ATA64985A - Verfahren zur herstellung von neuen 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivaten - Google Patents
Verfahren zur herstellung von neuen 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivatenInfo
- Publication number
- ATA64985A ATA64985A AT0064985A AT64985A ATA64985A AT A64985 A ATA64985 A AT A64985A AT 0064985 A AT0064985 A AT 0064985A AT 64985 A AT64985 A AT 64985A AT A64985 A ATA64985 A AT A64985A
- Authority
- AT
- Austria
- Prior art keywords
- fluorphenylbutyl
- pyrimidinyl
- piperazine derivatives
- producing new
- producing
- Prior art date
Links
- UUQHPHIBIJWHMU-UHFFFAOYSA-N 2-[4-[4-(1-fluorocyclohexa-2,4-dien-1-yl)butyl]piperazin-1-yl]pyrimidine Chemical class FC1(CC=CC=C1)CCCCN1CCN(CC1)C1=NC=CC=N1 UUQHPHIBIJWHMU-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Legs For Furniture In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58658084A | 1984-03-06 | 1984-03-06 | |
| US06/683,309 US4605655A (en) | 1984-03-06 | 1984-12-18 | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA64985A true ATA64985A (de) | 1990-01-15 |
| AT390951B AT390951B (de) | 1990-07-25 |
Family
ID=27079753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0064985A AT390951B (de) | 1984-03-06 | 1985-03-05 | Verfahren zur herstellung von neuen 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivaten |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4605655A (de) |
| KR (3) | KR920005113B1 (de) |
| AT (1) | AT390951B (de) |
| AU (1) | AU576555B2 (de) |
| BE (1) | BE901880A (de) |
| CA (1) | CA1256871A (de) |
| CH (1) | CH663022A5 (de) |
| CY (1) | CY1545A (de) |
| DE (1) | DE3507983A1 (de) |
| DK (1) | DK166149C (de) |
| ES (1) | ES8607254A1 (de) |
| FI (1) | FI84478C (de) |
| FR (1) | FR2560878B1 (de) |
| GB (1) | GB2155925B (de) |
| GR (1) | GR850561B (de) |
| HK (1) | HK82890A (de) |
| HU (1) | HU193949B (de) |
| IE (1) | IE58338B1 (de) |
| IT (1) | IT1183483B (de) |
| LU (1) | LU85796A1 (de) |
| MX (1) | MX9203177A (de) |
| MY (1) | MY102240A (de) |
| NL (1) | NL8500628A (de) |
| PT (1) | PT80058B (de) |
| SE (1) | SE462429B (de) |
| SG (1) | SG35590G (de) |
| ZA (1) | ZA851486B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| US4677104A (en) * | 1985-05-06 | 1987-06-30 | Bristol-Myers Company | Antipsychotic fused-ring pyridinylpiperazine derivatives |
| US4766215A (en) * | 1987-02-27 | 1988-08-23 | American Home Products Corporation | Histamine H1 -receptor antagonists |
| SE8701375D0 (sv) * | 1987-04-02 | 1987-04-02 | Leo Ab | Novel pyridyl- and pyrimidyl derivatives |
| US4826844A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| US4994455A (en) * | 1987-10-26 | 1991-02-19 | Pfizer Inc. | Anti-anxiety agents |
| US4882432A (en) * | 1989-01-09 | 1989-11-21 | American Home Products Corporation | Polycyclic-carbamic acid piperazinoalkyl esters and amides |
| GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
| DK0395313T3 (da) * | 1989-04-22 | 2000-06-19 | American Home Prod | Tertiære alkyl-funktionaliserede piperazin-derivater |
| US4994460A (en) * | 1989-06-01 | 1991-02-19 | Bristol-Myers Squibb Co. | Agents for treatment of brain ischemia |
| US5055470A (en) * | 1989-06-01 | 1991-10-08 | Bristol-Myers Squibb Co. | Method of treatment of ischemia in brain |
| FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
| US5646281A (en) * | 1990-12-28 | 1997-07-08 | Neurogen Corporation | Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands |
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
| EP0538693A3 (en) * | 1991-10-23 | 1994-08-17 | Squibb & Sons Inc | Stereoselective preparation of halophenyl alcohols |
| TW217382B (de) * | 1991-10-24 | 1993-12-11 | Bristol Myers Squibb Co | |
| SE9201239D0 (sv) * | 1992-04-21 | 1992-04-21 | Kabi Pharmacia Ab | Agents for treating substance abuse disorders |
| US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
| DE4243287A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| ES2074946B1 (es) * | 1993-07-19 | 1996-06-16 | Ferrer Int | Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida. |
| DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| WO1995028390A1 (en) * | 1994-04-18 | 1995-10-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Adamantane derivative, process for producing the same, and use thereof |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| ES2104509B1 (es) * | 1995-06-13 | 1998-07-01 | Ferrer Int | Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina. |
| US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
| KR101468553B1 (ko) * | 2007-05-14 | 2014-12-09 | 에스케이바이오팜 주식회사 | 신규 카바모일옥시 아릴알칸노일 아릴피페라진계 화합물,이를 함유하는 약제학적 조성물 및 상기 화합물 투여에의한 통증, 불안증 및 우울증 치료 방법 |
| EP3610890A1 (de) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Verfahren und zusammensetzungen zur behandlung von schizophrenie |
| EP4153209A1 (de) | 2020-05-20 | 2023-03-29 | The Board of Trustees of the University of Illinois | Verfahren zur behandlung lysosomaler speicherkrankheiten mit histatin-peptiden |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127061C (de) * | 1959-03-26 | |||
| US2979508A (en) * | 1959-10-12 | 1961-04-11 | Paul A J Janssen | Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols |
| US2985657A (en) * | 1959-10-12 | 1961-05-23 | Paul A J Janssen | 1-(aroylalkyl)-4-heterocyclylpiperazines |
| US2973360A (en) * | 1959-10-12 | 1961-02-28 | Paul A J Janssen | Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines |
| NL127996C (de) * | 1963-11-19 | |||
| GB1259685A (en) * | 1969-04-03 | 1972-01-12 | Soc D Etudes Prod Chimique | Amino-pyrimidine derivatives |
| BE758380A (fr) * | 1969-11-04 | 1971-04-16 | Sumitomo Chemical Co | Procede de preparation de derives d'aryl-cetones |
| GB1307256A (en) * | 1970-09-15 | 1973-02-14 | Science Union & Cie | Piperazine derivatives and a process for their preparation |
| BE882836A (fr) * | 1979-05-15 | 1980-08-18 | Soc D Etudes Prod Chimique | Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique |
| US4316899A (en) * | 1979-08-24 | 1982-02-23 | Beecham Group Limited | Chromanone derivatives, a process for their preparation and compositions containing them |
| DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
-
1984
- 1984-12-18 US US06/683,309 patent/US4605655A/en not_active Expired - Lifetime
-
1985
- 1985-02-27 ZA ZA851486A patent/ZA851486B/xx unknown
- 1985-03-01 FI FI850850A patent/FI84478C/fi not_active IP Right Cessation
- 1985-03-04 ES ES540901A patent/ES8607254A1/es not_active Expired
- 1985-03-04 AU AU39449/85A patent/AU576555B2/en not_active Expired
- 1985-03-05 LU LU85796A patent/LU85796A1/fr unknown
- 1985-03-05 GR GR850561A patent/GR850561B/el not_active IP Right Cessation
- 1985-03-05 PT PT80058A patent/PT80058B/pt unknown
- 1985-03-05 GB GB08505662A patent/GB2155925B/en not_active Expired
- 1985-03-05 BE BE0/214607A patent/BE901880A/fr not_active IP Right Cessation
- 1985-03-05 IE IE54685A patent/IE58338B1/en not_active IP Right Cessation
- 1985-03-05 DK DK100685A patent/DK166149C/da not_active IP Right Cessation
- 1985-03-05 CH CH991/85A patent/CH663022A5/de not_active IP Right Cessation
- 1985-03-05 IT IT19773/85A patent/IT1183483B/it active
- 1985-03-05 HU HU85831A patent/HU193949B/hu unknown
- 1985-03-05 FR FR8503220A patent/FR2560878B1/fr not_active Expired
- 1985-03-05 SE SE8501067A patent/SE462429B/sv not_active IP Right Cessation
- 1985-03-05 AT AT0064985A patent/AT390951B/de not_active IP Right Cessation
- 1985-03-06 NL NL8500628A patent/NL8500628A/nl active Search and Examination
- 1985-03-06 CA CA000475878A patent/CA1256871A/en not_active Expired
- 1985-03-06 KR KR1019850001414A patent/KR920005113B1/ko not_active Expired
- 1985-03-06 DE DE19853507983 patent/DE3507983A1/de not_active Ceased
-
1987
- 1987-10-01 MY MYPI87002690A patent/MY102240A/en unknown
-
1990
- 1990-05-19 SG SG355/90A patent/SG35590G/en unknown
- 1990-10-11 HK HK828/90A patent/HK82890A/xx not_active IP Right Cessation
-
1991
- 1991-03-22 CY CY1545A patent/CY1545A/en unknown
-
1992
- 1992-05-09 KR KR1019920007854A patent/KR920005114B1/ko not_active Expired
- 1992-05-09 KR KR1019920007855A patent/KR920005694B1/ko not_active Expired
- 1992-06-23 MX MX9203177A patent/MX9203177A/es unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELA | Expired due to lapse of time |