HUP9902471A2 - Piperazin- és piperidinvegyületek, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Piperazin- és piperidinvegyületek, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP9902471A2
HUP9902471A2 HU9902471A HUP9902471A HUP9902471A2 HU P9902471 A2 HUP9902471 A2 HU P9902471A2 HU 9902471 A HU9902471 A HU 9902471A HU P9902471 A HUP9902471 A HU P9902471A HU P9902471 A2 HUP9902471 A2 HU P9902471A2
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Hungary
Prior art keywords
atom
alkyl
piperazine
piperidine compounds
atoms
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HU9902471A
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English (en)
Inventor
Roelof Willem Feenstra
Cornelis Gerrit Kruse
Wilma Kuipers
Stephen Kenneth Long
Martinus Theodorus Maria Tulp
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Duphar International Research B.V.
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Application filed by Duphar International Research B.V. filed Critical Duphar International Research B.V.
Publication of HUP9902471A2 publication Critical patent/HUP9902471A2/hu
Publication of HUP9902471A3 publication Critical patent/HUP9902471A3/hu
Publication of HU227454B1 publication Critical patent/HU227454B1/hu

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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
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    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány közpőnti idegrendszeri rendellenességek kezelésérefelhasználható új, (a) általánős képletű piperazin- éspiperidinvegyületekre -, amelyek képletében A 5-7 gyűrűatőmős, ezen belül heterőatőmként 1-3 őxigén- és/vagynitrőgén- és/vagy kénatőmőt tartalmazó heterőciklűsős csőpőrt, R1 hidrőgén- vagy flűőratőm, R2 alkil-, alkőxi- vagy őxőcsőpőrt, p 0, 1 vagy 2, Z szénatőm vagy nitrőgénatőm, és a szaggatőtt vőnal egyes kötéstjelent, ha Z jelentése nitrőgénatőm, illetve egyes vagy kettős kötéstjelent, ha Z jelentése szénatőm, R3 és R4 hidrőgénatőm vagy alkilcsőpőrt, n 1 vagy 2, R5 halőgénatőm, hidrőxi-, alkőxi- vagy alkilcsőpőrt, q 0, 1, 2 vagy 3, és Y fenil-, fűril- vagy tienilcsőpőrt, amelyek mindegyike adőtt esetben1-3, a következők közül kiválasztőtt atőmmal és/vagy csőpőrttalszűbsztitűált: hidrőxicsőpőrt, halőgénatőm, alkőxi-, alkil-, cianő-,karbamőil-, mőnő- vagy dialkil-karbamőil-csőpőrt -, előállításieljárásaikra, a vegyületeket tartalmazó gyógyszerkészítményekre, agyógyszerkészítmények előállítási eljárásaira, valamint közpőntiidegrendszeri rendellenességek kezelési eljárásaira vőnatkőzik. ŕ
HU9902471A 1996-03-29 1997-03-20 Piperazine and piperidine compounds, process for their preparation and pharmaceutical compositions containing the same HU227454B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200864 1996-03-29
PCT/EP1997/001461 WO1997036893A1 (en) 1996-03-29 1997-03-20 Piperazine and piperidine compounds

Publications (3)

Publication Number Publication Date
HUP9902471A2 true HUP9902471A2 (hu) 2000-03-28
HUP9902471A3 HUP9902471A3 (en) 2000-04-28
HU227454B1 HU227454B1 (en) 2011-06-28

Family

ID=8223832

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902471A HU227454B1 (en) 1996-03-29 1997-03-20 Piperazine and piperidine compounds, process for their preparation and pharmaceutical compositions containing the same

Country Status (25)

Country Link
US (1) US6225312B1 (hu)
EP (1) EP0889889B1 (hu)
JP (1) JP3989554B2 (hu)
CN (1) CN1100055C (hu)
AT (1) ATE340173T1 (hu)
AU (1) AU708053B2 (hu)
BR (1) BRPI9708389B8 (hu)
CA (1) CA2250347C (hu)
CZ (1) CZ294413B6 (hu)
DE (1) DE69736704T2 (hu)
DK (1) DK0889889T3 (hu)
ES (1) ES2271967T3 (hu)
HU (1) HU227454B1 (hu)
IL (1) IL126187A0 (hu)
NO (1) NO320970B1 (hu)
NZ (1) NZ331860A (hu)
PL (1) PL189256B1 (hu)
PT (1) PT889889E (hu)
RU (1) RU2178414C2 (hu)
SK (1) SK285119B6 (hu)
TR (1) TR199801942T2 (hu)
TW (1) TW422846B (hu)
UA (1) UA52656C2 (hu)
WO (1) WO1997036893A1 (hu)
ZA (1) ZA972639B (hu)

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CA2250347C (en) 2006-02-21
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CN1215400A (zh) 1999-04-28
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