HUP0500201A2 - Policiklusos vegyületek, mint potenciális alfa2-adrenoceptor antagonisták és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Policiklusos vegyületek, mint potenciális alfa2-adrenoceptor antagonisták és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0500201A2 HUP0500201A2 HU0500201A HUP0500201A HUP0500201A2 HU P0500201 A2 HUP0500201 A2 HU P0500201A2 HU 0500201 A HU0500201 A HU 0500201A HU P0500201 A HUP0500201 A HU P0500201A HU P0500201 A2 HUP0500201 A2 HU P0500201A2
- Authority
- HU
- Hungary
- Prior art keywords
- alpha2
- antagonists
- compounds
- pharmaceutical compositions
- polycyclic compounds
- Prior art date
Links
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 3
- 125000003367 polycyclic group Chemical group 0.000 title abstract 2
- 102000015006 alpha2-adrenergic receptor activity proteins Human genes 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000003389 potentiating effect Effects 0.000 title 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000000670 adrenergic alpha-2 receptor antagonist Substances 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Secondary Cells (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A találmány tárgya policiklusos vegyületek, mint hatásos alfa2-adrenoceptor antagonisták. A vegyületek az (I) általános képletteljellemezhetők, ahol X jelentése -CR2R'2, O, S vagy NR2; Z jelentése -CHR8-(CH2)n- vagy vegyértékvonal; R1-R10 és R15 jelentése különbözőszubsztitunsek, R16 jelentése hidrogénatom vagy 1-6 szénatomosalkilcsoport, n értéke 0-2 vagy gyógyászatilagszatilag elfogadható sóivagy észterei. A vegyületek alfa2-antagonistaként használhatók, ésalkalmasak olyan központi idegrendszeri betegségek vagy állapotokkezelésére, ahol az alfa2-adrenoreceptorok antagonistái hatásosnakbizonyulnak. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36934702P | 2002-04-03 | 2002-04-03 | |
FI20020642A FI20020642A0 (fi) | 2002-04-03 | 2002-04-03 | Polysykliset yhdisteet tehokkaina alfa2-adrenoseptoriantagonisteina |
PCT/FI2003/000255 WO2003082866A1 (en) | 2002-04-03 | 2003-04-03 | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0500201A2 true HUP0500201A2 (hu) | 2005-07-28 |
Family
ID=28676457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500201A HUP0500201A2 (hu) | 2002-04-03 | 2003-04-03 | Policiklusos vegyületek, mint potenciális alfa2-adrenoceptor antagonisták és ezeket tartalmazó gyógyszerkészítmények |
Country Status (20)
Country | Link |
---|---|
US (1) | US7592350B2 (hu) |
EP (1) | EP1490361B1 (hu) |
JP (1) | JP2005522468A (hu) |
CN (1) | CN100372845C (hu) |
AT (1) | ATE374773T1 (hu) |
AU (1) | AU2003216760A1 (hu) |
BR (1) | BR0309028A (hu) |
CA (1) | CA2480695A1 (hu) |
DE (1) | DE60316672T2 (hu) |
EA (1) | EA008537B1 (hu) |
HK (1) | HK1075660A1 (hu) |
HR (1) | HRP20041026A2 (hu) |
HU (1) | HUP0500201A2 (hu) |
IL (1) | IL164203A0 (hu) |
IS (1) | IS7482A (hu) |
MX (1) | MXPA04009601A (hu) |
NZ (1) | NZ535950A (hu) |
PL (1) | PL372657A1 (hu) |
RS (1) | RS87204A (hu) |
WO (1) | WO2003082866A1 (hu) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
WO2009105776A1 (en) * | 2008-02-21 | 2009-08-27 | Sequoia Pharmaceuticals, Inc. | Diamide inhibitors of cytochrome p450 |
TW201024282A (en) | 2008-11-20 | 2010-07-01 | Orion Corp | New pharmaceutical compounds |
JP5791612B2 (ja) * | 2009-09-23 | 2015-10-07 | メディベイション テクノロジーズ, インコーポレイテッド | ピリド[3,4−b]インドールおよび使用方法 |
GB2503187A (en) * | 2011-09-15 | 2013-12-25 | Univ Sussex | Composition for use in the treatment of neurodevelopmental disorders |
TWI704145B (zh) | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
CN107286158A (zh) * | 2016-03-30 | 2017-10-24 | 中国科学院上海药物研究所 | 苯基[a]吲哚[2,3-g]并喹嗪类化合物、其制备方法、药物组合物及其应用 |
EP3478676A1 (en) | 2016-06-29 | 2019-05-08 | Orion Corporation | Benzodioxane derivatives and their pharmaceutical use |
US11083714B2 (en) | 2018-03-31 | 2021-08-10 | Molecular International Research, Inc. | Selective anti-cancer agent effective for prevention and treatment |
CN110922412A (zh) * | 2018-09-20 | 2020-03-27 | 复旦大学 | 具有抗精神病作用药物化合物的不对称合成方法 |
EP3860996A4 (en) | 2018-10-02 | 2022-08-31 | Northwestern University | BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C) |
US20220218677A1 (en) | 2019-05-09 | 2022-07-14 | Bayer Aktiengesellschaft | Arylquinoziline derivatives as alpha2-adrenoceptor subtype c (alpha-2c) antagonists for the treatment of sleep apnea |
CA3139298A1 (en) | 2019-05-09 | 2020-11-12 | Bayer Aktiengesellschaft | Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
CN111116578B (zh) * | 2019-12-26 | 2021-06-04 | 深圳市老年医学研究所 | 去亚甲基小檗碱的制备方法及其应用 |
IL299652A (en) | 2020-07-06 | 2023-03-01 | Bayer Ag | Combination of an alpha 2-adrenoceptor subtype C antagonist (ALPHA-2C) with a TASK1/3 channel blocker for the treatment of sleep apnea |
CN112457314A (zh) * | 2020-11-19 | 2021-03-09 | 烟台大学 | 手性吲哚并吲哚里西啶类化合物及其制备方法 |
TW202342011A (zh) | 2021-12-22 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α2-腎上腺素受體亞型C(α-2C)拮抗劑與蕈毒鹼受體拮抗劑之組合 |
TW202342033A (zh) | 2021-12-22 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α2-腎上腺素受體亞型C(α-2C)拮抗劑與正腎上腺素再吸收抑制劑之組合 |
WO2023131638A1 (en) | 2022-01-07 | 2023-07-13 | Bayer Aktiengesellschaft | 2,3-dihydrobenzo [b][1, 4]dioxin-2-ylmethyl)piperazin-1-yl derivates for the treatment of sleep apnea |
WO2023131640A1 (en) | 2022-01-07 | 2023-07-13 | Bayer Aktiengesellschaft | α2-ADRENOCEPTOR SUBTYPE C ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1209650A (fr) | 1957-09-12 | 1960-03-02 | Hoffmann La Roche | Procédé pour la préparation de dérivés d'indolo-quinolizines |
GB844342A (en) | 1958-04-24 | 1960-08-10 | Roche Products Ltd | Novel quinolizine derivatives and a process for the manufacture thereof |
GB983848A (en) | 1960-03-12 | 1965-02-17 | Philips Nv | Improvements in or relating to indoloquinolizine compounds |
FR1524953A (fr) | 1962-03-26 | 1968-05-17 | Konink Pharmaceutische Fabrike | Procédé de préparation des dérivés de la quinolizine |
GB1003645A (en) | 1962-10-09 | 1965-09-08 | Koninklijke Pharma Fab Nv | Indolo-indolizine compounds |
US3203961A (en) | 1963-03-21 | 1965-08-31 | Indolylethylpyrromdone compounds | |
US3492303A (en) | 1967-07-28 | 1970-01-27 | Warner Lambert Pharmaceutical | 1,2,3,4,4a,5,6,8,9,14,14b,14c-dodecahydrobenz(h)indolo(2,3-a)quinolizines |
GB1435573A (en) | 1973-05-25 | 1976-05-12 | Wyeth John & Brother Ltd | Indoloquinolizines |
US4044012A (en) | 1974-05-07 | 1977-08-23 | Richter Gedeon Vegyeszeti Gyar Rt. | Indolo-quinolizidine derivatives |
HU170495B (hu) | 1974-05-07 | 1977-06-28 | ||
FR2478639A1 (fr) | 1980-03-20 | 1981-09-25 | Sanofi Sa | Nouveaux derives de l'indolizino (8,7-b) indole et intermediaires, leur procede de preparation et leur utilisation en therapeutique |
GB2106909B (en) | 1981-10-07 | 1984-09-19 | Wyeth John & Brother Ltd | Benzoquinolizines |
EP0089926A3 (de) | 1982-03-24 | 1984-05-16 | Ciba-Geigy Ag | Pharmazeutische Präparate enthaltend stickstoffhaltige Tetracyclen sowie neue Verbindungen dieser Art |
HU188022B (en) | 1983-06-29 | 1986-03-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for production of derivatives of indolo /2,3-g/cyylopent /a/ indolizin |
GB2167408B (en) | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
HU194221B (en) | 1985-04-19 | 1988-01-28 | Richter Gedeon Vegyeszet | Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound |
US4710504A (en) | 1986-04-04 | 1987-12-01 | Merck & Co., Inc. | Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor |
NZ216283A (en) | 1985-06-03 | 1989-10-27 | Merck & Co Inc | Hexahydro arylquinolizine derivatives and pharmaceutical compositions |
AU582663B2 (en) | 1985-08-10 | 1989-04-06 | John Wyeth & Brother Limited | Sulphonamides |
US4686226A (en) | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
US5902807A (en) | 1997-05-12 | 1999-05-11 | Antti Haapalinna | Method for the treatment of mental illness in mammals and a composition therefor |
DK1036065T3 (da) | 1997-12-04 | 2004-08-30 | Allergan Inc | Substituerede imidazolderivater med agonistlignende aktivitet ved alfa-2B- eller 2B/2C-adrenerge receptorer |
FI20000480A0 (fi) | 2000-03-01 | 2000-03-01 | Orion Yhtymae Oyj | Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina |
-
2003
- 2003-04-03 MX MXPA04009601A patent/MXPA04009601A/es not_active Application Discontinuation
- 2003-04-03 CN CNB038084716A patent/CN100372845C/zh not_active Expired - Fee Related
- 2003-04-03 RS YU87204A patent/RS87204A/sr unknown
- 2003-04-03 EP EP03712185A patent/EP1490361B1/en not_active Expired - Lifetime
- 2003-04-03 AU AU2003216760A patent/AU2003216760A1/en not_active Abandoned
- 2003-04-03 CA CA002480695A patent/CA2480695A1/en not_active Abandoned
- 2003-04-03 HU HU0500201A patent/HUP0500201A2/hu unknown
- 2003-04-03 DE DE60316672T patent/DE60316672T2/de not_active Expired - Lifetime
- 2003-04-03 IL IL16420303A patent/IL164203A0/xx unknown
- 2003-04-03 WO PCT/FI2003/000255 patent/WO2003082866A1/en active IP Right Grant
- 2003-04-03 AT AT03712185T patent/ATE374773T1/de not_active IP Right Cessation
- 2003-04-03 BR BR0309028-0A patent/BR0309028A/pt not_active IP Right Cessation
- 2003-04-03 US US10/510,019 patent/US7592350B2/en not_active Expired - Fee Related
- 2003-04-03 NZ NZ535950A patent/NZ535950A/en unknown
- 2003-04-03 PL PL03372657A patent/PL372657A1/xx not_active Application Discontinuation
- 2003-04-03 EA EA200401301A patent/EA008537B1/ru not_active IP Right Cessation
- 2003-04-03 JP JP2003580331A patent/JP2005522468A/ja active Pending
-
2004
- 2004-10-01 IS IS7482A patent/IS7482A/is unknown
- 2004-11-02 HR HR20041026A patent/HRP20041026A2/xx not_active Application Discontinuation
-
2005
- 2005-09-05 HK HK05107766A patent/HK1075660A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE374773T1 (de) | 2007-10-15 |
EP1490361B1 (en) | 2007-10-03 |
EA008537B1 (ru) | 2007-06-29 |
EA200401301A1 (ru) | 2005-06-30 |
RS87204A (en) | 2006-10-27 |
IL164203A0 (en) | 2005-12-18 |
DE60316672D1 (de) | 2007-11-15 |
CN100372845C (zh) | 2008-03-05 |
CN1646528A (zh) | 2005-07-27 |
MXPA04009601A (es) | 2004-12-13 |
BR0309028A (pt) | 2005-02-15 |
HRP20041026A2 (en) | 2005-06-30 |
US20070293527A9 (en) | 2007-12-20 |
US7592350B2 (en) | 2009-09-22 |
US20060094740A1 (en) | 2006-05-04 |
AU2003216760A1 (en) | 2003-10-13 |
JP2005522468A (ja) | 2005-07-28 |
CA2480695A1 (en) | 2003-10-09 |
HK1075660A1 (en) | 2005-12-23 |
EP1490361A1 (en) | 2004-12-29 |
NZ535950A (en) | 2007-11-30 |
WO2003082866A1 (en) | 2003-10-09 |
PL372657A1 (en) | 2005-07-25 |
DE60316672T2 (de) | 2008-07-17 |
IS7482A (is) | 2004-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0500201A2 (hu) | Policiklusos vegyületek, mint potenciális alfa2-adrenoceptor antagonisták és ezeket tartalmazó gyógyszerkészítmények | |
HUP0102851A2 (hu) | Parazitaellenes artemizinin-származékok (endoperoxidok), eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
HUP0303756A2 (hu) | 1-Aril- vagy 1-alkilszulfonil-heterociklobenzazolok és eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények | |
HUP0400992A2 (hu) | Karbonsavval helyettesített oxazol-származékok, eljárás előállításukra és PPAR-alfa- és -gamma-aktivátorként való alkalmazásuk diabétesz kezelésére felhasználható gyógyszerek készítésére | |
HUP0303084A2 (hu) | Gyulladásgátló hatású 17béta-karbotioát-17alfa-arilkarboniloxiloxi androsztán-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
AR020727A1 (es) | Uso de compuestos derivados 3-amino-4-aril-maleimidas para la preparacion de medicamentos para condiciones asociadas a una necesidad de inhibicion de lagsk-3, dichos compuestos, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden | |
HUP0301195A2 (hu) | Alfa-4 integrin antagonista hatású aza-hidas biciklusos aminosav-származékok és ilyen vegyületeket tartalmazó gyógyszerkészítmények | |
WO2005092895A3 (en) | Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists | |
SE0104334D0 (sv) | Therapeutic agents | |
HUP9902471A2 (hu) | Piperazin- és piperidinvegyületek, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
HUP0401889A2 (hu) | 1,8-Naftiridin-származékok mint antidiabetikumok és ezeket tartalmazó gyógyszerkészítmények | |
HUP0300920A1 (hu) | Szubsztituált benzidszármazékok és gyógyszerként történő felhasználásuk | |
HUP0102425A2 (hu) | Gyomorsav-elválasztást gátló imidazo-piridin-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
HUP0301625A2 (hu) | Réztartalmú amin-oxidáz inhibitor hatású 1,3,4-oxadiazin-vegyületek, eljárás az előállításukra és alkalmazásuk gyógyszerkészítmények előállítására | |
NO20051303L (no) | Nye benzoimidazolderivater nyttige som antiproliferative midler | |
HUP0102422A2 (hu) | Rákellenes hatású izotiazolszármazékok, ilyen vegyületeket tartalmazó gyógyszerkészítmények és az előállítási eljárások | |
HUP0401009A2 (hu) | 5-Hidroxitriptamin-6-ligandumokként alkalmazható 1-aril- vagy 1- alkil-szulfonilbenzazol-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
HUP0100865A2 (hu) | Meta-azaciklusos csoporttal N-szubsztituált amino-benzoesav-vegyületek és származékaik mint integrin antagonista hatóanyagok, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk | |
TW200619212A (en) | Morpholine derivatives | |
HUP0303385A2 (hu) | Szerotonin újrafelvételt inhibeáló fenoxibenzilamin-származékok, előállítási eljárásuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
HUP0301272A2 (hu) | 4-Fenil-piridin-származékok, mint neurokinin-1-receptor antagonisták, eljárás az előállításukra és alkalmazásuk gyógyszerkészítmények előállítására | |
HUP0400682A2 (hu) | 5-Hidroxitriptamin-6-ligandumként használható heterociklilalkilindol- és -azaindol-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
EA200601194A1 (ru) | Новые производные бензофурана, используемые для профилактики или лечения нарушений, связанных с 5-ht-рецептором | |
HUP0003413A2 (hu) | Új kondenzált piridinszármazékok, eljárás előállításukra és az azokat tartalmazó gyógyászati készítmények | |
HUP0401883A2 (hu) | Muszkarin agonisták és ezeket tartalmazó gyógyászati készítmények |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |