BE901880A - Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine. - Google Patents

Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine.

Info

Publication number
BE901880A
BE901880A BE0/214607A BE214607A BE901880A BE 901880 A BE901880 A BE 901880A BE 0/214607 A BE0/214607 A BE 0/214607A BE 214607 A BE214607 A BE 214607A BE 901880 A BE901880 A BE 901880A
Authority
BE
Belgium
Prior art keywords
fluorophenylbutyl
pyrimidinyl
piperazine
derivatives
antipsychotic
Prior art date
Application number
BE0/214607A
Other languages
English (en)
Inventor
J P Yevich
W G Lobeck Jr
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE901880A publication Critical patent/BE901880A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Legs For Furniture In General (AREA)

Abstract

Dérivés N,N-disubstitués de la pipérazine de formule I, où X représente >C = O,>C(OCH2)2 ou >C(R) OH, R étant un atome de H, un radical alcoyle en C1-4 ou fluorophényle; Y représente un atome de halogène ou hydrogène et Z représente un atome de hydrogène ou un alkoxyinférieur. Ces composés ont des propriétés psychotropes, en particulier antipsychotiques atypiques.
BE0/214607A 1984-03-06 1985-03-05 Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine. BE901880A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58658084A 1984-03-06 1984-03-06
US06/683,309 US4605655A (en) 1984-03-06 1984-12-18 Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives

Publications (1)

Publication Number Publication Date
BE901880A true BE901880A (fr) 1985-09-05

Family

ID=27079753

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214607A BE901880A (fr) 1984-03-06 1985-03-05 Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine.

Country Status (27)

Country Link
US (1) US4605655A (fr)
KR (3) KR920005113B1 (fr)
AT (1) AT390951B (fr)
AU (1) AU576555B2 (fr)
BE (1) BE901880A (fr)
CA (1) CA1256871A (fr)
CH (1) CH663022A5 (fr)
CY (1) CY1545A (fr)
DE (1) DE3507983A1 (fr)
DK (1) DK166149C (fr)
ES (1) ES8607254A1 (fr)
FI (1) FI84478C (fr)
FR (1) FR2560878B1 (fr)
GB (1) GB2155925B (fr)
GR (1) GR850561B (fr)
HK (1) HK82890A (fr)
HU (1) HU193949B (fr)
IE (1) IE58338B1 (fr)
IT (1) IT1183483B (fr)
LU (1) LU85796A1 (fr)
MX (1) MX9203177A (fr)
MY (1) MY102240A (fr)
NL (1) NL8500628A (fr)
PT (1) PT80058B (fr)
SE (1) SE462429B (fr)
SG (1) SG35590G (fr)
ZA (1) ZA851486B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US4826844A (en) * 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
HU208690B (en) * 1987-10-26 1993-12-28 Pfizer Process for producing 1-hjeterocyclic sulfonyl-3-(pyrimidinyl piperazinyl)-propane derivatives and pharmaceutical compositions comprising same
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
ATE187718T1 (de) * 1989-04-22 2000-01-15 American Home Prod Tertiäre alkyl funktionalisierte piperazin- derivate
US5055470A (en) * 1989-06-01 1991-10-08 Bristol-Myers Squibb Co. Method of treatment of ischemia in brain
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5712392A (en) 1990-12-28 1998-01-27 Neurogen Corporation Certain 4-piperidine- and piperazinoalkyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5512584A (en) * 1991-04-16 1996-04-30 Basf Aktiengesellschaft 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
TW217382B (fr) * 1991-10-24 1993-12-11 Bristol Myers Squibb Co
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
CA2187542C (fr) * 1994-04-18 2000-02-01 Nobuyuki Takahashi Derive d'adamantane, procede de production et utilisation dudit derive
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
ES2104509B1 (es) * 1995-06-13 1998-07-01 Ferrer Int Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
WO2008140198A1 (fr) * 2007-05-14 2008-11-20 Sk Holdings Co., Ltd. Nouveau composé carbamoyloxy arylalcanoyl arylpipérazine, compositions pharmaceutiques comprenant ce composé et méthode de traitement de la douleur, de l'anxiété et de la dépression comprenant l'administration de ce composé
CA2891122C (fr) 2012-11-14 2021-07-20 The Johns Hopkins University Methodes et compositions pour le traitement de la schizophrenie
JP2023526515A (ja) 2020-05-20 2023-06-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ リソソーム蓄積症をヒスタチンペプチドで処置するための方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
US2973360A (en) * 1959-10-12 1961-02-28 Paul A J Janssen Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
NL127996C (fr) * 1963-11-19
GB1259685A (en) * 1969-04-03 1972-01-12 Soc D Etudes Prod Chimique Amino-pyrimidine derivatives
BE758380A (fr) * 1969-11-04 1971-04-16 Sumitomo Chemical Co Procede de preparation de derives d'aryl-cetones
GB1307256A (en) * 1970-09-15 1973-02-14 Science Union & Cie Piperazine derivatives and a process for their preparation
BE882836A (fr) * 1979-05-15 1980-08-18 Soc D Etudes Prod Chimique Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique
US4316899A (en) * 1979-08-24 1982-02-23 Beecham Group Limited Chromanone derivatives, a process for their preparation and compositions containing them
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
FI850850A0 (fi) 1985-03-01
SE462429B (sv) 1990-06-25
IT1183483B (it) 1987-10-22
CA1256871A (fr) 1989-07-04
MX9203177A (es) 1992-07-01
DE3507983A1 (de) 1985-09-12
HU193949B (en) 1987-12-28
FR2560878B1 (fr) 1988-10-14
FR2560878A1 (fr) 1985-09-13
DK100685A (da) 1985-09-07
HUT37781A (en) 1986-02-28
IE850546L (en) 1985-09-06
KR850006402A (ko) 1985-10-05
US4605655A (en) 1986-08-12
ES8607254A1 (es) 1986-05-16
KR920005113B1 (ko) 1992-06-26
LU85796A1 (fr) 1985-12-12
DK166149B (da) 1993-03-15
GB8505662D0 (en) 1985-04-03
AU576555B2 (en) 1988-09-01
KR920005114B1 (ko) 1992-06-26
SG35590G (en) 1990-07-13
IE58338B1 (en) 1993-09-08
DK166149C (da) 1993-08-09
FI850850L (fi) 1985-09-07
FI84478C (fi) 1991-12-10
IT8519773A0 (it) 1985-03-05
ZA851486B (en) 1985-11-27
NL8500628A (nl) 1985-10-01
FI84478B (fi) 1991-08-30
GB2155925B (en) 1987-11-25
AT390951B (de) 1990-07-25
SE8501067D0 (sv) 1985-03-05
SE8501067L (sv) 1985-09-07
GB2155925A (en) 1985-10-02
ATA64985A (de) 1990-01-15
PT80058B (pt) 1987-10-20
MY102240A (en) 1992-05-15
KR920005694B1 (ko) 1992-07-13
CH663022A5 (de) 1987-11-13
PT80058A (en) 1985-04-01
CY1545A (en) 1991-03-22
GR850561B (fr) 1985-07-03
HK82890A (en) 1990-10-19
ES540901A0 (es) 1986-05-16
AU3944985A (en) 1985-09-12
DK100685D0 (da) 1985-03-05

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BRISTOL-MYERS CY

Effective date: 20050305

RE20 Patent expired

Owner name: *BRISTOL-MYERS CY

Effective date: 20050305