MX2009003801A - Aminometil-4-imidazoles. - Google Patents
Aminometil-4-imidazoles.Info
- Publication number
- MX2009003801A MX2009003801A MX2009003801A MX2009003801A MX2009003801A MX 2009003801 A MX2009003801 A MX 2009003801A MX 2009003801 A MX2009003801 A MX 2009003801A MX 2009003801 A MX2009003801 A MX 2009003801A MX 2009003801 A MX2009003801 A MX 2009003801A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- halogen
- aryl
- disorders
- optionally substituted
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 229910052736 halogen Inorganic materials 0.000 abstract 11
- 150000002367 halogens Chemical group 0.000 abstract 11
- -1 2,2-difluoro-benzo[1,3]dioxol-5-yl Chemical group 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000017164 Chronobiology disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 abstract 1
- 230000027288 circadian rhythm Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 238000005265 energy consumption Methods 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000013632 homeostatic process Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007257 malfunction Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000007958 sleep Effects 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con los compuestos de de fórmula (I) en donde R1 es hidrógeno, alquilo inferior, -(CR2)n-OH, -(CH2)n-aril o -(CH2)n-heteroaril, que están sustituidos opcionalmente por halógeno, alcoxi inferior o alquilo inferior sustituido por halógeno, o es -(CR2)n-cicloalquil, opcionalmente sustituido por hidroxi, -(CH2)n-heterociclil, -(CH2)n-NH-S(O)2CH3 o es -(CR2)nO-alquilo inferior o alquilo inferior sustituido por halógeno; R es hidrógeno o alquilo inferior, y cuando están presentes dos grupos R, pueden ser iguales o no; R2 es 2,2-dioxo-2,3- dihidro-1H-benzo[c]tiofenjl, 6,7-dihidro-5H- ciclopentapirimidin-2-ilo, 2,2-difluor-benzo[l,3]d ioxol-5-il, 2,2,3,3-tetrafluor-2,3-dihidro-benzo[1,4]dioxin-6-il, o es arilo o heteroarilo, opcionalmente sustituido por uno o más sustituyentes, elegidos entre el grupo formado por halógeno, alquilo inferior, cicloalquil-C3-7, -(CH2)n-hidroxi, alquilo inferior sustituido por halógeno, alcoxi-C1-7 sustituido por halógeno, -S(O)2-alquilo inferior, -(CH2)n-S(O)2-NH-alquilo inferior, -(CH2)n-O-alquilo inferior, nitro, amino, ciano, -NHC(O)-alquilo inferior, -C(O)NH-alquilo inferior u O-tetrahidro-naftalenil, o están sustituidos por -(CH2)n-aril opcionalmente sustituido por halógeno, o por -CH=CH-aril opcionalmente sustituido por halógeno, o por-(CH2)n-O-aril opcionalmente sustituido por halógeno, alcoxi inferior o alquilo inferior sustituido por halógeno, o por -O-(CH2)n- arilo opcionalmente sustituido por halógeno, o por -(CH2)n- heteroaril, o por -(CH2)n-O-heteroaril o por -(CH2)n-heterociclil opcionalmente sustituido por =O, o por -(CH2)n-O- heterociclil opcionalmente sustituido por alquilo inferior, o por -S-aril, -CH(OH)-aril, -C(CH3)2-aril, -NR-aril, o por 2-oxo-2H-piridin-1-jl ; R3 es hidrógeno o alquilo inferior; R4 es hidrógeno o alquilo inferior; n es 0, 1, 2, 3 ó 4; y sus sales farmacéuticamente activas para el tratamiento de depresión, trastornos de ansiedad, trastorno bipolar, trastorno de hiperactividad con déficit de atención (ADHD), trastornos relacionados con el estrés, trastornos psicóticos tal como esquizofrenia, enfermedades neurológicas tal como enfermedad de Parkinson, trastornos neurodegenerativos tal como enfermedad de Alzheimer, epilepsia, migraña, hipertensión, abuso de sustancias y trastornos metabólicos como son los trastornos alimenticios, diabetes, complicaciones diabéticas, obesidad, dislipidemia, trastornos de consumo y asimilación de energía, trastornos y la disfunción de la temperatura corporal, homeostasis, trastornos del sueño y ritmo circadiano y trastornos cardiovasculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06122586 | 2006-10-19 | ||
PCT/EP2007/060666 WO2008046757A1 (en) | 2006-10-19 | 2007-10-09 | Aminomethyl-4-imidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003801A true MX2009003801A (es) | 2009-04-22 |
Family
ID=38876376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003801A MX2009003801A (es) | 2006-10-19 | 2007-10-09 | Aminometil-4-imidazoles. |
Country Status (20)
Country | Link |
---|---|
US (1) | US8586617B2 (es) |
EP (1) | EP2076497B1 (es) |
JP (2) | JP5335681B2 (es) |
KR (1) | KR101176699B1 (es) |
CN (1) | CN101528710B (es) |
AR (1) | AR063327A1 (es) |
AT (1) | ATE546437T1 (es) |
AU (1) | AU2007312390B2 (es) |
BR (1) | BRPI0717939A2 (es) |
CA (1) | CA2666762C (es) |
CL (1) | CL2007002971A1 (es) |
ES (1) | ES2381589T3 (es) |
IL (1) | IL197877A (es) |
MX (1) | MX2009003801A (es) |
NO (1) | NO20091478L (es) |
PE (1) | PE20080889A1 (es) |
RU (1) | RU2009112496A (es) |
TW (1) | TW200833685A (es) |
WO (1) | WO2008046757A1 (es) |
ZA (1) | ZA200902278B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009003939A (es) * | 2006-10-19 | 2009-05-11 | Hoffmann La Roche | Derivados de imidazolona e imidazolidinona como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 para diabetes. |
AU2007312390B2 (en) * | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
EP2562161A1 (en) | 2008-01-22 | 2013-02-27 | Dow AgroSciences LLC | 5-fluoro pyrimidine derivatives as fungicides |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
CN104521977A (zh) * | 2008-08-01 | 2015-04-22 | 陶氏益农公司 | 5-氟胞嘧啶作为杀真菌剂的用途 |
US8933227B2 (en) * | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
JP5539518B2 (ja) | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2−アミノ−5−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
EP2576540B1 (en) * | 2010-05-26 | 2019-09-04 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
KR101651208B1 (ko) | 2014-02-19 | 2016-08-26 | 충북대학교 산학협력단 | 클로로겐산 유도체 화합물 및 이를 유효성분으로 포함하는 항염증 및 피부미백용 조성물 |
US20190263818A1 (en) * | 2015-07-01 | 2019-08-29 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
WO2017132912A1 (zh) * | 2016-02-03 | 2017-08-10 | 华东理工大学 | 苯并脂肪环取代烷基胺类化合物及其用途 |
BR112018015389B1 (pt) | 2016-03-17 | 2023-12-19 | F. Hoffmann-La Roche Ag | Derivado de 5-etil-4-metil-pirazol-3-carboxamida, seu processo de fabricação, preparação farmacêutica oral e uso |
WO2017190050A1 (en) * | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
JP2019517524A (ja) * | 2016-06-02 | 2019-06-24 | パーデュー ファーマ エルピー | 疼痛治療のための微量アミン関連受容体1アゴニスト及び部分アゴニスト |
WO2023033681A1 (en) | 2021-09-01 | 2023-03-09 | Limited Liability Company «Excellena Research And Development» (Llc «Excellena») | Substituted 2-(5-aryl-4 h-1,2,4-triazol-3-yl)ethanamines as modulators of trace amine-associated receptor 1 (taar1) |
WO2023033680A1 (en) | 2021-09-01 | 2023-03-09 | Limited Liability Company «Excellena Research And Development» (Llc «Excellena») | Substituted 2,3,4,5-tetrahydrobenzo[ f][1,4]oxazepines as modulators of trace amine-associated receptor 1 (taar1) |
WO2023033679A1 (en) | 2021-09-01 | 2023-03-09 | Limited Liability Company «Excellena Research And Development» (Llc «Excellena») | (azacycloalkyl)methoxy-substituted benzamides as modulators of trace amine-associated receptor 1 (taar1) |
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-
2007
- 2007-10-09 AU AU2007312390A patent/AU2007312390B2/en not_active Ceased
- 2007-10-09 CN CN2007800388091A patent/CN101528710B/zh not_active Expired - Fee Related
- 2007-10-09 ES ES07821039T patent/ES2381589T3/es active Active
- 2007-10-09 MX MX2009003801A patent/MX2009003801A/es active IP Right Grant
- 2007-10-09 EP EP07821039A patent/EP2076497B1/en not_active Not-in-force
- 2007-10-09 BR BRPI0717939-1A2A patent/BRPI0717939A2/pt not_active IP Right Cessation
- 2007-10-09 AT AT07821039T patent/ATE546437T1/de active
- 2007-10-09 RU RU2009112496/04A patent/RU2009112496A/ru not_active Application Discontinuation
- 2007-10-09 KR KR1020097007948A patent/KR101176699B1/ko not_active IP Right Cessation
- 2007-10-09 CA CA2666762A patent/CA2666762C/en not_active Expired - Fee Related
- 2007-10-09 WO PCT/EP2007/060666 patent/WO2008046757A1/en active Application Filing
- 2007-10-09 JP JP2009532767A patent/JP5335681B2/ja not_active Expired - Fee Related
- 2007-10-15 US US11/872,203 patent/US8586617B2/en not_active Expired - Fee Related
- 2007-10-17 PE PE2007001403A patent/PE20080889A1/es not_active Application Discontinuation
- 2007-10-17 CL CL200702971A patent/CL2007002971A1/es unknown
- 2007-10-17 TW TW096138932A patent/TW200833685A/zh unknown
- 2007-10-17 AR ARP070104590A patent/AR063327A1/es unknown
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- 2009-03-26 IL IL197877A patent/IL197877A/en not_active IP Right Cessation
- 2009-04-01 ZA ZA200902278A patent/ZA200902278B/xx unknown
- 2009-04-17 NO NO20091478A patent/NO20091478L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
CN101528710A (zh) | 2009-09-09 |
US8586617B2 (en) | 2013-11-19 |
WO2008046757A1 (en) | 2008-04-24 |
ES2381589T3 (es) | 2012-05-29 |
ATE546437T1 (de) | 2012-03-15 |
IL197877A (en) | 2015-07-30 |
IL197877A0 (en) | 2009-12-24 |
AU2007312390B2 (en) | 2013-03-28 |
PE20080889A1 (es) | 2008-06-27 |
EP2076497B1 (en) | 2012-02-22 |
CA2666762C (en) | 2014-12-30 |
CL2007002971A1 (es) | 2008-05-30 |
CN101528710B (zh) | 2012-11-07 |
BRPI0717939A2 (pt) | 2013-12-03 |
KR20090055035A (ko) | 2009-06-01 |
AR063327A1 (es) | 2009-01-21 |
KR101176699B1 (ko) | 2012-08-23 |
NO20091478L (no) | 2009-05-05 |
JP2013173779A (ja) | 2013-09-05 |
CA2666762A1 (en) | 2008-04-24 |
ZA200902278B (en) | 2010-03-31 |
TW200833685A (en) | 2008-08-16 |
JP5567177B2 (ja) | 2014-08-06 |
JP2010506875A (ja) | 2010-03-04 |
RU2009112496A (ru) | 2010-11-27 |
EP2076497A1 (en) | 2009-07-08 |
JP5335681B2 (ja) | 2013-11-06 |
AU2007312390A1 (en) | 2008-04-24 |
US20080119535A1 (en) | 2008-05-22 |
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