AT374197B - Verfahren zur herstellung von neuen substituierten 5-(2-imidazolin-2-yl)-aminopyrimidinen und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen substituierten 5-(2-imidazolin-2-yl)-aminopyrimidinen und deren saeureadditionssalzen

Info

Publication number
AT374197B
AT374197B AT0727079A AT727079A AT374197B AT 374197 B AT374197 B AT 374197B AT 0727079 A AT0727079 A AT 0727079A AT 727079 A AT727079 A AT 727079A AT 374197 B AT374197 B AT 374197B
Authority
AT
Austria
Prior art keywords
aminopyrimidines
imidazolin
acid addition
addition salts
producing new
Prior art date
Application number
AT0727079A
Other languages
English (en)
Other versions
ATA727079A (de
Inventor
Wolfgang Dr Stenzel
Erich Dr Cohnen
Wolfgang Dr Fleck
Ben Dr Armah
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2849537A external-priority patent/DE2849537C2/de
Priority claimed from DE19792937023 external-priority patent/DE2937023A1/de
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of ATA727079A publication Critical patent/ATA727079A/de
Application granted granted Critical
Publication of AT374197B publication Critical patent/AT374197B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
AT0727079A 1978-11-15 1979-11-14 Verfahren zur herstellung von neuen substituierten 5-(2-imidazolin-2-yl)-aminopyrimidinen und deren saeureadditionssalzen AT374197B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2849537A DE2849537C2 (de) 1978-11-15 1978-11-15 Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE19792937023 DE2937023A1 (de) 1979-09-13 1979-09-13 Neue substituierte 5-(2-imidazolin-2-yl)-aminopyrimidine und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ATA727079A ATA727079A (de) 1983-08-15
AT374197B true AT374197B (de) 1984-03-26

Family

ID=25776489

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0727079A AT374197B (de) 1978-11-15 1979-11-14 Verfahren zur herstellung von neuen substituierten 5-(2-imidazolin-2-yl)-aminopyrimidinen und deren saeureadditionssalzen

Country Status (12)

Country Link
US (1) US4323570A (de)
AT (1) AT374197B (de)
AU (1) AU541305B1 (de)
CA (1) CA1138454A (de)
CH (1) CH642965A5 (de)
DK (1) DK150142C (de)
ES (1) ES486349A1 (de)
FR (1) FR2441625A1 (de)
GB (1) GB2039275B (de)
IT (1) IT1127225B (de)
NL (2) NL190553C (de)
SE (1) SE440079B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139477A3 (de) * 1983-09-23 1985-11-21 Eli Lilly And Company Verfahren zur Herstellung 5-substituierter Pyrimidine
DE3729299A1 (de) * 1987-09-02 1989-03-23 Beiersdorf Ag Transdermales therapeutisches system
DE3739779A1 (de) * 1987-11-24 1989-06-08 Beiersdorf Ag Pharmazeutische praeparate
DE3904795C2 (de) * 1989-02-17 2000-10-12 Lilly Pharma Produktion Gmbh & Pharmazeutisches Präparat und dessen Verwendung
US5972948A (en) * 1994-07-01 1999-10-26 Solvay Pharmaceuticals Gmbh Method of inhibiting hyperglycemia and pharmaceutical composition for use therein
DE4423177A1 (de) * 1994-07-01 1996-01-04 Kali Chemie Pharma Gmbh Antihyperglykämisch wirksame Arzneimittel
JPH11501020A (ja) * 1995-02-28 1999-01-26 バイエルスドルフ リリー ゲゼルシャフト ミット ベシュレンクテル ハフツング アテローム性動脈硬化症を治療するためのモキソニジンの使用
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
CA2182851A1 (en) * 1995-08-15 1997-02-16 August Masaru Watanabe Method for treating substance abuse withdrawal
BR9709546A (pt) * 1996-06-06 1999-08-10 Lilly Co Eli Formulação e método para tratamento de insuficiéncia cardíaca digestiva
ZA981029B (en) * 1997-02-11 1999-08-10 Lilly Co Eli Pharmaceutical agents.
DE19722322A1 (de) * 1997-05-28 1998-12-03 Solvay Pharm Gmbh Nephroprotektives Arzneimittel
CA2269971A1 (en) * 1997-09-03 1999-03-11 Trent Lee Abraham Pyrimidine derivatives
DE19911371A1 (de) 1999-03-15 2000-09-21 Solvay Pharm Gmbh Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen
WO2004000312A2 (de) * 2002-06-19 2003-12-31 Solvay Pharmaceuticals Gmbh Arzneimittel zur behandlung von eine inhibition oder aktivitätsverminderung von ph-wert-regulierenden bikarbonat-transporter-proteinen erfordernden erkrangungen
CA2637292A1 (en) * 2006-01-27 2007-08-16 F. Hoffmann-La Roche Ag Use of 2-imidazoles for the treatment of cns disorders
EP1894926A1 (de) * 2006-06-26 2008-03-05 Chemagis Ltd. Polymorphe von Moxonidine und Verfahren zu deren Herstellung
DK1873152T3 (da) * 2006-06-26 2009-02-09 Chemagis Ltd Hidtil ukendt fremgangsmåde til oprensning af Moxonidin
ATE520685T1 (de) * 2006-06-26 2011-09-15 Chemagis Ltd Verbessertes verfahren zur herstellung von moxonidin
EP2054391A4 (de) * 2006-08-17 2009-08-26 Chemagis Ltd Ein einzelnes tautomer enthaltendes, kristallines moxonidin und verfahren zu dessen herstellung
ATE487712T1 (de) * 2006-08-31 2010-11-15 Chemagis Ltd Verwendung der monoxidinssalze zur reinigung von monoxidin
BRPI0717939A2 (pt) * 2006-10-19 2013-12-03 Hoffmann La Roche Aminometil-4-imidazóis
KR101172940B1 (ko) * 2006-10-19 2012-08-10 에프. 호프만-라 로슈 아게 트레이스 아민 관련 수용체에 대해 친화도를 갖는 아미노메틸-2-이미다졸
AU2007316257A1 (en) * 2006-11-02 2008-05-08 F. Hoffmann-La Roche Ag Substituted 2-imidazoles as modulators of the trace amine associated receptors
AU2007321376A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
WO2008073125A1 (en) * 2006-12-12 2008-06-19 Chemagis Ltd. Moxonidine analogs, preparation processes and uses therefor
ATE509628T1 (de) * 2006-12-13 2011-06-15 Hoffmann La Roche Neue 2-imidazole als liganden für trace amine associated receptors (taar)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
BRPI0806940A2 (pt) * 2007-02-02 2014-05-06 Hoffmann La Roche 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc
CN101616902B (zh) * 2007-02-15 2013-03-27 弗·哈夫曼-拉罗切有限公司 作为taar1配体的2-氨基*唑啉类化合物
MX2009013742A (es) 2007-07-02 2010-01-26 Hoffmann La Roche 2-imidazolinas.
CA2691704A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
AU2008281918A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
JP2010535172A (ja) * 2007-08-02 2010-11-18 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のためのベンズアミド誘導体の使用
JP5341084B2 (ja) * 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
PE20110215A1 (es) * 2008-07-24 2011-03-31 Hoffmann La Roche Derivados de 4,5-dihidro-oxazol-2-ilo
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
EP2586779A1 (de) 2011-10-24 2013-05-01 Hetero Research Foundation Verfahren zur Herstellung von Moxonidine
DE102012215896A1 (de) 2012-09-07 2014-03-13 Wörwag Pharma GmbH & Co.KG Moxonidinsynthese mit Hilfe organischer Basen
ES2608004T3 (es) 2012-12-03 2017-04-05 WÖRWAG PHARMA GmbH & Co. KG Método mediante catálisis por transferencia de fase
EP2765131B1 (de) 2013-02-08 2016-11-23 Arevipharma GmbH Verfahren zur Herstellung von Moxonidin
CN105121431A (zh) * 2013-03-14 2015-12-02 法尔马克有限公司 用于制造莫索尼定的改进方法
EP2829540A1 (de) 2013-07-26 2015-01-28 Abbott Healthcare Products B.V. Synthese von substituierten Aminopyridinen
EP3030252B1 (de) 2013-08-09 2018-11-07 Ardelyx, Inc. Verbindungen und verfahren zur hemmung eines phosphattransports
RS60825B1 (sr) 2016-03-17 2020-10-30 Hoffmann La Roche Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a
WO2022101435A1 (en) 2020-11-12 2022-05-19 3Z Ehf Novel treatments of attention deficit/hyperactivity disorder

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (fr) 1969-08-14 1971-02-15 Beecham Group Ltd Iminazolines
GB1319840A (en) * 1970-08-27 1973-06-13 Beecham Group Ltd Substituted 5-amino imidazoles
BE795636A (fr) * 1972-02-19 1973-08-20 Schering Ag Nitroimidazolylpyrimidines, et leur procede de preparation
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
DE2220906A1 (de) * 1972-04-28 1973-11-15 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung
BE503170A (de) * 1975-09-02

Also Published As

Publication number Publication date
DK150142C (da) 1987-06-01
ATA727079A (de) 1983-08-15
FR2441625A1 (fr) 1980-06-13
IT1127225B (it) 1986-05-21
DK150142B (da) 1986-12-15
CH642965A5 (de) 1984-05-15
NL190553C (nl) 1994-04-18
GB2039275A (en) 1980-08-06
CA1138454A (en) 1982-12-28
NL940011I2 (nl) 1998-05-06
NL7908192A (nl) 1980-05-19
SE7909392L (sv) 1980-05-16
DK481879A (da) 1980-05-16
IT7927284A0 (it) 1979-11-14
FR2441625B1 (de) 1981-12-31
AU541305B1 (en) 1985-01-03
NL190553B (nl) 1993-11-16
GB2039275B (en) 1982-11-17
NL940011I1 (nl) 1994-08-01
ES486349A1 (es) 1980-06-16
US4323570A (en) 1982-04-06
SE440079B (sv) 1985-07-15

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Legal Events

Date Code Title Description
EIH Change in the person of patent owner
EFA Change in the company name
SZA Application filed for a certificate of protection

Free format text: SZ06/94, 940829

EZF Grant of a certificate of protection

Free format text: SZ 6/94, 940829, EXPIRES:20060815

EZF Grant of a certificate of protection

Free format text: SZ 6/1994, 19940829, EXPIRES:20060815

ELA Expired due to lapse of time