IT8519773A0 - Derivati di 1-fluorofenilbutil-4-(2-pirimidinil) piperazina antipsicotici. - Google Patents

Derivati di 1-fluorofenilbutil-4-(2-pirimidinil) piperazina antipsicotici.

Info

Publication number
IT8519773A0
IT8519773A0 IT8519773A IT1977385A IT8519773A0 IT 8519773 A0 IT8519773 A0 IT 8519773A0 IT 8519773 A IT8519773 A IT 8519773A IT 1977385 A IT1977385 A IT 1977385A IT 8519773 A0 IT8519773 A0 IT 8519773A0
Authority
IT
Italy
Prior art keywords
pyrimidinil
fluorophenylbutyl
antipsychotics
piperazine
derivatives
Prior art date
Application number
IT8519773A
Other languages
English (en)
Other versions
IT1183483B (it
Inventor
Joseph P Yevich
G Lobeck J Walter
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8519773A0 publication Critical patent/IT8519773A0/it
Application granted granted Critical
Publication of IT1183483B publication Critical patent/IT1183483B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Legs For Furniture In General (AREA)
IT19773/85A 1984-03-06 1985-03-05 Derivati di 1-fluorofenilbutil-4-(2-pirimidinil)fiperazina antipsicotici IT1183483B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58658084A 1984-03-06 1984-03-06
US06/683,309 US4605655A (en) 1984-03-06 1984-12-18 Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives

Publications (2)

Publication Number Publication Date
IT8519773A0 true IT8519773A0 (it) 1985-03-05
IT1183483B IT1183483B (it) 1987-10-22

Family

ID=27079753

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19773/85A IT1183483B (it) 1984-03-06 1985-03-05 Derivati di 1-fluorofenilbutil-4-(2-pirimidinil)fiperazina antipsicotici

Country Status (27)

Country Link
US (1) US4605655A (it)
KR (3) KR920005113B1 (it)
AT (1) AT390951B (it)
AU (1) AU576555B2 (it)
BE (1) BE901880A (it)
CA (1) CA1256871A (it)
CH (1) CH663022A5 (it)
CY (1) CY1545A (it)
DE (1) DE3507983A1 (it)
DK (1) DK166149C (it)
ES (1) ES8607254A1 (it)
FI (1) FI84478C (it)
FR (1) FR2560878B1 (it)
GB (1) GB2155925B (it)
GR (1) GR850561B (it)
HK (1) HK82890A (it)
HU (1) HU193949B (it)
IE (1) IE58338B1 (it)
IT (1) IT1183483B (it)
LU (1) LU85796A1 (it)
MX (1) MX9203177A (it)
MY (1) MY102240A (it)
NL (1) NL8500628A (it)
PT (1) PT80058B (it)
SE (1) SE462429B (it)
SG (1) SG35590G (it)
ZA (1) ZA851486B (it)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US4826844A (en) * 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
HU208690B (en) * 1987-10-26 1993-12-28 Pfizer Process for producing 1-hjeterocyclic sulfonyl-3-(pyrimidinyl piperazinyl)-propane derivatives and pharmaceutical compositions comprising same
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
CA2015033C (en) * 1989-04-22 2000-06-06 American Home Products Corporation Tertiary alkyl functionalized piperazine derivatives
US5055470A (en) * 1989-06-01 1991-10-08 Bristol-Myers Squibb Co. Method of treatment of ischemia in brain
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5646281A (en) 1990-12-28 1997-07-08 Neurogen Corporation Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
US5512584A (en) * 1991-04-16 1996-04-30 Basf Aktiengesellschaft 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
IL103499A0 (en) * 1991-10-24 1993-03-15 Bristol Myers Squibb Co Pharmaceutical compositions for treating anxiety in benzodiazepine withdrawn patients
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
RU2124511C1 (ru) * 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
CA2187542C (en) * 1994-04-18 2000-02-01 Nobuyuki Takahashi Adamantane derivative, process for producing the same, and use thereof
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
ES2104509B1 (es) * 1995-06-13 1998-07-01 Ferrer Int Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
KR101451799B1 (ko) * 2007-05-14 2014-10-16 에스케이바이오팜 주식회사 신규 카바모일옥시 아릴알칸 아릴피페라진계 화합물, 이를함유하는 약제학적 조성물 및 상기 화합물 투여에 의한통증, 불안증 및 우울증 치료 방법
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
US20230190870A1 (en) 2020-05-20 2023-06-22 The Board Of Trustees Of The University Of Illinois Method for Treating Lysosomal Storage Diseases with Histatin Peptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL249827A (it) * 1959-03-26
US2973360A (en) * 1959-10-12 1961-02-28 Paul A J Janssen Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
NL127996C (it) * 1963-11-19
GB1259685A (en) * 1969-04-03 1972-01-12 Soc D Etudes Prod Chimique Amino-pyrimidine derivatives
BE758380A (fr) * 1969-11-04 1971-04-16 Sumitomo Chemical Co Procede de preparation de derives d'aryl-cetones
GB1307256A (en) * 1970-09-15 1973-02-14 Science Union & Cie Piperazine derivatives and a process for their preparation
BE882836A (fr) * 1979-05-15 1980-08-18 Soc D Etudes Prod Chimique Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique
US4316899A (en) * 1979-08-24 1982-02-23 Beecham Group Limited Chromanone derivatives, a process for their preparation and compositions containing them
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
AU3944985A (en) 1985-09-12
GR850561B (it) 1985-07-03
FI850850L (fi) 1985-09-07
GB2155925A (en) 1985-10-02
NL8500628A (nl) 1985-10-01
DK100685D0 (da) 1985-03-05
GB2155925B (en) 1987-11-25
BE901880A (fr) 1985-09-05
FI84478C (fi) 1991-12-10
SE8501067L (sv) 1985-09-07
ATA64985A (de) 1990-01-15
MX9203177A (es) 1992-07-01
AT390951B (de) 1990-07-25
HK82890A (en) 1990-10-19
ZA851486B (en) 1985-11-27
DK100685A (da) 1985-09-07
SE8501067D0 (sv) 1985-03-05
ES540901A0 (es) 1986-05-16
KR850006402A (ko) 1985-10-05
HU193949B (en) 1987-12-28
MY102240A (en) 1992-05-15
HUT37781A (en) 1986-02-28
DK166149B (da) 1993-03-15
DK166149C (da) 1993-08-09
GB8505662D0 (en) 1985-04-03
CY1545A (en) 1991-03-22
FI84478B (fi) 1991-08-30
CA1256871A (en) 1989-07-04
US4605655A (en) 1986-08-12
SE462429B (sv) 1990-06-25
DE3507983A1 (de) 1985-09-12
PT80058B (pt) 1987-10-20
AU576555B2 (en) 1988-09-01
IT1183483B (it) 1987-10-22
IE58338B1 (en) 1993-09-08
CH663022A5 (de) 1987-11-13
FR2560878B1 (fr) 1988-10-14
ES8607254A1 (es) 1986-05-16
LU85796A1 (fr) 1985-12-12
SG35590G (en) 1990-07-13
KR920005114B1 (ko) 1992-06-26
FI850850A0 (fi) 1985-03-01
KR920005113B1 (ko) 1992-06-26
IE850546L (en) 1985-09-06
PT80058A (en) 1985-04-01
FR2560878A1 (fr) 1985-09-13
KR920005694B1 (ko) 1992-07-13

Similar Documents

Publication Publication Date Title
IT8519773A0 (it) Derivati di 1-fluorofenilbutil-4-(2-pirimidinil) piperazina antipsicotici.
IT1196250B (it) Derivati di 1-eteroaril-4-((2,5-pirrolidindion-1-il)alchil) piperazine
IT8521865A0 (it) Derivati di etilendiamminomonoammidi.
IT8619081A0 (it) Derivati con immidi cicliche di 2-(4-butilpiperazin-1-il)piridine antipsicotici.
IT1203608B (it) Derivati di prolina
IT7924749A0 (it) Derivati di fenil-1 piperazina.
IT8421583A0 (it) Derivati di composti a struttura catecolamminica.
IT8322629A0 (it) Derivati di benzammidi.
IT8522392A0 (it) Pantotenil derivati.
IT1206736B (it) Complesso con beta-ciclodestrina di derivati della benzensolfonilurea.
IT8619481A0 (it) Derivati eterociclici.
IT8619486A0 (it) Derivati eterociclici.
IT8424269A0 (it) Derivati della 2-arilbenzotiazolina.
IT8419778A0 (it) Derivati di benzammidi.
IT8521657A0 (it) 1-(2-pirimidinil)-piperazinilderivati di 1-pirrolidin-2-oni psicogeriatrici.
IT1216999B (it) Derivati di prolina.
IT8219457A0 (it) Impiego terapeutico di derivati (1-cinnamoil oppure 1-fenetil-carbonil)piperazinici.
IT8519442A0 (it) Derivati di fenilpropargilammine
IT8448956A0 (it) Derivati del 2-amino-tiazolo
IT1136673B (it) Derivati di 3-aril- e 3-eterociclil -2,3-diidro-1,4-benzos sazina
IT1178768B (it) Derivati di pirazolo piridina
IT8422459A0 (it) Derivati di 11-desossi-17alfa-ossicorticosterone.
IT8619485A0 (it) Derivati eterociclici.
IT8619482A0 (it) Derivati eterociclici.
IT1178772B (it) Derivati di pirazolo piridine

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970329