ATE227289T1 - Verfahren zur herstellung von azyklischen nukleosiden - Google Patents

Verfahren zur herstellung von azyklischen nukleosiden

Info

Publication number
ATE227289T1
ATE227289T1 AT98906239T AT98906239T ATE227289T1 AT E227289 T1 ATE227289 T1 AT E227289T1 AT 98906239 T AT98906239 T AT 98906239T AT 98906239 T AT98906239 T AT 98906239T AT E227289 T1 ATE227289 T1 AT E227289T1
Authority
AT
Austria
Prior art keywords
azyclic
nucleosides
producing
monounsaturated
saturated
Prior art date
Application number
AT98906239T
Other languages
English (en)
Inventor
M Robert Leanna
Steven M Hannick
Michael Rasmussen
Jien-Heh J Tien
Lakshmi Bhagavatula
Pulla Reddy Singam
Bradley D Gates
Lawrence Kolaczkowski
Ramesh R Patel
Greg Wayne
Greg Lannoye
Weijiang Zhang
Zhenping Tian
Kirill L Lukin
Bikshandarkor A Narayanan
David A Riley
Howard Morton
Sou-Jen Chang
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/798,216 external-priority patent/US5869493A/en
Application filed by Medivir Ab filed Critical Medivir Ab
Application granted granted Critical
Publication of ATE227289T1 publication Critical patent/ATE227289T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98906239T 1997-02-10 1998-02-06 Verfahren zur herstellung von azyklischen nukleosiden ATE227289T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3751797P 1997-02-10 1997-02-10
US08/798,216 US5869493A (en) 1996-02-16 1997-02-10 Acyclic nucleoside derivatives
US90875497A 1997-08-08 1997-08-08
PCT/US1998/002439 WO1998034917A2 (en) 1997-02-10 1998-02-06 Synthesis of acyclic nucleoside derivatives

Publications (1)

Publication Number Publication Date
ATE227289T1 true ATE227289T1 (de) 2002-11-15

Family

ID=27365230

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98906239T ATE227289T1 (de) 1997-02-10 1998-02-06 Verfahren zur herstellung von azyklischen nukleosiden

Country Status (7)

Country Link
EP (1) EP0971923B1 (de)
JP (1) JP4425352B2 (de)
AT (1) ATE227289T1 (de)
CA (2) CA2572577C (de)
DE (1) DE69809205T2 (de)
ES (1) ES2186127T3 (de)
WO (1) WO1998034917A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
SE0102273D0 (sv) * 2001-06-26 2001-06-26 Medivir Ab Improved synthesis of branched acyclic nucleosides
PT1371658E (pt) * 2002-06-13 2007-10-23 Oreal Derivado da glucose e de vitamina f, composições que o compreendem, utilizações e processo de preparação
CA2700227A1 (en) 2007-09-21 2009-04-02 Epiphany Biosciences, Inc. Valomaciclovir polymorphs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives

Also Published As

Publication number Publication date
CA2277151A1 (en) 1998-08-13
ES2186127T3 (es) 2003-05-01
EP0971923A2 (de) 2000-01-19
DE69809205T2 (de) 2003-05-28
CA2572577C (en) 2011-04-05
WO1998034917A2 (en) 1998-08-13
EP0971923B1 (de) 2002-11-06
CA2572577A1 (en) 1998-08-13
WO1998034917A3 (en) 1999-01-14
DE69809205D1 (de) 2002-12-12
JP2001512442A (ja) 2001-08-21
JP4425352B2 (ja) 2010-03-03
CA2277151C (en) 2007-04-17

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties