DE69823868T2 - Substituierte imidazole derivate mit agonistischähnlicher wirkung auf die alpha 2b oder 2b/2c adrenergischen rezeptoren - Google Patents

Substituierte imidazole derivate mit agonistischähnlicher wirkung auf die alpha 2b oder 2b/2c adrenergischen rezeptoren Download PDF

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Publication number
DE69823868T2
DE69823868T2 DE69823868T DE69823868T DE69823868T2 DE 69823868 T2 DE69823868 T2 DE 69823868T2 DE 69823868 T DE69823868 T DE 69823868T DE 69823868 T DE69823868 T DE 69823868T DE 69823868 T2 DE69823868 T2 DE 69823868T2
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Prior art keywords
alpha
adrenergic receptors
imidazole derivatives
substituted imidazole
agonistic effect
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Expired - Fee Related
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DE69823868T
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DE69823868D1 (de
Inventor
Ken Chow
W Gil
A Burke
A Harcourt
E Garst
A Wheeler
A Munk
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Allergan Inc
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Allergan Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D495/04—Ortho-condensed systems

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  • Ophthalmology & Optometry (AREA)
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  • Pulmonology (AREA)
  • Endocrinology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69823868T 1997-12-04 1998-12-03 Substituierte imidazole derivate mit agonistischähnlicher wirkung auf die alpha 2b oder 2b/2c adrenergischen rezeptoren Expired - Fee Related DE69823868T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98534797A 1997-12-04 1997-12-04
PCT/US1998/025669 WO1999028300A1 (en) 1997-12-04 1998-12-03 Substituted imidazole derivatives having agonist-like activity at alpha 2b or 2b/2c adrenergic receptors

Publications (2)

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DE69823868D1 DE69823868D1 (de) 2004-06-17
DE69823868T2 true DE69823868T2 (de) 2005-04-21

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DE69823868T Expired - Fee Related DE69823868T2 (de) 1997-12-04 1998-12-03 Substituierte imidazole derivate mit agonistischähnlicher wirkung auf die alpha 2b oder 2b/2c adrenergischen rezeptoren

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EP (2) EP1036065B1 (de)
JP (3) JP4783502B2 (de)
KR (1) KR100544787B1 (de)
CN (1) CN1284066A (de)
AR (1) AR017807A1 (de)
AT (1) ATE266643T1 (de)
AU (1) AU744798B2 (de)
BR (1) BR9813381A (de)
CA (1) CA2312334A1 (de)
DE (1) DE69823868T2 (de)
DK (1) DK1036065T3 (de)
ES (1) ES2216339T3 (de)
HU (1) HUP0004557A3 (de)
IL (2) IL136388A0 (de)
NO (2) NO317292B1 (de)
NZ (1) NZ504667A (de)
PL (1) PL341009A1 (de)
PT (1) PT1036065E (de)
RU (1) RU2235092C2 (de)
SK (1) SK8542000A3 (de)
TW (1) TW577878B (de)
WO (1) WO1999028300A1 (de)

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US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
JP2006036636A (ja) * 2000-11-22 2006-02-09 Nippon Shinyaku Co Ltd 消化管機能障害治療剤及びスクリーニング方法
HUP0500201A2 (hu) 2002-04-03 2005-07-28 Orion Corp. Policiklusos vegyületek, mint potenciális alfa2-adrenoceptor antagonisták és ezeket tartalmazó gyógyszerkészítmények
AU2003235310A1 (en) * 2002-04-22 2003-11-03 Takeda Chemical Industries, Ltd. Novel screening method
US7323485B2 (en) 2002-05-21 2008-01-29 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7345065B2 (en) * 2002-05-21 2008-03-18 Allergan, Inc. Methods and compositions for alleviating pain
US7091232B2 (en) 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7276522B2 (en) 2002-05-21 2007-10-02 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7358269B2 (en) 2002-05-21 2008-04-15 Allergan, Inc. 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
KR20050056235A (ko) * 2002-10-08 2005-06-14 알러간, 인코포레이티드 (2-이미다졸린-2-일아미노)퀴녹살린을 사용하여 치매 및파킨슨병을 처치하는 방법
JP4724421B2 (ja) * 2002-10-08 2011-07-13 アラーガン、インコーポレイテッド 神経変性を処置するためのα２Ｂまたは２Ｂ／２Ｃアドレナリン受容体アゴニスト
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SI1796664T1 (sl) 2004-09-20 2014-02-28 Janssen Pharmaceutica N.V. Novi tetraciklični derivati, ki vsebujejo heteroatome, in so uporabni kot modulatorji receptorja spolnega steoidnega hormona
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KR100544787B1 (ko) 2006-01-23
IL136388A0 (en) 2001-06-14
CN1284066A (zh) 2001-02-14
AU1802599A (en) 1999-06-16
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DE69823868D1 (de) 2004-06-17
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IL136388A (en) 2006-12-31
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CA2312334A1 (en) 1999-06-10
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