HUP9802393A2 - Benzotiazolonszármazékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények, eljárás a vegyületek előállítására és intermedierjeik - Google Patents

Benzotiazolonszármazékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények, eljárás a vegyületek előállítására és intermedierjeik

Info

Publication number
HUP9802393A2
HUP9802393A2 HU9802393A HUP9802393A HUP9802393A2 HU P9802393 A2 HUP9802393 A2 HU P9802393A2 HU 9802393 A HU9802393 A HU 9802393A HU P9802393 A HUP9802393 A HU P9802393A HU P9802393 A2 HUP9802393 A2 HU P9802393A2
Authority
HU
Hungary
Prior art keywords
intermediates
preparation
pharmaceutical compositions
compositions containing
benzothiazolone derivatives
Prior art date
Application number
HU9802393A
Other languages
English (en)
Inventor
Roger Victor Bonnert
Roger Charles Brown
Peter Alan Cage
Francis Ince
Garry Pairaudeau
Original Assignee
Astra Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9518952.8A external-priority patent/GB9518952D0/en
Priority claimed from GBGB9614346.6A external-priority patent/GB9614346D0/en
Application filed by Astra Pharmaceuticals Limited filed Critical Astra Pharmaceuticals Limited
Publication of HUP9802393A2 publication Critical patent/HUP9802393A2/hu
Publication of HUP9802393A3 publication Critical patent/HUP9802393A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A találmány tárgyát az (I) általánős képletű, új, dőpamin-DA2-receptőrés 2-adrenőceptőr agőnista hatású 7-(2-aminő-etil)-benzőtiazőlőn-származékők -, ahől X -SO2-NH- vagy -NH-SO2- képletű csőpőrt, p, q és r 2 vagy 3, Y adőtt esetben alkilcsőpőrttal vagy halőgénatőmmal szűbsztitűálttienil-, fenil-tiő- vagy fenilcsőpőrt, és R hidrőgénatőm vagy alkilcsőpőrt. - és az előállításűkra szőlgáló eljárásők, ezeket tartalmazógyógyszerkészítmények, tővábbá a szintézis egyes új köztitermékeiképezik. ŕ
HU9802393A 1995-09-15 1996-09-12 Benzothiazolone derivatives, their use, pharmaceutical compositions containing them, process for the preparation thereof and intermediates HUP9802393A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9518952.8A GB9518952D0 (en) 1995-09-15 1995-09-15 Compounds
GBGB9614346.6A GB9614346D0 (en) 1996-07-10 1996-07-10 Benzothiazolone derivatives

Publications (2)

Publication Number Publication Date
HUP9802393A2 true HUP9802393A2 (hu) 1999-04-28
HUP9802393A3 HUP9802393A3 (en) 2000-01-28

Family

ID=26307771

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802393A HUP9802393A3 (en) 1995-09-15 1996-09-12 Benzothiazolone derivatives, their use, pharmaceutical compositions containing them, process for the preparation thereof and intermediates

Country Status (29)

Country Link
US (5) US5846989A (hu)
EP (1) EP0850232B1 (hu)
JP (1) JP3213327B2 (hu)
KR (1) KR19990044674A (hu)
CN (2) CN1073098C (hu)
AR (1) AR004512A1 (hu)
AT (1) ATE190610T1 (hu)
AU (1) AU706094B2 (hu)
BR (1) BR9610316A (hu)
CA (1) CA2231003A1 (hu)
CY (1) CY2227B1 (hu)
CZ (1) CZ74098A3 (hu)
DE (1) DE69607183T2 (hu)
EE (1) EE03395B1 (hu)
ES (1) ES2146901T3 (hu)
GR (1) GR3033681T3 (hu)
HK (1) HK1008781A1 (hu)
HU (1) HUP9802393A3 (hu)
IL (4) IL123639A (hu)
IS (1) IS4679A (hu)
MY (1) MY113518A (hu)
NO (1) NO310721B1 (hu)
NZ (4) NZ318007A (hu)
PL (1) PL325517A1 (hu)
PT (1) PT850232E (hu)
SK (1) SK282394B6 (hu)
TR (1) TR199800457T2 (hu)
TW (1) TW356468B (hu)
WO (1) WO1997010227A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2287617T3 (es) * 1997-10-17 2007-12-16 Ark Therapeutics Limited Utilizacion de inhibidores del sistema renina-angiotensina.
SE0004750D0 (sv) * 2000-12-19 2000-12-19 Astrazeneca Ab Novel formulation
PE20050130A1 (es) * 2002-08-09 2005-03-29 Novartis Ag Compuestos organicos
GB0218629D0 (en) * 2002-08-09 2002-09-18 Novartis Ag Organic compounds
CA2543858C (en) 2003-11-21 2014-04-15 Theravance, Inc. Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
UA94235C2 (en) * 2005-08-09 2011-04-26 Астразенека Аб Novel benzothiazolone derivatives
TW200740781A (en) * 2005-08-29 2007-11-01 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
EP2094646A1 (en) * 2006-12-20 2009-09-02 AstraZeneca AB Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
WO2009154557A1 (en) 2008-06-18 2009-12-23 Astrazeneca Ab Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders
AU2009260904A1 (en) * 2008-06-20 2009-12-23 Astrazeneca Ab Pharmaceutical composition comprising a 4-hydroxy-2-oxo-2, 3- dihydro-1, 3-benzothiazol-7-yl compound for modulation of beta2-adrenoreceptor activity

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
GB8426200D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
US4554287A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones
ES8606847A1 (es) * 1984-11-08 1986-05-16 Syntex Inc Procedimiento para la preparacion de derivados de dialquila-mino-etilanilina antihipertensos
DE3728695A1 (de) * 1987-08-25 1989-03-09 Schering Ag Neue benzimidazol-derivate
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds
GB9211172D0 (en) * 1992-05-27 1992-07-08 Fisons Plc Compounds
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines

Also Published As

Publication number Publication date
HK1008781A1 (en) 1999-05-21
NZ332397A (en) 1999-02-25
WO1997010227A1 (en) 1997-03-20
EP0850232A1 (en) 1998-07-01
IL141955A0 (en) 2002-03-10
EP0850232B1 (en) 2000-03-15
KR19990044674A (ko) 1999-06-25
DE69607183T2 (de) 2000-11-23
NZ332395A (en) 1999-02-25
SK282394B6 (sk) 2002-01-07
EE9800069A (et) 1998-10-15
BR9610316A (pt) 1999-07-06
AR004512A1 (es) 1998-12-16
US5846989A (en) 1998-12-08
IL123639A (en) 2002-04-21
ES2146901T3 (es) 2000-08-16
ATE190610T1 (de) 2000-04-15
CN1073098C (zh) 2001-10-17
MX9801963A (es) 1998-08-30
TR199800457T2 (xx) 1998-07-21
NZ332396A (en) 1999-02-25
DE69607183D1 (de) 2000-04-20
GR3033681T3 (en) 2000-10-31
HUP9802393A3 (en) 2000-01-28
CY2227B1 (en) 2003-04-18
CN1356323A (zh) 2002-07-03
JP3213327B2 (ja) 2001-10-02
AU706094B2 (en) 1999-06-10
US5977384A (en) 1999-11-02
NZ318007A (en) 1999-07-29
AU6937196A (en) 1997-04-01
EE03395B1 (et) 2001-04-16
IL141954A0 (en) 2002-03-10
NO981104L (no) 1998-05-14
TW356468B (en) 1999-04-21
PT850232E (pt) 2000-08-31
US6008365A (en) 1999-12-28
CN1202163A (zh) 1998-12-16
JPH11512422A (ja) 1999-10-26
IS4679A (is) 1998-03-04
SK29598A3 (en) 1999-01-11
IL141956A0 (en) 2002-03-10
CA2231003A1 (en) 1997-03-20
IL123639A0 (en) 1998-10-30
US6080869A (en) 2000-06-27
CZ74098A3 (cs) 1998-08-12
US5973167A (en) 1999-10-26
NO310721B1 (no) 2001-08-20
PL325517A1 (en) 1998-08-03
MY113518A (en) 2002-03-30
NO981104D0 (no) 1998-03-12

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