ES8604128A1 - Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida - Google Patents

Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida

Info

Publication number
ES8604128A1
ES8604128A1 ES544526A ES544526A ES8604128A1 ES 8604128 A1 ES8604128 A1 ES 8604128A1 ES 544526 A ES544526 A ES 544526A ES 544526 A ES544526 A ES 544526A ES 8604128 A1 ES8604128 A1 ES 8604128A1
Authority
ES
Spain
Prior art keywords
derivatives
halo
trifluoromethyl
benzenesulfonamido
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544526A
Other languages
English (en)
Other versions
ES544526A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8604128A1 publication Critical patent/ES8604128A1/es
Publication of ES544526A0 publication Critical patent/ES544526A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENCENOSULFONAMIDA, DE FORMULA (I), EN LA QUE R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE X E Y SON DIFERENTES Y REPRESENTAN LOS GRUPOS NH2 O NCO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EMPLEANDO CANTIDADES EQUIMOLECULARES DE LAS DOS SUSTANCIAS REACCIONANTES, EN UN DISOLVENTE ORGANICO, APROTICO, INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y LA DE EBULLICION DE LA MEZCLA DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE NEOPLASMAS SUSCEPTIBLES.-
ES544526A 1984-06-27 1985-06-25 Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida Expired ES8604128A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62528084A 1984-06-27 1984-06-27

Publications (2)

Publication Number Publication Date
ES8604128A1 true ES8604128A1 (es) 1986-01-16
ES544526A0 ES544526A0 (es) 1986-01-16

Family

ID=24505356

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544526A Expired ES8604128A1 (es) 1984-06-27 1985-06-25 Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida

Country Status (19)

Country Link
US (1) US4845128A (es)
EP (1) EP0166615B1 (es)
JP (1) JPH0714881B2 (es)
KR (1) KR870000741B1 (es)
CN (1) CN1006548B (es)
AR (1) AR240916A1 (es)
AT (1) ATE89733T1 (es)
AU (1) AU571706B2 (es)
CA (1) CA1291163C (es)
DE (1) DE3587359T2 (es)
DK (1) DK288785A (es)
ES (1) ES8604128A1 (es)
GR (1) GR851538B (es)
HU (1) HU197298B (es)
IL (1) IL75616A0 (es)
NZ (1) NZ212521A (es)
PH (1) PH22825A (es)
PT (1) PT80708B (es)
ZA (1) ZA854744B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260338A (en) * 1984-06-27 1993-11-09 Eli Lilly And Company Anti-tumor method and compounds
US5110830A (en) * 1984-06-27 1992-05-05 Eli Lilly And Company Benzenesulfonamides treatment of tumors susceptible to
IL80032A (en) * 1985-09-23 1992-07-15 Lilly Co Eli Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them
US5116874A (en) * 1985-09-23 1992-05-26 Eli Lilly And Company Anti-tumor method and compounds
IL98784A0 (en) * 1990-07-17 1992-07-15 Lilly Co Eli Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them
US5216026A (en) * 1990-07-17 1993-06-01 Eli Lilly And Company Antitumor compositions and methods of treatment
EP0493642A1 (en) * 1991-01-02 1992-07-08 Takeo Dr. Takayanagi Novel sulfonyl derivatives
US5254589A (en) * 1991-10-15 1993-10-19 Warner-Lambert Company Sulfonyl urea and carbamate ACAT inhibitors
US5262440A (en) * 1991-12-10 1993-11-16 Eli Lilly And Company Antitumor compositions and methods of treatment
US5258406A (en) * 1991-12-20 1993-11-02 Eli Lilly And Company Sulfonimidamides
US5234955A (en) * 1991-12-20 1993-08-10 Eli Lilly And Company Antitumor compositions and methods of treatment
US5254582A (en) * 1992-02-05 1993-10-19 Eli Lilly And Company Antitumor compositions and methods
US5169860A (en) * 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
US5387681A (en) * 1992-08-19 1995-02-07 Eli Lilly And Company Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides and sulfonamides
US5270329A (en) * 1992-12-10 1993-12-14 Eli Lilly And Company Antitumor compositions and methods of treatment
CA2110524A1 (en) * 1992-12-10 1994-06-11 Gerald Burr Grindey Antitumor compositions and methods of treatment
US5529999A (en) * 1994-03-04 1996-06-25 Eli Lilly And Company Antitumor compositions and methods of treatment
JP3025860U (ja) * 1995-09-18 1996-06-25 将一 川▲崎▼ 野良猫回避板
CA2263353C (en) * 1996-08-22 2002-04-23 Dong Wha Pharm. Ind. Co., Ltd. Arylsulfonylimidazolone derivatives as an antitumor agent
WO1998014440A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment
CA2267852A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment
US6174921B1 (en) 1997-10-02 2001-01-16 Eli Lilly And Company Antitumor compositions and methods of treatment
DK1401806T3 (da) * 2001-06-06 2006-11-27 Lilly Co Eli Benzoylsulfonamider og sulfonylbenzamidiner til anvendelse som antitumormidler
AU2003224917A1 (en) * 2002-04-11 2003-10-27 Carbomer Diabetes imaging probes
WO2011009059A2 (en) * 2009-07-17 2011-01-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of treating or preventing cancer
CN114761379A (zh) * 2019-11-28 2022-07-15 三菱化学株式会社 显色剂及热敏记录材料

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1144259B (de) * 1956-05-29 1963-02-28 Hoechst Ag Verfahren zur Herstellung von Sulfonylharnstoffen
US3097241A (en) * 1956-08-10 1963-07-09 Hoechst Ag Nu-cyclohexane-sulphonyl-n'-(beta-phenylethyl)-urea
DE1159937B (de) * 1960-06-29 1963-12-27 Heyden Chem Fab Verfahren zur Herstellung von Hydrindensulfonylharnstoffen
US3097242A (en) * 1960-06-29 1963-07-09 Olin Mathieson Hydrindene sulfonylureas
DE1240866B (de) * 1961-06-29 1967-05-24 Heyden Chem Fab Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen
US3849110A (en) * 1963-01-07 1974-11-19 Lilly Co Eli Herbicidal method employing aryl-sulfonylureas or salts thereof
US3736122A (en) * 1969-04-10 1973-05-29 C Tung Method of controlling plant growth
US4276290A (en) * 1977-10-10 1981-06-30 Rohm And Haas Company Phosphonoureide and phosphonothioureide anthelmintics
US4634465A (en) * 1982-07-16 1987-01-06 Ciba-Geigy Corporation Fused N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'triazinylureas
IT1161220B (it) * 1983-04-21 1987-03-18 Montedison Spa Diidro-benzofurano derivati ad attivita' erbicida
CA1208561A (en) * 1984-01-19 1986-07-29 Marius S. Brouwer Pharmaceutical compositions containing benzoylurea compounds
IL80032A (en) * 1985-09-23 1992-07-15 Lilly Co Eli Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0166615A3 (en) 1990-03-21
CA1291163C (en) 1991-10-22
DK288785A (da) 1985-12-28
CN1006548B (zh) 1990-01-24
ZA854744B (en) 1987-02-25
EP0166615A2 (en) 1986-01-02
EP0166615B1 (en) 1993-05-26
DK288785D0 (da) 1985-06-26
PH22825A (en) 1989-01-19
KR870000741B1 (ko) 1987-04-13
CN85104893A (zh) 1987-01-07
PT80708A (en) 1985-07-01
NZ212521A (en) 1989-02-24
IL75616A0 (en) 1985-10-31
HUT38093A (en) 1986-04-28
PT80708B (pt) 1987-10-20
ATE89733T1 (de) 1993-06-15
KR860000253A (ko) 1986-01-27
JPH0714881B2 (ja) 1995-02-22
JPS6118754A (ja) 1986-01-27
AU571706B2 (en) 1988-04-21
AR240916A2 (es) 1991-03-27
AR240916A1 (es) 1991-03-27
US4845128A (en) 1989-07-04
ES544526A0 (es) 1986-01-16
AU4419285A (en) 1986-01-02
DE3587359D1 (de) 1993-07-01
HU197298B (en) 1989-03-28
DE3587359T2 (de) 1993-11-04
GR851538B (es) 1985-11-25

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