstellung von Levetiracetam |
| US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
| CN106631961A (zh) * | 2013-06-19 | 2017-05-10 | 成都百途医药科技有限公司 | 一种奥拉西坦的合成方法 |
| CN103553998B (zh) * | 2013-11-06 | 2015-11-25 | 温州智创科技有限公司 | (s)-奥拉西坦晶型iii的制备方法 |
| CN103553997B (zh) * | 2013-11-06 | 2015-11-25 | 温州智创科技有限公司 | 一种(s)-奥拉西坦晶型iii的制备方法 |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| WO2016191435A1 (en) * | 2015-05-25 | 2016-12-01 | Peng Wang | Processes to produce brivaracetam |
| CN106591179B (zh) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用 |
| WO2019028671A1 (zh) * | 2017-08-08 | 2019-02-14 | 浙江华海药业股份有限公司 | 一种左乙拉西坦的制备方法 |
| CN110799494B (zh) * | 2017-08-08 | 2023-06-06 | 浙江华海药业股份有限公司 | 一种无溶剂制备左乙拉西坦的方法 |
| CN110799495B (zh) * | 2017-08-08 | 2022-12-13 | 浙江华海药业股份有限公司 | 一种左乙拉西坦的合成方法 |
| CN110452157B (zh) * | 2018-12-28 | 2020-11-03 | 广州市朗启医药科技有限责任公司 | 常山酮及其中间体的合成方法 |
| CN113816872A (zh) * | 2020-06-19 | 2021-12-21 | 浙江华海药业股份有限公司 | 一种（s）-2-氨基丁酰胺的合成方法 |
| US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
| CN114409586A (zh) * | 2021-12-23 | 2022-04-29 | 山东诚汇双达药业有限公司 | 一种左乙拉西坦的制备方法 |
| WO2023178538A1 (zh) | 2022-03-23 | 2023-09-28 | 浙江华海药业股份有限公司 | 一种纯化左乙拉西坦中间体的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| GB8412357D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6686477B2 (en) * | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
| ATE410412T1 (de) * | 2001-08-10 | 2008-10-15 | Ucb Pharma Sa | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
-
2002
- 2002-08-05 AT AT02764832T patent/ATE410412T1/de not_active IP Right Cessation
- 2002-08-05 US US10/486,342 patent/US7122682B2/en not_active Expired - Fee Related
- 2002-08-05 DE DE60229267T patent/DE60229267D1/de not_active Expired - Lifetime
- 2002-08-05 JP JP2003519030A patent/JP4334344B2/ja not_active Expired - Fee Related
- 2002-08-05 ES ES02764832T patent/ES2314090T3/es not_active Expired - Lifetime
- 2002-08-05 AU AU2002329233A patent/AU2002329233B2/en not_active Ceased
- 2002-08-05 CA CA2455155A patent/CA2455155C/en not_active Expired - Fee Related
- 2002-08-05 EP EP02764832A patent/EP1419144B1/de not_active Expired - Lifetime
- 2002-08-05 WO PCT/EP2002/008717 patent/WO2003014080A2/en active Application Filing
- 2002-08-05 IL IL16004502A patent/IL160045A0/xx unknown
-
2004
- 2004-01-26 IL IL160045A patent/IL160045A/en not_active IP Right Cessation
-
2006
- 2006-07-18 US US11/488,073 patent/US7563912B2/en not_active Expired - Fee Related
- 2006-10-02 US US11/540,519 patent/US20070142647A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60229267D1 (de) | 2008-11-20 |
| WO2003014080A3 (en) | 2003-11-06 |
| IL160045A0 (en) | 2004-06-20 |
| US20060258734A1 (en) | 2006-11-16 |
| US20040204476A1 (en) | 2004-10-14 |
| EP1419144A2 (de) | 2004-05-19 |
| CA2455155C (en) | 2012-04-10 |
| WO2003014080A2 (en) | 2003-02-20 |
| ES2314090T3 (es) | 2009-03-16 |
| US7563912B2 (en) | 2009-07-21 |
| US7122682B2 (en) | 2006-10-17 |
| JP4334344B2 (ja) | 2009-09-30 |
| US20070142647A1 (en) | 2007-06-21 |
| AU2002329233B2 (en) | 2007-08-16 |
| EP1419144B1 (de) | 2008-10-08 |
| JP2005507378A (ja) | 2005-03-17 |
| IL160045A (en) | 2010-06-30 |
| CA2455155A1 (en) | 2003-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE410412T1 (de) | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen | |
| DE59108707D1 (de) | Verfahren zur Herstellung von Oxetanonen | |
| DE69207429D1 (de) | Verfahren zur herstellung von substituierten piperidinen | |
| DE69627166D1 (de) | Verfahren zur herstellung von 2-chlor-5-chlomethyl-thiazol-derivaten | |
| ATE190614T1 (de) | Dihydrat des n-(4-amino-6,7-dimethoxychinazol-2- yl)-n-methyl-n'-(tetrahydrofuroyl-2)- propylendiamin hydrochlorids(=alfuzosin hydrochlorid dihydrat) und ein verfahren zur herstellung | |
| ATE407127T1 (de) | Verfahren zur herstellung von beraprost und dessen salzen | |
| DE69518164D1 (de) | Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen | |
| ATE197150T1 (de) | Verfahren zur herstellung von dihydroxypyrimidin- derivaten | |
| DE60105441D1 (de) | Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens | |
| DE60015563D1 (de) | Verfahren zur herstellung von benzoperhydroisoindolen | |
| ATE355296T1 (de) | Verfahren zur herstellung von (e,z) 3-(2- aminoethoxyimino)-androstane-6,17-dione und analoge | |
| DE69929736D1 (de) | Verfahren zur Herstellung von perhalogenierten fünfgliedrigen zyklischen Verbindungen | |
| DE60224884D1 (de) | Verfahren zur herstellung von 3, 3', 6, 6'-tetraalkylen-2, 2'-biphenolen und 3, 3', 6, 6'-tetraalkylen-5, 5'-dihalo-2, 2' biphenolen | |
| DE50309260D1 (de) | Verfahren zur herstellung von bicalutamid | |
| ATE282594T1 (de) | Verfahren zur herstellung von (+)-trans-4-p- fluorophenyl-3-hydroxymethyl-1-methylpiperidin | |
| DE69926223D1 (de) | Verfahren zur herstellung von zwischenprodukten | |
| ATE239713T1 (de) | Verfahren zur herstellung von alkoxyfuranon-amin- derivaten, durch dieses verfahren erhaltene verbindungen und verwendung dieser verbindungen | |
| ATE176463T1 (de) | Verfahren zur herstellung von 2-substituierten 4,6-dialkoxypyrimidinen | |
| ATE273278T1 (de) | Verfahren zur herstellung von 5-aminomethyl-2- chlorpyridinen | |
| DE60335805D1 (de) | Verfahren zur herstellung von 1,3-dioxolan-nucleosiden | |
| DE69707603D1 (de) | Verfahren zur Herstellung von N2-Arylsulfonyl-L-Argininamiden | |
| ATE207062T1 (de) | Verfahren zur herstellung von substituierten pyrimidinderivaten | |
| ATE208388T1 (de) | Eintopfverfahren zur herstellung von 2- oxazolidinonderivate | |
| ATE330612T1 (de) | Verfahren zur herstellung von benazeprilhydrochloride | |
| DE50104847D1 (de) | Verfahren zur herstellung chiraler verbindungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |