ES486349A1 - Procedimiento para la preparacion de 5-(2-imidazolin-2-il)- aminopirimidinas - Google Patents

Procedimiento para la preparacion de 5-(2-imidazolin-2-il)- aminopirimidinas

Info

Publication number
ES486349A1
ES486349A1 ES486349A ES486349A ES486349A1 ES 486349 A1 ES486349 A1 ES 486349A1 ES 486349 A ES486349 A ES 486349A ES 486349 A ES486349 A ES 486349A ES 486349 A1 ES486349 A1 ES 486349A1
Authority
ES
Spain
Prior art keywords
hydrogen
carbon atoms
present
aminopyrimidines
substituted aminopyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES486349A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2849537A external-priority patent/DE2849537C2/de
Priority claimed from DE19792937023 external-priority patent/DE2937023A1/de
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of ES486349A1 publication Critical patent/ES486349A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de 5-(2-imidazolin-2-il)- aminopirimidinas substituidas, de la fórmula general (I) **(Fórmula)** en la que R1, R2 y R3, que pueden ser iguales o diferentes, significan un átomo de hidrógeno o de halógeno, un grupo de alcoxilo, alquiltio o alquilo con 1 a 4 átomos de carbono o un grupo de cicloalquilo con 3 a 5 átomos de carbono, y R4 significa un átomo de hidrógeno o un grupo de acilo alifático o aromático, así como sus sales de adición de ácido compatibles fisiológicamente.
ES486349A 1978-11-15 1979-11-14 Procedimiento para la preparacion de 5-(2-imidazolin-2-il)- aminopirimidinas Expired ES486349A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2849537A DE2849537C2 (de) 1978-11-15 1978-11-15 Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE19792937023 DE2937023A1 (de) 1979-09-13 1979-09-13 Neue substituierte 5-(2-imidazolin-2-yl)-aminopyrimidine und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES486349A1 true ES486349A1 (es) 1980-06-16

Family

ID=25776489

Family Applications (1)

Application Number Title Priority Date Filing Date
ES486349A Expired ES486349A1 (es) 1978-11-15 1979-11-14 Procedimiento para la preparacion de 5-(2-imidazolin-2-il)- aminopirimidinas

Country Status (12)

Country Link
US (1) US4323570A (es)
AT (1) AT374197B (es)
AU (1) AU541305B1 (es)
CA (1) CA1138454A (es)
CH (1) CH642965A5 (es)
DK (1) DK150142C (es)
ES (1) ES486349A1 (es)
FR (1) FR2441625A1 (es)
GB (1) GB2039275B (es)
IT (1) IT1127225B (es)
NL (2) NL190553C (es)
SE (1) SE440079B (es)

Families Citing this family (51)

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GB2146986B (en) * 1983-09-23 1987-06-17 Lilly Co Eli Process for preparing 5-substituted pyrimidines
DE3729299A1 (de) * 1987-09-02 1989-03-23 Beiersdorf Ag Transdermales therapeutisches system
DE3739779A1 (de) * 1987-11-24 1989-06-08 Beiersdorf Ag Pharmazeutische praeparate
DE3904795C2 (de) * 1989-02-17 2000-10-12 Lilly Pharma Produktion Gmbh & Pharmazeutisches Präparat und dessen Verwendung
US5972948A (en) * 1994-07-01 1999-10-26 Solvay Pharmaceuticals Gmbh Method of inhibiting hyperglycemia and pharmaceutical composition for use therein
DE4423177A1 (de) * 1994-07-01 1996-01-04 Kali Chemie Pharma Gmbh Antihyperglykämisch wirksame Arzneimittel
US5977121A (en) * 1995-02-28 1999-11-02 Eli Lilly And Company Use of moxonidine for the treatment of atherosclerosis
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
CA2182851A1 (en) * 1995-08-15 1997-02-16 August Masaru Watanabe Method for treating substance abuse withdrawal
EP0914128A1 (en) * 1996-06-06 1999-05-12 Eli Lilly And Company Formulation and method for treating congestive heart failure
ZA981029B (en) * 1997-02-11 1999-08-10 Lilly Co Eli Pharmaceutical agents.
DE19722322A1 (de) * 1997-05-28 1998-12-03 Solvay Pharm Gmbh Nephroprotektives Arzneimittel
AU9302298A (en) * 1997-09-03 1999-03-22 Eli Lilly And Company Pyrimidine derivatives
DE19911371A1 (de) 1999-03-15 2000-09-21 Solvay Pharm Gmbh Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen
EP1517688A2 (de) * 2002-06-19 2005-03-30 Solvay Pharmaceuticals GmbH Arzneimittel zur behandlung von eine inhibition oder aktivitätsverminderung von ph-wert-regulierenden bikarbonat-transporter-proteinen erfordernden erkrangungen
EP1981498A2 (en) * 2006-01-27 2008-10-22 F. Hoffmann-la Roche AG Use of 2-imidazoles for the treatment of cns disorders
ATE411310T1 (de) * 2006-06-26 2008-10-15 Chemagis Ltd Reinigungsverfahren von moxonidine
EP1894926A1 (en) * 2006-06-26 2008-03-05 Chemagis Ltd. Polymorphs of moxonidine and processes for preparation therefor
EP1982983B1 (en) 2006-06-26 2011-08-17 Chemagis Ltd. Improved process for producing moxonidine
WO2008020425A1 (en) * 2006-08-17 2008-02-21 Chemagis Ltd. Crystalline moxonidine comprising single tautomer and preparation process therefor
EP1894927B1 (en) * 2006-08-31 2010-11-10 Chemagis Ltd. The use of moxonidine salts for purification of moxonidine
CA2666762C (en) * 2006-10-19 2014-12-30 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
WO2008046756A1 (en) * 2006-10-19 2008-04-24 F. Hoffmann-La Roche Ag Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
EP2086959B1 (en) * 2006-11-02 2011-11-16 F. Hoffmann-La Roche AG Substituted 2-imidazoles as modulators of the trace amine associated receptors
MX2009005047A (es) * 2006-11-16 2009-05-25 Hoffmann La Roche 4-imidazoles sustituidos.
WO2008073125A1 (en) * 2006-12-12 2008-06-19 Chemagis Ltd. Moxonidine analogs, preparation processes and uses therefor
MX2009005920A (es) * 2006-12-13 2009-06-16 Hoffmann La Roche Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina.
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
MX2009008255A (es) * 2007-02-02 2009-08-12 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos taar1.
KR101222412B1 (ko) * 2007-02-15 2013-01-15 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
CN101687812A (zh) 2007-07-02 2010-03-31 弗·哈夫曼-拉罗切有限公司 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物
WO2009003867A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
WO2009016048A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
CN101765425A (zh) * 2007-08-02 2010-06-30 弗·哈夫曼-拉罗切有限公司 苯甲酰胺衍生物用于治疗cns障碍的用途
BRPI0814758A2 (pt) * 2007-08-03 2015-03-03 Hoffmann La Roche Piridinacarboxamida e derivados de benzamida como ligantes taar1
CN102083805A (zh) * 2008-07-24 2011-06-01 弗·哈夫曼-拉罗切有限公司 4,5-二氢-唑-2-基衍生物
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
EP2586779A1 (en) 2011-10-24 2013-05-01 Hetero Research Foundation Process for the preparation of moxonidine
DE102012215896A1 (de) * 2012-09-07 2014-03-13 Wörwag Pharma GmbH & Co.KG Moxonidinsynthese mit Hilfe organischer Basen
EP2738165B1 (en) 2012-12-03 2016-10-12 WÖRWAG PHARMA GmbH & Co. KG Method by means of phase transfer catalysis
EP2765131B1 (en) 2013-02-08 2016-11-23 Arevipharma GmbH Process for the production of Moxonidine
EP2970214A1 (en) * 2013-03-14 2016-01-20 Farmak, A.S. Improved process for the manufacture of moxonidine
EP2829540A1 (en) 2013-07-26 2015-01-28 Abbott Healthcare Products B.V. Synthesis of substituted aminopyridines
EP3492106B1 (en) 2013-08-09 2021-02-17 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP6814814B2 (ja) 2016-03-17 2021-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｔａａｒのアゴニストとしての活性を有する５−エチル−４−メチル−ピラゾール−３−カルボキサミド誘導体
EP4243826A1 (en) 2020-11-12 2023-09-20 3Z Ehf Novel treatments of attention deficit/hyperactivity disorder
GB202103400D0 (en) * 2021-03-11 2021-04-28 3Z Ehf Novel treatments

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (fr) 1969-08-14 1971-02-15 Beecham Group Ltd Iminazolines
GB1319840A (en) * 1970-08-27 1973-06-13 Beecham Group Ltd Substituted 5-amino imidazoles
BE795636A (fr) * 1972-02-19 1973-08-20 Schering Ag Nitroimidazolylpyrimidines, et leur procede de preparation
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
DE2220906A1 (de) * 1972-04-28 1973-11-15 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung
BE503170A (es) * 1975-09-02

Also Published As

Publication number Publication date
IT1127225B (it) 1986-05-21
NL7908192A (nl) 1980-05-19
GB2039275A (en) 1980-08-06
AU541305B1 (en) 1985-01-03
AT374197B (de) 1984-03-26
NL940011I2 (nl) 1998-05-06
FR2441625A1 (fr) 1980-06-13
GB2039275B (en) 1982-11-17
ATA727079A (de) 1983-08-15
CA1138454A (en) 1982-12-28
CH642965A5 (de) 1984-05-15
DK150142C (da) 1987-06-01
SE440079B (sv) 1985-07-15
NL190553C (nl) 1994-04-18
NL190553B (nl) 1993-11-16
SE7909392L (sv) 1980-05-16
US4323570A (en) 1982-04-06
IT7927284A0 (it) 1979-11-14
FR2441625B1 (es) 1981-12-31
DK481879A (da) 1980-05-16
DK150142B (da) 1986-12-15
NL940011I1 (nl) 1994-08-01

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