DE69518164D1 - Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen - Google Patents
Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffenInfo
- Publication number
- DE69518164D1 DE69518164D1 DE69518164T DE69518164T DE69518164D1 DE 69518164 D1 DE69518164 D1 DE 69518164D1 DE 69518164 T DE69518164 T DE 69518164T DE 69518164 T DE69518164 T DE 69518164T DE 69518164 D1 DE69518164 D1 DE 69518164D1
- Authority
- DE
- Germany
- Prior art keywords
- beta
- alanine
- amidinophenyl
- producing
- pyrrolidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CVJRRJMEMYTWRC-UHFFFAOYSA-N 1-phenylpyrrolidine-2-carboximidamide Chemical compound NC(=N)C1CCCN1C1=CC=CC=C1 CVJRRJMEMYTWRC-UHFFFAOYSA-N 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 trimethylsulfonium halide Chemical class 0.000 abstract 4
- DSJRMYGLIXGHHM-UHFFFAOYSA-N 3-aminopropanoic acid;urea Chemical class NC(N)=O.NCCC(O)=O DSJRMYGLIXGHHM-UHFFFAOYSA-N 0.000 abstract 2
- 150000002742 methionines Chemical class 0.000 abstract 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/349,333 US5610296A (en) | 1994-12-05 | 1994-12-05 | Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs |
| PCT/US1995/014948 WO1996017827A1 (en) | 1994-12-05 | 1995-12-04 | PROCESS FOR THE PREPARATION OF AMIDINO PHENYL PYRROLIDINE β-ALANINE UREA ANALOGS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69518164D1 true DE69518164D1 (de) | 2000-08-31 |
| DE69518164T2 DE69518164T2 (de) | 2001-03-22 |
Family
ID=23371935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69518164T Expired - Fee Related DE69518164T2 (de) | 1994-12-05 | 1995-12-04 | Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US5610296A (de) |
| EP (1) | EP0796245B1 (de) |
| JP (1) | JPH10509960A (de) |
| AT (1) | ATE194976T1 (de) |
| AU (1) | AU4163696A (de) |
| DE (1) | DE69518164T2 (de) |
| DK (1) | DK0796245T3 (de) |
| ES (1) | ES2150592T3 (de) |
| GR (1) | GR3034516T3 (de) |
| PT (1) | PT796245E (de) |
| WO (1) | WO1996017827A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE261969T1 (de) * | 1996-03-28 | 2004-04-15 | Glaxo Group Ltd | Pyrrolopyrrolone als inhibitoren von neutrophiler elastase |
| ZA988469B (en) * | 1997-09-17 | 1999-03-17 | Biocryst Pharm Inc | Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors |
| ZA988735B (en) | 1997-10-06 | 2000-03-23 | Du Pont Pharm Co | An efficient method for the conversion of nitriles to amidines. |
| US5986107A (en) * | 1998-04-08 | 1999-11-16 | G. D. Searle & Co. | Process for the preparation of a 2-oxopyrrolidine compound |
| US6025358A (en) * | 1998-06-11 | 2000-02-15 | G. D. Searle & Co. | Double prodrugs of potent GP IIb/IIIa antagonists |
| DE19841895A1 (de) * | 1998-09-11 | 2000-03-23 | Degussa | Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung |
| ES2296625T3 (es) * | 1999-05-07 | 2008-05-01 | Encysive Pharmaceuticals, Inc | Derivados del acido carboxilico que inhiben el enlace de las integrinas con sus receptores. |
| US6972296B2 (en) * | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| SI21096B (sl) * | 2001-10-09 | 2012-05-31 | Encysive Pharmaceuticals Inc | Derivati karboksilne kisline ki inhibirajo vezavo integrinov na njihove receptorje |
| WO2003055856A2 (en) | 2001-10-17 | 2003-07-10 | Bristol-Myers Squibb Company | BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE) |
| WO2009032057A2 (en) | 2007-08-29 | 2009-03-12 | Adam Lubin | Method for the selective therapy of disease |
| JP5977349B2 (ja) | 2012-06-15 | 2016-08-24 | 田辺三菱製薬株式会社 | 芳香族複素環化合物 |
| CN111440149A (zh) * | 2020-03-31 | 2020-07-24 | 浙江美诺华药物化学有限公司 | 一种达比加群酯中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL55573A0 (en) * | 1977-10-03 | 1978-12-17 | Erba Carlo Spa | Substituted n-(ss-alkoxy-ethyl)-n-(4-phenoxybenzyl)-dichloroacetamides and process for their preparation |
| US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
| AU681396B2 (en) * | 1993-03-31 | 1997-08-28 | G.D. Searle & Co. | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors |
-
1994
- 1994-12-05 US US08/349,333 patent/US5610296A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/463,657 patent/US5484946A/en not_active Expired - Fee Related
- 1995-06-05 US US08/465,212 patent/US5576447A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,417 patent/US5659063A/en not_active Expired - Fee Related
- 1995-12-04 EP EP95940016A patent/EP0796245B1/de not_active Expired - Lifetime
- 1995-12-04 AU AU41636/96A patent/AU4163696A/en not_active Abandoned
- 1995-12-04 JP JP8517599A patent/JPH10509960A/ja not_active Abandoned
- 1995-12-04 DE DE69518164T patent/DE69518164T2/de not_active Expired - Fee Related
- 1995-12-04 ES ES95940016T patent/ES2150592T3/es not_active Expired - Lifetime
- 1995-12-04 WO PCT/US1995/014948 patent/WO1996017827A1/en active IP Right Grant
- 1995-12-04 DK DK95940016T patent/DK0796245T3/da active
- 1995-12-04 PT PT95940016T patent/PT796245E/pt unknown
- 1995-12-04 AT AT95940016T patent/ATE194976T1/de not_active IP Right Cessation
-
2000
- 2000-09-29 GR GR20000402206T patent/GR3034516T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69518164T2 (de) | 2001-03-22 |
| AU4163696A (en) | 1996-06-26 |
| ATE194976T1 (de) | 2000-08-15 |
| DK0796245T3 (da) | 2000-09-11 |
| JPH10509960A (ja) | 1998-09-29 |
| PT796245E (pt) | 2000-12-29 |
| GR3034516T3 (en) | 2000-12-29 |
| US5484946A (en) | 1996-01-16 |
| EP0796245A1 (de) | 1997-09-24 |
| WO1996017827A1 (en) | 1996-06-13 |
| EP0796245B1 (de) | 2000-07-26 |
| ES2150592T3 (es) | 2000-12-01 |
| US5659063A (en) | 1997-08-19 |
| US5610296A (en) | 1997-03-11 |
| US5576447A (en) | 1996-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |