PT80058B - Processo para a preparacao de derivados de 1-fluorofenilbutil-4-(2-pirimidinil)-piperazina com actividade antipsicotica e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados de 1-fluorofenilbutil-4-(2-pirimidinil)-piperazina com actividade antipsicotica e de composicoes farmaceuticas que os contem

Info

Publication number
PT80058B
PT80058B PT80058A PT8005885A PT80058B PT 80058 B PT80058 B PT 80058B PT 80058 A PT80058 A PT 80058A PT 8005885 A PT8005885 A PT 8005885A PT 80058 B PT80058 B PT 80058B
Authority
PT
Portugal
Prior art keywords
pyerazine
fluorofenylbutyl
pyrimidinyl
derivatives
contain
Prior art date
Application number
PT80058A
Other languages
English (en)
Other versions
PT80058A (en
Inventor
Joseph P Yevich
Walter G Lobeck Jr
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of PT80058A publication Critical patent/PT80058A/pt
Publication of PT80058B publication Critical patent/PT80058B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Legs For Furniture In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT80058A 1984-03-06 1985-03-05 Processo para a preparacao de derivados de 1-fluorofenilbutil-4-(2-pirimidinil)-piperazina com actividade antipsicotica e de composicoes farmaceuticas que os contem PT80058B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58658084A 1984-03-06 1984-03-06
US06/683,309 US4605655A (en) 1984-03-06 1984-12-18 Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives

Publications (2)

Publication Number Publication Date
PT80058A PT80058A (en) 1985-04-01
PT80058B true PT80058B (pt) 1987-10-20

Family

ID=27079753

Family Applications (1)

Application Number Title Priority Date Filing Date
PT80058A PT80058B (pt) 1984-03-06 1985-03-05 Processo para a preparacao de derivados de 1-fluorofenilbutil-4-(2-pirimidinil)-piperazina com actividade antipsicotica e de composicoes farmaceuticas que os contem

Country Status (27)

Country Link
US (1) US4605655A (pt)
KR (3) KR920005113B1 (pt)
AT (1) AT390951B (pt)
AU (1) AU576555B2 (pt)
BE (1) BE901880A (pt)
CA (1) CA1256871A (pt)
CH (1) CH663022A5 (pt)
CY (1) CY1545A (pt)
DE (1) DE3507983A1 (pt)
DK (1) DK166149C (pt)
ES (1) ES8607254A1 (pt)
FI (1) FI84478C (pt)
FR (1) FR2560878B1 (pt)
GB (1) GB2155925B (pt)
GR (1) GR850561B (pt)
HK (1) HK82890A (pt)
HU (1) HU193949B (pt)
IE (1) IE58338B1 (pt)
IT (1) IT1183483B (pt)
LU (1) LU85796A1 (pt)
MX (1) MX9203177A (pt)
MY (1) MY102240A (pt)
NL (1) NL8500628A (pt)
PT (1) PT80058B (pt)
SE (1) SE462429B (pt)
SG (1) SG35590G (pt)
ZA (1) ZA851486B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US4826844A (en) * 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
HU206109B (en) * 1987-10-26 1992-08-28 Pfizer Process for producing heterocyclic carbonylpropyl pyrimidinyl piperazine derivatives and pharmaceutical compositions comprising same
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
PT93824B (pt) * 1989-04-22 1996-09-30 Wyeth John & Brother Ltd Processo para a preparacao de derivados de piperazina
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US5055470A (en) * 1989-06-01 1991-10-08 Bristol-Myers Squibb Co. Method of treatment of ischemia in brain
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5712392A (en) * 1990-12-28 1998-01-27 Neurogen Corporation Certain 4-piperidine- and piperazinoalkyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
US5512584A (en) * 1991-04-16 1996-04-30 Basf Aktiengesellschaft 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
CA2081062A1 (en) * 1991-10-24 1993-04-25 Frank D. Yocca Treatment of anxiety in benzodiazepine-withdrawn patients
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
CA2187542C (en) * 1994-04-18 2000-02-01 Nobuyuki Takahashi Adamantane derivative, process for producing the same, and use thereof
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
ES2104509B1 (es) * 1995-06-13 1998-07-01 Ferrer Int Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
PT2155736E (pt) * 2007-05-14 2012-03-28 Sk Biopharmaceuticals Co Ltd Novo composto carbamoiloxiarilalcanoilarilpiperazina, composições farmacêuticas compreendendo este composto e método para tratamento da dor, ansiedade e depressão pela administração do composto
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
US20230190870A1 (en) 2020-05-20 2023-06-22 The Board Of Trustees Of The University Of Illinois Method for Treating Lysosomal Storage Diseases with Histatin Peptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2973360A (en) * 1959-10-12 1961-02-28 Paul A J Janssen Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
NL127996C (pt) * 1963-11-19
GB1259685A (en) * 1969-04-03 1972-01-12 Soc D Etudes Prod Chimique Amino-pyrimidine derivatives
BE758380A (fr) * 1969-11-04 1971-04-16 Sumitomo Chemical Co Procede de preparation de derives d'aryl-cetones
GB1307256A (en) * 1970-09-15 1973-02-14 Science Union & Cie Piperazine derivatives and a process for their preparation
BE882836A (fr) * 1979-05-15 1980-08-18 Soc D Etudes Prod Chimique Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique
US4316899A (en) * 1979-08-24 1982-02-23 Beecham Group Limited Chromanone derivatives, a process for their preparation and compositions containing them
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
AU3944985A (en) 1985-09-12
SE462429B (sv) 1990-06-25
BE901880A (fr) 1985-09-05
HU193949B (en) 1987-12-28
LU85796A1 (fr) 1985-12-12
KR920005114B1 (ko) 1992-06-26
KR850006402A (ko) 1985-10-05
GB2155925B (en) 1987-11-25
HUT37781A (en) 1986-02-28
HK82890A (en) 1990-10-19
FR2560878B1 (fr) 1988-10-14
DK100685A (da) 1985-09-07
AU576555B2 (en) 1988-09-01
SE8501067D0 (sv) 1985-03-05
ZA851486B (en) 1985-11-27
DE3507983A1 (de) 1985-09-12
DK166149C (da) 1993-08-09
FI850850L (fi) 1985-09-07
AT390951B (de) 1990-07-25
CH663022A5 (de) 1987-11-13
FR2560878A1 (fr) 1985-09-13
KR920005694B1 (ko) 1992-07-13
US4605655A (en) 1986-08-12
MX9203177A (es) 1992-07-01
SG35590G (en) 1990-07-13
ATA64985A (de) 1990-01-15
IT8519773A0 (it) 1985-03-05
MY102240A (en) 1992-05-15
IE850546L (en) 1985-09-06
FI850850A0 (fi) 1985-03-01
GR850561B (pt) 1985-07-03
CY1545A (en) 1991-03-22
IE58338B1 (en) 1993-09-08
KR920005113B1 (ko) 1992-06-26
SE8501067L (sv) 1985-09-07
NL8500628A (nl) 1985-10-01
FI84478C (fi) 1991-12-10
GB8505662D0 (en) 1985-04-03
GB2155925A (en) 1985-10-02
DK100685D0 (da) 1985-03-05
PT80058A (en) 1985-04-01
ES8607254A1 (es) 1986-05-16
CA1256871A (en) 1989-07-04
FI84478B (fi) 1991-08-30
IT1183483B (it) 1987-10-22
ES540901A0 (es) 1986-05-16
DK166149B (da) 1993-03-15

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