HUP9802487A2 - Intermedierek félszintetikus taxánokhoz és eljárás előállításukra - Google Patents

Intermedierek félszintetikus taxánokhoz és eljárás előállításukra

Info

Publication number
HUP9802487A2
HUP9802487A2 HU9802487A HUP9802487A HUP9802487A2 HU P9802487 A2 HUP9802487 A2 HU P9802487A2 HU 9802487 A HU9802487 A HU 9802487A HU P9802487 A HUP9802487 A HU P9802487A HU P9802487 A2 HUP9802487 A2 HU P9802487A2
Authority
HU
Hungary
Prior art keywords
taxanes
hemisynthesis
preparation
intermediary compounds
xazolidines
Prior art date
Application number
HU9802487A
Other languages
English (en)
Inventor
Luc Chanteloup
Bruno Chauveau
Christine Corbin
Robert Dhal
Arnaud Lamy
Sonia Le Guen
Antoine Leze
Jean-Pierre Robin
Original Assignee
Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm filed Critical Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm
Publication of HUP9802487A2 publication Critical patent/HUP9802487A2/hu
Publication of HUP9802487A3 publication Critical patent/HUP9802487A3/hu
Publication of HU225507B1 publication Critical patent/HU225507B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Abstract

A találmány tárgya félszintetikűs taxánők előállításáhőz használható(I), (IIb), (II'a), (IIIb), (III'b) és (V) általánős képletű, újintermedierek és a cisz--aril-glicidátőkból való előállításűkraszőlgáló eljárás képezi. A találmány tárgyát közelebbről őxazőlidinekvagy őxazőlidinőnők, tővábbá a baccatin III új származékai képezik. ŕ
HU9802487A 1995-10-27 1996-10-25 Intermediary compounds for hemisynthesis of taxanes and preparation of them HU225507B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9512739A FR2740451B1 (fr) 1995-10-27 1995-10-27 Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
PCT/FR1996/001676 WO1997015562A1 (fr) 1995-10-27 1996-10-25 Intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation

Publications (3)

Publication Number Publication Date
HUP9802487A2 true HUP9802487A2 (hu) 1999-09-28
HUP9802487A3 HUP9802487A3 (en) 2000-07-28
HU225507B1 HU225507B1 (en) 2007-01-29

Family

ID=9484016

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802487A HU225507B1 (en) 1995-10-27 1996-10-25 Intermediary compounds for hemisynthesis of taxanes and preparation of them

Country Status (25)

Country Link
US (5) US6265587B1 (hu)
EP (1) EP0863887B1 (hu)
JP (1) JP2000500437A (hu)
KR (1) KR100489865B1 (hu)
CN (1) CN100374428C (hu)
AT (1) ATE212342T1 (hu)
AU (1) AU710314B2 (hu)
BR (1) BR9610908A (hu)
CZ (1) CZ125598A3 (hu)
DE (1) DE69618812T2 (hu)
DK (1) DK0863887T3 (hu)
EE (1) EE03610B1 (hu)
ES (1) ES2170876T3 (hu)
FR (1) FR2740451B1 (hu)
GE (1) GEP20001938B (hu)
HU (1) HU225507B1 (hu)
IL (1) IL155876A (hu)
NO (1) NO981823D0 (hu)
NZ (1) NZ320356A (hu)
PL (1) PL327458A1 (hu)
PT (1) PT863887E (hu)
RU (1) RU2159237C2 (hu)
SK (1) SK52398A3 (hu)
TR (1) TR199800713T2 (hu)
WO (1) WO1997015562A1 (hu)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US6150537A (en) 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
KR100267596B1 (ko) * 1998-04-17 2000-10-16 강재헌 베타-아미노-알파-하이드록시산과 균등한 옥사졸린 유도체의 입체선택적 합성방법
US6143900A (en) * 1999-10-26 2000-11-07 Dong Kook Pharmaceutical Co., Ltd. Stereoselective synthesis of oxazoline derivative
ES2178539B1 (es) * 2000-03-14 2004-08-01 Dong Kook Pharmaceutical Co., Ltd. Procedimiento para la preparacion de un compuesto de oxazolina.
WO2002066448A1 (en) * 2001-02-20 2002-08-29 Dabur India Limited Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid
FR2846327B1 (fr) * 2002-10-25 2006-03-24 Merck Sante Sas Derives de n-benzodioxolyl, n-benzodioxanyl et n-benzodioxepinyl arylcarboxamides utilisables dans le traitement de dyslipidemies et compositions pharmaceutiques les contenant.
MX2007015595A (es) * 2005-06-10 2008-03-07 Univ Florida State Res Found Procesos para la produccion de compuestos de anillo fusionado policiclico.
AU2006258012B2 (en) * 2005-06-10 2011-04-07 Florida State University Research Foundation, Inc. Processes for the preparation of docetaxel
GB0701523D0 (en) * 2007-01-26 2007-03-07 Chatham Biotec Ltd Semi-synthetic process for the preparation of taxane derivatives
CN101468974B (zh) * 2007-12-28 2011-02-09 上海百灵医药科技有限公司 多烯紫杉醇的半合成方法
ES2862980T3 (es) 2009-12-30 2021-10-08 Basf Pharma Callanish Ltd Composiciones de ácido graso poliinsaturado obtenibles mediante un proceso de separación cromatográfica en lecho móvil simulado
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
CN103508918B (zh) * 2012-06-18 2015-09-09 上海医药工业研究院 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP3118186B1 (fr) 2013-12-11 2022-02-09 Novasep Process Installation chromatographique de production d acides gras polyinsatures
KR102165406B1 (ko) 2014-01-07 2020-10-14 노바셉 프로세스 방향족 아미노산의 정제 방법
JP6205530B2 (ja) * 2015-07-07 2017-09-27 忠勝 萬代 パクリタキセル及びドセタキセルの側鎖前駆体の製造方法
CN112876503B (zh) * 2021-03-18 2022-04-29 中国科学院兰州化学物理研究所 用于癌症硼中子俘获治疗药物的硼酸盐化合物及其制备
CN114195820B (zh) * 2021-12-17 2023-11-10 中山大学 异丝氨酸衍生物及其制备与在紫杉醇合成中的应用

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US5008411A (en) * 1988-05-24 1991-04-16 Hoffmann-La Roche Inc. Glycidic acid ester and process of preparation
US5274300A (en) * 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
US5304670A (en) 1989-08-23 1994-04-19 Centre National De La Recherche Scientifique Process for the enantioselective preparation of phenylisoserine derivatives
CA2023645C (fr) * 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5244803A (en) * 1989-09-13 1993-09-14 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-phenylglycidic acid esters
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
WO1993010076A1 (en) * 1991-11-22 1993-05-27 The University Of Mississippi Synthesis and optical resolution of the taxol side chain and related compounds
EP0626953A4 (en) * 1992-12-23 1995-05-03 Bristol Myers Squibb Co NEW SIDE CHAINS WEARING TAXANS AND THEIR INTERMEDIATE PRODUCTS.
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US6228955B1 (en) * 1996-04-19 2001-05-08 Chirotech Technology, Ltd. Asymmetric epoxides, their synthesis and use

Also Published As

Publication number Publication date
EP0863887A1 (fr) 1998-09-16
IL155876A (en) 2008-07-08
US7220871B2 (en) 2007-05-22
US6825365B2 (en) 2004-11-30
US7432383B2 (en) 2008-10-07
BR9610908A (pt) 1999-07-13
PT863887E (pt) 2002-07-31
NZ320356A (en) 2000-01-28
US20040220256A1 (en) 2004-11-04
US20050222089A1 (en) 2005-10-06
CN1200731A (zh) 1998-12-02
EE9800149A (et) 1998-12-15
FR2740451B1 (fr) 1998-01-16
CN100374428C (zh) 2008-03-12
JP2000500437A (ja) 2000-01-18
TR199800713T2 (xx) 1998-09-21
US7279586B2 (en) 2007-10-09
EP0863887B1 (fr) 2002-01-23
HUP9802487A3 (en) 2000-07-28
NO981823L (no) 1998-04-23
CZ125598A3 (cs) 1998-08-12
EE03610B1 (et) 2002-02-15
HU225507B1 (en) 2007-01-29
DE69618812D1 (de) 2002-03-14
DE69618812T2 (de) 2002-08-29
SK52398A3 (en) 1998-09-09
US20020068833A1 (en) 2002-06-06
GEP20001938B (en) 2000-02-05
PL327458A1 (en) 1998-12-07
ATE212342T1 (de) 2002-02-15
KR100489865B1 (ko) 2006-01-27
NO981823D0 (no) 1998-04-23
US20070208185A1 (en) 2007-09-06
AU7308696A (en) 1997-05-15
AU710314B2 (en) 1999-09-16
KR19990067124A (ko) 1999-08-16
ES2170876T3 (es) 2002-08-16
DK0863887T3 (da) 2002-04-22
RU2159237C2 (ru) 2000-11-20
WO1997015562A1 (fr) 1997-05-01
FR2740451A1 (fr) 1997-04-30
US6265587B1 (en) 2001-07-24

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