DE3668621D1 - Verfahren zur herstellung von pteridinderivaten. - Google Patents

Verfahren zur herstellung von pteridinderivaten.

Info

Publication number
DE3668621D1
DE3668621D1 DE8686402544T DE3668621T DE3668621D1 DE 3668621 D1 DE3668621 D1 DE 3668621D1 DE 8686402544 T DE8686402544 T DE 8686402544T DE 3668621 T DE3668621 T DE 3668621T DE 3668621 D1 DE3668621 D1 DE 3668621D1
Authority
DE
Germany
Prior art keywords
producing
pteridine derivatives
image
pteridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686402544T
Other languages
English (en)
Inventor
Pierre Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Application granted granted Critical
Publication of DE3668621D1 publication Critical patent/DE3668621D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8686402544T 1985-11-19 1986-11-17 Verfahren zur herstellung von pteridinderivaten. Expired - Fee Related DE3668621D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8517057A FR2590255B1 (fr) 1985-11-19 1985-11-19 Procede de preparation de derives de la pteridine

Publications (1)

Publication Number Publication Date
DE3668621D1 true DE3668621D1 (de) 1990-03-08

Family

ID=9324943

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686402544T Expired - Fee Related DE3668621D1 (de) 1985-11-19 1986-11-17 Verfahren zur herstellung von pteridinderivaten.

Country Status (7)

Country Link
US (1) US4767859A (de)
EP (1) EP0225823B1 (de)
JP (1) JPS62120386A (de)
AT (1) ATE49969T1 (de)
CA (1) CA1261324A (de)
DE (1) DE3668621D1 (de)
FR (1) FR2590255B1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382582A (en) * 1993-03-26 1995-01-17 Chan; Carcy L. Methotrexate analogs and methods of using same
US5698556A (en) * 1995-06-07 1997-12-16 Chan; Carcy L. Methotrexate analogs and methods of using same
EP2002846B1 (de) 1996-12-06 2017-01-25 Amgen Inc. Kombinationstherapie mit einem IL-1-Inhibitor zur Behandlung von IL-1-vermittelten Krankheiten
WO1999020626A1 (en) * 1997-10-17 1999-04-29 Purdue Research Foundation Folic acid derivatives
JP2006517191A (ja) * 2002-12-30 2006-07-20 アムジエン・インコーポレーテツド 共刺激因子を用いた併用療法
US6921667B2 (en) 2003-03-07 2005-07-26 Prometheus Laboratories, Inc. Methods for direct detection of individual methotrexate metabolites
US7582282B2 (en) 2003-08-29 2009-09-01 Prometheus Laboratories Inc. Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics
US7612071B2 (en) 2004-03-12 2009-11-03 Syntrix Biosystems, Inc. Compositions and methods employing aminopterin
US20080312201A1 (en) * 2004-09-10 2008-12-18 Patrick Fogarty Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
US7312217B2 (en) 2005-03-11 2007-12-25 Syntrix Biosystems, Inc. Aminopterin dosage forms and methods for inflammatory disorders
US20060286571A1 (en) 2005-04-28 2006-12-21 Prometheus Laboratories, Inc. Methods of predicting methotrexate efficacy and toxicity
JP2009517402A (ja) 2005-11-28 2009-04-30 ディー． ロウェ，バーノン 腎毒性の低減に有用な組成物及びその使用方法
US7235660B1 (en) 2007-01-02 2007-06-26 Zebala John A Facile process for the preparation of high-purity aminopterin
CA2729613C (en) 2008-03-03 2017-02-07 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same
WO2012037068A1 (en) 2010-09-13 2012-03-22 De Novo Diagnostics, Inc. Methods for monitoring methotrexate therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2122991C2 (de) * 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden
BE792914A (fr) * 1971-12-18 1973-06-18 Schering Ag Derives amino de n-heterocycles et leur procede de preparation
DE2621645C3 (de) * 1976-05-13 1981-08-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von Aminoderivaten von N-Heterocyclen
FI68400C (fi) * 1980-09-12 1985-09-10 Farmos Oy Foerfarande foer framstaellning av n-(4-(((2,4-diamino-6-pteridinyl)-metyl)metylamino)bensoyl)glutaminsyra

Also Published As

Publication number Publication date
EP0225823B1 (de) 1990-01-31
CA1261324A (fr) 1989-09-26
US4767859A (en) 1988-08-30
FR2590255A1 (fr) 1987-05-22
EP0225823A1 (de) 1987-06-16
JPS62120386A (ja) 1987-06-01
ATE49969T1 (de) 1990-02-15
FR2590255B1 (fr) 1987-12-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee